Cd247 (Cd247 molecule) - Rat Genome Database

Name: Cd247
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Cd247 (Cd247 molecule) Rattus norvegicus

Analyze

Symbol:

Cd247

Name:

Cd247 molecule

RGD ID:

2305

Description:

Predicted to enable protein heterodimerization activity; protein homodimerization activity; and protein tyrosine kinase binding activity. Involved in cell surface receptor signaling pathway. Part of T cell receptor complex. Human ortholog(s) of this gene implicated in immunodeficiency 25. Orthologous to human CD247 (CD247 molecule); PARTICIPATES IN interleukin-12 signaling pathway; Chagas disease pathway; T cell receptor signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

CD247 antigen; CD3 antigen, zeta polypeptide; Cd3z; T-cell receptor CD3 subunit zeta; T-cell receptor CD3, subunit zeta; T-cell surface glycoprotein CD3 zeta chain; TCRzeta

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CD247 (CD247 molecule)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Cd247 (CD247 antigen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cd247 (CD247 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CD247 (CD247 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CD247 (CD247 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cd247 (CD247 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CD247 (CD247 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CD247 (CD247 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cd247 (CD247 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Cd247 (CD247 antigen)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CD247 (CD247 molecule)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cd247l (CD247 antigen like)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector)

Allele / Splice:

Cd247^em1Mcwi Cd247^em5Mcwi Cd247^em3Mcwi

Genetic Models:

SS-Cd247^em5Mcwi SS-Cd247^em3Mcwi

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	78,043,302 - 78,118,437 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	78,043,307 - 78,122,263 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	80,661,216 - 80,736,398 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	13	81,965,153 - 82,040,261 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	13	79,212,301 - 79,287,410 (+)	NCBI	Rnor_WKY
Rnor_6.0	13	83,996,045 - 84,071,408 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	83,996,080 - 84,071,400 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	88,876,046 - 88,951,003 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	81,515,383 - 81,594,699 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	81,529,570 - 81,608,887 (+)	NCBI
Celera	13	77,754,426 - 77,829,099 (+)	NCBI		Celera
Cytogenetic Map	13	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

gastrointestinal stromal tumor (ISO)

immunodeficiency 25 (ISO)

parathyroid carcinoma (ISO)

systemic scleroderma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1-naphthyl isothiocyanate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

calcidiol (ISO)

calcitriol (ISO)

CGP 52608 (ISO)

chloroprene (ISO)

clofibrate (ISO)

crocidolite asbestos (ISO)

dextran sulfate (ISO)

dioxygen (ISO)

folic acid (ISO)

fulvestrant (ISO)

furan (EXP)

gentamycin (EXP)

hexachlorobenzene (EXP)

isotretinoin (ISO)

ketoconazole (ISO)

lead diacetate (ISO)

Licochalcone B (ISO)

lipopolysaccharide (ISO)

methotrexate (ISO)

nickel atom (ISO)

oxaliplatin (EXP)

ozone (EXP,ISO)

paracetamol (EXP,ISO)

progesterone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

testosterone (ISO)

tetrachloromethane (EXP)

titanium dioxide (ISO)

topotecan (EXP)

Tributyltin oxide (EXP)

trichloroethene (EXP,ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell surface receptor signaling pathway (IDA)

Fc-gamma receptor signaling pathway (ISO)

positive regulation of protein localization to cell surface (ISO)

protein-containing complex assembly (ISO)

T cell receptor signaling pathway (IBA,ISO)

Cellular Component

alpha-beta T cell receptor complex (IBA,ISO)

cytoplasm (ISO)

Fc-gamma receptor III complex (ISO)

Golgi apparatus (ISO)

plasma membrane (ISO)

T cell receptor complex (IDA,ISO)

Molecular Function

identical protein binding (ISO)

molecular_function (ND)

protein binding (ISO)

protein heterodimerization activity (ISO)

protein homodimerization activity (ISO)

protein tyrosine kinase binding (ISO)

transmembrane signaling receptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

Chagas disease pathway (IEA)

interleukin-12 signaling pathway (ISO)

