Cd36 (CD36 molecule) - Rat Genome Database

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Gene: Cd36 (CD36 molecule) Rattus norvegicus
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Symbol: Cd36 (Ensembl: RGD1565355)
Name: CD36 molecule (Ensembl:similar to fatty acid translocase/CD36)
RGD ID: 2301
Description: Enables several functions, including oleic acid binding activity; scavenger receptor activity; and thrombospondin receptor activity. Involved in several processes, including fatty acid metabolic process; positive regulation of macromolecule biosynthetic process; and response to peptide hormone. Located in several cellular components, including brush border membrane; caveola; and sarcolemma. Part of protein-containing complex. Used to study interstitial lung disease (multiple); macular degeneration; myocardial infarction; obesity; and polycystic ovary syndrome. Biomarker of artery disease (multiple); hypertrophic cardiomyopathy; nephrosis; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human CD36 (CD36 molecule (CD36 blood group)); PARTICIPATES IN retinol metabolic pathway; cell-extracellular matrix signaling pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH (R,R,R)-alpha-tocopherol; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adipocyte membrane protein; CD36 antigen; CD36 antigen (collagen type I receptor, thrombospondin receptor); Cd36 antigen-like; CD36 molecule (thrombospondin receptor); collagen type I receptor thrombospondin receptor; Fat; fatty acid translocase; fatty acid transport protein; glycoprotein IIIb; GPIIIB; GPIV; LOC499984; MGC108510; MGC91634; PAS IV; PAS-4; platelet glycoprotein 4; platelet glycoprotein IV; RGD1562323; similar to fatty acid translocase/CD36
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   BN   SHR   WKY   BN.SHR-(Il6-Cd36)/Cub   SHR-Tg(EEF1A1-Cd36)10Ipcv   SHR-Tg(EEF1A1-Cd36)19Ipcv   SHR-Tg(EEF1A1-Cd36)93Ipcv   SHR-Tg(EEF1A1-Cd36)106Ipcv   SHR/4Dmcr   SHRSP/3Dmcr   SHR/2Dmcr   SHR/3Dmcr   SHRSP/4Dmcr   SHRSP/5Dmcr   SHRSP/2Dmcr  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8418,209,088 - 18,302,142 (+)NCBIGRCr8
mRatBN7.2417,317,343 - 17,410,084 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl417,354,466 - 17,513,903 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx422,477,636 - 22,533,306 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0418,290,445 - 18,348,857 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0416,675,588 - 16,731,247 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0414,150,309 - 14,191,498 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl414,001,761 - 14,249,749 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0414,125,297 - 14,166,434 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4413,534,582 - 13,554,416 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera412,880,238 - 12,941,086 (+)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
Alcoholic Fatty Liver  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
arteriosclerosis  (ISO)
atherosclerosis  (IEP,ISO)
atrial fibrillation  (ISO)
blood platelet disease  (ISO)
brain ischemia  (ISO)
Cardiac Arrhythmias  (IMP)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
celiac disease  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
cerebral malaria  (ISO)
chronic myeloid leukemia  (ISO)
colitis  (ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
dermatomyositis  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (IEP)
dilated cardiomyopathy  (ISO)
endometriosis  (ISO)
epilepsy  (ISO)
essential thrombocythemia  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (ISO)
glucose intolerance  (ISO)
granulomatosis with polyangiitis  (ISO)
Hematoma  (ISO)
hemolytic-uremic syndrome  (ISO)
Hypercholesterolemia  (ISO)
hypertension  (IEP,ISO)
hypertrophic cardiomyopathy  (IEP)
inclusion body myositis  (ISO)
Inflammation  (ISO)
Insulin Resistance  (IMP,ISO)
Knee Osteoarthritis  (IEP,ISO)
liver cirrhosis  (ISO)
macular degeneration  (IAGP)
malaria  (ISO)
maturity-onset diabetes of the young type 1  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (IAGP,ISO)
middle cerebral artery infarction  (ISO)
Mycobacterium Infections  (ISO)
myeloid neoplasm  (ISO)
myocardial infarction  (IMP)
Myocardial Ischemia  (ISO)
nephrosis  (IEP)
obesity  (IEP,IMP,ISO)
osteoarthritis  (ISO)
pemphigus  (ISO)
Penetrating Wounds  (ISO)
Plaque, Atherosclerotic  (ISO)
platelet-type bleeding disorder 10  (ISO,ISS)
pleomorphic xanthoastrocytoma  (ISO)
polycystic ovary syndrome  (IDA)
polycythemia vera  (ISO)
primary immunodeficiency disease  (ISO)
pulmonary fibrosis  (IMP,ISO)
pulmonary tuberculosis  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
Reperfusion Injury  (ISO)
Retroperitoneal Fibrosis  (ISO)
rheumatic heart disease  (ISO)
Sepsis  (ISO)
sickle cell anemia  (ISO)
silicosis  (IMP)
Staphylococcal Infections  (ISO)
steatotic liver disease  (ISO)
Stroke  (ISO)
Tachycardia  (IEP)
thrombotic thrombocytopenic purpura  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
Weight Gain  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+/-)-Aegeline  (ISO)
(1->4)-beta-D-glucan  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(9E,11E)-octadecadienoic acid  (ISO)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
