Cd81 (Cd81 molecule) - Rat Genome Database

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Gene: Cd81 (Cd81 molecule) Rattus norvegicus
Analyze
Symbol: Cd81
Name: Cd81 molecule
RGD ID: 2315
Description: Predicted to enable cholesterol binding activity; signaling receptor binding activity; and virus receptor activity. Involved in regulation of cell population proliferation and regulation of growth. Located in apical plasma membrane. Human ortholog(s) of this gene implicated in common variable immunodeficiency 6. Orthologous to human CD81 (CD81 molecule); PARTICIPATES IN B cell receptor signaling pathway; hepatitis C pathway; malaria pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-di-tert-butyl-4-methylphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 26 kDa cell surface protein TAPA-1; CD 81 antigen; CD81 antigen; CD81 antigen (target of antiproliferative antibody 1); Tapa1; target of the antiproliferative antibody 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Hcar4
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81207,665,274 - 207,681,094 (+)NCBIGRCr8
mRatBN7.21198,235,861 - 198,251,660 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1198,241,484 - 198,251,660 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1206,614,397 - 206,630,285 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,700,545 - 213,716,337 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01206,374,702 - 206,390,494 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01216,237,663 - 216,253,460 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1216,237,697 - 216,253,311 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01223,099,328 - 223,114,942 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41203,327,287 - 203,342,901 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11203,480,739 - 203,496,354 (+)NCBI
Celera1195,804,757 - 195,820,558 (+)NCBICelera
Cytogenetic Map1q41-q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
benzoates  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
chloropicrin  (ISO)
cisplatin  (EXP)
clobetasol  (ISO)
clotrimazole  (EXP)
cocaine  (EXP,ISO)
cyclosporin A  (ISO)
DDE  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
enniatin  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
fenthion  (ISO)
flavonoids  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
linuron  (EXP)
Mesaconitine  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
monosodium L-glutamate  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
PhIP  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
procymidone  (EXP)
pyrene  (EXP)
resveratrol  (ISO)
rotenone  (EXP,ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
triptonide  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
CD4-positive, alpha-beta T cell costimulation  (IEA,ISO,ISS)
cellular response to low-density lipoprotein particle stimulus  (ISO,ISS)
humoral immune response mediated by circulating immunoglobulin  (IEA,ISO,ISS)
immunological synapse formation  (IEA,ISO,ISS)
macrophage fusion  (IEA,ISO,ISS)
myoblast fusion involved in skeletal muscle regeneration  (ISO,ISS)
osteoclast fusion  (ISO,ISS)
positive regulation of adaptive immune memory response  (IEA,ISO)
positive regulation of B cell activation  (ISO,ISS)
positive regulation of B cell proliferation  (IEA,ISO)
positive regulation of B cell receptor signaling pathway  (IEA,ISO,ISS)
positive regulation of CD4-positive, alpha-beta T cell proliferation  (IEA,ISO,ISS)
positive regulation of inflammatory response to antigenic stimulus  (ISO,ISS)
positive regulation of MAPK cascade  (IEA,ISO,ISS)
positive regulation of protein catabolic process in the vacuole  (IEA,ISO)
positive regulation of protein exit from endoplasmic reticulum  (IEA,ISO,ISS)
positive regulation of receptor clustering  (IEA,ISO,ISS)
positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  (IEA,ISO,ISS)
positive regulation of T cell receptor signaling pathway  (IEA,ISO,ISS)
positive regulation of T-helper 2 cell cytokine production  (IEA,ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
protein localization to lysosome  (IEA,ISO)
protein localization to plasma membrane  (IEA,ISO,ISS)
receptor internalization  (ISO,ISS)
regulation of cell motility  (ISO)
regulation of cell population proliferation  (IDA)
regulation of growth  (IEP)
regulation of macrophage migration  (ISO,ISS)
regulation of protein stability  (IEA,ISO)
symbiont entry into host cell  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Tetraspanin CD81 is required for the alpha v beta5-integrin-dependent particle-binding step of RPE phagocytosis. Chang Y and Finnemann SC, J Cell Sci. 2007 Sep 1;120(Pt 17):3053-63. Epub 2007 Aug 7.
2. The major CD9 and CD81 molecular partner. Identification and characterization of the complexes. Charrin S, etal., J Biol Chem. 2001 Apr 27;276(17):14329-37. Epub 2001 Jan 18.
3. Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein. Crotta S, etal., J Exp Med 2002 Jan 7;195(1):35-41.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Retinal pigment epithelium of the rat express CD81, the target of the anti-proliferative antibody (TAPA). Geisert EE Jr, etal., Invest Ophthalmol Vis Sci 2002 Jan;43(1):274-80.
6. Astrocyte growth, reactivity, and the target of the antiproliferative antibody, TAPA. Geisert EE Jr, etal., J Neurosci 1996 Sep 1;16(17):5478-87.
7. A novel cell adhesion molecule, G-CAM, found on cultured rat glia. Geisert EE Jr, etal., Neurosci Lett 1991 Dec 9;133(2):262-6.
8. The upregulation of a glial cell surface antigen at the astrocytic scar in the rat. Irwin MH and Geisert EE Jr, Neurosci Lett 1993 May 14;154(1-2):57-60.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8409388   PMID:8766544   PMID:9360996   PMID:10400713   PMID:11046035   PMID:11673522   PMID:12565133   PMID:12796480   PMID:14676841   PMID:15908444   PMID:16449649   PMID:16557522  
PMID:17327823   PMID:17481908   PMID:18662991   PMID:19028452   PMID:19056867   PMID:19199708   PMID:19946888   PMID:20237408   PMID:20375010   PMID:20407874   PMID:20458337   PMID:21235781  
PMID:21276792   PMID:21423176   PMID:21930792   PMID:22307619   PMID:23376485   PMID:23395392   PMID:23499492   PMID:23533145   PMID:23575678   PMID:23858057   PMID:24038174   PMID:25002582  
PMID:25635054   PMID:27881302   PMID:27993971   PMID:28167787   PMID:28871089   PMID:30871575   PMID:32830152   PMID:36961378  


Genomics

Comparative Map Data
Cd81
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81207,665,274 - 207,681,094 (+)NCBIGRCr8
mRatBN7.21198,235,861 - 198,251,660 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1198,241,484 - 198,251,660 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1206,614,397 - 206,630,285 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,700,545 - 213,716,337 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01206,374,702 - 206,390,494 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01216,237,663 - 216,253,460 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1216,237,697 - 216,253,311 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01223,099,328 - 223,114,942 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41203,327,287 - 203,342,901 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11203,480,739 - 203,496,354 (+)NCBI
Celera1195,804,757 - 195,820,558 (+)NCBICelera
Cytogenetic Map1q41-q42NCBI
CD81
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,376,180 - 2,397,397 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl112,376,177 - 2,397,802 (+)EnsemblGRCh38hg38GRCh38
GRCh37112,397,410 - 2,418,627 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,355,123 - 2,375,225 (+)NCBINCBI36Build 36hg18NCBI36
Build 34112,355,315 - 2,375,202NCBI
Celera112,433,431 - 2,453,456 (+)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef112,188,870 - 2,209,001 (+)NCBIHuRef
CHM1_1112,397,498 - 2,417,522 (+)NCBICHM1_1
T2T-CHM13v2.0112,465,548 - 2,486,747 (+)NCBIT2T-CHM13v2.0
Cd81
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,606,487 - 142,621,667 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,606,476 - 142,621,671 (+)EnsemblGRCm39 Ensembl
GRCm387143,052,750 - 143,067,930 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7143,052,739 - 143,067,934 (+)EnsemblGRCm38mm10GRCm38
MGSCv377150,238,655 - 150,253,835 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367142,862,185 - 142,877,314 (+)NCBIMGSCv36mm8
Celera7142,808,354 - 142,823,535 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.1NCBI
Cd81
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542214,155,682 - 14,175,181 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542214,155,682 - 14,175,181 (+)NCBIChiLan1.0ChiLan1.0
CD81
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v294,780,374 - 4,806,793 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1113,992,792 - 4,018,491 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0112,400,503 - 2,421,132 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1112,442,322 - 2,449,308 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,437,991 - 2,449,308 (+)Ensemblpanpan1.1panPan2
CD81
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,466,484 - 46,474,236 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,466,499 - 46,473,868 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1845,067,559 - 45,083,899 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01847,137,460 - 47,153,838 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11846,585,393 - 46,601,749 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,165,925 - 46,182,254 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,912,742 - 46,929,121 (+)NCBIUU_Cfam_GSD_1.0
Cd81
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049472,718,486 - 2,727,090 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936794664,115 - 669,800 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936794664,089 - 670,294 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD81
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl21,625,736 - 1,641,663 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.121,625,728 - 1,641,662 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CD81