T cell receptor signaling pathway (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

absent alpha-beta T cells (IMP)

decreased B cell number (IMP)

decreased mean systemic arterial blood pressure (IMP)

decreased T cell number (IMP)

decreased T cell proliferation (IMP)

decreased urine albumin level (IMP)

salt-sensitive hypertension (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Rat class III Fc gamma receptor isoforms differ in IgG subclass-binding specificity and fail to associate productively with rat CD3 zeta.	Farber DL, etal., J Immunol 1993 May 15;150(10):4364-75.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Structural analysis of the CD3 zeta/eta locus of the rat. Expression of zeta but not eta transcripts by rat T cells.	Itoh Y, etal., J Immunol 1993 Nov 1;151(9):4705-17.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Comprehensive gene review and curation	RGD comprehensive gene curation
14.	CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney.	Rudemiller N, etal., Hypertension. 2014 Mar;63(3):559-64. doi: 10.1161/HYPERTENSIONAHA.113.02191. Epub 2013 Dec 16.
15.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16.	Convergence of experimental, computational and evolutionary approaches predicts the presence of a tetrameric form for CD3-zeta.	Torres J, etal., J Mol Biol 2002 Feb 15;316(2):375-84.

Additional References at PubMed

PMID:1390434	PMID:8176201	PMID:8417118	PMID:8681956	PMID:9064344	PMID:9208839	PMID:11390434	PMID:11435465	PMID:12477932	PMID:14967045	PMID:15184345	PMID:16940250
PMID:17055436	PMID:18367546	PMID:21809042	PMID:24502978	PMID:28669876

Genomics

Comparative Map Data

Cd247
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	78,043,302 - 78,118,437 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	78,043,307 - 78,122,263 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	80,661,216 - 80,736,398 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	13	81,965,153 - 82,040,261 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	13	79,212,301 - 79,287,410 (+)	NCBI	Rnor_WKY
Rnor_6.0	13	83,996,045 - 84,071,408 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	83,996,080 - 84,071,400 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	88,876,046 - 88,951,003 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	81,515,383 - 81,594,699 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	81,529,570 - 81,608,887 (+)	NCBI
Celera	13	77,754,426 - 77,829,099 (+)	NCBI		Celera
Cytogenetic Map	13	q23	NCBI

CD247
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	167,430,640 - 167,518,529 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	1	167,425,027 - 167,518,640 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	167,399,877 - 167,487,766 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	165,666,505 - 165,754,450 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	164,131,542 - 164,219,484	NCBI
Celera	1	140,509,330 - 140,597,130 (-)	NCBI		Celera
Cytogenetic Map	1	q24.2	NCBI
HuRef	1	138,645,985 - 138,733,880 (-)	NCBI		HuRef
CHM1_1	1	168,822,340 - 168,910,166 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	166,781,991 - 166,869,980 (-)	NCBI		T2T-CHM13v2.0

Cd247
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	165,607,514 - 165,698,722 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	165,616,250 - 165,704,846 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	165,779,952 - 165,871,153 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	165,788,681 - 165,877,277 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	167,718,820 - 167,804,117 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	167,625,398 - 167,704,109 (+)	NCBI		MGSCv36	mm8
Celera	1	168,233,349 - 168,319,834 (+)	NCBI		Celera
Cytogenetic Map	1	H2.3	NCBI
cM Map	1	73.14	NCBI

Cd247
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955462	9,469,255 - 9,538,882 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955462	9,466,706 - 9,539,897 (+)	NCBI	ChiLan1.0	ChiLan1.0

CD247
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	146,648,733 - 146,736,071 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	146,648,733 - 146,736,071 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	142,863,860 - 142,951,851 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

CD247
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	30,961,169 - 30,972,143 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	30,436,526 - 30,511,145 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	30,718,692 - 30,793,466 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	30,717,802 - 30,793,463 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	30,557,903 - 30,632,136 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	30,657,066 - 30,664,032 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	30,828,331 - 30,902,528 (+)	NCBI		UU_Cfam_GSD_1.0

