Cd247 (Cd247 molecule) - Rat Genome Database

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Gene: Cd247 (Cd247 molecule) Rattus norvegicus
Analyze
Symbol: Cd247
Name: Cd247 molecule
RGD ID: 2305
Description: Predicted to enable protein heterodimerization activity; protein homodimerization activity; and protein tyrosine kinase binding activity. Involved in cell surface receptor signaling pathway. Part of T cell receptor complex. Human ortholog(s) of this gene implicated in immunodeficiency 25. Orthologous to human CD247 (CD247 molecule); PARTICIPATES IN interleukin-12 signaling pathway; Chagas disease pathway; T cell receptor signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD247 antigen; CD3 antigen, zeta polypeptide; Cd3z; T-cell receptor CD3 subunit zeta; T-cell receptor CD3, subunit zeta; T-cell surface glycoprotein CD3 zeta chain; TCRzeta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Cd247em1Mcwi   Cd247em5Mcwi   Cd247em3Mcwi  
Genetic Models: SS-Cd247em5Mcwi SS-Cd247em3Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21378,043,302 - 78,118,437 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1378,043,307 - 78,122,263 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1380,661,216 - 80,736,398 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01381,965,153 - 82,040,261 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01379,212,301 - 79,287,410 (+)NCBIRnor_WKY
Rnor_6.01383,996,045 - 84,071,408 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1383,996,080 - 84,071,400 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01388,876,046 - 88,951,003 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41381,515,383 - 81,594,699 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11381,529,570 - 81,608,887 (+)NCBI
Celera1377,754,426 - 77,829,099 (+)NCBICelera
Cytogenetic Map13q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Rat class III Fc gamma receptor isoforms differ in IgG subclass-binding specificity and fail to associate productively with rat CD3 zeta. Farber DL, etal., J Immunol 1993 May 15;150(10):4364-75.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Structural analysis of the CD3 zeta/eta locus of the rat. Expression of zeta but not eta transcripts by rat T cells. Itoh Y, etal., J Immunol 1993 Nov 1;151(9):4705-17.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney. Rudemiller N, etal., Hypertension. 2014 Mar;63(3):559-64. doi: 10.1161/HYPERTENSIONAHA.113.02191. Epub 2013 Dec 16.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16. Convergence of experimental, computational and evolutionary approaches predicts the presence of a tetrameric form for CD3-zeta. Torres J, etal., J Mol Biol 2002 Feb 15;316(2):375-84.
Additional References at PubMed
PMID:1390434   PMID:8176201   PMID:8417118   PMID:8681956   PMID:9064344   PMID:9208839   PMID:11390434   PMID:11435465   PMID:12477932   PMID:14967045   PMID:15184345   PMID:16940250  
PMID:17055436   PMID:18367546   PMID:21809042   PMID:24502978   PMID:28669876  


