Cd59b (CD59b molecule) - Rat Genome Database

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Gene: Cd59b (CD59b molecule) Rattus norvegicus
Analyze
Symbol: Cd59b
Name: CD59b molecule
RGD ID: 2311
Description: Enables complement binding activity. Involved in several processes, including negative regulation of activation of membrane attack complex; negative regulation of complement-dependent cytotoxicity; and positive regulation of T cell proliferation. Located in compact myelin; extracellular space; and sarcolemma. Used to study anterior uveitis; colorectal carcinoma; glomerulonephritis; nephrosis; and neuromyelitis optica. Biomarker of acute necrotizing pancreatitis; diabetic retinopathy; and myocardial infarction. Human ortholog(s) of this gene implicated in colorectal carcinoma and ovarian cancer. Orthologous to human CD59 (CD59 molecule (CD59 blood group)); PARTICIPATES IN coagulation cascade pathway; complement system pathway; INTERACTS WITH (+)-schisandrin B; 1,3-Propane sultone; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cb59b molecule; Cd59; CD59 antigen; CD59 glycoprotein; CD59 molecule, complement regulatory protein; Cd59a; CD59b moleucle, complement regulatory protein; MAC-inhibitory protein; MAC-IP; MACIF; MACIP; membrane attack complex inhibition factor; protectin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: Cd59em1Ask  
Genetic Models: SD-Cd59em1Ask-/-
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83110,914,008 - 110,932,489 (+)NCBIGRCr8
mRatBN7.2390,459,085 - 90,477,571 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl390,459,162 - 90,478,847 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx393,952,281 - 93,970,470 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03102,551,356 - 102,569,545 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03100,381,722 - 100,399,939 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0394,010,481 - 94,028,660 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl394,010,475 - 94,028,621 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03100,650,411 - 100,668,036 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4389,243,600 - 89,245,129 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1389,318,629 - 89,333,534 (-)NCBI
Celera389,520,423 - 89,538,310 (+)NCBICelera
Cytogenetic Map3q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,3-Propane sultone  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-naphthylamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitroquinoline N-oxide  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
aristolochic acids  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorambucil  (EXP)
choline  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethidium  (ISO)
ethyl methanesulfonate  (EXP,ISO)
etoposide  (ISO)
fenthion  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
gallic acid  (ISO)
glafenine  (EXP)
glyphosate  (EXP)
hexachlorobenzene  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
melphalan  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-ethyl-N-nitrosourea  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP)
nicotine  (ISO)
nimesulide  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
sulfasalazine  (EXP)
temozolomide  (EXP,ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
Thiotepa  (EXP)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Ascitic complement system in ovarian cancer. Bjorge L, etal., Br J Cancer. 2005 Mar 14;92(5):895-905.
2. Rafts in adult peripheral nerve myelin contain major structural myelin proteins and myelin and lymphocyte protein (MAL) and CD59 as specific markers. Erne B, etal., J Neurochem 2002 Aug;82(3):550-62.
3. Generation of a recombinant, membrane-targeted form of the complement regulator CD59: activity in vitro and in vivo. Fraser DA, etal., J Biol Chem. 2003 Dec 5;278(49):48921-7. Epub 2003 Sep 30.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Membrane-bound complement regulatory proteins inhibit complement activation by an immunotherapeutic mAb in a syngeneic rat colorectal cancer model. Gelderman KA, etal., Mol Immunol. 2003 Sep;40(1):13-23.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Complement inhibitors targeted to the proximal tubule prevent injury in experimental nephrotic syndrome and demonstrate a key role for C5b-9. He C, etal., J Immunol. 2005 May 1;174(9):5750-7.
8. C5b-9 membrane attack complex mediates endothelial cell apoptosis in experimental glomerulonephritis. Hughes J, etal., Am J Physiol Renal Physiol. 2000 May;278(5):F747-57.
9. Isolation and characterization of a membrane protein from rat erythrocytes which inhibits lysis by the membrane attack complex of rat complement. Hughes TR, etal., Biochem J. 1992 May 15;284 ( Pt 1):169-76.
10. Role of complement regulatory membrane proteins in ischaemia-reperfusion injury of rat gastric mucosa. Iwata F, etal., J Gastroenterol Hepatol. 1999 Oct;14(10):967-72.
11. Activation of complement components and reduced regulator expression in alcohol-induced liver injury in the rat. Jarvelainen HA, etal., Clin Immunol. 2002 Oct;105(1):57-63.