Cd247
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	100,696,707 - 100,758,231 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936481	18,597,335 - 18,604,097 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936481	18,544,129 - 18,605,239 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CD247
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	83,494,395 - 83,586,647 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	83,494,266 - 83,586,887 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	91,170,039 - 91,260,282 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CD247
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	61,508,256 - 61,596,464 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	61,508,283 - 61,595,414 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	63,232,781 - 63,332,026 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cd247
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624826	5,505,569 - 5,573,783 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624826	5,504,676 - 5,574,037 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cd247
523 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	459
Count of miRNA genes:	193
Interacting mature miRNAs:	219
Transcripts:	ENSRNOT00000004403, ENSRNOT00000070958
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	31241331	93395974	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	34535218	79535218	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	37262092	82262092	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	37415584	80753406	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	37415584	82415584	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	38433408	83433408	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	39754544	84754544	Rat
12879444	Bp397	Blood pressure QTL 397			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45049404	90049404	Rat
12879471	Bp398	Blood pressure QTL 398			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45514719	90514719	Rat
12879441	Bp396	Blood pressure QTL 396			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45699983	90699983	Rat
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	46088046	91088046	Rat
71119	Thym2	Thymus enlargement QTL 2	3.8		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	13	46197976	84753113	Rat
1641901	Alcrsp6	Alcohol response QTL 6			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	13	52362171	97362171	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	56056920	101056920	Rat
738026	Lnnr5	Liver neoplastic nodule remodeling QTL 5	3.29		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	59874408	85581182	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	61825626	106807694	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	65103704	106807694	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	65103704	106807694	Rat
8655945	Rf61	Renal function QTL 61	3.6		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	13	69060519	86800898	Rat
1331783	Bp221	Blood pressure QTL 221	3.72886		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	69060519	86800898	Rat
1300166	Kidm6	Kidney mass QTL 6	3.93		kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	13	69060519	86800898	Rat
11530006	Niddm72	Non-insulin dependent diabetes mellitus QTL 72		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	74023918	80753406	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	74023918	97213863	Rat
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	74862117	85581182	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	74862117	101339893	Rat

Markers in Region

RH94658

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	78,117,818 - 78,117,930 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	84,070,787 - 84,070,898	NCBI	Rnor6.0
Rnor_5.0	13	88,950,382 - 88,950,493	UniSTS	Rnor5.0
RGSC_v3.4	13	81,594,104 - 81,594,215	UniSTS	RGSC3.4
Celera	13	77,828,481 - 77,828,592	UniSTS
Cytogenetic Map	13	q23	UniSTS

RH94479

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	78,117,588 - 78,117,758 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	84,070,557 - 84,070,726	NCBI	Rnor6.0
Rnor_5.0	13	88,950,152 - 88,950,321	UniSTS	Rnor5.0
RGSC_v3.4	13	81,593,874 - 81,594,043	UniSTS	RGSC3.4
Celera	13	77,828,251 - 77,828,420	UniSTS
Cytogenetic Map	13	q23	UniSTS

PMC197251P5

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	78,117,282 - 78,117,765 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	84,070,251 - 84,070,733	NCBI	Rnor6.0
Rnor_5.0	13	88,949,846 - 88,950,328	UniSTS	Rnor5.0
RGSC_v3.4	13	81,593,568 - 81,594,050	UniSTS	RGSC3.4
Celera	13	77,827,945 - 77,828,427	UniSTS
Cytogenetic Map	13	q23	UniSTS

Genetic Models

This gene Cd247 is modified in the following models/strains

SS-Cd247^em5Mcwi

SS-Cd247^em3Mcwi

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2		8		19							6
Low	1	15	19	11		11	6	7	13	15	16	5	6
Below cutoff		16	24	24		24	2	4	37	14	20		2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001205304	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_170789	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250147	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC097933	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO562119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D13555	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000244	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L08447	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000004403 ⟹ ENSRNOP00000004403

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	78,043,307 - 78,118,432 (+)	Ensembl
Rnor_6.0 Ensembl	13	83,996,080 - 84,071,400 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000070958 ⟹ ENSRNOP00000064534

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	78,043,307 - 78,122,263 (+)	Ensembl
Rnor_6.0 Ensembl	13	83,996,080 - 84,071,400 (+)	Ensembl

RefSeq Acc Id:

NM_001205304 ⟹ NP_001192233

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	78,043,307 - 78,118,437 (+)	NCBI
Rnor_6.0	13	83,996,080 - 84,071,405 (+)	NCBI
Rnor_5.0	13	88,876,046 - 88,951,003 (+)	NCBI
Celera	13	77,754,426 - 77,829,099 (+)	NCBI