Genomics

Comparative Map Data
Cd247
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21378,043,302 - 78,118,437 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1378,043,307 - 78,122,263 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1380,661,216 - 80,736,398 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01381,965,153 - 82,040,261 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01379,212,301 - 79,287,410 (+)NCBIRnor_WKY
Rnor_6.01383,996,045 - 84,071,408 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1383,996,080 - 84,071,400 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01388,876,046 - 88,951,003 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41381,515,383 - 81,594,699 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11381,529,570 - 81,608,887 (+)NCBI
Celera1377,754,426 - 77,829,099 (+)NCBICelera
Cytogenetic Map13q23NCBI
CD247
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381167,430,640 - 167,518,529 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1167,425,027 - 167,518,640 (-)EnsemblGRCh38hg38GRCh38
GRCh371167,399,877 - 167,487,766 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,666,505 - 165,754,450 (-)NCBINCBI36Build 36hg18NCBI36
Build 341164,131,542 - 164,219,484NCBI
Celera1140,509,330 - 140,597,130 (-)NCBICelera
Cytogenetic Map1q24.2NCBI
HuRef1138,645,985 - 138,733,880 (-)NCBIHuRef
CHM1_11168,822,340 - 168,910,166 (-)NCBICHM1_1
T2T-CHM13v2.01166,781,991 - 166,869,980 (-)NCBIT2T-CHM13v2.0
Cd247
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391165,607,514 - 165,698,722 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1165,616,250 - 165,704,846 (+)EnsemblGRCm39 Ensembl
GRCm381165,779,952 - 165,871,153 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1165,788,681 - 165,877,277 (+)EnsemblGRCm38mm10GRCm38
MGSCv371167,718,820 - 167,804,117 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361167,625,398 - 167,704,109 (+)NCBIMGSCv36mm8
Celera1168,233,349 - 168,319,834 (+)NCBICelera
Cytogenetic Map1H2.3NCBI
cM Map173.14NCBI
Cd247
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554629,469,255 - 9,538,882 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554629,466,706 - 9,539,897 (+)NCBIChiLan1.0ChiLan1.0
CD247
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11146,648,733 - 146,736,071 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1146,648,733 - 146,736,071 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01142,863,860 - 142,951,851 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CD247
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1730,961,169 - 30,972,143 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha730,436,526 - 30,511,145 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0730,718,692 - 30,793,466 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl730,717,802 - 30,793,463 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1730,557,903 - 30,632,136 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0730,657,066 - 30,664,032 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0730,828,331 - 30,902,528 (+)NCBIUU_Cfam_GSD_1.0
Cd247
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344100,696,707 - 100,758,231 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648118,597,335 - 18,604,097 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493648118,544,129 - 18,605,239 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD247
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl483,494,395 - 83,586,647 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1483,494,266 - 83,586,887 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2491,170,039 - 91,260,282 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CD247
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12561,508,256 - 61,596,464 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2561,508,283 - 61,595,414 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605563,232,781 - 63,332,026 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd247
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248265,505,569 - 5,573,783 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248265,504,676 - 5,574,037 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cd247
523 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:459
Count of miRNA genes:193
Interacting mature miRNAs:219
Transcripts:ENSRNOT00000004403, ENSRNOT00000070958
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)137402391880753406Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat

Markers in Region
RH94658  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21378,117,818 - 78,117,930 (+)MAPPERmRatBN7.2
Rnor_6.01384,070,787 - 84,070,898NCBIRnor6.0
Rnor_5.01388,950,382 - 88,950,493UniSTSRnor5.0
RGSC_v3.41381,594,104 - 81,594,215UniSTSRGSC3.4
Celera1377,828,481 - 77,828,592UniSTS
Cytogenetic Map13q23UniSTS
RH94479  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21378,117,588 - 78,117,758 (+)MAPPERmRatBN7.2
Rnor_6.01384,070,557 - 84,070,726NCBIRnor6.0
Rnor_5.01388,950,152 - 88,950,321UniSTSRnor5.0
RGSC_v3.41381,593,874 - 81,594,043UniSTSRGSC3.4
Celera1377,828,251 - 77,828,420UniSTS
Cytogenetic Map13q23UniSTS
PMC197251P5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21378,117,282 - 78,117,765 (+)MAPPERmRatBN7.2
Rnor_6.01384,070,251 - 84,070,733NCBIRnor6.0
Rnor_5.01388,949,846 - 88,950,328UniSTSRnor5.0
RGSC_v3.41381,593,568 - 81,594,050UniSTSRGSC3.4
Celera1377,827,945 - 77,828,427UniSTS
Cytogenetic Map13q23UniSTS


