Cimip2b (ciliary microtubule inner protein 2B) - Rat Genome Database

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Gene: Cimip2b (ciliary microtubule inner protein 2B) Rattus norvegicus
Analyze
Symbol: Cimip2b
Name: ciliary microtubule inner protein 2B
RGD ID: 2318060
Description: Predicted to be located in axonemal microtubule. Orthologous to human CIMIP2B (ciliary microtubule inner protein 2B); INTERACTS WITH 6-propyl-2-thiouracil; 2-hydroxypropanoic acid (ortholog); aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fam166b; family with sequence similarity 166, member B; LOC100365928; UPF0605 protein FAM166B-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,471,246 - 62,477,812 (-)NCBIGRCr8
mRatBN7.2557,675,537 - 57,680,133 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,675,462 - 57,678,611 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0558,883,064 - 58,884,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0563,407,869 - 63,408,778 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera556,257,243 - 56,260,232 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Cimip2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,471,246 - 62,477,812 (-)NCBIGRCr8
mRatBN7.2557,675,537 - 57,680,133 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,675,462 - 57,678,611 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0558,883,064 - 58,884,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0563,407,869 - 63,408,778 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera556,257,243 - 56,260,232 (-)NCBICelera
Cytogenetic Map5q22NCBI
CIMIP2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38935,561,831 - 35,563,878 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl935,561,831 - 35,563,899 (-)EnsemblGRCh38hg38GRCh38
GRCh37935,561,828 - 35,563,875 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,551,946 - 35,553,896 (-)NCBINCBI36Build 36hg18NCBI36
Celera935,495,505 - 35,497,455 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef935,517,450 - 35,519,507 (-)NCBIHuRef
CHM1_1935,561,615 - 35,563,684 (-)NCBICHM1_1
T2T-CHM13v2.0935,582,504 - 35,584,551 (-)NCBIT2T-CHM13v2.0
Cimip2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39443,427,014 - 43,431,451 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl443,427,019 - 43,429,134 (-)EnsemblGRCm39 Ensembl
GRCm38443,427,014 - 43,432,131 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl443,427,019 - 43,429,134 (-)EnsemblGRCm38mm10GRCm38
MGSCv37443,439,892 - 43,442,006 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36443,448,118 - 43,450,234 (-)NCBIMGSCv36mm8
Celera443,457,880 - 43,459,953 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map423.03NCBI
Cimip2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955472696,157 - 697,922 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955472695,955 - 698,086 (+)NCBIChiLan1.0ChiLan1.0
CIMIP2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,983,565 - 89,027,436 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,988,509 - 89,033,356 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0935,411,930 - 35,442,971 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,216,030 - 36,247,009 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,216,030 - 36,260,042 (-)Ensemblpanpan1.1panPan2
CIMIP2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,144,806 - 52,164,782 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,144,801 - 52,146,823 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1150,712,692 - 50,733,829 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01153,210,226 - 53,231,165 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,210,222 - 53,212,244 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11151,754,916 - 51,775,827 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01151,738,156 - 51,759,223 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01152,440,221 - 52,461,383 (-)NCBIUU_Cfam_GSD_1.0
Cimip2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947167,046,919 - 167,049,481 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365243,594,552 - 3,596,371 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365243,594,530 - 3,597,055 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CIMIP2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,322,897 - 236,324,981 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,322,893 - 236,325,008 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21264,047,558 - 264,050,843 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CIMIP2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,991,633 - 45,041,573 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1245,039,593 - 45,041,415 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603842,147,571 - 42,151,282 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cimip2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624915701,983 - 708,079 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cimip2b
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:82
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000072968
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat

Markers in Region
AI840675  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2557,675,184 - 57,675,383 (+)MAPPERmRatBN7.2
Rnor_6.0558,882,813 - 58,883,011NCBIRnor6.0
Rnor_5.0563,407,455 - 63,407,653UniSTSRnor5.0
Celera556,256,992 - 56,257,190UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000096323   ⟹   ENSRNOP00000090412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl557,675,462 - 57,678,611 (-)Ensembl
RefSeq Acc Id: XM_039111005   ⟹   XP_038966933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,471,246 - 62,474,426 (-)NCBI
mRatBN7.2557,675,566 - 57,678,633 (-)NCBI
RefSeq Acc Id: XM_039111006   ⟹   XP_038966934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,471,246 - 62,474,426 (-)NCBI
mRatBN7.2557,675,537 - 57,680,132 (-)NCBI
RefSeq Acc Id: XM_039111007   ⟹   XP_038966935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,471,246 - 62,474,426 (-)NCBI
mRatBN7.2557,675,566 - 57,678,633 (-)NCBI
RefSeq Acc Id: XM_039111008   ⟹   XP_038966936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,471,246 - 62,474,426 (-)NCBI
mRatBN7.2557,675,537 - 57,678,633 (-)NCBI
RefSeq Acc Id: XM_063288529   ⟹   XP_063144599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,471,246 - 62,477,810 (-)NCBI
RefSeq Acc Id: XM_063288530   ⟹   XP_063144600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,471,246 - 62,477,812 (-)NCBI
RefSeq Acc Id: XM_063288531   ⟹   XP_063144601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,471,246 - 62,477,810 (-)NCBI
RefSeq Acc Id: XM_063288532   ⟹   XP_063144602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,471,246 - 62,474,426 (-)NCBI
RefSeq Acc Id: XM_063288533   ⟹   XP_063144603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,471,246 - 62,474,426 (-)NCBI
RefSeq Acc Id: XP_038966934   ⟸   XM_039111006
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038966936   ⟸   XM_039111008
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038966935   ⟸   XM_039111007
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038966933   ⟸   XM_039111005
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000090412   ⟸   ENSRNOT00000096323
RefSeq Acc Id: XP_063144600   ⟸   XM_063288530
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063144601   ⟸   XM_063288531
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063144599   ⟸   XM_063288529
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063144602   ⟸   XM_063288532
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063144603   ⟸   XM_063288533
- Peptide Label: isoform X9
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2318060 AgrOrtholog
BioCyc Gene G2FUF-41513 BioCyc
Ensembl Genes ENSRNOG00000065204 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000096323.1 UniProtKB/TrEMBL
InterPro FAM166/UPF0605 UniProtKB/TrEMBL
NCBI Gene 100365928 ENTREZGENE
PANTHER CAT EYE SYNDROME CRITICAL REGION PROTEIN 6 UniProtKB/TrEMBL
  PROTEIN FAM166B UniProtKB/TrEMBL
Pfam DUF2475 UniProtKB/TrEMBL
PhenoGen Cimip2b PhenoGen
RatGTEx ENSRNOG00000065204 RatGTEx
UniProt A0A8I6AEA7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-05 Cimip2b  ciliary microtubule inner protein 2B  Fam166b  family with sequence similarity 166, member B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-06-02 Fam166b  family with sequence similarity 166, member B  Fam166b  family with sequence similarity 166, member B  Data merged from RGD:149736154 737654 PROVISIONAL
2021-08-09 Fam166b  family with sequence similarity 166, member B      Symbol and Name status set to provisional 45752 PROVISIONAL
2013-08-08 Fam166b  family with sequence similarity 166, member B  LOC100365928  UPF0605 protein FAM166B-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100365928  UPF0605 protein FAM166B-like      Symbol and Name status set to provisional 70820 PROVISIONAL