Cav3 (caveolin 3) - Rat Genome Database

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Gene: Cav3 (caveolin 3) Rattus norvegicus
Analyze
Symbol: Cav3
Name: caveolin 3
RGD ID: 2281
Description: Enables several functions, including nitric-oxide synthase binding activity; potassium channel inhibitor activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; positive regulation of cellular component organization; and response to ischemia. Located in several cellular components, including T-tubule; cell surface; and neuromuscular junction. Part of protein-containing complex. Colocalizes with several cellular components, including Z disc; intercalated disc; and sarcolemma. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); isolated elevated serum creatine phosphokinase levels; and muscle tissue disease (multiple). Orthologous to human CAV3 (caveolin 3); PARTICIPATES IN platelet-derived growth factor signaling pathway; endocytosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: caveolin-3; MGC105449
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24145,582,168 - 145,598,142 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4145,582,060 - 145,598,137 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4150,974,343 - 150,990,337 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04146,755,146 - 146,771,143 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04145,376,415 - 145,392,431 (+)NCBIRnor_WKY
Rnor_6.04144,382,945 - 144,398,919 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4144,382,945 - 144,398,917 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04207,683,202 - 207,699,176 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44148,294,428 - 148,310,380 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14148,539,268 - 148,555,221 (+)NCBI
Celera4134,152,488 - 134,168,462 (+)NCBICelera
Cytogenetic Map4q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (ISO)
calcium ion transport  (ISO)
cardiac muscle cell development  (ISO)
cardiac muscle hypertrophy  (ISO)
caveola assembly  (IBA,ISO)
cell differentiation  (IBA,IEP)
cellular response to organonitrogen compound  (IEP)
cholesterol homeostasis  (ISO)
cytoplasmic microtubule organization  (ISO)
detection of muscle stretch  (ISO)
endocytosis  (ISO)
establishment of localization in cell  (ISO)
glucose homeostasis  (ISO)
heart trabecula formation  (ISO)
MAPK cascade  (ISO)
membrane raft organization  (ISO)
myoblast fusion  (ISO)
myotube differentiation  (ISO)
negative regulation of calcium ion transport  (ISO)
negative regulation of cardiac muscle hypertrophy  (ISO)
negative regulation of cell growth involved in cardiac muscle cell development  (IMP)
negative regulation of cell size  (ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of MAPK cascade  (ISO)
negative regulation of membrane depolarization during cardiac muscle cell action potential  (ISO)
negative regulation of nitric-oxide synthase activity  (ISO)
negative regulation of potassium ion transmembrane transport  (IMP)
negative regulation of potassium ion transmembrane transporter activity  (IMP)
negative regulation of protein kinase activity  (ISO)
negative regulation of sarcomere organization  (ISO)
nucleus localization  (ISO)
plasma membrane organization  (ISO)
plasma membrane repair  (ISO)
positive regulation of caveolin-mediated endocytosis  (IMP)
positive regulation of cell population proliferation  (IMP)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of microtubule polymerization  (IMP)
positive regulation of myotube differentiation  (ISO)
protein localization  (ISO)
protein localization to plasma membrane  (ISO)
regulation of branching involved in mammary gland duct morphogenesis  (ISO)
regulation of calcium ion import  (ISO)
regulation of calcium ion transmembrane transporter activity  (ISO)
regulation of calcium ion transport  (ISO)
regulation of cardiac muscle cell action potential involved in regulation of contraction  (ISO)
regulation of cardiac muscle contraction  (ISO)
regulation of cytosolic calcium ion concentration  (IBA)
regulation of heart rate  (ISO)
regulation of membrane depolarization during cardiac muscle cell action potential  (IBA,ISO)
regulation of membrane potential  (ISO)
regulation of nerve growth factor receptor activity  (ISO)
regulation of p38MAPK cascade  (ISO)
regulation of protein kinase B signaling  (ISO)
regulation of signal transduction by receptor internalization  (ISO)
regulation of skeletal muscle contraction  (ISO)
regulation of sodium ion transmembrane transporter activity  (ISO)
regulation of transforming growth factor beta receptor signaling pathway  (ISO)
regulation of ventricular cardiac muscle cell membrane depolarization  (ISO)
regulation of ventricular cardiac muscle cell membrane repolarization  (ISO)
response to hypoxia  (IEP)
response to ischemia  (IEP)
triglyceride metabolic process  (ISO)
ventricular cardiac muscle cell action potential  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. alpha1-adrenoceptors regulate only the caveolae-located subpopulation of cardiac K(V)4 channels. Alday A, etal., Channels (Austin). 2010 May-Jun;4(3):168-78.