(Z)-ligustilide  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-dichloropropan-2-ol  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP,ISO)
2-arachidonoylglycerol  (ISO)
2-butoxyethanol  (ISO)
26-hydroxycholesterol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-aminobenzamide  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
7alpha-hydroxycholesterol  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
Acetyl tributyl citrate  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP,ISO)
alpha-hexachlorocyclohexane  (EXP)
aluminium oxide  (ISO)
amentoflavone  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apocynin  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP,ISO)
azathioprine  (EXP)
benazepril  (EXP)
benzbromarone  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzylpenicillin  (ISO)
berberine  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bezafibrate  (EXP,ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (EXP)
candesartan  (EXP,ISO)
captan  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
cholic acid  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciprofibrate  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corn oil  (EXP)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
cucurbitacin B  (ISO)
cucurbitacin I  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cyproconazole  (EXP,ISO)
D-glucose  (ISO)
dapagliflozin  (EXP)
DDE  (ISO)
demethoxycurcumin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
Diosbulbin B  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (ISO)
duvoglustat  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (EXP,ISO)
erythromycin A  (ISO)
ethanol  (EXP,ISO)
eugenol  (ISO)
fenofibrate  (EXP,ISO)
fenvalerate  (ISO)
fipronil  (EXP)
fluoxetine  (EXP)
flutamide  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glutathione  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (ISO)
GW 4064  (ISO)
GW 6471  (ISO)
GW 7647  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
ibuprofen  (ISO)
imidacloprid  (ISO)
indinavir  (ISO)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
isoprenaline  (EXP)
isosilybin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
lead diacetate  (ISO)
linoleic acid  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
LLY-507  (ISO)
losartan  (ISO)
LY294002  (ISO)
malathion  (ISO)
malonaldehyde  (ISO)
mangiferin  (EXP)
melatonin  (ISO)
menadione  (ISO)
Mesaconitine  (EXP)
methamphetamine  (ISO)
methapyrilene  (EXP,ISO)
methotrexate  (ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
miquelianin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
Muraglitazar  (EXP)
myxothiazol  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nevirapine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotinamide  (EXP)
nicotinic acid  (EXP,ISO)
nitenpyram  (ISO)
NMN zwitterion  (ISO)
nordihydroguaiaretic acid  (EXP)
oleic acid  (EXP,ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
pentane-2,3-dione  (EXP)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorododecanoic acid  (EXP,ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (EXP,ISO)
Phenelzine  (ISO)
phenobarbital  (EXP,ISO)
Phenylamil  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
picolinic acid  (ISO)
pioglitazone  (EXP,ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
progesterone  (EXP)
propamocarb  (ISO)
propiconazole  (ISO)
PX-866  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
rifampicin  (ISO)
rifaximin  (ISO)
rimonabant  (ISO)
ritodrine  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
saquinavir  (ISO)
saroglitazar  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
Sodium oleate  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tebuconazole  (EXP,ISO)
telmisartan  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
theophylline  (ISO)
thiacloprid  (ISO)
thioacetamide  (EXP)
thiophanate-methyl  (ISO)
titanium dioxide  (ISO)
tolcapone  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
varenicline  (ISO)
vinclozolin  (EXP)
vincristine  (EXP)
wortmannin  (ISO)
yohimbine  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc oxide  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid fibril formation  (IEA,ISO,ISS)
amyloid-beta clearance by cellular catabolic process  (IBA,IEA,IMP,ISO)
apoptotic cell clearance  (IEA,ISO)
cell adhesion  (IEA)
cell surface receptor signaling pathway  (IEA,ISO)
cell-cell adhesion via plasma-membrane adhesion molecules  (IEP)
cellular response to amyloid-beta  (IEA,ISO)
cellular response to bacterial lipopeptide  (ISO)
cellular response to diacyl bacterial lipopeptide  (IEA,ISO,ISS)
cellular response to hydroperoxide  (IEA,ISO)
cellular response to insulin stimulus  (IEP)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to lipoteichoic acid  (IEA,ISO)
cellular response to low-density lipoprotein particle stimulus  (ISO,ISS)
cellular response to oxidative stress  (ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (IEA,ISO)
cGMP-mediated signaling  (ISO)
cholesterol import  (IEA,ISO,ISS)
cholesterol transport  (ISO)
defense response to Gram-positive bacterium  (IEA,ISO)
digestive tract development  (IEP)
eating behavior  (IMP)
energy homeostasis  (IEA,IMP,ISO)
fatty acid metabolic process  (IDA,IMP)
fatty acid oxidation  (IMP)
fatty acid transport  (IDA,IEP,IMP,ISO)
intestinal absorption  (ISO,ISS)
intestinal cholesterol absorption  (IEA,ISO,ISS)
