NPS (neuropeptide S) - Rat Genome Database

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Gene: NPS (neuropeptide S) Homo sapiens
Analyze
Symbol: NPS
Name: neuropeptide S
RGD ID: 2291750
HGNC Page HGNC:33940
Description: Predicted to be involved in positive regulation of GABAergic synaptic transmission; positive regulation of action potential; and positive regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within visual learning. Predicted to be located in extracellular region.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: prepro-neuropeptide S
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810127,549,309 - 127,553,540 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10127,549,309 - 127,553,540 (+)EnsemblGRCh38hg38GRCh38
GRCh3710129,347,573 - 129,351,804 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610129,237,603 - 129,240,925 (+)NCBINCBI36Build 36hg18NCBI36
Celera10123,018,049 - 123,021,372 (+)NCBICelera
Cytogenetic Map10q26.2NCBI
HuRef10122,920,598 - 122,923,921 (+)NCBIHuRef
CHM1_110129,629,918 - 129,633,240 (+)NCBICHM1_1
T2T-CHM13v2.010128,444,335 - 128,448,567 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular region  (IEA,TAS)
synapse  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Morphine dependence is associated with changes in neuropeptide S receptor expression and function in rat brain. Ghazal P, etal., Peptides. 2013 Aug;46:6-12. doi: 10.1016/j.peptides.2013.05.001. Epub 2013 May 16.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Neuropeptide S receptor gene expression in alcohol withdrawal and protracted abstinence in postdependent rats. Ruggeri B, etal., Alcohol Clin Exp Res. 2010 Jan;34(1):90-7. doi: 10.1111/j.1530-0277.2009.01070.x. Epub 2009 Oct 23.
Additional References at PubMed
PMID:12036966   PMID:15312648   PMID:15947423   PMID:16279934   PMID:16282594   PMID:16574794   PMID:16720571   PMID:16790440   PMID:16926187   PMID:18181564   PMID:18376418   PMID:19240061  
PMID:19824051   PMID:20405330   PMID:20705147   PMID:21873635   PMID:23142110   PMID:24386135   PMID:28463995   PMID:31326375   PMID:33556445   PMID:34252586   PMID:38287231  


Genomics

Comparative Map Data
NPS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810127,549,309 - 127,553,540 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10127,549,309 - 127,553,540 (+)EnsemblGRCh38hg38GRCh38
GRCh3710129,347,573 - 129,351,804 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610129,237,603 - 129,240,925 (+)NCBINCBI36Build 36hg18NCBI36
Celera10123,018,049 - 123,021,372 (+)NCBICelera
Cytogenetic Map10q26.2NCBI
HuRef10122,920,598 - 122,923,921 (+)NCBIHuRef
CHM1_110129,629,918 - 129,633,240 (+)NCBICHM1_1
T2T-CHM13v2.010128,444,335 - 128,448,567 (+)NCBIT2T-CHM13v2.0
Nps
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397134,870,348 - 134,874,671 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7134,860,432 - 134,874,671 (+)EnsemblGRCm39 Ensembl
GRCm387135,268,619 - 135,272,942 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7135,258,703 - 135,272,942 (+)EnsemblGRCm38mm10GRCm38
MGSCv377142,460,302 - 142,464,625 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367142,436,414 - 142,464,444 (+)NCBIMGSCv36mm8
Celera7135,088,015 - 135,092,338 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map781.27NCBI
Nps
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81199,505,772 - 199,510,915 (+)NCBIGRCr8
