Nrg1<sup>Tn(sb-T2/Bart3)2.183Mcwi</sup> (neuregulin 1; transposon insertion 2.183, Medical College of Wisconsin) - Rat Genome Database

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Gene: Nrg1Tn(sb-T2/Bart3)2.183Mcwi (neuregulin 1; transposon insertion 2.183, Medical College of Wisconsin) Rattus norvegicus
Symbol: Nrg1Tn(sb-T2/Bart3)2.183Mcwi
Name: neuregulin 1; transposon insertion 2.183, Medical College of Wisconsin
RGD ID: 2290090
Description: this mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Nrg1 gene
ASSOCIATED WITH impaired cued conditioning behavior; increased body weight; increased circulating corticosterone level
Type: allele  of Nrg1  
Previously known as: Nrg1Tn(sb-T2/Bart3)2.183Mcwi
Is Marker For: Strains:   F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Cytogenetic Map16 RGD

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system. Lu B, etal., Mamm Genome. 2007 May;18(5):338-46. Epub 2007 Jun 8.
2. PhysGen Strains PhysGen strains
3. The interaction of disrupted type II neuregulin 1 and chronic adolescent stress on adult anxiety- and fear-related behaviors. Taylor SB, etal., Neuroscience. 2013 Sep 26;249:31-42. doi: 10.1016/j.neuroscience.2012.09.045. Epub 2012 Sep 25.
4. Disruption of the neuregulin 1 gene in the rat alters HPA axis activity and behavioral responses to environmental stimuli. Taylor SB, etal., Physiol Behav. 2011 Aug 3;104(2):205-14. doi: 10.1016/j.physbeh.2010.11.015. Epub 2010 Nov 16.


Related Rat Strains
The following Strains have been annotated to Nrg1Tn(sb-T2/Bart3)2.183Mcwi



Nucleotide Sequences
RefSeq Transcripts NM_031588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Additional Information