12. Suppression of complement regulatory proteins (CRPs) exacerbates experimental autoimmune anterior uveitis (EAAU). Jha P, etal., J Immunol. 2006 Jun 15;176(12):7221-31.
13. Binding of human and rat CD59 to the terminal complement complexes. Lehto T, etal., Immunology. 1997 Jan;90(1):121-8.
14. CD59 and CD48 expressed by rat retinal pigment epithelial cells are major ligands for the CD2-mediated alternative pathway of T cell activation. Liversidge J, etal., J Immunol. 1996 May 15;156(10):3696-703.
15. Loss of CD59 expression in breast tumours correlates with poor survival. Madjd Z, etal., J Pathol. 2003 Aug;200(5):633-9.
16. Role of CD59 in experimental glomerulonephritis in rats. Matsuo S, etal., Kidney Int. 1994 Jul;46(1):191-200.
17. Complement activation and CD59 expression in the motor facial nucleus following intracranial transection of the facial nerve in the adult rat. Mattsson P, etal., J Neuroimmunol. 1998 Nov 2;91(1-2):180-9.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Expression of complement regulatory proteins-CD 35, CD 46, CD 55, and CD 59-in benign and malignant endometrial tissue. Murray KP, etal., Gynecol Oncol. 2000 Feb;76(2):176-82.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Molecular cloning of the rat analogue of human CD59: structural comparison with human CD59 and identification of a putative active site. Rushmere NK, etal., Biochem J 1994 Dec 1;304 ( Pt 2):595-601.
27. PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression. Sahni S, etal., Biochim Biophys Acta Gen Subj. 2020 Nov;1864(11):129682. doi: 10.1016/j.bbagen.2020.129682. Epub 2020 Jul 12.
28. CD59 silencing via retrovirus-mediated RNA interference enhanced complement-mediated cell damage in ovary cancer. Shi XX, etal., Cell Mol Immunol. 2009 Feb;6(1):61-6.
29. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
30. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
31. Time course of complement activation and inhibitor expression after ischemic injury of rat myocardium. Vakeva A, etal., Am J Pathol. 1994 Jun;144(6):1357-68.
32. The expression of CD59 in experimental allergic neuritis. Vedeler CA, etal., J Neurol Sci. 1999 Jun 1;165(2):154-9.
33. Complement regulatory protein CD59 involves c-SRC related tyrosine phosphorylation of the creatine transporter in skeletal muscle during sepsis. Wang W, etal., Surgery 2002 Aug;132(2):334-40.
34. Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G. Yao X and Verkman AS, Acta Neuropathol Commun. 2017 Feb 17;5(1):15. doi: 10.1186/s40478-017-0417-9.
35. Effect of IL-4 on altered expression of complement activation regulators in rat pancreatic cells during severe acute pancreatitis. Zhang C, etal., World J Gastroenterol. 2005 Nov 21;11(43):6770-4.
36. Early complement activation and decreased levels of glycosylphosphatidylinositol-anchored complement inhibitors in human and experimental diabetic retinopathy. Zhang J, etal., Diabetes. 2002 Dec;51(12):3499-504.