mRatBN7.21190,077,040 - 190,080,821 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1190,077,040 - 190,080,821 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1198,437,750 - 198,441,531 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01205,597,306 - 205,601,071 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01198,270,805 - 198,274,570 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01207,508,414 - 207,512,195 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1207,508,414 - 207,512,195 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01214,442,729 - 214,446,510 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41194,887,958 - 194,892,866 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1187,793,965 - 187,797,746 (+)NCBICelera
Cytogenetic Map1q41NCBI
NPS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28139,426,346 - 139,429,899 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110139,431,697 - 139,435,932 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010124,135,616 - 124,139,845 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110128,384,897 - 128,388,217 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10128,384,897 - 128,388,217 (+)Ensemblpanpan1.1panPan2
NPS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12836,488,430 - 36,492,524 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2836,488,500 - 36,492,090 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2836,544,343 - 36,548,486 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02837,120,629 - 37,124,769 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2837,120,699 - 37,124,289 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12836,596,914 - 36,601,058 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02836,595,559 - 36,599,690 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02836,850,200 - 36,854,347 (+)NCBIUU_Cfam_GSD_1.0
Nps
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721310,385,430 - 10,389,542 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648615,172,256 - 15,175,339 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648615,172,068 - 15,175,568 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14136,836,352 - 136,839,510 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114136,835,630 - 136,839,511 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214148,566,054 - 148,569,278 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19120,168,749 - 120,176,288 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604881,554,586 - 81,558,810 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nps
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473719,447,495 - 19,451,005 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NPS
4 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q25.2-26.3(chr10:111313099-133620674)x3 copy number gain See cases [RCV000051218] Chr10:111313099..133620674 [GRCh38]
Chr10:113072857..135434178 [GRCh37]
Chr10:113062847..135284168 [NCBI36]
Chr10:10q25.2-26.3		 pathogenic
GRCh38/hg38 10q26.13-26.3(chr10:122265252-133620674)x1 copy number loss See cases [RCV000051069] Chr10:122265252..133620674 [GRCh38]
Chr10:124024767..135434178 [GRCh37]
Chr10:124014757..135284168 [NCBI36]
Chr10:10q26.13-26.3		 pathogenic
GRCh38/hg38 10q26.12-26.3(chr10:120454430-133620674)x1 copy number loss See cases [RCV000051103] Chr10:120454430..133620674 [GRCh38]
Chr10:122213942..135434178 [GRCh37]
Chr10:122203932..135284168 [NCBI36]
Chr10:10q26.12-26.3		 pathogenic
GRCh38/hg38 10q26.13-26.3(chr10:123307835-133620674)x1 copy number loss See cases [RCV000051150] Chr10:123307835..133620674 [GRCh38]