2. Caveolae modulate excitation-contraction coupling and beta2-adrenergic signalling in adult rat ventricular myocytes. Calaghan S and White E, Cardiovasc Res. 2006 Mar 1;69(4):816-24. Epub 2005 Nov 28.
3. Concentration of caveolin-3 at the neuromuscular junction in young and old rat skeletal muscle fibers. Carlson BM, etal., J Histochem Cytochem. 2003 Sep;51(9):1113-8.
4. 17 beta-estradiol attenuates pressure overload-induced myocardial hypertrophy through regulating caveolin-3 protein in ovariectomized female rats. Cui YH, etal., Mol Biol Rep. 2011 Nov;38(8):4885-92. Epub 2010 Dec 18.
5. Generation of survival signal by differential interaction of p38MAPKalpha and p38MAPKbeta with caveolin-1 and caveolin-3 in the adapted heart. Das M, etal., J Mol Cell Cardiol. 2007 Jan;42(1):206-13. Epub 2006 Oct 25.
6. Regulation of ATP-sensitive K+ channels by caveolin-enriched microdomains in cardiac myocytes. Garg V, etal., Cardiovasc Res. 2009 Apr 1;82(1):51-8. doi: 10.1093/cvr/cvp039. Epub 2009 Jan 30.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Cell surface expression of human ether-a-go-go-related gene (hERG) channels is regulated by caveolin-3 protein via the ubiquitin ligase Nedd4-2. Guo J, etal., J Biol Chem. 2012 Sep 28;287(40):33132-41. Epub 2012 Aug 9.
9. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. Head BP, etal., J Biol Chem. 2005 Sep 2;280(35):31036-44. Epub 2005 Jun 16.
10. Caveolin 3-mediated integrin beta1 signaling is required for the proliferation of folliculostellate cells in rat anterior pituitary gland under the influence of extracellular matrix. Horiguchi K, etal., J Endocrinol. 2011 Jul;210(1):29-36. Epub 2011 Apr 20.
11. Caveolin-3 expression and caveolae are required for isoflurane-induced cardiac protection from hypoxia and ischemia/reperfusion injury. Horikawa YT, etal., J Mol Cell Cardiol. 2008 Jan;44(1):123-30. Epub 2007 Oct 11.
12. Cathepsin B localizes to plasma membrane caveolae of differentiating myoblasts and is secreted in an active form at physiological pH. Jane DT, etal., Biol Chem. 2006 Feb;387(2):223-34.
13. Caveolin regulates microtubule polymerization in the vascular smooth muscle cells. Kawabe J, etal., Biochem Biophys Res Commun. 2006 Mar 31;342(1):164-9. Epub 2006 Feb 3.
14. Behavior of caveolae and caveolin-3 during the development of myocyte hypertrophy. Kikuchi T, etal., J Cardiovasc Pharmacol. 2005 Mar;45(3):204-10.
15. REDOX REGULATION OF ISCHEMIC PRECONDITIONING IS MEDIATED BY THE DIFFERENTIAL ACTIVATION OF CAVEOLINS AND THEIR ASSOCIATION WITH eNOS AND GLUT-4. Koneru S, etal., Am J Physiol Heart Circ Physiol. 2007 Feb 2;.