lipid storage  (IBA,IEA,ISO)
lipid transport  (IEA)
lipid transport across blood-brain barrier  (IEA,ISO)
lipoprotein transport  (IBA,IEA,ISO)
long-chain fatty acid import across plasma membrane  (IEA,ISO)
long-chain fatty acid import into cell  (IBA,ISO,ISS)
long-chain fatty acid metabolic process  (IMP)
long-chain fatty acid transport  (IMP,ISO)
low-density lipoprotein particle clearance  (IBA,IEA,ISO)
low-density lipoprotein particle mediated signaling  (IEA,ISO)
MAPK cascade  (IEA,ISO)
maternal placenta development  (IEP)
negative regulation of angiogenesis  (IMP,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of protein import into nucleus  (IEA,ISO)
negative regulation of systemic arterial blood pressure  (IMP)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
nitric oxide-cGMP-mediated signaling  (IEA,ISO)
oxidised low-density lipoprotein particle clearance  (IEA,ISO)
phagocytosis, recognition  (IEA,ISO)
plasma lipoprotein particle clearance  (ISO)
positive regulation of blood coagulation  (IEA,ISO)
positive regulation of blood microparticle formation  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of cell-matrix adhesion  (IEA,ISO)
positive regulation of cholesterol storage  (IEA,ISO)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of cytokine production  (IMP)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO,ISS)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of glycogen biosynthetic process  (IDA)
positive regulation of interleukin-1 beta production  (IEA,ISO,ISS)
positive regulation of interleukin-12 production  (IEA,ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of macrophage cytokine production  (IEA,ISO)
positive regulation of macrophage derived foam cell differentiation  (IEA,ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of NLRP3 inflammasome complex assembly  (IEA,ISO,ISS)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of phagocytosis  (IMP)
positive regulation of phagocytosis, engulfment  (IEA,ISO)
positive regulation of reactive oxygen species biosynthetic process  (IEA,ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of triglyceride metabolic process  (IDA)
positive regulation of tumor necrosis factor production  (IEA,ISO)
receptor internalization  (IEA,ISO,ISS)
receptor-mediated endocytosis  (IBA,IMP,ISO)
regulation of action potential  (IEA,ISO)
regulation of protein-containing complex assembly  (ISO)
regulation of removal of superoxide radicals  (IEA,ISO)
regulation of toll-like receptor signaling pathway  (IEA,ISO)
response to activity  (IEP)
response to bacterium  (ISO)
response to estradiol  (IEP)
response to fatty acid  (IDA,IMP,ISO)
response to growth hormone  (IEP)
response to linoleic acid  (IEA,ISO,ISS)
response to lipid  (IMP,ISO)
response to mechanical stimulus  (IMP)
response to nutrient  (IEP)
response to stilbenoid  (IEA,ISO)
response to vitamin B3  (IEP)
response to xenobiotic stimulus  (IEP)
sensory perception of taste  (IEA,ISO,ISS)
short-chain fatty acid transport  (IEA,ISO)
triglyceride metabolic process  (IMP)
triglyceride transport  (IEA,ISO,ISS)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Key role of CD36 in Toll-like receptor 2 signaling in cerebral ischemia. Abe T, etal., Stroke. 2010 May;41(5):898-904. Epub 2010 Apr 1.
2. Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36. Abumrad NA, etal., J Biol Chem 1993 Aug 25;268(24):17665-8.
3. Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Aitman TJ, etal., Nat Genet 1999 Jan;21(1):76-83.
4. Capillary sprout endothelial cells exhibit a CD36 low phenotype: regulation by shear stress and vascular endothelial growth factor-induced mechanism for attenuating anti-proliferative thrombospondin-1 signaling. Anderson CR, etal., Am J Pathol. 2008 Oct;173(4):1220-8. Epub 2008 Sep 4.
5. Pathognomonic genetic expression profile within peripheral blood mononuclear cells of rheumatic heart disease patients. Baba MI, etal., Mol Cell Biochem. 2006 Oct;291(1-2):213-7. Epub 2006 Jun 2.
6. CD36 is a novel serum amyloid A (SAA) receptor mediating SAA binding and SAA-induced signaling in human and rodent cells. Baranova IN, etal., J Biol Chem. 2010 Mar 12;285(11):8492-506. Epub 2010 Jan 14.
7. CD36 in myocytes channels fatty acids to a lipase-accessible triglyceride pool that is related to cell lipid and insulin responsiveness. Bastie CC, etal., Diabetes. 2004 Sep;53(9):2209-16.
8. Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells. Bieghs V, etal., PLoS One. 2012;7(3):e34378. Epub 2012 Mar 28.
9. Scavenger receptor CD36 expression contributes to adipose tissue inflammation and cell death in diet-induced obesity. Cai L, etal., PLoS One. 2012;7(5):e36785. Epub 2012 May 16.
10. A novel function for fatty acid translocase (FAT)/CD36: involvement in long chain fatty acid transfer into the mitochondria. Campbell SE, etal., J Biol Chem. 2004 Aug 27;279(35):36235-41. Epub 2004 May 25.
11. Multiphasic triacylglycerol dynamics in the intact heart during acute in vivo overexpression of CD36. Carley AN, etal., J Lipid Res. 2013 Jan;54(1):97-106. doi: 10.1194/jlr.M029991. Epub 2012 Oct 25.
12. The pattern recognition receptor CD36 is a chondrocyte hypertrophy marker associated with suppression of catabolic responses and promotion of repair responses to inflammatory stimuli. Cecil DL, etal., J Immunol. 2009 Apr 15;182(8):5024-31.