Sequence:

show sequence

GGGTGTCAGCCACAGAACAAAGCCAAGTGAGACTCCTTCAGTACCTCCCTTTCTCCTCATCCTC
CCAGGCATAGCTGCCTCTGCCCCTGCCTCTGGGCACCCTCCCAGGGTTGCAGAAGATGAAGTGG
ACGGCATCAGTCCTCGCCTGCATCCTTCAAGTGCAGTTCCCAGGAGCAGAGGCACAGAGCTTTG
GTCTGCTGGATCCCAAACTCTGCTATATGCTAGATGGAATCCTCTTCATCTACGGAGTCATCGT
CACGGCCCTGTACCTGAGAGCAAAATTCAGCAGGAGTGCAGATGCTGCTGCTTACCTTCAGGAC
CCCAACCAGCTCTATAACCAGAGGAGGAGGAACCCCCAGGAAGGCGTGTACAATGCACTGCAGA
AAGACAAGATGGCAGAGGCCTACAGTGAGATTGGCATGAAAGGCGAGAGGCGGAGAGGCAAGGG
GCACGACGGCCTTTACCAGGGTCTCAGCACTGCCACCAAGGACACCTATGACGCCCTGCATATG
CAGACCCTGCCCCCTCGCTAACAGCCAGGGGATTTCTCACTCAAAGGCTTCACCTGCTGACGTC
ACTTGTGAAGGACGAGGACAAAGCATTTACAACTCAGTTTATTAACTTCACAGACACCGTTTCC
TGAAGAGGATGCTTCTCCCACTTGTCACATTTGTCTTCTCCAGTCCCAAAGTATTGTACATAGA
CTGTCACCCCTGGACTCTCTAAAGGGAGAGCTCCCCTCGCTCATACCCCAGCCCAGTTCTTGGG
TCTCTTGGCAGGCCCCTCTCCCTGCAGAGTCCAGCCCTAACCAGGAGCTGGGGGGTGGGGCATG
AATACATTCCCTCTTGCAGCTAGCGGGAGTTCAGTTTGCTTTGTAAAGTCCCCAGAGCCGCCTC
AGGTACTGACTGTATTGTTCCACTGATACTGACTCACTTTGCTCCTGCTGTAAATTTGGCTTCT
GTTGTCATACTTCCCAGTGTCAAGGTAACATGTAATTAGGTCACATTGTGAAAGGCAGAGAGGC
AGGTACAAGGGAACCCAGGCAAGTGTCAGCCAGAGGTGGCTCAAACAAGGGAAGCAACATGCAA
GGATGTTCCTAGCAGAGGAACAGTAACAAGGGGCCTCTTTCTATCAAGGATACCTTCCACATCT
CCCAGTCCATGCCAGATACTCCAGGAATGTTAAGATGTCTTACCTTCACGGAGACCACGCTTTT
AGAGTGCAAATAACTTGTGTATCAACTGGCGCAGAAGATAGGGTATGTCATAACTGCCAATGAC
AAGGGGGTGAGAGAAAAGGAAGCAAGTCCTGCTTTCTTCCAGGAACTCTGTTCTTCCCCATCCA
GTGGCAGGAAGACCCAGACCACCCAGTTCTGTAGTGCTCCCACAGTAATGGCACAATGACAGTC
AGTGGACAGCTACATCATTGTGTAATTAAAGTGCCTGCTGGGGATTTAGCTCAGTGGTAGAGCG
CTTACCTAGGAAGCACAAGGCCCTGGGTTCGGTCCCCAGCTCCGGGAAAAAAAAAAAAAAAAAA
AAAGTGCCTGTGACCATGGATGGGAAACGCTCTGATCTCCAGGGTTTTAATTTATACTGGCTTG
CTATTTTGCATAATAAATGCTTTGCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_170789 ⟹ NP_740770

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	78,043,307 - 78,118,437 (+)	NCBI
Rnor_6.0	13	83,996,080 - 84,071,405 (+)	NCBI
Rnor_5.0	13	88,876,046 - 88,951,003 (+)	NCBI
RGSC_v3.4	13	81,515,383 - 81,594,699 (+)	RGD
Celera	13	77,754,426 - 77,829,099 (+)	NCBI

Sequence:

show sequence

GGGTGTCAGCCACAGAACAAAGCCAAGTGAGACTCCTTCAGTACCTCCCTTTCTCCTCATCCTC
CCAGGCATAGCTGCCTCTGCCCCTGCCTCTGGGCACCCTCCCAGGGTTGCAGAAGATGAAGTGG
ACGGCATCAGTCCTCGCCTGCATCCTTCAAGTGCAGTTCCCAGGAGCAGAGGCACAGAGCTTTG
GTCTGCTGGATCCCAAACTCTGCTATATGCTAGATGGAATCCTCTTCATCTACGGAGTCATCGT
CACGGCCCTGTACCTGAGAGCAAAATTCAGCAGGAGTGCAGATGCTGCTGCTTACCTTCAGGAC
CCCAACCAGCTCTATAACGAGCTCAACCTAGGGCGAAGAGAGGAATATGATGTTTTGGACAAGA
AGCGGCCTCGGGATCCGGAGATGGGGGGCAAACAGCAGAGGAGGAGGAACCCCCAGGAAGGCGT
GTACAATGCACTGCAGAAAGACAAGATGGCAGAGGCCTACAGTGAGATTGGCATGAAAGGCGAG
AGGCGGAGAGGCAAGGGGCACGACGGCCTTTACCAGGGTCTCAGCACTGCCACCAAGGACACCT
ATGACGCCCTGCATATGCAGACCCTGCCCCCTCGCTAACAGCCAGGGGATTTCTCACTCAAAGG
CTTCACCTGCTGACGTCACTTGTGAAGGACGAGGACAAAGCATTTACAACTCAGTTTATTAACT
TCACAGACACCGTTTCCTGAAGAGGATGCTTCTCCCACTTGTCACATTTGTCTTCTCCAGTCCC
AAAGTATTGTACATAGACTGTCACCCCTGGACTCTCTAAAGGGAGAGCTCCCCTCGCTCATACC
CCAGCCCAGTTCTTGGGTCTCTTGGCAGGCCCCTCTCCCTGCAGAGTCCAGCCCTAACCAGGAG
CTGGGGGGTGGGGCATGAATACATTCCCTCTTGCAGCTAGCGGGAGTTCAGTTTGCTTTGTAAA
GTCCCCAGAGCCGCCTCAGGTACTGACTGTATTGTTCCACTGATACTGACTCACTTTGCTCCTG
CTGTAAATTTGGCTTCTGTTGTCATACTTCCCAGTGTCAAGGTAACATGTAATTAGGTCACATT
GTGAAAGGCAGAGAGGCAGGTACAAGGGAACCCAGGCAAGTGTCAGCCAGAGGTGGCTCAAACA
AGGGAAGCAACATGCAAGGATGTTCCTAGCAGAGGAACAGTAACAAGGGGCCTCTTTCTATCAA
GGATACCTTCCACATCTCCCAGTCCATGCCAGATACTCCAGGAATGTTAAGATGTCTTACCTTC
ACGGAGACCACGCTTTTAGAGTGCAAATAACTTGTGTATCAACTGGCGCAGAAGATAGGGTATG
TCATAACTGCCAATGACAAGGGGGTGAGAGAAAAGGAAGCAAGTCCTGCTTTCTTCCAGGAACT
CTGTTCTTCCCCATCCAGTGGCAGGAAGACCCAGACCACCCAGTTCTGTAGTGCTCCCACAGTA
ATGGCACAATGACAGTCAGTGGACAGCTACATCATTGTGTAATTAAAGTGCCTGCTGGGGATTT
AGCTCAGTGGTAGAGCGCTTACCTAGGAAGCACAAGGCCCTGGGTTCGGTCCCCAGCTCCGGGA
AAAAAAAAAAAAAAAAAAAAGTGCCTGTGACCATGGATGGGAAACGCTCTGATCTCCAGGGTTT
TAATTTATACTGGCTTGCTATTTTGCATAATAAATGCTTTGCTAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006250147 ⟹ XP_006250209

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	78,043,302 - 78,118,437 (+)	NCBI
Rnor_6.0	13	83,996,045 - 84,071,408 (+)	NCBI
Rnor_5.0	13	88,876,046 - 88,951,003 (+)	NCBI

Sequence:

show sequence

TGCTGTCTCAAAGGCCCACAGTCCTCCACTTCCTGGGGTGTCAGCCACAGAACAAAGCCAAGTG
AGACTCCTTCAGTACCTCCCTTTCTCCTCATCCTCCCAGGCATAGCTGCCTCTGCCCCTGCCTC
TGGGCACCCTCCCAGGGTTGCAGAAGATGAAGTGGACGGCATCAGTCCTCGCCTGCATCCTTCA
AGTGCAGTTCCCAGGAGCAGAGGCACAGAGCTTTGGTCTGCTGGATCCCAAACTCTGCTATATG
CTAGATGGAATCCTCTTCATCTACGGAGTCATCGTCACGGCCCTGTACCTGAGAGCAAAATTCA
GCAGGAGTGCAGATGCTGCTGCTTACCTTCAGGACCCCAACCAGCTCTATAACGAGCTCAACCT
AGGGCGAAGAGAGGAATATGATGTTTTGGACAAGAAGCGGCCTCGGGATCCGGAGATGGGGGGC
AAACAGAGGAGGAGGAACCCCCAGGAAGGCGTGTACAATGCACTGCAGAAAGACAAGATGGCAG
AGGCCTACAGTGAGATTGGCATGAAAGGCGAGAGGCGGAGAGGCAAGGGGCACGACGGCCTTTA
CCAGGGTCTCAGCACTGCCACCAAGGACACCTATGACGCCCTGCATATGCAGACCCTGCCCCCT
CGCTAACAGCCAGGGGATTTCTCACTCAAAGGCTTCACCTGCTGACGTCACTTGTGAAGGACGA
GGACAAAGCATTTACAACTCAGTTTATTAACTTCACAGACACCGTTTCCTGAAGAGGATGCTTC
TCCCACTTGTCACATTTGTCTTCTCCAGTCCCAAAGTATTGTACATAGACTGTCACCCCTGGAC
TCTCTAAAGGGAGAGCTCCCCTCGCTCATACCCCAGCCCAGTTCTTGGGTCTCTTGGCAGGCCC
CTCTCCCTGCAGAGTCCAGCCCTAACCAGGAGCTGGGGGGTGGGGCATGAATACATTCCCTCTT
GCAGCTAGCGGGAGTTCAGTTTGCTTTGTAAAGTCCCCAGAGCCGCCTCAGGTACTGACTGTAT
TGTTCCACTGATACTGACTCACTTTGCTCCTGCTGTAAATTTGGCTTCTGTTGTCATACTTCCC
AGTGTCAAGGTAACATGTAATTAGGTCACATTGTGAAAGGCAGAGAGGCAGGTACAAGGGAACC
CAGGCAAGTGTCAGCCAGAGGTGGCTCAAACAAGGGAAGCAACATGCAAGGATGTTCCTAGCAG
AGGAACAGTAACAAGGGGCCTCTTTCTATCAAGGATACCTTCCACATCTCCCAGTCCATGCCAG
ATACTCCAGGAATGTTAAGATGTCTTACCTTCACGGAGACCACGCTTTTAGAGTGCAAATAACT
TGTGTATCAACTGGCGCAGAAGATAGGGTATGTCATAACTGCCAATGACAAGGGGGTGAGAGAA
AAGGAAGCAAGTCCTGCTTTCTTCCAGGAACTCTGTTCTTCCCCATCCAGTGGCAGGAAGACCC
AGACCACCCAGTTCTGTAGTGCTCCCACAGTAATGGCACAATGACAGTCAGTGGACAGCTACAT
CATTGTGTAATTAAAGTGCCTGCTGGGGATTTAGCTCAGTGGTAGAGCGCTTACCTAGGAAGCA
CAAGGCCCTGGGTTCGGTCCCCAGCTCCGGGAAAAAAAAAAAAAAAAAAAAAGTGCCTGTGACC
ATGGATGGGAAACGCTCTGATCTCCAGGGTTTTAATTTATACTGGCTTGCTATTTTGCATAATA
AATGCTTTGCTAAAAATGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001192233	(Get FASTA)	NCBI Sequence Viewer
	NP_740770	(Get FASTA)	NCBI Sequence Viewer
	XP_006250209	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA40900	(Get FASTA)	NCBI Sequence Viewer
	AAH97933	(Get FASTA)	NCBI Sequence Viewer
	BAA02753	(Get FASTA)	NCBI Sequence Viewer
	EDM09312	(Get FASTA)	NCBI Sequence Viewer
	EDM09313	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_740770 ⟸ NM_170789
- Peptide Label:	isoform 1 precursor
- UniProtKB:	Q4V7G0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKWTASVLACILQVQFPGAEAQSFGLLDPKLCYMLDGILFIYGVIVTALYLRAKFSRSADAAAY LQDPNQLYNELNLGRREEYDVLDKKRPRDPEMGGKQQRRRNPQEGVYNALQKDKMAEAYSEIGM KGERRRGKGHDGLYQGLSTATKDTYDALHMQTLPPR hide sequence