Chr10:125067351..135434178 [GRCh37]
Chr10:125057341..135284168 [NCBI36]
Chr10:10q26.13-26.3		 pathogenic
GRCh38/hg38 10q26.2(chr10:127435985-127992839)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051655]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051655]|See cases [RCV000051655] Chr10:127435985..127992839 [GRCh38]
Chr10:129234249..129791103 [GRCh37]
Chr10:129124239..129681093 [NCBI36]
Chr10:10q26.2		 uncertain significance
GRCh38/hg38 10q26.2-26.3(chr10:126256585-133613938)x1 copy number loss See cases [RCV000052612] Chr10:126256585..133613938 [GRCh38]
Chr10:127945154..135427442 [GRCh37]
Chr10:127935144..135277432 [NCBI36]
Chr10:10q26.2-26.3		 pathogenic
GRCh38/hg38 10q26.2-26.3(chr10:127500483-133620674)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052613]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052613]|See cases [RCV000052613] Chr10:127500483..133620674 [GRCh38]
Chr10:129298747..135434178 [GRCh37]
Chr10:129188737..135284168 [NCBI36]
Chr10:10q26.2-26.3		 pathogenic
GRCh38/hg38 10q26.13-26.2(chr10:122973296-128210291)x1 copy number loss See cases [RCV000052610] Chr10:122973296..128210291 [GRCh38]
Chr10:124732812..130008555 [GRCh37]
Chr10:124722802..129898545 [NCBI36]
Chr10:10q26.13-26.2		 pathogenic
GRCh38/hg38 10q26.13-26.3(chr10:123580320-133558988)x1 copy number loss See cases [RCV000052611] Chr10:123580320..133558988 [GRCh38]
Chr10:125339836..135372492 [GRCh37]
Chr10:125329826..135222482 [NCBI36]
Chr10:10q26.13-26.3		 pathogenic
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|See cases [RCV000053560] Chr10:91048545..133620674 [GRCh38]
Chr10:92808302..135434178 [GRCh37]
Chr10:92798282..135284168 [NCBI36]
Chr10:10q23.31-26.3		 pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100194215-132432797)x3 copy number gain See cases [RCV000053564] Chr10:100194215..132432797 [GRCh38]
Chr10:101953972..134246301 [GRCh37]
Chr10:101943962..134096291 [NCBI36]
Chr10:10q24.31-26.3		 pathogenic
GRCh38/hg38 10q25.1-26.3(chr10:106925303-133620815)x3 copy number gain See cases [RCV000053588] Chr10:106925303..133620815 [GRCh38]
Chr10:108685061..135434319 [GRCh37]
Chr10:108675051..135284309 [NCBI36]
Chr10:10q25.1-26.3		 pathogenic
GRCh38/hg38 10q26.11-26.3(chr10:117866565-133554210)x3 copy number gain See cases [RCV000053589] Chr10:117866565..133554210 [GRCh38]
Chr10:119626076..135367714 [GRCh37]
Chr10:119616066..135217704 [NCBI36]
Chr10:10q26.11-26.3		 pathogenic
GRCh37/hg19 10q25.2-26.3(chr10:114544537-135427143)x3 copy number gain not provided [RCV000847820] Chr10:114544537..135427143 [GRCh37]
Chr10:10q25.2-26.3		 pathogenic
GRCh38/hg38 10q25.1-26.3(chr10:108102587-133620674)x3 copy number gain See cases [RCV000133688] Chr10:108102587..133620674 [GRCh38]
Chr10:109862345..135434178 [GRCh37]
Chr10:109852335..135284168 [NCBI36]
Chr10:10q25.1-26.3		 pathogenic
GRCh38/hg38 10q26.13-26.3(chr10:125657472-133620674)x1 copy number loss See cases [RCV000133741] Chr10:125657472..133620674 [GRCh38]
Chr10:127346041..135434178 [GRCh37]
Chr10:127336031..135284168 [NCBI36]
Chr10:10q26.13-26.3		 pathogenic
GRCh38/hg38 10q26.2-26.3(chr10:126730896-133620609)x1 copy number loss See cases [RCV000134040] Chr10:126730896..133620609 [GRCh38]
Chr10:128419465..135434113 [GRCh37]
Chr10:128409455..135284103 [NCBI36]
Chr10:10q26.2-26.3		 pathogenic
GRCh38/hg38 10q26.13-26.3(chr10:124834858-133622588)x1 copy number loss See cases [RCV000137653] Chr10:124834858..133622588 [GRCh38]
Chr10:126523427..135436092 [GRCh37]