13. Fatty acid transport and FAT/CD36 are increased in red but not in white skeletal muscle of ZDF rats. Chabowski A, etal., Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E675-82. Epub 2006 May 9.
14. The subcellular compartmentation of fatty acid transporters is regulated differently by insulin and by AICAR. Chabowski A, etal., FEBS Lett. 2005 Apr 25;579(11):2428-32.
15. Gut expression and regulation of FAT/CD36: possible role in fatty acid transport in rat enterocytes. Chen M, etal., Am J Physiol Endocrinol Metab 2001 Nov;281(5):E916-23.
16. The role of hyperglycemia in FAT/CD36 expression and function. Chen M, etal., Pediatr Surg Int. 2006 Aug;22(8):647-54. Epub 2006 Jul 13.
17. Hormonal and nutritional regulation of alternative CD36 transcripts in rat liver--a role for growth hormone in alternative exon usage. Cheung L, etal., BMC Mol Biol. 2007 Jul 17;8:60.
18. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Cho KH, etal., Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28.
19. Downregulation of CD36 results in reduced phagocytic ability of peritoneal macrophages of women with endometriosis. Chuang PC, etal., J Pathol. 2009 Oct;219(2):232-41.
20. CD36-deficient mice are resistant to alcohol- and high-carbohydrate-induced hepatic steatosis. Clugston RD, etal., J Lipid Res. 2014 Feb;55(2):239-46. doi: 10.1194/jlr.M041863. Epub 2013 Nov 26.
21. Increased FAT (fatty acid translocase)/CD36-mediated long-chain fatty acid uptake in cardiac myocytes from obese Zucker rats. Coort SL, etal., Biochem Soc Trans. 2004 Feb;32(Pt 1):83-5.
22. Direct association of a promoter polymorphism in the CD36/FAT fatty acid transporter gene with Type 2 diabetes mellitus and insulin resistance. Corpeleijn E, etal., Diabet Med. 2006 Aug;23(8):907-11.
23. Bone marrow chimeric mice reveal a dual role for CD36 in Plasmodium berghei ANKA infection. Cunha-Rodrigues M, etal., Malar J. 2007 Mar 16;6:32.
24. Modulation of CD36 protein expression by AGEs and insulin in aortic VSMCs from diabetic and non-diabetic rats. de Oliveira Silva C, etal., Nutr Metab Cardiovasc Dis. 2008 Jan;18(1):23-30. Epub 2006 Nov 28.
25. Trauma-hemorrhagic shock induces a CD36-dependent RBC endothelial-adhesive phenotype. Deitch EA, etal., Crit Care Med. 2014 Mar;42(3):e200-10. doi: 10.1097/CCM.0000000000000119.
26. CD36-mediated hematoma absorption following intracerebral hemorrhage: negative regulation by TLR4 signaling. Fang H, etal., J Immunol. 2014 Jun 15;192(12):5984-92. doi: 10.4049/jimmunol.1400054. Epub 2014 May 7.
27. Characterization of immune cell subsets during the active phase of multiple sclerosis reveals disease and c-Jun N-terminal kinase pathway biomarkers. Ferrandi C, etal., Mult Scler. 2011 Jan;17(1):43-56. Epub 2010 Sep 20.
28. Expression of the putative membrane fatty acid transporter (FAT) in taste buds of the circumvallate papillae in rats. Fukuwatari T, etal., FEBS Lett 1997 Sep 8;414(2):461-4.
29. Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease. Gaemers IC, etal., Biochim Biophys Acta. 2011 Apr;1812(4):447-58. Epub 2011 Jan 7.
30. Microarray analysis of the infrapatellar fat pad in knee osteoarthritis: relationship with joint inflammation. Gandhi R, etal., J Rheumatol. 2011 Sep;38(9):1966-72. Epub 2011 Jul 15.
31. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
32. The leukocyte expression of CD36 is low in patients with Alzheimer's disease and mild cognitive impairment. Giunta M, etal., Neurobiol Aging. 2007 Apr;28(4):515-8. Epub 2006 Mar 23.
33. Molecular basis of the Cd36 chromosomal deletion underlying SHR defects in insulin action and fatty acid metabolism. Glazier AM, etal., Mamm Genome 2002 Feb;13(2):108-13.
34. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
35. CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice. Goudriaan JR, etal., J Lipid Res. 2003 Dec;44(12):2270-7. Epub 2003 Aug 16.
36. Heart CD36 expression is increased in murine models of diabetes and in mice fed a high fat diet. Greenwalt DE, etal., J Clin Invest. 1995 Sep;96(3):1382-8.
37. A nonsense mutation of the ATRX gene causing mild mental retardation and epilepsy. Guerrini R, etal., Ann Neurol. 2000 Jan;47(1):117-21.
38. Phagocytosis of cholesteryl ester is amplified in diabetic mouse macrophages and is largely mediated by CD36 and SR-A. Guest CB, etal., PLoS ONE. 2007 Jun 6;2(6):e511.
