C2orf74 (chromosome 2 open reading frame 74) - Rat Genome Database

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Gene: C2orf74 (chromosome 2 open reading frame 74) Homo sapiens
Analyze
Symbol: C2orf74
Name: chromosome 2 open reading frame 74
RGD ID: 2298736
HGNC Page HGNC:34439
Description: Predicted to be located in membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC339804; uncharacterized protein C2orf74
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38261,145,116 - 61,164,828 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl261,145,068 - 61,164,828 (+)EnsemblGRCh38hg38GRCh38
GRCh37261,372,251 - 61,391,963 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36261,225,792 - 61,245,468 (+)NCBINCBI36Build 36hg18NCBI36
Celera261,215,846 - 61,236,014 (+)NCBICelera
Cytogenetic Map2p15NCBI
HuRef261,113,262 - 61,133,063 (+)NCBIHuRef
CHM1_1261,302,780 - 61,322,493 (+)NCBICHM1_1
T2T-CHM13v2.0261,150,976 - 61,170,676 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:21102463   PMID:21988832   PMID:22412388   PMID:23128233   PMID:32296183   PMID:33571247   PMID:37249651   PMID:38113892  


Genomics

Comparative Map Data
C2orf74
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38261,145,116 - 61,164,828 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl261,145,068 - 61,164,828 (+)EnsemblGRCh38hg38GRCh38
GRCh37261,372,251 - 61,391,963 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36261,225,792 - 61,245,468 (+)NCBINCBI36Build 36hg18NCBI36
Celera261,215,846 - 61,236,014 (+)NCBICelera
Cytogenetic Map2p15NCBI
HuRef261,113,262 - 61,133,063 (+)NCBIHuRef
CHM1_1261,302,780 - 61,322,493 (+)NCBICHM1_1
T2T-CHM13v2.0261,150,976 - 61,170,676 (+)NCBIT2T-CHM13v2.0
1700093K21Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391123,466,203 - 23,471,915 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1123,466,203 - 23,471,155 (-)EnsemblGRCm39 Ensembl
GRCm381123,516,202 - 23,521,319 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1123,516,203 - 23,521,155 (-)EnsemblGRCm38mm10GRCm38
MGSCv371123,416,203 - 23,419,942 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361123,416,203 - 23,419,195 (-)NCBIMGSCv36mm8
Celera1125,643,964 - 25,647,707 (-)NCBICelera
Cytogenetic Map11A3.2NCBI
cM Map1114.32NCBI
C14h2orf74
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814101,694,721 - 101,697,842 (-)NCBIGRCr8
mRatBN7.21497,493,579 - 97,496,697 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1497,493,658 - 97,496,679 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14101,825,814 - 101,828,841 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014103,070,175 - 103,073,202 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01499,541,741 - 99,544,768 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014108,281,908 - 108,285,008 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14108,281,907 - 108,285,008 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014105,117,765 - 105,120,865 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414104,443,532 - 104,446,553 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1496,470,624 - 96,473,645 (-)NCBICelera
Cytogenetic Map14q22NCBI
CUNH2orf74
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542422,709,676 - 22,712,178 (-)NCBIChiLan1.0ChiLan1.0
C12H2orf74
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21265,212,265 - 65,232,116 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A65,216,227 - 65,236,067 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A61,236,580 - 61,256,389 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A62,377,116 - 62,395,225 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A62,392,633 - 62,395,225 (+)Ensemblpanpan1.1panPan2
C10H2orf74
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11061,199,711 - 61,231,862 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1061,229,922 - 61,231,834 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1061,089,577 - 61,121,728 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01062,208,401 - 62,240,704 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1062,238,753 - 62,240,667 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11061,911,317 - 61,943,472 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01062,195,570 - 62,228,168 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01062,491,291 - 62,523,461 (+)NCBIUU_Cfam_GSD_1.0
CUNH2orf74
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629221,913,425 - 21,917,216 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364916,654,380 - 6,657,560 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364916,654,389 - 6,657,560 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C3H2orf74
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl380,626,159 - 80,648,230 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1380,626,056 - 80,651,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2384,514,795 - 84,517,948 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CUNH2orf74
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11445,819,831 - 45,824,090 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1445,820,129 - 45,822,162 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604565,963,324 - 65,981,598 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CUNH2orf74
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624833746,124 - 749,415 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624833746,419 - 748,845 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in C2orf74
2 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2p16.1-15(chr2:59658846-62336083)x1 copy number loss See cases [RCV000050796] Chr2:59658846..62336083 [GRCh38]
Chr2:59885981..62563218 [GRCh37]
Chr2:59739485..62416722 [NCBI36]
Chr2:2p16.1-15		 pathogenic
GRCh38/hg38 2p16.1-15(chr2:60009106-62006709)x3 copy number gain See cases [RCV000052660] Chr2:60009106..62006709 [GRCh38]
Chr2:60236241..62233844 [GRCh37]
Chr2:60089745..62087348 [NCBI36]
Chr2:2p16.1-15		 uncertain significance
GRCh38/hg38 2p16.1-15(chr2:56738054-62473668)x1 copy number loss See cases [RCV000054020] Chr2:56738054..62473668 [GRCh38]
Chr2:56965189..62700803 [GRCh37]
Chr2:56818693..62554307 [NCBI36]
Chr2:2p16.1-15		 pathogenic
GRCh38/hg38 2p16.1-15(chr2:57249378-61842734)x1 copy number loss See cases [RCV000054021] Chr2:57249378..61842734 [GRCh38]
Chr2:57476513..62069869 [GRCh37]
Chr2:57330017..61923373 [NCBI36]
Chr2:2p16.1-15		 pathogenic
GRCh38/hg38 2p16.1-14(chr2:58873039-64190332)x1 copy number loss See cases [RCV000054022] Chr2:58873039..64190332 [GRCh38]
Chr2:59100174..64417466 [GRCh37]
Chr2:58953678..64270970 [NCBI36]
Chr2:2p16.1-14		 pathogenic
GRCh38/hg38 2p16.1-15(chr2:59224998-61621710)x1 copy number loss See cases [RCV000054052] Chr2:59224998..61621710 [GRCh38]
Chr2:59452133..61848845 [GRCh37]
Chr2:59305637..61702349 [NCBI36]
Chr2:2p16.1-15		 pathogenic
GRCh38/hg38 2p16.1-11.2(chr2:58279519-83586962)x3 copy number gain See cases [RCV000136053] Chr2:58279519..83586962 [GRCh38]
Chr2:58506654..83814086 [GRCh37]
Chr2:58360158..83667597 [NCBI36]
Chr2:2p16.1-11.2		 pathogenic
GRCh38/hg38 2p16.1-15(chr2:60359313-61775405)x3 copy number gain See cases [RCV000137542] Chr2:60359313..61775405 [GRCh38]
Chr2:60586448..62002540 [GRCh37]
Chr2:60439952..61856044 [NCBI36]
Chr2:2p16.1-15		 uncertain significance
GRCh38/hg38 2p16.3-11.2(chr2:47620388-86702722)x3 copy number gain See cases [RCV000137586] Chr2:47620388..86702722 [GRCh38]
Chr2:47847527..86929845 [GRCh37]
Chr2:47701031..86783356 [NCBI36]