Chr10:126513417..135286082 [NCBI36]
Chr10:10q26.13-26.3		 pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100600492-133622588)x3 copy number gain See cases [RCV000137747] Chr10:100600492..133622588 [GRCh38]
Chr10:102360249..135436092 [GRCh37]
Chr10:102350239..135286082 [NCBI36]
Chr10:10q24.31-26.3		 pathogenic
GRCh38/hg38 10q26.13-26.3(chr10:122881207-133620609)x1 copy number loss See cases [RCV000138435] Chr10:122881207..133620609 [GRCh38]
Chr10:124640723..135434113 [GRCh37]
Chr10:124630713..135284103 [NCBI36]
Chr10:10q26.13-26.3		 pathogenic
GRCh38/hg38 10q26.12-26.3(chr10:120970558-133622588)x1 copy number loss See cases [RCV000139344] Chr10:120970558..133622588 [GRCh38]
Chr10:122730071..135436092 [GRCh37]
Chr10:122720061..135286082 [NCBI36]
Chr10:10q26.12-26.3		 pathogenic
GRCh38/hg38 10q26.13-26.3(chr10:125316124-130269667)x1 copy number loss See cases [RCV000139127] Chr10:125316124..130269667 [GRCh38]
Chr10:127004693..132067931 [GRCh37]
Chr10:126994683..131957921 [NCBI36]
Chr10:10q26.13-26.3		 likely benign
GRCh38/hg38 10q26.2(chr10:127257925-127873894)x3 copy number gain See cases [RCV000139873] Chr10:127257925..127873894 [GRCh38]
Chr10:129056189..129672158 [GRCh37]
Chr10:128946179..129562148 [NCBI36]
Chr10:10q26.2		 likely benign|uncertain significance
GRCh38/hg38 10q26.13-26.3(chr10:125021995-133620609)x1 copy number loss See cases [RCV000139588] Chr10:125021995..133620609 [GRCh38]
Chr10:126710564..135434113 [GRCh37]
Chr10:126700554..135284103 [NCBI36]
Chr10:10q26.13-26.3		 pathogenic
GRCh38/hg38 10q26.13-26.3(chr10:125452905-133785874)x3 copy number gain See cases [RCV000141337] Chr10:125452905..133785874 [GRCh38]
Chr10:127141474..135523199 [GRCh37]
Chr10:127131464..135373189 [NCBI36]
Chr10:10q26.13-26.3		 pathogenic
GRCh38/hg38 10q26.11-26.3(chr10:119707856-133613639)x3 copy number gain See cases [RCV000142005] Chr10:119707856..133613639 [GRCh38]
Chr10:121467368..135427143 [GRCh37]
Chr10:121457358..135277133 [NCBI36]
Chr10:10q26.11-26.3		 pathogenic
GRCh38/hg38 10q26.2-26.3(chr10:127507503-129782976)x3 copy number gain See cases [RCV000141892] Chr10:127507503..129782976 [GRCh38]
Chr10:129305767..131581240 [GRCh37]
Chr10:129195757..131471230 [NCBI36]
Chr10:10q26.2-26.3		 uncertain significance
GRCh38/hg38 10q26.13-26.3(chr10:121588992-133620674)x1 copy number loss See cases [RCV000142441] Chr10:121588992..133620674 [GRCh38]
Chr10:123348506..135434178 [GRCh37]
Chr10:123338496..135284168 [NCBI36]
Chr10:10q26.13-26.3		 pathogenic
GRCh38/hg38 10q26.13-26.3(chr10:121918547-133620674)x1 copy number loss See cases [RCV000142737] Chr10:121918547..133620674 [GRCh38]
Chr10:123678062..135434178 [GRCh37]
Chr10:123668052..135284168 [NCBI36]
Chr10:10q26.13-26.3		 pathogenic
GRCh38/hg38 10q26.2-26.3(chr10:127435985-133622588)x1 copy number loss See cases [RCV000143241] Chr10:127435985..133622588 [GRCh38]
Chr10:129234249..135436092 [GRCh37]
Chr10:129124239..135286082 [NCBI36]
Chr10:10q26.2-26.3		 pathogenic
GRCh38/hg38 10q26.13-26.3(chr10:123986772-133613639)x1 copy number loss See cases [RCV000143623] Chr10:123986772..133613639 [GRCh38]
Chr10:125746288..135427143 [GRCh37]
Chr10:125736278..135277133 [NCBI36]
Chr10:10q26.13-26.3		 pathogenic
GRCh38/hg38 10q26.13-26.3(chr10:123576393-133613639)x1 copy number loss See cases [RCV000143544] Chr10:123576393..133613639 [GRCh38]
Chr10:125335909..135427143 [GRCh37]
Chr10:125325899..135277133 [NCBI36]
Chr10:10q26.13-26.3		 pathogenic