39. Fatty acid translocase/CD36 mediates the uptake of palmitate by type II pneumocytes. Guthmann F, etal., Am J Physiol 1999 Jul;277(1 Pt 1):L191-6.
40. Identification of cryptic splice site, exon skipping, and novel point mutations in type I CD36 deficiency. Hanawa H, etal., J Med Genet. 2002 Apr;39(4):286-91.
41. Identification of the oxidized low-density lipoprotein scavenger receptor CD36 in plasma: a novel marker of insulin resistance. Handberg A, etal., Circulation. 2006 Sep 12;114(11):1169-76. Epub 2006 Sep 4.
42. Soluble CD36 in plasma is increased in patients with symptomatic atherosclerotic carotid plaques and is related to plaque instability. Handberg A, etal., Stroke. 2008 Nov;39(11):3092-5. Epub 2008 Aug 21.
43. The role of the scavenger receptor CD36 in regulating mononuclear phagocyte trafficking to atherosclerotic lesions and vascular inflammation. Harb D, etal., Cardiovasc Res. 2009 Jul 1;83(1):42-51. Epub 2009 Mar 5.
44. Binding of sulfosuccinimidyl fatty acids to adipocyte membrane proteins: isolation and amino-terminal sequence of an 88-kD protein implicated in transport of long-chain fatty acids. Harmon CM and Abumrad NA, J Membr Biol. 1993 Apr;133(1):43-9.
45. Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids. Harrison EH Biochim Biophys Acta. 2012 Jan;1821(1):70-7. Epub 2011 Jun 12.
46. CD36 deficiency attenuates experimental mycobacterial infection. Hawkes M, etal., BMC Infect Dis. 2010 Oct 15;10:299.
47. Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice. Heron-Milhavet L, etal., Endocrinology. 2004 Oct;145(10):4667-76. Epub 2004 Jul 1.
48. CD36 deficiency leads to choroidal involution via COX2 down-regulation in rodents. Houssier M, etal., PLoS Med. 2008 Feb;5(2):e39.
49. Impact of circulating monocyte CD36 level on atrial fibrillation and subsequent catheter ablation. Hu YF, etal., Heart Rhythm. 2011 May;8(5):650-6. Epub 2010 Dec 30.
50. Amyloid-beta-induced astrocytic phagocytosis is mediated by CD36, CD47 and RAGE. Jones RS, etal., J Neuroimmune Pharmacol. 2013 Mar;8(1):301-11. doi: 10.1007/s11481-012-9427-3. Epub 2012 Dec 14.
51. New targets of pemphigus vulgaris antibodies identified by protein array technology. Kalantari-Dehaghi M, etal., Exp Dermatol. 2011 Feb;20(2):154-6. doi: 10.1111/j.1600-0625.2010.01193.x.
52. CD36 in the periphery and brain synergizes in stroke injury in hyperlipidemia. Kim E, etal., Ann Neurol. 2012 Jun;71(6):753-64. doi: 10.1002/ana.23569.
53. Targeting CD36-mediated inflammation reduces acute brain injury in transient, but not permanent, ischemic stroke. Kim EH, etal., CNS Neurosci Ther. 2015 Apr;21(4):385-91. doi: 10.1111/cns.12326. Epub 2014 Sep 12.
54. Sterol Regulatory Element-Binding Proteins, Liver X Receptor, ABCA1 Transporter, CD36, Scavenger Receptors A1 and B1 in Nephrotic Kidney. Kim HJ and Vaziri ND, Am J Nephrol. 2009 Jan 16;29(6):607-614.
55. Evaluation of the relationship between MARCO and CD36 single-nucleotide polymorphisms and susceptibility to pulmonary tuberculosis in a Chinese Han population. Lao W, etal., BMC Infect Dis. 2017 Jul 11;17(1):488. doi: 10.1186/s12879-017-2595-2.
56. Roles of adipose restriction and metabolic factors in progression of steatosis to steatohepatitis in obese, diabetic mice. Larter CZ, etal., J Gastroenterol Hepatol. 2009 Oct;24(10):1658-68.
57. Molecular signatures of a disturbed nasal barrier function in the primary tissue of Wegener's granulomatosis. Laudien M, etal., Mucosal Immunol. 2011 Sep;4(5):564-73. doi: 10.1038/mi.2011.9. Epub 2011 Mar 16.
58. Role of FAT/CD36 in fatty acid sensing, energy, and glucose homeostasis regulation in DIO and DR rats. Le Foll C, etal., Am J Physiol Regul Integr Comp Physiol. 2015 Feb 1;308(3):R188-98. doi: 10.1152/ajpregu.00367.2014. Epub 2014 Dec 4.
59. FAT/CD36: a major regulator of neuronal fatty acid sensing and energy homeostasis in rats and mice. Le Foll C, etal., Diabetes. 2013 Aug;62(8):2709-16. doi: 10.2337/db12-1689. Epub 2013 Apr 4.
60. Class B scavenger receptor types I and II and CD36 targeting improves sepsis survival and acute outcomes in mice. Leelahavanichkul A, etal., J Immunol. 2012 Mar 15;188(6):2749-58. Epub 2012 Feb 10.