16. Caveolin-3 and eNOS colocalize and interact in ciliated airway epithelial cells in the rat. Krasteva G, etal., Int J Biochem Cell Biol. 2007;39(3):615-25. Epub 2006 Oct 29.
17. Evidence for cyclooxygenase-2 association with caveolin-3 in primary cultured rat chondrocytes. Kwak JO, etal., J Korean Med Sci. 2006 Feb;21(1):100-6.
18. Beta-subunit of cardiac Na+-K+-ATPase dictates the concentration of the functional enzyme in caveolae. Liu L and Askari A, Am J Physiol Cell Physiol. 2006 Oct;291(4):C569-78. Epub 2006 Apr 19.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Mutations in the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy. Minetti C, etal., Nat Genet. 1998 Apr;18(4):365-8.
21. The coiled-coil domain of MURC/cavin-4 is involved in membrane trafficking of caveolin-3 in cardiomyocytes. Naito D, etal., Am J Physiol Heart Circ Physiol. 2015 Dec 15;309(12):H2127-36. doi: 10.1152/ajpheart.00446.2015. Epub 2015 Oct 23.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Nitric oxide inhibition of adenylyl cyclase type 6 activity is dependent upon lipid rafts and caveolin signaling complexes. Ostrom RS, etal., J Biol Chem. 2004 May 7;279(19):19846-53. Epub 2004 Mar 8.
25. Protection of adult rat cardiac myocytes from ischemic cell death: role of caveolar microdomains and delta-opioid receptors. Patel HH, etal., Am J Physiol Heart Circ Physiol. 2006 Jul;291(1):H344-50. Epub 2006 Feb 24.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. Caveolin-3 is associated with the T-tubules of mature skeletal muscle fibers. Ralston E and Ploug T, Exp Cell Res. 1999 Feb 1;246(2):510-5.
29. Caveolin-1 and -3 dissociations from caveolae to cytosol in the heart during aging and after myocardial infarction in rat. Ratajczak P, etal., Cardiovasc Res. 2003 Feb;57(2):358-69.
30. GOA pipeline RGD automated data pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Caveolae-associated proteins in cardiomyocytes: caveolin-2 expression and interactions with caveolin-3. Rybin VO, etal., Am J Physiol Heart Circ Physiol 2003 Jul;285(1):H325-32. Epub 2003 Mar 20.
34. Caveolin-3 is adjacent to a group of extradyadic ryanodine receptors. Scriven DR, etal., Biophys J. 2005 Sep;89(3):1893-901. Epub 2005 Jun 24.
35. Expression of caveolin-1, -2, and -3 in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis. Shin T, etal., J Neuroimmunol. 2005 Aug;165(1-2):11-20.
36. Caveolin isoform expression during differentiation of C6 glioma cells. Silva WI, etal., Int J Dev Neurosci. 2005 Nov;23(7):599-612. Epub 2005 Aug 30.
37. Caveolin-3 directly interacts with the C-terminal tail of beta -dystroglycan. Identification of a central WW-like domain within caveolin family members. Sotgia F, etal., J Biol Chem. 2000 Dec 1;275(48):38048-58.
38. Role for SUR2A in coupling cardiac K(ATP) channels to caveolin-3. Sun W and Hu K, Cell Physiol Biochem. 2010;25(4-5):409-18. doi: 10.1159/000303045. Epub 2010 Mar 23.
39. Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle. Tang Z, etal., J Biol Chem 1996 Jan 26;271(4):2255-61.
40. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
41. Localization of caveolin-3 in the sinus endothelial cells of the rat spleen. Uehara K and Miyoshi M, Cell Tissue Res 2002 Mar;307(3):329-36. Epub 2002 Feb 23.
42. Caveolin-1 and caveolin-3 form heterooligomeric complexes in atrial cardiac myocytes that are required for doxorubicin-induced apoptosis. Volonte D, etal., Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H392-401. Epub 2007 Nov 2.