GRCh38/hg38 10q26.2-26.3(chr10:126794646-133613639)x1 copy number loss See cases [RCV000143615] Chr10:126794646..133613639 [GRCh38]
Chr10:128483215..135427143 [GRCh37]
Chr10:128473205..135277133 [NCBI36]
Chr10:10q26.2-26.3		 pathogenic
GRCh37/hg19 10q26.13-26.3(chr10:123731209-135353867)x1 copy number loss See cases [RCV000203440] Chr10:123731209..135353867 [GRCh37]
Chr10:10q26.13-26.3		 pathogenic|likely pathogenic
GRCh37/hg19 10q24.32-26.3(chr10:103288313-135512075)x3 copy number gain See cases [RCV000240457] Chr10:103288313..135512075 [GRCh37]
Chr10:10q24.32-26.3		 pathogenic
GRCh37/hg19 10q26.12-26.3(chr10:122125760-135062972)x3 copy number gain See cases [RCV000449169] Chr10:122125760..135062972 [GRCh37]
Chr10:10q26.12-26.3		 likely pathogenic
GRCh37/hg19 10q26.13-26.3(chr10:124147428-135370736)x1 copy number loss See cases [RCV000449336] Chr10:124147428..135370736 [GRCh37]
Chr10:10q26.13-26.3		 pathogenic
GRCh37/hg19 10q26.12-26.3(chr10:122343861-135427143)x1 copy number loss See cases [RCV000446095] Chr10:122343861..135427143 [GRCh37]
Chr10:10q26.12-26.3		 pathogenic
GRCh37/hg19 10q24.2-26.3(chr10:100780957-135427143)x3 copy number gain See cases [RCV000446733] Chr10:100780957..135427143 [GRCh37]
Chr10:10q24.2-26.3		 pathogenic
GRCh37/hg19 10q26.2-26.3(chr10:128465436-135427143)x1 copy number loss See cases [RCV000447132] Chr10:128465436..135427143 [GRCh37]
Chr10:10q26.2-26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10q26.2-26.3(chr10:127658004-135427143)x1 copy number loss See cases [RCV000511813] Chr10:127658004..135427143 [GRCh37]
Chr10:10q26.2-26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic|uncertain significance
GRCh37/hg19 10q25.1-26.3(chr10:106003533-135427143)x3 copy number gain See cases [RCV000510813] Chr10:106003533..135427143 [GRCh37]
Chr10:10q25.1-26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3		 drug response
GRCh37/hg19 10q26.2-26.3(chr10:129007673-135427143)x3 copy number gain See cases [RCV000512398] Chr10:129007673..135427143 [GRCh37]
Chr10:10q26.2-26.3		 pathogenic
GRCh37/hg19 10q26.13-26.3(chr10:127375792-135427143)x1 copy number loss not provided [RCV000683283] Chr10:127375792..135427143 [GRCh37]
Chr10:10q26.13-26.3		 pathogenic
GRCh37/hg19 10q26.2(chr10:128876823-129645456)x1 copy number loss not provided [RCV000683247] Chr10:128876823..129645456 [GRCh37]
Chr10:10q26.2		 uncertain significance
GRCh37/hg19 10q26.11-26.3(chr10:121269222-135427143)x3 copy number gain not provided [RCV000683288] Chr10:121269222..135427143 [GRCh37]
Chr10:10q26.11-26.3		 pathogenic
GRCh37/hg19 10q26.13-26.3(chr10:125450893-135427143)x1 copy number loss not provided [RCV000683285] Chr10:125450893..135427143 [GRCh37]
Chr10:10q26.13-26.3		 pathogenic
GRCh37/hg19 10q26.12-26.3(chr10:122509781-135427143)x1 copy number loss not provided [RCV000683287] Chr10:122509781..135427143 [GRCh37]
Chr10:10q26.12-26.3		 pathogenic
GRCh37/hg19 10q24.33-26.3(chr10:105613040-135427143)x3 copy number gain not provided [RCV000683290] Chr10:105613040..135427143 [GRCh37]
Chr10:10q24.33-26.3		 pathogenic
GRCh37/hg19 10q23.33-26.3(chr10:94346520-135427143)x3 copy number gain not provided [RCV000683291] Chr10:94346520..135427143 [GRCh37]
Chr10:10q23.33-26.3		 pathogenic
GRCh37/hg19 10q26.2(chr10:129242231-129367991)x3 copy number gain not provided [RCV000845586] Chr10:129242231..129367991 [GRCh37]
Chr10:10q26.2		 uncertain significance
GRCh37/hg19 10q26.12-26.3(chr10:122443197-135477883)x1 copy number loss not provided [RCV000737305] Chr10:122443197..135477883 [GRCh37]
Chr10:10q26.12-26.3		 pathogenic