61. A CD36 nonsense mutation associated with insulin resistance and familial type 2 diabetes. Lepretre F, etal., Hum Mutat. 2004 Jul;24(1):104.
62. Effect of V(IV)O(dipic-Cl)(H2O)2 on Lipid Metabolism Disorders in the Liver of STZ-Induced Diabetic Rats. Liu F, etal., J Diabetes Res. 2013;2013:956737. doi: 10.1155/2013/956737. Epub 2013 Mar 20.
63. Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol. Love-Gregory L, etal., Hum Mol Genet. 2008 Jun 1;17(11):1695-704. Epub 2008 Feb 27.
64. Parasite burden and CD36-mediated sequestration are determinants of acute lung injury in an experimental malaria model. Lovegrove FE, etal., PLoS Pathog. 2008 May 16;4(5):e1000068.
65. Decreased contractility due to energy deprivation in a transgenic rat model of hypertrophic cardiomyopathy. Luedde M, etal., J Mol Med. 2009 Apr;87(4):411-22. Epub 2009 Feb 3.
66. Contraction-induced fatty acid translocase/CD36 translocation in rat cardiac myocytes is mediated through AMP-activated protein kinase signaling. Luiken JJ, etal., Diabetes. 2003 Jul;52(7):1627-34.
67. Permissive action of protein kinase C-zeta in insulin-induced CD36- and GLUT4 translocation in cardiac myocytes. Luiken JJ, etal., J Endocrinol. 2009 May;201(2):199-209. Epub 2009 Mar 9.
68. Atorvastatin downregulates monocyte CD36 expression, nuclear NFkappaB and TNFalpha levels in type 2 diabetes. Mandosi E, etal., J Atheroscler Thromb. 2010 Jun 30;17(6):539-45. Epub 2010 Feb 5.
69. Hyperinsulinemia and ectopic fat deposition can develop in the face of hyperadiponectinemia in young obese rats. Marecki JC, etal., J Nutr Biochem. 2011 Feb;22(2):142-52.
70. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
71. Dysregulation of monocyte/macrophage phenotype in wounds of diabetic mice. Mirza R and Koh TJ, Cytokine. 2011 Nov;56(2):256-64. Epub 2011 Jul 30.
72. Increased levels of circulating endothelial cells in chronic periaortitis as a marker of active disease. Moroni G, etal., Kidney Int. 2005 Aug;68(2):562-8.
73. Activation of CD36 inhibits and induces regression of inflammatory corneal neovascularization. Mwaikambo BR, etal., Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4356-64.
74. Effect of cerivastatin on endothelial dysfunction and aortic CD36 expression in diabetic hyperlipidemic rats. Nakamura T, etal., Hypertens Res. 2004 Aug;27(8):589-98.
75. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
76. CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis. Neckar J, etal., Physiol Genomics. 2012 Feb 1;44(2):173-82. Epub 2011 Nov 29.
77. Modulation of erythroid adhesion receptor expression by hydroxyurea in children with sickle cell disease. Odievre MH, etal., Haematologica. 2008 Apr;93(4):502-10. Epub 2008 Mar 5.
78. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
79. Pattern recognition scavenger receptors, SR-A and CD36, have an additive role in the development of colitis in mice. Oz HS, etal., Dig Dis Sci. 2009 Dec;54(12):2561-7.
80. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
81. Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats. Pravenec M, etal., Nat Genet 2001 Feb;27(2):156-8.
82. Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension. Pravenec M, etal., Nat Genet. 2008 Aug;40(8):952-4. Epub 2008 Jun 29.
83. Transgenic expression of CD36 in the spontaneously hypertensive rat is associated with amelioration of metabolic disturbances but has no effect on hypertension. Pravenec M, etal., Physiol Res. 2003;52(6):681-8.
84. CD36 is indispensable for thermogenesis under conditions of fasting and cold stress. Putri M, etal., Biochem Biophys Res Commun. 2015 Feb 20;457(4):520-5. doi: 10.1016/j.bbrc.2014.12.124. Epub 2015 Jan 13.
85. GOA pipeline RGD automated data pipeline
86. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
87. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
88. Haemolytic uraemic syndrome is an immune-mediated disease: role of anti-CD36 antibodies. Rock G, etal., Br J Haematol. 2005 Oct;131(2):247-52.
89. Surface expression of fatty acid translocase (FAT/CD36) on platelets in myeloproliferative disorders and non-insulin dependent diabetes mellitus: effect on arachidonic acid uptake. Salah-Uddin H, etal., Mol Cell Biochem. 2002 Oct;239(1-2):203-11.
90. Upregulation of thrombospondin-1(TSP-1) and its binding partners, CD36 and CD47, in sporadic inclusion body myositis. Salajegheh M, etal., J Neuroimmunol. 2007 Jul;187(1-2):166-74. Epub 2007 Jun 18.
91. IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia. Shimizu E, etal., J Immunol. 2008 Nov 1;181(9):6503-13.
92. A novel multiprotein complex is required to generate the prechylomicron transport vesicle from intestinal ER. Siddiqi S, etal., J Lipid Res. 2010 Jul;51(7):1918-28. Epub 2010 Mar 17.