Additional References at PubMed
PMID:9724629   PMID:10946279   PMID:11471050   PMID:11485913   PMID:15489334   PMID:15907827   PMID:16034134   PMID:16502470   PMID:17166698   PMID:19056867   PMID:19190083   PMID:19199708  
PMID:20458337   PMID:21423176   PMID:22206666   PMID:23376485   PMID:23533145   PMID:25284781   PMID:28750658   PMID:31412214   PMID:31989689  


Genomics

Comparative Map Data
Cd59b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83110,914,008 - 110,932,489 (+)NCBIGRCr8
mRatBN7.2390,459,085 - 90,477,571 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl390,459,162 - 90,478,847 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx393,952,281 - 93,970,470 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03102,551,356 - 102,569,545 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03100,381,722 - 100,399,939 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0394,010,481 - 94,028,660 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl394,010,475 - 94,028,621 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03100,650,411 - 100,668,036 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4389,243,600 - 89,245,129 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1389,318,629 - 89,333,534 (-)NCBI
Celera389,520,423 - 89,538,310 (+)NCBICelera
Cytogenetic Map3q32NCBI
CD59
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381133,703,010 - 33,736,479 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1133,703,010 - 33,736,479 (-)EnsemblGRCh38hg38GRCh38
GRCh371133,724,556 - 33,758,025 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361133,681,132 - 33,714,600 (-)NCBINCBI36Build 36hg18NCBI36
Build 341133,681,133 - 33,714,600NCBI
Celera1133,872,059 - 33,905,528 (-)NCBICelera
Cytogenetic Map11p13NCBI
HuRef1133,421,201 - 33,454,193 (-)NCBIHuRef
CHM1_11133,724,069 - 33,757,538 (-)NCBICHM1_1
T2T-CHM13v2.01133,840,023 - 33,873,492 (-)NCBIT2T-CHM13v2.0
Cd59b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392103,900,127 - 103,920,619 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2103,896,142 - 103,921,534 (+)EnsemblGRCm39 Ensembl
GRCm382104,069,781 - 104,085,790 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2104,069,849 - 104,091,187 (+)EnsemblGRCm38mm10GRCm38
MGSCv372103,911,167 - 103,925,114 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362103,871,849 - 103,885,796 (+)NCBIMGSCv36mm8
Cytogenetic Map2E2NCBI
cM Map254.51NCBI
Cd59
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542212,500,572 - 12,528,738 (+)NCBIChiLan1.0ChiLan1.0
CD59
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2935,924,653 - 35,961,425 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11135,929,328 - 35,965,188 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01133,680,580 - 33,708,479 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11133,558,898 - 33,590,156 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1133,552,164 - 33,590,157 (-)Ensemblpanpan1.1panPan2
CD59
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11833,977,433 - 33,999,145 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1833,977,480 - 33,998,329 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1833,582,994 - 33,604,719 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01834,588,535 - 34,610,237 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1834,588,574 - 34,610,237 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11834,147,266 - 34,158,335 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01833,740,409 - 33,762,219 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01834,376,094 - 34,397,903 (+)NCBIUU_Cfam_GSD_1.0
Cd59
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494731,117,789 - 31,137,338 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365334,242,589 - 4,263,136 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD59
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1227,186,587 - 27,207,303 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2229,777,121 - 29,797,735 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD59
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1131,547,876 - 31,571,720 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl131,547,937 - 31,570,835 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038128,644,490 - 128,668,102 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Cd59b
80 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:177
Count of miRNA genes:134
Interacting mature miRNAs:146
Transcripts:ENSRNOT00000067085
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)384091273129091273Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat

Markers in Region
D3Wox16  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2390,477,202 - 90,477,342 (+)MAPPERmRatBN7.2
Rnor_6.0394,028,502 - 94,028,641NCBIRnor6.0
Rnor_5.03100,667,666 - 100,667,805UniSTSRnor5.0
RGSC_v3.4389,244,971 - 89,245,110UniSTSRGSC3.4
Celera389,538,152 - 89,538,291UniSTS
Cytogenetic Map3q32UniSTS
RH127373  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2390,477,243 - 90,477,436 (+)MAPPERmRatBN7.2
Rnor_6.0394,028,543 - 94,028,735NCBIRnor6.0
Rnor_5.03100,667,707 - 100,667,899UniSTSRnor5.0
RGSC_v3.4389,245,012 - 89,245,204UniSTSRGSC3.4
Celera389,538,193 - 89,538,385UniSTS
RH 3.4 Map3720.8UniSTS
Cytogenetic Map3q32UniSTS