GRCh37/hg19 10q26.2(chr10:128546740-129597382)x1 copy number loss not provided [RCV000737313] Chr10:128546740..129597382 [GRCh37]
Chr10:10q26.2		 uncertain significance
GRCh37/hg19 10q26.2(chr10:129321875-129350641)x1 copy number loss not provided [RCV000737321] Chr10:129321875..129350641 [GRCh37]
Chr10:10q26.2		 benign
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
NM_001030013.2(NPS):c.256A>G (p.Arg86Gly) single nucleotide variant not provided [RCV000969597] Chr10:127552625 [GRCh38]
Chr10:129350889 [GRCh37]
Chr10:10q26.2		 benign
GRCh37/hg19 10q25.1-26.3(chr10:110022170-135439095) copy number gain not provided [RCV000767665] Chr10:110022170..135439095 [GRCh37]
Chr10:10q25.1-26.3		 pathogenic
GRCh37/hg19 10q26.13-26.3(chr10:124988334-135427143)x3 copy number gain not provided [RCV000848791] Chr10:124988334..135427143 [GRCh37]
Chr10:10q26.13-26.3		 pathogenic
GRCh37/hg19 10q26.2(chr10:128831247-129527379)x1 copy number loss not provided [RCV000849267] Chr10:128831247..129527379 [GRCh37]
Chr10:10q26.2		 uncertain significance
GRCh37/hg19 10q26.11-26.3(chr10:119996339-135427143)x3 copy number gain not provided [RCV001006356] Chr10:119996339..135427143 [GRCh37]
Chr10:10q26.11-26.3		 pathogenic
GRCh37/hg19 10q26.2(chr10:129048455-129594596)x3 copy number gain not provided [RCV001006363] Chr10:129048455..129594596 [GRCh37]
Chr10:10q26.2		 uncertain significance
GRCh37/hg19 10q26.2(chr10:129297102-129802813)x3 copy number gain not provided [RCV000846591] Chr10:129297102..129802813 [GRCh37]
Chr10:10q26.2		 uncertain significance
GRCh37/hg19 10q26.2-26.3(chr10:129009772-135427143)x1 copy number loss not provided [RCV001006362] Chr10:129009772..135427143 [GRCh37]
Chr10:10q26.2-26.3		 pathogenic
GRCh37/hg19 10q26.2(chr10:129160805-129922819)x3 copy number gain not provided [RCV002473640] Chr10:129160805..129922819 [GRCh37]
Chr10:10q26.2		 uncertain significance
GRCh37/hg19 10q26.2(chr10:128766925-129645385)x1 copy number loss not provided [RCV002473881] Chr10:128766925..129645385 [GRCh37]
Chr10:10q26.2		 uncertain significance
GRCh37/hg19 10q26.2(chr10:129303032-129814581)x3 copy number gain not provided [RCV001259084] Chr10:129303032..129814581 [GRCh37]
Chr10:10q26.2		 uncertain significance
GRCh37/hg19 10q26.2-26.3(chr10:129031265-135427143)x1 copy number loss not provided [RCV001259085] Chr10:129031265..135427143 [GRCh37]
Chr10:10q26.2-26.3		 pathogenic
GRCh37/hg19 10q25.3-26.3(chr10:118247181-135435319)x3 copy number gain not provided [RCV001537903] Chr10:118247181..135435319 [GRCh37]
Chr10:10q25.3-26.3		 pathogenic
Single allele deletion Distal 10q deletion syndrome [RCV001391670] Chr10:127548166..135440251 [GRCh37]
Chr10:10q26.2-26.3		 pathogenic
GRCh37/hg19 10q26.12-26.3(chr10:122785023-135457222)x1 copy number loss See cases [RCV001526488] Chr10:122785023..135457222 [GRCh37]
Chr10:10q26.12-26.3		 pathogenic
GRCh37/hg19 10q26.2(chr10:129160805-129405859)x3 copy number gain not provided [RCV001836535] Chr10:129160805..129405859 [GRCh37]
Chr10:10q26.2		 uncertain significance
GRCh37/hg19 10q26.2(chr10:128876823-129645457) copy number loss not specified [RCV002052905] Chr10:128876823..129645457 [GRCh37]
Chr10:10q26.2		 uncertain significance
GRCh37/hg19 10q26.12-26.3(chr10:122125760-135062972) copy number gain not specified [RCV002052894] Chr10:122125760..135062972 [GRCh37]
Chr10:10q26.12-26.3		 likely pathogenic
GRCh37/hg19 10q26.12-26.3(chr10:122343861-135427143) copy number loss not specified [RCV002052895] Chr10:122343861..135427143 [GRCh37]