Genetic Models
This gene Cd247 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8 19 6
Low 1 15 19 11 11 6 7 13 15 16 5 6
Below cutoff 16 24 24 24 2 4 37 14 20 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004403   ⟹   ENSRNOP00000004403
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1378,043,307 - 78,118,432 (+)Ensembl
Rnor_6.0 Ensembl1383,996,080 - 84,071,400 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000070958   ⟹   ENSRNOP00000064534
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1378,043,307 - 78,122,263 (+)Ensembl
Rnor_6.0 Ensembl1383,996,080 - 84,071,400 (+)Ensembl
RefSeq Acc Id: NM_001205304   ⟹   NP_001192233
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21378,043,307 - 78,118,437 (+)NCBI
Rnor_6.01383,996,080 - 84,071,405 (+)NCBI
Rnor_5.01388,876,046 - 88,951,003 (+)NCBI
Celera1377,754,426 - 77,829,099 (+)NCBI
Sequence:
RefSeq Acc Id: NM_170789   ⟹   NP_740770
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21378,043,307 - 78,118,437 (+)NCBI
Rnor_6.01383,996,080 - 84,071,405 (+)NCBI
Rnor_5.01388,876,046 - 88,951,003 (+)NCBI
RGSC_v3.41381,515,383 - 81,594,699 (+)RGD
Celera1377,754,426 - 77,829,099 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250147   ⟹   XP_006250209
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21378,043,302 - 78,118,437 (+)NCBI
Rnor_6.01383,996,045 - 84,071,408 (+)NCBI
Rnor_5.01388,876,046 - 88,951,003 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_740770   ⟸   NM_170789
- Peptide Label: isoform 1 precursor
- UniProtKB: Q4V7G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001192233   ⟸   NM_001205304
- Peptide Label: isoform 2 precursor
- UniProtKB: M0R576 (UniProtKB/TrEMBL),   Q4V7G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250209   ⟸   XM_006250147
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000064534   ⟸   ENSRNOT00000070958
RefSeq Acc Id: ENSRNOP00000004403   ⟸   ENSRNOT00000004403

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V7G0-F1-model_v2 AlphaFold Q4V7G0 1-164 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698964
Promoter ID:EPDNEW_R9489
Type:multiple initiation site
Name:Cd247_1
Description:Cd247 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01383,996,126 - 83,996,186EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2305 AgrOrtholog
BioCyc Gene G2FUF-17556 BioCyc
Ensembl Genes ENSRNOG00000003298 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000004403 ENTREZGENE
  ENSRNOP00000004403.5 UniProtKB/TrEMBL
  ENSRNOP00000064534.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004403 ENTREZGENE
  ENSRNOT00000004403.9 UniProtKB/TrEMBL
  ENSRNOT00000070958.2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7384006 IMAGE-MGC_LOAD
InterPro CR3_zeta/IgE_Fc_rcpt_gamma UniProtKB/TrEMBL
  Phos_immunorcpt_sig_ITAM UniProtKB/TrEMBL
  T-cell_CD3_zeta/eta UniProtKB/TrEMBL
KEGG Report rno:25300 UniProtKB/TrEMBL
MGC_CLONE MGC:116047 IMAGE-MGC_LOAD
NCBI Gene 25300 ENTREZGENE
PANTHER PTHR10035 UniProtKB/TrEMBL
Pfam ITAM UniProtKB/TrEMBL
  TCR_zetazeta UniProtKB/TrEMBL
PhenoGen Cd247 PhenoGen
PROSITE ITAM_1 UniProtKB/TrEMBL
SMART ITAM UniProtKB/TrEMBL
TIGR TC216715
UniProt M0R576 ENTREZGENE, UniProtKB/TrEMBL
  Q4V7G0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-06-27 Cd247  Cd247 molecule  Cd247  CD247 antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Cd247  CD247 antigen  Cd3z  CD3 antigen, zeta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Cd3z  CD3 antigen, zeta polypeptide    T-cell receptor CD3, subunit zeta  Name updated 625702 APPROVED
2002-06-10 Cd3z  T-cell receptor CD3, subunit zeta      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function component of T cell receptor complex 634717
gene_process has a role in TCR assembly and TCR-mediated signaling 634717
gene_process does not promote surface expression of Fc gamma RIII, unlike human CD3 zeta chain 728653