BF403416  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2390,477,605 - 90,477,756 (+)MAPPERmRatBN7.2
Rnor_6.0394,028,905 - 94,029,055NCBIRnor6.0
Rnor_5.03100,668,069 - 100,668,219UniSTSRnor5.0
RGSC_v3.4389,245,374 - 89,245,524UniSTSRGSC3.4
Celera389,538,555 - 89,538,705UniSTS
RH 3.4 Map3718.91UniSTS
Cytogenetic Map3q32UniSTS


Genetic Models
This gene Cd59b is modified in the following models/strains:
SD-Cd59em1Ask-/-    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000067085   ⟹   ENSRNOP00000060967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl390,459,212 - 90,478,847 (+)Ensembl
Rnor_6.0 Ensembl394,010,475 - 94,028,621 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103453   ⟹   ENSRNOP00000092965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl390,460,264 - 90,478,847 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105770   ⟹   ENSRNOP00000092232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl390,459,162 - 90,476,321 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111042   ⟹   ENSRNOP00000082990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl390,466,705 - 90,478,847 (+)Ensembl
RefSeq Acc Id: NM_012925   ⟹   NP_037057
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83110,914,097 - 110,932,281 (+)NCBI
mRatBN7.2390,459,175 - 90,477,361 (+)NCBI
Rnor_6.0394,010,481 - 94,028,660 (+)NCBI
Rnor_5.03100,650,411 - 100,668,036 (+)NCBI
RGSC_v3.4389,243,600 - 89,245,129 (+)RGD
Celera389,520,423 - 89,538,310 (+)RGD
Sequence:
RefSeq Acc Id: XM_039104370   ⟹   XP_038960298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83110,915,225 - 110,932,489 (+)NCBI
mRatBN7.2390,460,422 - 90,477,571 (+)NCBI
RefSeq Acc Id: XM_039104371   ⟹   XP_038960299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83110,914,008 - 110,932,489 (+)NCBI
mRatBN7.2390,459,085 - 90,477,571 (+)NCBI
RefSeq Acc Id: NP_037057   ⟸   NM_012925
- Peptide Label: precursor
- UniProtKB: P27274 (UniProtKB/Swiss-Prot),   A6HNT4 (UniProtKB/TrEMBL),   A0A8I6AF42 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060967   ⟸   ENSRNOT00000067085
RefSeq Acc Id: XP_038960299   ⟸   XM_039104371
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038960298   ⟸   XM_039104370
- Peptide Label: isoform X1
- UniProtKB: P27274 (UniProtKB/Swiss-Prot),   A6HNT4 (UniProtKB/TrEMBL),   A0A8I6AF42 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000092965   ⟸   ENSRNOT00000103453
Ensembl Acc Id: ENSRNOP00000092232   ⟸   ENSRNOT00000105770
Ensembl Acc Id: ENSRNOP00000082990   ⟸   ENSRNOT00000111042
Protein Domains
UPAR/Ly6

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27274-F1-model_v2 AlphaFold P27274 1-126 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692258
Promoter ID:EPDNEW_R2783
Type:initiation region
Name:Cd59_1
Description:CD59 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0394,010,470 - 94,010,530EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2311 AgrOrtholog
BioCyc Gene G2FUF-48541 BioCyc
Ensembl Genes ENSRNOG00000042821 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055023884 UniProtKB/Swiss-Prot
  ENSRNOG00060001969 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000067085.4 UniProtKB/Swiss-Prot
  ENSRNOT00000103453.1 UniProtKB/TrEMBL
  ENSRNOT00000105770.1 UniProtKB/TrEMBL
  ENSRNOT00000111042.1 UniProtKB/TrEMBL
  ENSRNOT00055040993 UniProtKB/Swiss-Prot
  ENSRNOT00060003073 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.60.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6891456 IMAGE-MGC_LOAD
InterPro CD59_antigen_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LY6_UPA_recep-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Snake_toxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25407 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72927 IMAGE-MGC_LOAD
NCBI Gene 25407 ENTREZGENE
PANTHER CD59 GLYCOPROTEIN UniProtKB/Swiss-Prot
  CD59 GLYCOPROTEIN UniProtKB/Swiss-Prot
  CD59 GLYCOPROTEIN UniProtKB/TrEMBL
  CD59 GLYCOPROTEIN UniProtKB/TrEMBL
Pfam UPAR_LY6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd59b PhenoGen
PROSITE LY6_UPAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042821 RatGTEx
  ENSRNOG00055023884 RatGTEx
  ENSRNOG00060001969 RatGTEx
SMART SM00134 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57302 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204015
UniProt A0A8I5ZW00_RAT UniProtKB/TrEMBL
  A0A8I6AF42 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AWC9_RAT UniProtKB/TrEMBL
  A6HNT4 ENTREZGENE, UniProtKB/TrEMBL
  CD59_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-02-28 Cd59b  CD59b molecule  Cd59  CD59 molecule  Name and Symbol changed 629549 APPROVED
2016-01-13 Cd59  CD59 molecule  Cd59  CD59 molecule, complement regulatory protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-11 Cd59  CD59 molecule, complement regulatory protein  Cd59  Cd59 molecule  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-15 Cd59  Cd59 molecule  Cd59  Cb59b molecule  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-29 Cd59  Cb59b molecule  Cd59b  CD59b moleucle, complement regulatory protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-27 Cd59b  CD59b moleucle, complement regulatory protein  Cd59  CD59 antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Cd59  CD59 antigen      Symbol and Name status set to approved 70586 APPROVED