Chr10:10q26.12-26.3		 pathogenic
GRCh37/hg19 10q25.1-26.3(chr10:108455687-135427143) copy number gain not specified [RCV002052891] Chr10:108455687..135427143 [GRCh37]
Chr10:10q25.1-26.3		 pathogenic
GRCh37/hg19 10q26.2-26.3(chr10:128465436-135427143) copy number loss not specified [RCV002052902] Chr10:128465436..135427143 [GRCh37]
Chr10:10q26.2-26.3		 pathogenic
GRCh37/hg19 10q26.13-26.3(chr10:127198625-135427143)x3 copy number gain See cases [RCV002292400] Chr10:127198625..135427143 [GRCh37]
Chr10:10q26.13-26.3		 pathogenic
GRCh37/hg19 10q26.13-26.3(chr10:126914469-135427143)x1 copy number loss See cases [RCV002292397] Chr10:126914469..135427143 [GRCh37]
Chr10:10q26.13-26.3		 pathogenic
GRCh37/hg19 10q26.2-26.3(chr10:128877896-131842835)x1 copy number loss not provided [RCV002472530] Chr10:128877896..131842835 [GRCh37]
Chr10:10q26.2-26.3		 pathogenic
GRCh37/hg19 10q26.2(chr10:129298285-129812992)x3 copy number gain not provided [RCV002474627] Chr10:129298285..129812992 [GRCh37]
Chr10:10q26.2		 uncertain significance
GRCh37/hg19 10q26.13-26.3(chr10:126662496-133985966)x3 copy number gain not provided [RCV002474692] Chr10:126662496..133985966 [GRCh37]
Chr10:10q26.13-26.3		 uncertain significance
NM_001030013.2(NPS):c.139A>C (p.Thr47Pro) single nucleotide variant not specified [RCV004230558] Chr10:127552508 [GRCh38]
Chr10:129350772 [GRCh37]
Chr10:10q26.2		 uncertain significance
NM_001030013.2(NPS):c.215G>A (p.Arg72His) single nucleotide variant not specified [RCV004264011] Chr10:127552584 [GRCh38]
Chr10:129350848 [GRCh37]
Chr10:10q26.2		 uncertain significance
NM_001030013.2(NPS):c.230C>A (p.Thr77Lys) single nucleotide variant not specified [RCV004268585] Chr10:127552599 [GRCh38]
Chr10:129350863 [GRCh37]
Chr10:10q26.2		 uncertain significance
GRCh37/hg19 10q26.12-26.3(chr10:122610933-135439810)x1 copy number loss not provided [RCV003222684] Chr10:122610933..135439810 [GRCh37]
Chr10:10q26.12-26.3		 pathogenic
GRCh37/hg19 10p14-q26.3(chr10:11138692-135427143) copy number gain Distal trisomy 10q [RCV003319593] Chr10:11138692..135427143 [GRCh37]
Chr10:10p14-q26.3		 pathogenic
GRCh37/hg19 10q26.13-26.3(chr10:123477898-135427143) copy number loss Distal 10q deletion syndrome [RCV003319590] Chr10:123477898..135427143 [GRCh37]
Chr10:10q26.13-26.3		 pathogenic
GRCh37/hg19 10q26.2-26.3(chr10:128925940-135427143)x1 copy number loss not provided [RCV003483108] Chr10:128925940..135427143 [GRCh37]
Chr10:10q26.2-26.3		 pathogenic
GRCh37/hg19 10q25.1-26.3(chr10:111378692-135427143)x3 copy number gain Distal trisomy 10q [RCV003458955] Chr10:111378692..135427143 [GRCh37]
Chr10:10q25.1-26.3		 pathogenic
GRCh37/hg19 10q26.2-26.3(chr10:128289206-135427143)x1 copy number loss Distal 10q deletion syndrome [RCV003458182] Chr10:128289206..135427143 [GRCh37]
Chr10:10q26.2-26.3		 pathogenic
GRCh37/hg19 10q25.1-26.3(chr10:111447991-133435388)x3 copy number gain not provided [RCV003484817] Chr10:111447991..133435388 [GRCh37]
Chr10:10q25.1-26.3		 pathogenic
GRCh38/hg38 10q26.2-26.3(chr10:125976998-133427130)x1 copy number loss Duane syndrome type 1 [RCV003984306] Chr10:125976998..133427130 [GRCh38]
Chr10:10q26.2-26.3		 pathogenic
GRCh37/hg19 10q26.2(chr10:128334180-129645457)x1 copy number loss not specified [RCV003986896] Chr10:128334180..129645457 [GRCh37]
Chr10:10q26.2		 uncertain significance
GRCh37/hg19 10q26.13-26.3(chr10:125987494-135427143)x1 copy number loss not specified [RCV003986904] Chr10:125987494..135427143 [GRCh37]
Chr10:10q26.13-26.3		 pathogenic
