Ppp2cal1 (protein phosphatase 2 catalytic subunit alpha like 1)

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Gene: Ppp2cal1 (protein phosphatase 2 catalytic subunit alpha like 1) Rattus norvegicus

Analyze

No known orthologs.

Symbol:

Ppp2cal1 (Ensembl: LOC100362453)

Name:

protein phosphatase 2 catalytic subunit alpha like 1 (Ensembl:serine/threonine-protein phosphatase 2A catalytic subunit alpha-like)

RGD ID:

2318135

Description:

Predicted to enable metal ion binding activity and myosin phosphatase activity. Predicted to be located in cytoplasm. Orthologous to human PPP2CA (protein phosphatase 2 catalytic subunit alpha).

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC100362453; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like; serine/threonine-protein phosphatase 2A catalytic subunit alpha-like

RGD Orthologs

Alliance Genes

More Info

homologs ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Other homologs ²				less info ...
Homo sapiens (human):	PPP2CA (protein phosphatase 2 catalytic subunit alpha)	HGNC	Ensembl, OrthoDB, Panther
Homo sapiens (human):	PPP2CB (protein phosphatase 2 catalytic subunit beta)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	PPP2CA (protein phosphatase 2 catalytic subunit alpha)	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Ppp2ca (protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Danio rerio (zebrafish):	ppp2ca (protein phosphatase 2, catalytic subunit, alpha isozyme)	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	PPH21	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	let-92	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	mts	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PPH22	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Danio rerio (zebrafish):	ppp2cab	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ppp2ca	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	82,278,288 - 82,280,159 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	82,278,292 - 82,280,174 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	11	86,421,047 - 86,422,802 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	86,421,106 - 86,422,907 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	89,521,786 - 89,523,541 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	84,270,087 - 84,271,016 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Cytogenetic Map	11	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mitotic cell cycle (IBA)

Cellular Component

cytoplasm (IEA)

cytosol (IBA)

Molecular Function

metal ion binding (IEA)

myosin phosphatase activity (IEA)

protein serine/threonine phosphatase activity (IBA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

Variants in Ppp2cal1
6 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	20
Count of miRNA genes:	20
Interacting mature miRNAs:	20
Transcripts:	ENSRNOT00000002599
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	27672410	82846715	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	29528418	82566702	Rat
1300135	Rf19	Renal function QTL 19	3.38		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	11	40946188	82566702	Rat
2312566	Glom20	Glomerulus QTL 20	3.6	0.001	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	44285759	82566702	Rat
1581565	Pur10	Proteinuria QTL 10		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	44803318	82846466	Rat
1581572	Uae35	Urinary albumin excretion QTL 35		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	44803318	82846466	Rat
724561	Plsm4	Polydactyly-luxate syndrome (PLS) morphotypes QTL 4		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	11	54457534	86241447	Rat
4889521	Gluco62	Glucose level QTL 62	2.82	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	55136729	82993457	Rat
7411658	Foco27	Food consumption QTL 27	16.2	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	11	56351424	86241447	Rat
631506	Bp104	Blood pressure QTL 104	2.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	59802794	82566545	Rat
70208	Niddm22	Non-insulin dependent diabetes mellitus QTL 22	3.61		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	59802794	82566553	Rat
10058954	Gmadr7	Adrenal mass QTL 7	2.49	0.0049	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	60346590	86241447	Rat
634339	Niddm50	Non-insulin dependent diabetes mellitus QTL 50	3.32		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	66422148	86241447	Rat
1354593	Stl12	Serum triglyceride level QTL 12	3.36		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	11	66422148	86241447	Rat
1354656	Bvd3	Brain ventricular dilatation QTL 3	3.64	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	11	69446070	82846715	Rat
10450831	Scl80	Serum cholesterol level QTL 80	4.7	0.01	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	11	76957131	83051965	Rat

Markers in Region

RH127380

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	82,279,884 - 82,280,069 (+)	MAPPER	mRatBN7.2
mRatBN7.2	10	36,377,586 - 36,377,771 (+)	MAPPER	mRatBN7.2
mRatBN7.2	10	36,377,586 - 36,377,771 (-)	MAPPER	mRatBN7.2
mRatBN7.2	11	82,279,884 - 82,280,069 (-)	MAPPER	mRatBN7.2
Rnor_6.0	11	86,422,634 - 86,422,818	NCBI	Rnor6.0
Rnor_6.0	10	37,535,201 - 37,535,385	NCBI	Rnor6.0
Rnor_5.0	11	89,523,373 - 89,523,557	UniSTS	Rnor5.0
Rnor_5.0	10	37,343,708 - 37,343,892	UniSTS	Rnor5.0
RGSC_v3.4	10	37,640,731 - 37,640,915	UniSTS	RGSC3.4
RGSC_v3.4	11	84,271,502 - 84,271,686	UniSTS	RGSC3.4
Celera	11	81,056,435 - 81,056,619	UniSTS
Celera	10	35,732,660 - 35,732,844	UniSTS
Cytogenetic Map	10	q22	UniSTS