Chr2:2p16.3-11.2		 uncertain significance
GRCh38/hg38 2p16.1-15(chr2:60359313-61704436)x3 copy number gain See cases [RCV000139201] Chr2:60359313..61704436 [GRCh38]
Chr2:60586448..61931571 [GRCh37]
Chr2:60439952..61785075 [NCBI36]
Chr2:2p16.1-15		 likely pathogenic|likely benign
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2		 benign
GRCh38/hg38 2p16.1-15(chr2:58031916-63611810)x1 copy number loss See cases [RCV000143007] Chr2:58031916..63611810 [GRCh38]
Chr2:58259051..63838944 [GRCh37]
Chr2:58112555..63692448 [NCBI36]
Chr2:2p16.1-15		 pathogenic
GRCh37/hg19 2p16.1-15(chr2:60405806-62442792)x3 copy number gain See cases [RCV000239924] Chr2:60405806..62442792 [GRCh37]
Chr2:2p16.1-15		 uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p16.1-15(chr2:58837279-63720819)x1 copy number loss See cases [RCV000449133] Chr2:58837279..63720819 [GRCh37]
Chr2:2p16.1-15		 pathogenic
GRCh37/hg19 2p15(chr2:61384966-61439049)x3 copy number gain See cases [RCV000445703] Chr2:61384966..61439049 [GRCh37]
Chr2:2p15		 uncertain significance
GRCh37/hg19 2p15(chr2:61335464-61757267)x1 copy number loss See cases [RCV000445835] Chr2:61335464..61757267 [GRCh37]
Chr2:2p15		 likely pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p16.1-15(chr2:60308869-62368583) copy number gain Global developmental delay [RCV000626531] Chr2:60308869..62368583 [GRCh37]
Chr2:2p16.1-15		 likely pathogenic
GRCh37/hg19 2p16.1-15(chr2:60339550-61374752)x3 copy number gain not provided [RCV000682113] Chr2:60339550..61374752 [GRCh37]
Chr2:2p16.1-15		 uncertain significance
GRCh37/hg19 2p16.1-15(chr2:60573620-61767847)x3 copy number gain not provided [RCV000682120] Chr2:60573620..61767847 [GRCh37]
Chr2:2p16.1-15		 uncertain significance
Single allele deletion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3		 likely pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p16.1-15(chr2:61249676-61414183)x3 copy number gain not provided [RCV000740469] Chr2:61249676..61414183 [GRCh37]
Chr2:2p16.1-15		 benign
GRCh37/hg19 2p16.1-15(chr2:57445335-62733206) copy number loss not provided [RCV000767552] Chr2:57445335..62733206 [GRCh37]
Chr2:2p16.1-15		 likely pathogenic
GRCh37/hg19 2p15(chr2:61327948-61436931)x3 copy number gain not provided [RCV001005280] Chr2:61327948..61436931 [GRCh37]
Chr2:2p15		 uncertain significance
GRCh37/hg19 2p15(chr2:61343158-61409905)x1 copy number loss not provided [RCV001260156] Chr2:61343158..61409905 [GRCh37]
Chr2:2p15		 uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373) copy number gain Mosaic trisomy 2 [RCV002280628] Chr2:1..243199373 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p16.1-15(chr2:61288377-61639509)x1 copy number loss not provided [RCV001829241] Chr2:61288377..61639509 [GRCh37]
Chr2:2p16.1-15		 uncertain significance
GRCh37/hg19 2p16.1-15(chr2:61288351-61394867)x3 copy number gain not provided [RCV001827916] Chr2:61288351..61394867 [GRCh37]
Chr2:2p16.1-15		 uncertain significance
NC_000002.11:g.(?_61108976)_(62081176_?)del deletion Peroxisome biogenesis disorder 11A (Zellweger) [RCV001975094] Chr2:61108976..62081176 [GRCh37]
Chr2:2p16.1-15		 pathogenic
NC_000002.11:g.(?_61258534)_(62063264_?)dup duplication Peroxisome biogenesis disorder 11A (Zellweger) [RCV001900545] Chr2:61258534..62063264 [GRCh37]
Chr2:2p16.1-15		 uncertain significance
GRCh37/hg19 2p25.1-q13(chr2:11504318-111365996)x1 copy number loss See cases [RCV002287563] Chr2:11504318..111365996 [GRCh37]
Chr2:2p25.1-q13		 pathogenic
GRCh37/hg19 2p16.1-15(chr2:61238958-61414470)x3 copy number gain not provided [RCV002473839] Chr2:61238958..61414470 [GRCh37]
Chr2:2p16.1-15		 uncertain significance
GRCh37/hg19 2p16.1-15(chr2:60680467-61527143)x3 copy number gain not provided [RCV002474560] Chr2:60680467..61527143 [GRCh37]
Chr2:2p16.1-15		 likely pathogenic
GRCh37/hg19 2p16.1-15(chr2:61215497-61714418)x1 copy number loss not provided [RCV002472493] Chr2:61215497..61714418 [GRCh37]
Chr2:2p16.1-15		 pathogenic
GRCh37/hg19 2p15(chr2:61379352-61928100)x1 copy number loss not provided [RCV002472544] Chr2:61379352..61928100 [GRCh37]
Chr2:2p15		 pathogenic
GRCh37/hg19 2p16.1-15(chr2:61215496-62175386)x3 copy number gain not specified [RCV003986317] Chr2:61215496..62175386 [GRCh37]
Chr2:2p16.1-15		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:168
Count of miRNA genes:77
Interacting mature miRNAs:80
Transcripts:ENST00000426997, ENST00000432605
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407028018GWAS676994_Hfree androgen index QTL GWAS676994 (human)7e-09free androgen index26116417061164171Human
407382345GWAS1031321_Hreticulocyte measurement QTL GWAS1031321 (human)2e-10reticulocyte morphology trait (VT:0002424)red blood cell measurement (CMO:0001356)26115215161152152Human
407087570GWAS736546_HCrohn's disease QTL GWAS736546 (human)5e-14Crohn's disease26116416561164166Human
407392571GWAS1041547_Hneuroticism measurement QTL GWAS1041547 (human)1e-08neuroticism measurement26116011961160120Human
407088064GWAS737040_Hsex interaction measurement, inflammatory bowel disease QTL GWAS737040 (human)3e-12sex interaction measurement, inflammatory bowel disease26116416561164166Human
407126354GWAS775330_Hepithelial cell adhesion molecule measurement QTL GWAS775330 (human)9e-10epithelial cell adhesion molecule measurement26114938961149390Human
407088907GWAS737883_Hinflammatory bowel disease QTL GWAS737883 (human)2e-12inflammatory bowel disease26116416561164166Human
407089498GWAS738474_Hsex interaction measurement, Crohn's disease QTL GWAS738474 (human)3e-13sex interaction measurement, Crohn's disease26116416561164166Human
407149386GWAS798362_Hneuroticism measurement QTL GWAS798362 (human)4e-08neuroticism measurement26115777161157772Human


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2378 2788 2252 4973 1723 2337 6 621 1945 462 2270 7234 6456 53 3733 1 840 1711 1606 174 1

Sequence


Ensembl Acc Id: ENST00000398622   ⟹   ENSP00000381621
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl261,145,131 - 61,163,163 (+)Ensembl
Ensembl Acc Id: ENST00000426997   ⟹   ENSP00000398725
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl261,145,068 - 61,164,808 (+)Ensembl
Ensembl Acc Id: ENST00000432605   ⟹   ENSP00000402915
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl261,162,188 - 61,164,828 (+)Ensembl
Ensembl Acc Id: ENST00000464909   ⟹   ENSP00000482798
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl261,145,108 - 61,164,809 (+)Ensembl
Ensembl Acc Id: ENST00000488469   ⟹   ENSP00000484061
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl261,162,191 - 61,164,825 (+)Ensembl
Ensembl Acc Id: ENST00000489686   ⟹   ENSP00000481253
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl261,145,130 - 61,163,142 (+)Ensembl
RefSeq Acc Id: NM_001143959   ⟹   NP_001137431
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38261,162,188 - 61,164,828 (+)NCBI
GRCh37261,372,221 - 61,391,964 (+)NCBI
Celera261,215,846 - 61,236,014 (+)RGD
HuRef261,113,262 - 61,133,063 (+)RGD
CHM1_1261,320,158 - 61,322,493 (+)NCBI
T2T-CHM13v2.0261,168,036 - 61,170,676 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001143960   ⟹   NP_001137432
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38261,145,116 - 61,164,828 (+)NCBI
GRCh37261,372,221 - 61,391,964 (+)NCBI
Celera261,215,846 - 61,236,014 (+)RGD
HuRef261,113,262 - 61,133,063 (+)RGD
CHM1_1261,302,740 - 61,322,493 (+)NCBI
T2T-CHM13v2.0261,150,976 - 61,170,676 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001316317   ⟹   NP_001303246
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38261,145,116 - 61,164,828 (+)NCBI
CHM1_1261,302,740 - 61,322,493 (+)NCBI
T2T-CHM13v2.0261,150,976 - 61,170,676 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001367069   ⟹   NP_001353998
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38261,145,116 - 61,164,828 (+)NCBI
T2T-CHM13v2.0261,150,976 - 61,170,676 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001367070   ⟹   NP_001353999
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38261,145,116 - 61,164,828 (+)NCBI
T2T-CHM13v2.0261,150,976 - 61,170,676 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001367071   ⟹   NP_001354000
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38261,145,116 - 61,164,828 (+)NCBI
T2T-CHM13v2.0261,150,976 - 61,170,676 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001137432   ⟸   NM_001143960
- Peptide Label: isoform 2
- UniProtKB: C9JBF1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001137431   ⟸   NM_001143959
- Peptide Label: isoform 1
- UniProtKB: A8MZ97 (UniProtKB/Swiss-Prot),   C9JP62 (UniProtKB/Swiss-Prot),   A0A087X1C3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001303246   ⟸   NM_001316317
- Peptide Label: isoform 2
- UniProtKB: C9JBF1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001353999   ⟸   NM_001367070
- Peptide Label: isoform 2
- UniProtKB: C9JBF1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001353998   ⟸   NM_001367069
- Peptide Label: isoform 2
- UniProtKB: C9JBF1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001354000   ⟸   NM_001367071
- Peptide Label: isoform 2
- UniProtKB: C9JBF1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSP00000381621   ⟸   ENST00000398622
Ensembl Acc Id: ENSP00000482798   ⟸   ENST00000464909
Ensembl Acc Id: ENSP00000398725   ⟸   ENST00000426997
Ensembl Acc Id: ENSP00000402915   ⟸   ENST00000432605
Ensembl Acc Id: ENSP00000484061   ⟸   ENST00000488469
Ensembl Acc Id: ENSP00000481253   ⟸   ENST00000489686

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A8MZ97-F1-model_v2 AlphaFold A8MZ97 1-187 view protein structure

Promoters
RGD ID:6860402
Promoter ID:EPDNEW_H3366
Type:initiation region
Name:C2orf74_1
Description:chromosome 2 open reading frame 74
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38261,145,116 - 61,145,176EPDNEW
RGD ID:6796913
Promoter ID:HG_KWN:32795
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000398622,   NM_001143960,   OTTHUMT00000325484,   OTTHUMT00000325544,   OTTHUMT00000325686,   OTTHUMT00000325687,   OTTHUMT00000325688,   UC002SBA.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36261,225,411 - 61,225,911 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:34439 AgrOrtholog
COSMIC C2orf74 COSMIC
Ensembl Genes ENSG00000237651 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000398622.3 UniProtKB/TrEMBL
  ENST00000426997 ENTREZGENE
  ENST00000426997.5 UniProtKB/TrEMBL
  ENST00000432605 ENTREZGENE
  ENST00000432605.3 UniProtKB/Swiss-Prot
  ENST00000464909 ENTREZGENE
  ENST00000464909.2 UniProtKB/TrEMBL
  ENST00000488469.4 UniProtKB/TrEMBL
  ENST00000489686.5 UniProtKB/TrEMBL
GTEx ENSG00000237651 GTEx
HGNC ID HGNC:34439 ENTREZGENE
Human Proteome Map C2orf74 Human Proteome Map
InterPro DUF4642 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 339804 ENTREZGENE
PANTHER HYPOTHETICAL PROTEIN LOC690352 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR37882 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF4642 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA162379547 PharmGKB
UniProt A0A087WXS6_HUMAN UniProtKB/TrEMBL
  A0A087X1C3 ENTREZGENE, UniProtKB/TrEMBL
  A8MZ97 ENTREZGENE
  C9JBF1 ENTREZGENE, UniProtKB/TrEMBL
  C9JP62 ENTREZGENE
  CB074_HUMAN UniProtKB/Swiss-Prot
  F8VY72_HUMAN UniProtKB/TrEMBL
UniProt Secondary C9JP62 UniProtKB/Swiss-Prot