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112,190,896 - 2,211,838 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12,190,845 - 2,211,389 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603899,392,792 - 99,413,678 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd81
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476715,192,452 - 15,210,922 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476715,192,446 - 15,210,923 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cd81
112 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:303
Count of miRNA genes:174
Interacting mature miRNAs:202
Transcripts:ENSRNOT00000027760
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1192485903199050587Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1198211513225126682Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1197489281200611765Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
6480780Insul18Insulin level QTL 184.11blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1189607473200611765Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat

Markers in Region
RH127728  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,251,331 - 198,251,548 (+)MAPPERmRatBN7.2
Rnor_6.01216,253,132 - 216,253,348NCBIRnor6.0
Rnor_5.01223,114,763 - 223,114,979UniSTSRnor5.0
RGSC_v3.41203,342,722 - 203,342,938UniSTSRGSC3.4
Celera1195,820,230 - 195,820,446UniSTS
Cytogenetic Map1q41UniSTS
RH94618  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,251,329 - 198,251,507 (+)MAPPERmRatBN7.2
Rnor_6.01216,253,130 - 216,253,307NCBIRnor6.0
Rnor_5.01223,114,761 - 223,114,938UniSTSRnor5.0
RGSC_v3.41203,342,720 - 203,342,897UniSTSRGSC3.4
Celera1195,820,228 - 195,820,405UniSTS
Cytogenetic Map1q41UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2
Medium 3 43 57 41 19 41 8 11 74 35 39 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000027760   ⟹   ENSRNOP00000027760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1198,241,484 - 198,251,660 (+)Ensembl
Rnor_6.0 Ensembl1216,237,697 - 216,253,311 (+)Ensembl
RefSeq Acc Id: NM_013087   ⟹   NP_037219
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,665,297 - 207,681,094 (+)NCBI
mRatBN7.21198,235,861 - 198,251,660 (+)NCBI
Rnor_6.01216,237,663 - 216,253,460 (+)NCBI
Rnor_5.01223,099,328 - 223,114,942 (+)NCBI
RGSC_v3.41203,327,287 - 203,342,901 (+)RGD
Celera1195,804,757 - 195,820,558 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063282108   ⟹   XP_063138178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,665,274 - 207,681,094 (+)NCBI
Protein Sequences
Protein RefSeqs NP_037219 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138178 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53103 (Get FASTA)   NCBI Sequence Viewer  
  AAH60583 (Get FASTA)   NCBI Sequence Viewer  
  EDM12179 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027760.5
GenBank Protein Q62745 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037219   ⟸   NM_013087
- UniProtKB: Q62745 (UniProtKB/Swiss-Prot),   Q6P9V1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027760   ⟸   ENSRNOT00000027760
RefSeq Acc Id: XP_063138178   ⟸   XM_063282108
- Peptide Label: isoform X1
- UniProtKB: Q62745 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62745-F1-model_v2 AlphaFold Q62745 1-236 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690569
Promoter ID:EPDNEW_R1094
Type:multiple initiation site
Name:Cd81_1
Description:Cd81 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01216,237,698 - 216,237,758EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2315 AgrOrtholog
BioCyc Gene G2FUF-56880 BioCyc
Ensembl Genes ENSRNOG00000020451 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027760.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1450.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6918296 IMAGE-MGC_LOAD
InterPro Tetraspanin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tetraspanin/Peripherin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tetraspanin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tetraspanin_EC2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25621 UniProtKB/TrEMBL
MGC_CLONE MGC:72925 IMAGE-MGC_LOAD
NCBI Gene 25621 ENTREZGENE
PANTHER CD81 ANTIGEN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19282 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Tetraspanin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd81 PhenoGen
PIRSF Tetraspanin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TMFOUR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TM4_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020451 RatGTEx
Superfamily-SCOP SSF48652 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216937
UniProt CD81_RAT UniProtKB/Swiss-Prot
  F7EXZ2_RAT UniProtKB/TrEMBL
  Q62745 ENTREZGENE
  Q6P9V1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-29 Cd81  Cd81 molecule  Cd81  CD 81 antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Cd81  CD 81 antigen    CD81 antigen (target of antiproliferative antibody 1)  Name updated 625702 APPROVED
2002-06-10 Cd81  CD81 antigen (target of antiproliferative antibody 1)      Symbol and Name status set to approved 70586 APPROVED