PMC22838P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	82,278,463 - 82,278,570 (+)	MAPPER	mRatBN7.2
mRatBN7.2	10	36,358,300 - 36,358,407 (+)	MAPPER	mRatBN7.2
mRatBN7.2	10	36,358,300 - 36,358,407 (-)	MAPPER	mRatBN7.2
mRatBN7.2	11	82,278,463 - 82,278,570 (-)	MAPPER	mRatBN7.2
Rnor_6.0	11	86,421,213 - 86,421,319	NCBI	Rnor6.0
Rnor_6.0	10	37,554,564 - 37,554,670	NCBI	Rnor6.0
Rnor_5.0	11	89,521,952 - 89,522,058	UniSTS	Rnor5.0
Rnor_5.0	10	37,324,424 - 37,324,530	UniSTS	Rnor5.0
RGSC_v3.4	10	37,621,447 - 37,621,553	UniSTS	RGSC3.4
RGSC_v3.4	11	84,270,081 - 84,270,187	UniSTS	RGSC3.4
Celera	11	81,056,065 - 81,056,171	UniSTS
Celera	10	35,713,345 - 35,713,451	UniSTS
Cytogenetic Map	10	q22	UniSTS

Ppp2ca

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	82,278,604 - 82,279,072 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	86,421,354 - 86,421,821	NCBI	Rnor6.0
Rnor_5.0	11	89,522,093 - 89,522,560	UniSTS	Rnor5.0
RGSC_v3.4	11	84,270,222 - 84,270,689	UniSTS	RGSC3.4
Cytogenetic Map	10	q22	UniSTS

Ppp2ca

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	36,373,858 - 36,373,905 (+)	MAPPER	mRatBN7.2
mRatBN7.2	11	82,279,039 - 82,279,090 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	86,421,789 - 86,421,839	NCBI	Rnor6.0
Rnor_5.0	11	89,522,528 - 89,522,578	UniSTS	Rnor5.0
RGSC_v3.4	11	84,270,657 - 84,270,707	UniSTS	RGSC3.4
Cytogenetic Map	10	q22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_039088980	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_595173	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACYVU010000222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000002599 ⟹ ENSRNOP00000070579

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	82,278,292 - 82,280,174 (+)	Ensembl
Rnor_6.0 Ensembl	11	86,421,106 - 86,422,907 (+)	Ensembl

RefSeq Acc Id:

XM_039088980 ⟹ XP_038944908

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	82,278,288 - 82,280,159 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_038944908	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000070579
	ENSRNOP00000070579.1
	ENSRNOP00000084457.1

RefSeq Acc Id:

ENSRNOP00000070579 ⟸ ENSRNOT00000002599

RefSeq Acc Id:	XP_038944908 ⟸ XM_039088980
- UniProtKB:	A0A0G2JYA4 (UniProtKB/TrEMBL), A0A8I5ZZ39 (UniProtKB/TrEMBL)

Protein Domains

Serine/threonine specific protein phosphatases

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2JYA4-F1-model_v2	AlphaFold	A0A0G2JYA4	1-309	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698301

Promoter ID:

EPDNEW_R8822

Type:

multiple initiation site

Name:

LOC100362453_1

Description:

serine/threonine-protein phosphatase 2A catalytic subunit alpha-like

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	86,421,041 - 86,421,101	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2318135	AgrOrtholog
BioCyc Gene	G2FUF-20670	BioCyc
Ensembl Genes	ENSRNOG00000001893	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00000005389	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000002599	ENTREZGENE
	ENSRNOT00000002599.7	UniProtKB/TrEMBL
	ENSRNOT00000101942.1	UniProtKB/TrEMBL
Gene3D-CATH	3.60.21.10	UniProtKB/TrEMBL
InterPro	Calcineurin-like_PHP_apaH	UniProtKB/TrEMBL
	Metallo-depent_PP-like	UniProtKB/TrEMBL
	PPA2-like	UniProtKB/TrEMBL
	Ser/Thr-sp_prot-phosphatase	UniProtKB/TrEMBL
NCBI Gene	100362453	ENTREZGENE
PANTHER	SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM	UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED	UniProtKB/TrEMBL
Pfam	Metallophos	UniProtKB/TrEMBL
PhenoGen	Ppp2cal1	PhenoGen
PRINTS	STPHPHTASE	UniProtKB/TrEMBL
PROSITE	SER_THR_PHOSPHATASE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001893	RatGTEx
	ENSRNOG00000005389	RatGTEx
SMART	PP2Ac	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56300	UniProtKB/TrEMBL
UniProt	A0A0G2JYA4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZZ39	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-09-19	Ppp2cal1	protein phosphatase 2 catalytic subunit alpha like 1	LOC100362453	serine/threonine-protein phosphatase 2A catalytic subunit alpha-like	Symbol and Name Changed	1299863	APPROVED
2010-05-05	LOC100362453	serine/threonine-protein phosphatase 2A catalytic subunit alpha-like			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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