93. Metformin and exercise reduce muscle FAT/CD36 and lipid accumulation and blunt the progression of high-fat diet-induced hyperglycemia. Smith AC, etal., Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E172-81. Epub 2007 Mar 20.
94. Immunopurification and characterization of rat adipocyte caveolae suggest their dissociation from insulin signaling. Souto RP, etal., J Biol Chem. 2003 May 16;278(20):18321-9. Epub 2003 Mar 11.
95. Female-predominant expression of fatty acid translocase/CD36 in rat and human liver. Stahlberg N, etal., Endocrinology. 2004 Apr;145(4):1972-9. Epub 2003 Dec 18.
96. Fatty acid transport proteins chronically relocate to the transverse-tubules in muscle from obese Zucker rats but are resistant to further insulin-induced translocation. Stefanyk LE, etal., Metabolism. 2013 Sep;62(9):1296-304. doi: 10.1016/j.metabol.2013.04.015. Epub 2013 Jun 3.
97. Chronic leptin administration decreases fatty acid uptake and fatty acid transporters in rat skeletal muscle. Steinberg GR, etal., J Biol Chem 2002 Mar 15;277(11):8854-60.
98. CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Stewart CR, etal., Nat Immunol. 2010 Feb;11(2):155-61. Epub 2009 Dec 27.
99. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
100. Multiple metabolic hits converge on CD36 as novel mediator of tubular epithelial apoptosis in diabetic nephropathy. Susztak K, etal., PLoS Med. 2005 Feb;2(2):e45. Epub 2005 Feb 22.
101. Is CD36 deficiency an etiology of hereditary hypertrophic cardiomyopathy? Tanaka T, etal., J Mol Cell Cardiol 1997 Jan;29(1):121-7.
102. Anti-CD36 antibodies in thrombotic thrombocytopenic purpura. Tandon NN, etal., Br J Haematol. 1994 Dec;88(4):816-25.
103. Cardiac fatty acid uptake and metabolism in the rat model of polycystic ovary syndrome. Tepavcevic S, etal., Endocrine. 2015 Sep;50(1):193-201. doi: 10.1007/s12020-015-0558-1. Epub 2015 Feb 22.
104. CD36 mRNA expression is increased in CD14+ monocytes of patients with coronary heart disease. Teupser D, etal., Clin Exp Pharmacol Physiol. 2008 May;35(5-6):552-6. Epub 2007 Dec 7.
105. Increased platelet CD36 constitutes a common marker in myeloproliferative disorders. Thibert V, etal., Br J Haematol. 1995 Nov;91(3):618-24.
106. Luminal lipid regulates CD36 levels and downstream signaling to stimulate chylomicron synthesis. Tran TT, etal., J Biol Chem. 2011 Jul 15;286(28):25201-10. doi: 10.1074/jbc.M111.233551. Epub 2011 May 24.
107. Intercellular adhesion molecule-4 and CD36 are implicated in the abnormal adhesiveness of sickle cell SAD mouse erythrocytes to endothelium. Trinh-Trang-Tan MM, etal., Haematologica. 2010 May;95(5):730-7. doi: 10.3324/haematol.2009.017392. Epub 2009 Dec 16.
108. Association study of candidate genes for the prevalence and progression of knee osteoarthritis. Valdes AM, etal., Arthritis Rheum. 2004 Aug;50(8):2497-507.
109. The effect of gestational age on angiogenic gene expression in the rat placenta. Vaswani K, etal., PLoS One. 2013 Dec 31;8(12):e83762. doi: 10.1371/journal.pone.0083762. eCollection 2013.
110. The Role of CD36 in the Effect of Arginine in Atherosclerotic Rats. Wang X, etal., Med Sci Monit. 2015 May 24;21:1494-9. doi: 10.12659/MSM.893388.
111. Silencing CD36 gene expression results in the inhibition of latent-TGF-beta1 activation and suppression of silica-induced lung fibrosis in the rat. Wang X, etal., Respir Res. 2009 May 13;10(1):36.
112. A CD36 synthetic peptide inhibits silica-induced lung fibrosis in the mice. Wang X, etal., Toxicol Ind Health. 2010 Feb;26(1):47-53. Epub 2010 Jan 7.
113. [The inhibitory effect of latent transforming growth factor ß1 activation and silicosis by CD36 targeted RNA interference in silicosis model of rat]. Wang X, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2013 Jul;31(7):518-21.
114. Effect of tachycardia on lipid metabolism and expression of fatty acid transporters in heart ventricles of the rat. Wojcik B, etal., J Physiol Pharmacol. 2015 Oct;66(5):691-9.
115. Role of KCa3.1 Channels in Macrophage Polarization and Its Relevance in Atherosclerotic Plaque Instability. Xu R, etal., Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):226-236. doi: 10.1161/ATVBAHA.116.308461. Epub 2016 Dec 29.
116. Rapid alternative absorption of dietary long-chain fatty acids with upregulation of intestinal glycosylated CD36 in liver cirrhosis. Yamamoto Y, etal., Am J Clin Nutr. 2012 Jul;96(1):90-101. Epub 2012 May 30.
