MIR92B (microRNA 92b) - Rat Genome Database

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Gene: MIR92B (microRNA 92b) Homo sapiens
Analyze
Symbol: MIR92B
Name: microRNA 92b
RGD ID: 2312875
HGNC Page HGNC:32920
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in miRNA-mediated post-transcriptional gene silencing. Located in extracellular space and extracellular vesicle.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-92b; mir-92b; MIRN92B
RGD Orthologs
Mouse
Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381155,195,177 - 155,195,272 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1155,195,177 - 155,195,272 (+)EnsemblGRCh38hg38GRCh38
GRCh371155,164,968 - 155,165,063 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera1128,238,250 - 128,238,345 (+)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1126,528,072 - 126,528,167 (+)NCBIHuRef
CHM1_11156,560,475 - 156,560,570 (+)NCBICHM1_1
T2T-CHM13v2.01154,333,740 - 154,333,835 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:16505370   PMID:17604727   PMID:17616659   PMID:18624795   PMID:21030610   PMID:21037258   PMID:23416699   PMID:23892108   PMID:24099768   PMID:24162673   PMID:24325785  
PMID:26646931   PMID:26893028   PMID:26934001   PMID:26993249   PMID:27100897   PMID:27430302   PMID:27453764   PMID:27659550   PMID:28036265   PMID:28081742   PMID:28798470   PMID:29116117  
PMID:29638162   PMID:29719295   PMID:29749758   PMID:30066891   PMID:30518907   PMID:30544064   PMID:31106881   PMID:31304676   PMID:31320936   PMID:31456594   PMID:31588188   PMID:31713929  
PMID:31841197   PMID:31933377   PMID:31975504   PMID:32072603   PMID:32138771   PMID:32143670   PMID:32271434   PMID:32538743   PMID:32627866   PMID:32728103   PMID:32860827   PMID:33618248  
PMID:34047469   PMID:34076140   PMID:34380511   PMID:34905435   PMID:35083632   PMID:35194770   PMID:36190643   PMID:36901753   PMID:37268992   PMID:37563688   PMID:37597242  


Genomics

Comparative Map Data
MIR92B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381155,195,177 - 155,195,272 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1155,195,177 - 155,195,272 (+)EnsemblGRCh38hg38GRCh38
GRCh371155,164,968 - 155,165,063 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera1128,238,250 - 128,238,345 (+)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1126,528,072 - 126,528,167 (+)NCBIHuRef
CHM1_11156,560,475 - 156,560,570 (+)NCBICHM1_1
T2T-CHM13v2.01154,333,740 - 154,333,835 (+)NCBIT2T-CHM13v2.0
Mir92b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,134,423 - 89,134,505 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl389,134,423 - 89,134,505 (-)EnsemblGRCm39 Ensembl
GRCm38389,227,116 - 89,227,198 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,227,116 - 89,227,198 (-)EnsemblGRCm38mm10GRCm38
MGSCv37389,031,038 - 89,031,120 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera389,261,008 - 89,261,090 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.02NCBI
Mir92b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,931,653 - 176,931,735 (-)NCBIGRCr8
mRatBN7.22174,633,890 - 174,633,972 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,633,890 - 174,633,972 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,779,778 - 181,779,860 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,802,150 - 179,802,232 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,401,958 - 174,402,040 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,541,034 - 188,541,116 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,541,034 - 188,541,116 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,955,680 - 207,955,762 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2168,576,266 - 168,576,348 (-)NCBICelera
Cytogenetic Map2q34NCBI


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_002456.5(MUC1):c.235C>T (p.Pro79Ser) single nucleotide variant Malignant melanoma [RCV000059908] Chr1:155188210 [GRCh38]
Chr1:155160686 [GRCh37]
Chr1:153427310 [NCBI36]
Chr1:1q22		 not provided
GRCh38/hg38 1q21.3-22(chr1:155006546-155464263)x3 copy number gain See cases [RCV000140157] Chr1:155006546..155464263 [GRCh38]
Chr1:154979022..155434054 [GRCh37]
Chr1:153245646..153700678 [NCBI36]
Chr1:1q21.3-22		 uncertain significance
GRCh38/hg38 1q21.3-23.1(chr1:154566501-157624084)x3 copy number gain See cases [RCV000139902] Chr1:154566501..157624084 [GRCh38]
Chr1:154538977..157593874 [GRCh37]
Chr1:152805601..155860498 [NCBI36]
Chr1:1q21.3-23.1		 pathogenic
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3 copy number gain See cases [RCV000143515] Chr1:149854269..180267197 [GRCh38]
Chr1:149825831..180236332 [GRCh37]
Chr1:148092455..178502955 [NCBI36]
Chr1:1q21.2-25.2		 pathogenic
GRCh38/hg38 1q22(chr1:155182457-155787428)x3 copy number gain See cases [RCV000051164] Chr1:155182457..155787428 [GRCh38]
Chr1:155154933..155757219 [GRCh37]
Chr1:153421557..154023843 [NCBI36]
Chr1:1q22		 uncertain significance
GRCh38/hg38 1q21.3-22(chr1:154575689-155292901)x1 copy number loss See cases [RCV000053912] Chr1:154575689..155292901 [GRCh38]
Chr1:154548165..155262692 [GRCh37]
Chr1:152814789..153529316 [NCBI36]
Chr1:1q21.3-22		 pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
KIAA1671hsa-miR-92b-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
SLC15A1hsa-miR-92b-3pMirtarbaseexternal_infoGFP reporter assay//Luciferase reporter assay//qRTFunctional MTI21030610
CDKN1Chsa-miR-92b-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19544458
PRMT5hsa-miR-92b-3pMirtarbaseexternal_infoWestern blotFunctional MTI18694959
NLKhsa-miR-92b-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23416699
EFNB1hsa-miR-92b-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
CDKN1Chsa-miR-92b-3pMirecordsexternal_infoNANA19544458
DKK3hsa-miR-92b-3pOncomiRDBexternal_infoNANA21572098
ESR2hsa-miR-92b-3pOncomiRDBexternal_infoNANA20484043

Predicted Targets
Summary Value
Count of predictions:33432
Count of gene targets:13578
Count of transcripts:26999
Interacting mature miRNAs:hsa-miR-92b-3p, hsa-miR-92b-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357381BW57_HBody weight QTL 57 (human)10.0001Body weightfat free mass after exercise training1140630236166630236Human


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENST00000607575
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1155,195,177 - 155,195,272 (+)Ensembl
RefSeq Acc Id: NR_030281
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381155,195,177 - 155,195,272 (+)NCBI
GRCh371155,164,968 - 155,165,063 (+)RGD
Celera1128,238,250 - 128,238,345 (+)RGD
HuRef1126,528,072 - 126,528,167 (+)ENTREZGENE
CHM1_11156,560,475 - 156,560,570 (+)NCBI
T2T-CHM13v2.01154,333,740 - 154,333,835 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:32920 AgrOrtholog
COSMIC MIR92B COSMIC
Ensembl Genes ENSG00000284586 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000607575 ENTREZGENE
GTEx ENSG00000284586 GTEx
HGNC ID HGNC:32920 ENTREZGENE
Human Proteome Map MIR92B Human Proteome Map
miRBase MI0003560 ENTREZGENE
NCBI Gene 693235 ENTREZGENE
PharmGKB PA164723004 PharmGKB
RNAcentral URS00001A7F58 RNACentral
  URS000025576D RNACentral
  URS000075BA3A RNACentral