RefSeq Acc Id:	NP_001192233 ⟸ NM_001205304
- Peptide Label:	isoform 2 precursor
- UniProtKB:	M0R576 (UniProtKB/TrEMBL), Q4V7G0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKWTASVLACILQVQFPGAEAQSFGLLDPKLCYMLDGILFIYGVIVTALYLRAKFSRSADAAAY LQDPNQLYNQRRRNPQEGVYNALQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDA LHMQTLPPR hide sequence

RefSeq Acc Id:	XP_006250209 ⟸ XM_006250147
- Peptide Label:	isoform X1
- Sequence:	show sequence MKWTASVLACILQVQFPGAEAQSFGLLDPKLCYMLDGILFIYGVIVTALYLRAKFSRSADAAAY LQDPNQLYNELNLGRREEYDVLDKKRPRDPEMGGKQRRRNPQEGVYNALQKDKMAEAYSEIGMK GERRRGKGHDGLYQGLSTATKDTYDALHMQTLPPR hide sequence

RefSeq Acc Id:

ENSRNOP00000064534 ⟸ ENSRNOT00000070958

RefSeq Acc Id:

ENSRNOP00000004403 ⟸ ENSRNOT00000004403

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4V7G0-F1-model_v2	AlphaFold	Q4V7G0	1-164	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698964

Promoter ID:

EPDNEW_R9489

Type:

multiple initiation site

Name:

Cd247_1

Description:

Cd247 molecule

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	83,996,126 - 83,996,186	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2305	AgrOrtholog
BioCyc Gene	G2FUF-17556	BioCyc
Ensembl Genes	ENSRNOG00000003298	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000004403	ENTREZGENE
	ENSRNOP00000004403.5	UniProtKB/TrEMBL
	ENSRNOP00000064534.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000004403	ENTREZGENE
	ENSRNOT00000004403.9	UniProtKB/TrEMBL
	ENSRNOT00000070958.2	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7384006	IMAGE-MGC_LOAD
InterPro	CR3_zeta/IgE_Fc_rcpt_gamma	UniProtKB/TrEMBL
	Phos_immunorcpt_sig_ITAM	UniProtKB/TrEMBL
	T-cell_CD3_zeta/eta	UniProtKB/TrEMBL
KEGG Report	rno:25300	UniProtKB/TrEMBL
MGC_CLONE	MGC:116047	IMAGE-MGC_LOAD
NCBI Gene	25300	ENTREZGENE
PANTHER	PTHR10035	UniProtKB/TrEMBL
Pfam	ITAM	UniProtKB/TrEMBL
	TCR_zetazeta	UniProtKB/TrEMBL
PhenoGen	Cd247	PhenoGen
PROSITE	ITAM_1	UniProtKB/TrEMBL
SMART	ITAM	UniProtKB/TrEMBL
TIGR	TC216715
UniProt	M0R576	ENTREZGENE, UniProtKB/TrEMBL
	Q4V7G0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-06-27	Cd247	Cd247 molecule	Cd247	CD247 antigen	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-15	Cd247	CD247 antigen	Cd3z	CD3 antigen, zeta polypeptide	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-11-06	Cd3z	CD3 antigen, zeta polypeptide		T-cell receptor CD3, subunit zeta	Name updated	625702	APPROVED
2002-06-10	Cd3z	T-cell receptor CD3, subunit zeta			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_function	component of T cell receptor complex	634717
gene_process	has a role in TCR assembly and TCR-mediated signaling	634717
gene_process	does not promote surface expression of Fc gamma RIII, unlike human CD3 zeta chain	728653

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

Mammalian Phenotype