117. Human CD36 deficiency is associated with elevation in low-density lipoprotein-cholesterol. Yanai H, etal., Am J Med Genet. 2000 Aug 14;93(4):299-304.
118. CD36 deficiency rescues lipotoxic cardiomyopathy. Yang J, etal., Circ Res. 2007 Apr 27;100(8):1208-17. Epub 2007 Mar 15.
119. Activation of rat alveolar macrophage-derived latent transforming growth factor beta-1 by plasmin requires interaction with thrombospondin-1 and its cell surface receptor, CD36. Yehualaeshet T, etal., Am J Pathol. 1999 Sep;155(3):841-51.
120. Familial macrothrombocytopenia associated with decreased glycosylation of platelet membrane glycoprotein IV. Yufu Y, etal., Am J Hematol 1990 Apr;33(4):271-3.
121. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
122. Cardiospecific CD36 suppression by lentivirus-mediated RNA interference prevents cardiac hypertrophy and systolic dysfunction in high-fat-diet induced obese mice. Zhang Y, etal., Cardiovasc Diabetol. 2015 Jun 3;14:69. doi: 10.1186/s12933-015-0234-z.
123. Hematoma resolution as a therapeutic target: the role of microglia/macrophages. Zhao X, etal., Stroke. 2009 Mar;40(3 Suppl):S92-4. Epub 2008 Dec 8.
Additional References at PubMed
PMID:7504047   PMID:9568716   PMID:10772654   PMID:12376530   PMID:14729860   PMID:15166001   PMID:15220187   PMID:15280390   PMID:15496455   PMID:15647754   PMID:15690042   PMID:15752738  
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PMID:32965022   PMID:34490487   PMID:36067926   PMID:36279933   PMID:37053180   PMID:37914358  


Genomics

Comparative Map Data
Cd36
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8418,209,088 - 18,302,142 (+)NCBIGRCr8
mRatBN7.2417,317,343 - 17,410,084 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl417,354,466 - 17,513,903 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx422,477,636 - 22,533,306 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0418,290,445 - 18,348,857 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0416,675,588 - 16,731,247 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0414,150,309 - 14,191,498 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl414,001,761 - 14,249,749 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0414,125,297 - 14,166,434 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4413,534,582 - 13,554,416 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera412,880,238 - 12,941,086 (+)NCBICelera
Cytogenetic Map4q11NCBI
CD36
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38780,602,207 - 80,679,274 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl780,369,575 - 80,679,277 (+)EnsemblGRCh38hg38GRCh38
GRCh37780,231,523 - 80,308,590 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36780,069,459 - 80,144,262 (+)NCBINCBI36Build 36hg18NCBI36
Build 34779,912,607 - 79,950,974NCBI
Celera774,932,098 - 75,009,206 (+)NCBICelera
Cytogenetic Map7q21.11NCBI
HuRef774,834,319 - 74,911,371 (+)NCBIHuRef
CHM1_1780,162,020 - 80,239,042 (+)NCBICHM1_1
T2T-CHM13v2.0781,853,488 - 81,930,588 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2779,562,929 - 79,640,010 (+)NCBI
Cd36
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39517,986,680 - 18,093,828 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl517,986,688 - 18,093,799 (-)EnsemblGRCm39 Ensembl
GRCm38517,781,690 - 17,888,959 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl517,781,690 - 17,888,801 (-)EnsemblGRCm38mm10GRCm38
MGSCv37517,287,508 - 17,394,777 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36517,293,840 - 17,347,520 (-)NCBIMGSCv36mm8
Celera514,757,802 - 14,864,361 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map58.11NCBI
Cd36
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554105,003,668 - 5,075,313 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554105,003,720 - 5,120,903 (-)NCBIChiLan1.0ChiLan1.0
CD36
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2698,337,667 - 98,528,488 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17146,740,194 - 146,795,378 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0772,566,478 - 72,643,517 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1786,228,856 - 86,305,865 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl786,265,114 - 86,305,865 (+)Ensemblpanpan1.1panPan2
CD36
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11820,299,808 - 20,375,856 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1820,339,050 - 20,372,639 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1820,015,595 - 20,045,069 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01820,745,564 - 20,821,666 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1820,542,818 - 20,821,688 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11820,418,233 - 20,447,673 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01819,970,682 - 20,000,166 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01820,626,442 - 20,655,919 (+)NCBIUU_Cfam_GSD_1.0
Cd36
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511862,188,852 - 62,269,004 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936810758,182 - 838,365 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936810791,823 - 838,303 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD36
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl999,605,181 - 99,782,105 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1999,685,748 - 99,782,296 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29110,037,583 - 110,106,975 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD36
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12168,214,875 - 68,309,336 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2168,216,201 - 68,268,669 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604235,654,688 - 35,734,209 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd36
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473929,407,568 - 29,441,333 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473929,341,620 - 29,441,232 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

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Variants in Cd36
1306 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:556
Count of miRNA genes:234
Interacting mature miRNAs:270
Transcripts:ENSRNOT00000008319, ENSRNOT00000061687
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat

Markers in Region
RH132455  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4q11UniSTS


Related Rat Strains
The following Strains have been annotated to Cd36


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 31