GRCh37/hg19 10q26.13-26.3(chr10:126127397-135427143)x1 copy number loss not specified [RCV003986878] Chr10:126127397..135427143 [GRCh37]
Chr10:10q26.13-26.3		 pathogenic
GRCh37/hg19 10q23.33-26.3(chr10:95078198-135427143)x3 copy number gain not specified [RCV003986893] Chr10:95078198..135427143 [GRCh37]
Chr10:10q23.33-26.3		 pathogenic
GRCh37/hg19 10q26.12-26.3(chr10:122331280-135426386)x1 copy number loss not provided [RCV004442821] Chr10:122331280..135426386 [GRCh37]
Chr10:10q26.12-26.3		 pathogenic
GRCh37/hg19 10q26.13-26.3(chr10:124895517-135440296)x1 copy number loss Distal 10q deletion syndrome [RCV003329543] Chr10:124895517..135440296 [GRCh37]
Chr10:10q26.13-26.3		 pathogenic
GRCh38/hg38 10q26.13-26.3(chr10:124473108-133620609)x1 copy number loss See cases [RCV000136028] Chr10:124473108..133620609 [GRCh38]
Chr10:126161677..135434113 [GRCh37]
Chr10:126151667..135284103 [NCBI36]
Chr10:10q26.13-26.3		 pathogenic
GRCh37/hg19 10p13-q26.3(chr10:12829206-135427143) copy number loss Distal 10q deletion syndrome [RCV003319583] Chr10:12829206..135427143 [GRCh37]
Chr10:10p13-q26.3		 pathogenic
GRCh37/hg19 10q24.32-26.3(chr10:104633712-135427143)x3 copy number gain See cases [RCV000449386] Chr10:104633712..135427143 [GRCh37]
Chr10:10q24.32-26.3		 pathogenic
GRCh37/hg19 10q23.32-26.3(chr10:93283493-135427143)x3 copy number gain See cases [RCV000510972] Chr10:93283493..135427143 [GRCh37]
Chr10:10q23.32-26.3		 pathogenic
GRCh37/hg19 10q26.12-26.3(chr10:123019239-135427143)x1 copy number loss not provided [RCV000683286] Chr10:123019239..135427143 [GRCh37]
Chr10:10q26.12-26.3		 pathogenic
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:86
Interacting mature miRNAs:86
Transcripts:ENST00000398023
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
11 28 20 11 312 32 48 6 19 6 31 65 56 1 290 15 67 38 1

Sequence


Ensembl Acc Id: ENST00000398023   ⟹   ENSP00000381105
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl10127,549,309 - 127,553,540 (+)Ensembl
RefSeq Acc Id: NM_001030013   ⟹   NP_001025184
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810127,549,309 - 127,553,540 (+)NCBI
GRCh3710129,347,613 - 129,350,935 (+)ENTREZGENE
Build 3610129,237,603 - 129,240,925 (+)NCBI Archive
HuRef10122,920,598 - 122,923,921 (+)ENTREZGENE
CHM1_110129,629,918 - 129,633,240 (+)NCBI
T2T-CHM13v2.010128,444,335 - 128,448,567 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001025184 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000381105
  ENSP00000381105.2
GenBank Protein P0C0P6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001025184   ⟸   NM_001030013
- Peptide Label: precursor
- UniProtKB: P0C0P6 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000381105   ⟸   ENST00000398023

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C0P6-F1-model_v2 AlphaFold P0C0P6 1-89 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:33940 AgrOrtholog
COSMIC NPS COSMIC
Ensembl Genes ENSG00000214285 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000398023 ENTREZGENE
  ENST00000398023.3 UniProtKB/Swiss-Prot
GTEx ENSG00000214285 GTEx
HGNC ID HGNC:33940 ENTREZGENE
Human Proteome Map NPS Human Proteome Map
InterPro Neuropeptide_S UniProtKB/Swiss-Prot
KEGG Report hsa:594857 UniProtKB/Swiss-Prot
NCBI Gene 594857 ENTREZGENE
OMIM 609513 OMIM
PANTHER NEUROPEPTIDE S UniProtKB/Swiss-Prot
  PTHR36679 UniProtKB/Swiss-Prot
Pfam Neuropeptide_S UniProtKB/Swiss-Prot
PharmGKB PA162398160 PharmGKB
UniProt NPS_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE