Cd28 (Cd28 molecule) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Cd28 (Cd28 molecule) Rattus norvegicus
Symbol: Cd28
Name: Cd28 molecule
RGD ID: 2299
Description: Enables identical protein binding activity. Involved in T cell costimulation. Predicted to be located in cell surface and immunological synapse. Predicted to be part of protein complex involved in cell adhesion. Predicted to be active in external side of plasma membrane. Used to study lymphopenia. Human ortholog(s) of this gene implicated in multiple sclerosis and type 1 diabetes mellitus. Orthologous to human CD28 (CD28 molecule); PARTICIPATES IN allograft rejection pathway; autoimmune thyroiditis pathway; graft-versus-host disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-glucopyranose; aldehydo-D-glucosamine.
Type: protein-coding
Previously known as: CD28 antigen; CD28RNA; T-cell-specific surface glycoprotein CD28
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Tspe1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8969,660,316 - 69,689,192 (+)NCBIGRCr8
mRatBN7.2962,166,324 - 62,194,674 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl962,166,192 - 62,194,685 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx970,668,268 - 70,693,746 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0975,783,858 - 75,809,336 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0974,102,440 - 74,127,918 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0967,546,408 - 67,573,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl967,546,408 - 67,571,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0967,358,994 - 67,386,424 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4959,342,273 - 59,367,743 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1959,489,254 - 59,514,725 (+)NCBI
Celera959,589,124 - 59,614,592 (+)NCBICelera
RH 3.4 Map9504.6RGD
Cytogenetic Map9q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-aminoethoxydiphenylborane  (ISO)
3,7-dihydropurine-6-thione  (ISO)
acetohydrazide  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
buta-1,3-diene  (ISO)
calcidiol  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
carboxy-PTIO  (ISO)
chloroprene  (ISO)
cyclophosphamide  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
Diisodecyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diquat  (ISO)
endosulfan  (EXP)
fenvalerate  (EXP)
fingolimod hydrochloride  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
hydrazine  (ISO)
ketoconazole  (ISO)
lipopolysaccharide  (ISO)
magnesium dichloride  (ISO)
manganese(II) chloride  (ISO)
mercaptopurine  (ISO)
mercury dichloride  (ISO)
methotrexate  (ISO)
methylarsonic acid  (ISO)
mifepristone  (ISO)
nickel atom  (ISO)
nitric oxide  (ISO)
ozone  (ISO)
paracetamol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
pravastatin  (EXP,ISO)
purine-6-thiol  (ISO)
reactive oxygen species  (ISO)
rimexolone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
staurosporine  (ISO)
tebuconazole  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism. Arreaza GA, etal., J Clin Invest. 1997 Nov 1;100(9):2243-53.
2. Induction of autoimmunity in the absence of CD28 costimulation. Bachmaier K, etal., J Immunol. 1996 Aug 15;157(4):1752-7.
3. A role for dendritic cells in bleomycin-induced pulmonary fibrosis in mice? Bantsimba-Malanda C, etal., Am J Respir Crit Care Med. 2010 Aug 1;182(3):385-95. Epub 2010 Apr 15.
4. Phenotypic characterisation of T-lymphocytes in COPD: abnormal CD4+CD25+ regulatory T-lymphocyte response to tobacco smoking. Barcelo B, etal., Eur Respir J. 2008 Mar;31(3):555-62. Epub 2007 Dec 5.
5. Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis. Beyersdorf N, etal., J Exp Med. 2005 Aug 1;202(3):445-55.
6. Differences in allergen-induced T cell activation between allergic asthma and rhinitis: Role of CD28, ICOS and CTLA-4. Botturi K, etal., Respir Res. 2011 Feb 28;12:25.
7. A critical role for DAP10 and DAP12 in CD8+ T cell-mediated tissue damage in large granular lymphocyte leukemia. Chen X, etal., Blood. 2009 Apr 2;113(14):3226-34. Epub 2008 Dec 15.
8. Dendritic Cells and CD28 Costimulation Are Required To Sustain Virus-Specific CD8+ T Cell Responses during the Effector Phase In Vivo. Dolfi DV, etal., J Immunol. 2011 Apr 15;186(8):4599-608. Epub 2011 Mar 9.
9. Rapid recovery from T lymphopenia by CD28 superagonist therapy. Elflein K, etal., Blood. 2003 Sep 1;102(5):1764-70. Epub 2003 May 15.
10. CD28 exerts protective and detrimental effects in a pulmonary model of paracoccidioidomycosis. Felonato M, etal., Infect Immun. 2010 Nov;78(11):4922-35. Epub 2010 Aug 16.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Differential effect of CD28 versus B7 blockade on direct pathway of allorecognition and self-restricted responses. Haspot F, etal., Blood 2002 Mar 15;99(6):2228-34.
14. CD8+ T cell responses in bronchoalveolar lavage fluid and peripheral blood mononuclear cells of infants with severe primary respiratory syncytial virus infections. Heidema J, etal., J Immunol. 2007 Dec 15;179(12):8410-7.
15. T-cell activation profiles in different granulomatous interstitial lung diseases--a role for CD8+CD28(null) cells? Heron M, etal., Clin Exp Immunol. 2010 May;160(2):256-65. Epub 2009 Dec 17.
16. Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with type 1 diabetes in the Japanese population. Ihara K, etal., Immunogenetics. 2001 Aug;53(6):447-54.
17. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
18. T cell senescence and contraction of T cell repertoire diversity in patients with chronic obstructive pulmonary disease. Lambers C, etal., Clin Exp Immunol. 2009 Mar;155(3):466-75.
19. [Effects of Tongbi Mixture 2 on expressions of CD28 and CD152 and content of tumor necrosis factor-alpha in peripheral blood in rats with collagen-induced arthritis] Liu H, etal., Zhong Xi Yi Jie He Xue Bao. 2008 Jul;6(7):744-7.
20. Immunological aspects of chronic fatigue syndrome. Lorusso L, etal., Autoimmun Rev. 2009 Feb;8(4):287-91. Epub 2008 Sep 16.
21. The Th2-response in mercuric chloride-induced autoimmunity requires continuing costimulation via CD28. Macphee IA, etal., Clin Exp Immunol 2002 Sep;129(3):405-10.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. A CD28 superagonistic antibody elicits 2 functionally distinct waves of T cell activation in rats. Muller N, etal., J Clin Invest. 2008 Apr;118(4):1405-16.
24. Better-surviving liver grafts by the injection of anti-CD2 antibody: the important roles of host CD8+ and CD2+CD28+ T cells in chronic graft rejection and beta type platelet-derived growth factor receptor (PDGFR-beta) expression on apoptotic liver grafts. Nakatsuji T Tohoku J Exp Med. 1999 Mar;187(3):215-25.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. CD40 and CD80/86 act synergistically to regulate inflammation and mortality in polymicrobial sepsis. Nolan A, etal., Am J Respir Crit Care Med. 2008 Feb 1;177(3):301-8. Epub 2007 Nov 7.
27. [Surface expression of costimulatory molecules CD28/CTLA-4 on peripheral blood T lymphocytes in the course of type 1 diabetes mellitus in children and adolescents] Pawlowski P, etal., Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2004;10(2):81-5.
28. Low dose streptozotocin-induced diabetes in rat insulin promoter-mCD80-transgenic mice is T cell autoantigen-specific and CD28 dependent. Pechhold K, etal., J Immunol. 2001 Feb 15;166(4):2531-9.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. GOA pipeline RGD automated data pipeline
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Translocation of CD28 to lipid rafts and costimulation of IL-2. Sadra A, etal., Proc Natl Acad Sci U S A 2004 Aug 3;101(31):11422-7. Epub 2004 Jul 27.
33. Treatment and prevention of experimental autoimmune neuritis with superagonistic CD28-specific monoclonal antibodies. Schmidt J, etal., J Neuroimmunol. 2003 Jul;140(1-2):143-52.
34. Cellular distribution and costimulatory function of rat CD28. Regulated expression during thymocyte maturation and induction of cyclosporin A sensitivity of costimulated T cell responses by phorbol ester. Tacke M, etal., J Immunol. 1995 May 15;154(10):5121-7.
35. Association of common T cell activation gene polymorphisms with multiple sclerosis in Australian patients. Teutsch SM, etal., J Neuroimmunol 2004 Mar;148(1-2):218-30.
36. Treatment and prevention of experimental autoimmune myocarditis with CD28 superagonists. Wang S, etal., Cardiology. 2010;115(2):107-13. doi: 10.1159/000256660. Epub 2009 Nov 10.
Additional References at PubMed
PMID:1309509   PMID:3159820   PMID:3875683   PMID:7544393   PMID:7688139   PMID:7790813   PMID:8125140   PMID:8617933   PMID:9368605   PMID:10429671   PMID:10791997   PMID:11390434  
PMID:12707299   PMID:12777399   PMID:12867038   PMID:12874832   PMID:12925852   PMID:14973438   PMID:15067037   PMID:15240667   PMID:15491677   PMID:16809611   PMID:18089392   PMID:18337562  
PMID:18408588   PMID:18641304   PMID:18727698   PMID:19641626   PMID:19811406   PMID:21245484   PMID:21487638   PMID:21745657   PMID:22564625   PMID:23589618   PMID:23793062   PMID:23817958  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8969,660,316 - 69,689,192 (+)NCBIGRCr8
mRatBN7.2962,166,324 - 62,194,674 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl962,166,192 - 62,194,685 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx970,668,268 - 70,693,746 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0975,783,858 - 75,809,336 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0974,102,440 - 74,127,918 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0967,546,408 - 67,573,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl967,546,408 - 67,571,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0967,358,994 - 67,386,424 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4959,342,273 - 59,367,743 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1959,489,254 - 59,514,725 (+)NCBI
Celera959,589,124 - 59,614,592 (+)NCBICelera
RH 3.4 Map9504.6RGD
Cytogenetic Map9q32NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382203,706,482 - 203,738,912 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2203,706,475 - 203,738,912 (+)EnsemblGRCh38hg38GRCh38
GRCh372204,571,362 - 204,603,635 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362204,279,443 - 204,310,801 (+)NCBINCBI36Build 36hg18NCBI36
Build 342204,396,703 - 204,428,062NCBI
Celera2198,326,049 - 198,357,410 (+)NCBICelera
Cytogenetic Map2q33.2NCBI
HuRef2196,418,462 - 196,450,899 (+)NCBIHuRef
CHM1_12204,577,787 - 204,610,219 (+)NCBICHM1_1
T2T-CHM13v2.02204,188,401 - 204,220,837 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39160,785,547 - 60,812,521 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl160,755,959 - 60,812,518 (+)EnsemblGRCm39 Ensembl
GRCm38160,746,388 - 60,773,359 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl160,716,800 - 60,773,359 (+)EnsemblGRCm38mm10GRCm38
MGSCv37160,803,232 - 60,830,203 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36160,691,012 - 60,717,905 (+)NCBIMGSCv36mm8
Celera161,261,669 - 61,288,639 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map130.52NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495545711,162,282 - 11,192,991 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545711,159,769 - 11,253,099 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v213106,310,207 - 106,343,899 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B106,325,199 - 106,358,891 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B90,938,795 - 90,971,438 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B209,076,388 - 209,111,213 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B209,076,388 - 209,111,213 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13712,503,849 - 12,536,362 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3712,503,811 - 12,532,854 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3713,387,259 - 13,416,196 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03712,440,597 - 12,473,128 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3712,440,613 - 12,471,203 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13712,397,782 - 12,426,685 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03712,360,914 - 12,389,827 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03712,361,906 - 12,391,080 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405303160,682,644 - 160,728,827 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936631335,411 - 363,407 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936631335,411 - 363,407 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl15107,128,203 - 107,162,935 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115107,128,103 - 107,155,431 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215118,472,553 - 118,502,433 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11089,471,710 - 89,505,152 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1089,471,730 - 89,500,387 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040109,879,825 - 109,913,281 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462476512,650,092 - 12,667,168 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cd28
73 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:62
Interacting mature miRNAs:70
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1578659Tspe1Trichinella spiralis expulsion QTL 14.8parasite quantity (VT:0010441)logarithm of the intestinal adult Trichinella spiralis count (CMO:0002024)96138143465691299Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2962,191,596 - 62,191,782 (+)MAPPERmRatBN7.2
Rnor_6.0967,571,681 - 67,571,866NCBIRnor6.0
Rnor_5.0967,384,268 - 67,384,453UniSTSRnor5.0
RGSC_v3.4959,367,553 - 59,367,738UniSTSRGSC3.4
Celera959,614,402 - 59,614,587UniSTS
RH 3.4 Map9504.6UniSTS
Cytogenetic Map9q31UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 8 15
Low 2 24 13 6 4 6 8 9 16 25 23 11 8
Below cutoff 1 19 36 35 35 2 47 10 18


RefSeq Acc Id: ENSRNOT00000013701   ⟹   ENSRNOP00000013701
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl962,166,194 - 62,191,787 (+)Ensembl
Rnor_6.0 Ensembl967,546,408 - 67,571,871 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117401   ⟹   ENSRNOP00000087151
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl962,166,192 - 62,191,787 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119892   ⟹   ENSRNOP00000076494
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl962,166,194 - 62,194,685 (+)Ensembl
RefSeq Acc Id: NM_013121   ⟹   NP_037253
Rat AssemblyChrPosition (strand)Source
GRCr8969,660,316 - 69,685,779 (+)NCBI
mRatBN7.2962,166,324 - 62,191,787 (+)NCBI
Rnor_6.0967,546,408 - 67,571,871 (+)NCBI
Rnor_5.0967,358,994 - 67,386,424 (+)NCBI
RGSC_v3.4959,342,273 - 59,367,743 (+)RGD
Celera959,589,124 - 59,614,592 (+)RGD
RefSeq Acc Id: XM_008767078   ⟹   XP_008765300
Rat AssemblyChrPosition (strand)Source
GRCr8969,660,414 - 69,689,192 (+)NCBI
mRatBN7.2962,170,472 - 62,194,674 (+)NCBI
Rnor_6.0967,549,987 - 67,573,858 (+)NCBI
Protein Sequences
Protein RefSeqs NP_037253 (Get FASTA)   NCBI Sequence Viewer  
  XP_008765300 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA39003 (Get FASTA)   NCBI Sequence Viewer  
  EDL98926 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013701
GenBank Protein P31042 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037253   ⟸   NM_013121
- Peptide Label: precursor
- UniProtKB: P31042 (UniProtKB/Swiss-Prot),   A6IPD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765300   ⟸   XM_008767078
- Peptide Label: isoform X1
- UniProtKB: P31042 (UniProtKB/Swiss-Prot),   G3V7C2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013701   ⟸   ENSRNOT00000013701
RefSeq Acc Id: ENSRNOP00000076494   ⟸   ENSRNOT00000119892
RefSeq Acc Id: ENSRNOP00000087151   ⟸   ENSRNOT00000117401
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31042-F1-model_v2 AlphaFold P31042 1-218 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696707
Promoter ID:EPDNEW_R7232
Type:initiation region
Description:Cd28 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0967,546,375 - 67,546,435EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2299 AgrOrtholog
BioCyc Gene G2FUF-27371 BioCyc
Ensembl Genes ENSRNOG00000010283 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013701.4 UniProtKB/TrEMBL
  ENSRNOT00000117401.1 UniProtKB/TrEMBL
  ENSRNOT00000119892.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CD28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTLA4/CD28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25660 UniProtKB/Swiss-Prot
PANTHER PTHR11494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam V-set UniProtKB/TrEMBL
  V-set_2 UniProtKB/Swiss-Prot
PhenoGen Cd28 PhenoGen
RatGTEx ENSRNOG00000010283 RatGTEx
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y6P1_RAT UniProtKB/TrEMBL
  CD28_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-06-27 Cd28  Cd28 molecule  Cd28  CD28 antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Cd28  CD28 antigen      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds to B7-1 or B7-2 on Antigen Presenting Cells 634714
gene_process involved in initiation of the Th2-response; may be required to maintain basal IgE production during mercuric chloride (HgCl2)-induced autoimmunity 634715
gene_process costimulatory molecule for T-cell proliferation, particularly during T-cell mediated allograft responses 634714