43. Estrogen modulation of eNOS activity and its association with caveolin-3 and calmodulin in rat hearts. Wang X and Abdel-Rahman AA, Am J Physiol Heart Circ Physiol 2002 Jun;282(6):H2309-15.
44. Localization of cardiac sodium channels in caveolin-rich membrane domains: regulation of sodium current amplitude. Yarbrough TL, etal., Circ Res. 2002 Mar 8;90(4):443-9.
45. Membrane localization, Caveolin-3 association and rapid actions of vitamin D receptor in cardiac myocytes. Zhao G and Simpson RU, Steroids. 2010 Aug-Sep;75(8-9):555-9. Epub 2009 Dec 14.
46. FAT10 attenuates hypoxia-induced cardiomyocyte apoptosis by stabilizing caveolin-3. Zhou Q, etal., J Mol Cell Cardiol. 2018 Mar;116:115-124. doi: 10.1016/j.yjmcc.2018.02.008. Epub 2018 Feb 10.
Additional References at PubMed
PMID:8663016   PMID:9008709   PMID:9353265   PMID:10835421   PMID:11115849   PMID:11159934   PMID:11259414   PMID:12138167   PMID:12477932   PMID:12705878   PMID:12847114   PMID:14517320  
PMID:14600260   PMID:15155732   PMID:15277200   PMID:15314230   PMID:15466641   PMID:15489334   PMID:15499025   PMID:15541368   PMID:16319126   PMID:16455755   PMID:16565301   PMID:16648270  
PMID:16676355   PMID:17060380   PMID:17164264   PMID:17200204   PMID:17275750   PMID:17337601   PMID:17524427   PMID:18286598   PMID:18552160   PMID:18720574   PMID:18936328   PMID:18956885  
PMID:19101541   PMID:19164602   PMID:19238754   PMID:19299911   PMID:19380584   PMID:19523531   PMID:19535499   PMID:19544087   PMID:19800018   PMID:19923424   PMID:20304057   PMID:20472890  
PMID:20953984   PMID:21084288   PMID:21182936   PMID:21296051   PMID:22374691   PMID:22792322   PMID:23058350   PMID:23620341   PMID:24040945   PMID:24066022   PMID:24412535   PMID:25211146  
PMID:25257915   PMID:25450954   PMID:25661386   PMID:25849791   PMID:26071359   PMID:26191152   PMID:26313243   PMID:27733157   PMID:28825318   PMID:29101175   PMID:29486470   PMID:31050077  


Genomics

Comparative Map Data
Cav3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24145,582,168 - 145,598,142 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4145,582,060 - 145,598,137 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4150,974,343 - 150,990,337 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04146,755,146 - 146,771,143 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04145,376,415 - 145,392,431 (+)NCBIRnor_WKY
Rnor_6.04144,382,945 - 144,398,919 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4144,382,945 - 144,398,917 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04207,683,202 - 207,699,176 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44148,294,428 - 148,310,380 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14148,539,268 - 148,555,221 (+)NCBI
Celera4134,152,488 - 134,168,462 (+)NCBICelera
Cytogenetic Map4q41NCBI
CAV3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3838,733,802 - 8,746,758 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl38,733,802 - 8,841,808 (+)EnsemblGRCh38hg38GRCh38
GRCh3738,775,488 - 8,788,444 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3638,750,496 - 8,763,451 (+)NCBINCBI36Build 36hg18NCBI36
Build 3438,750,495 - 8,763,450NCBI
Celera38,710,271 - 8,723,238 (+)NCBICelera
Cytogenetic Map3p25.3NCBI
HuRef38,709,553 - 8,722,499 (+)NCBIHuRef
CHM1_138,725,885 - 8,738,871 (+)NCBICHM1_1
T2T-CHM13v2.038,724,971 - 8,737,928 (+)NCBIT2T-CHM13v2.0
Cav3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396112,436,466 - 112,449,833 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6112,436,466 - 112,449,833 (+)EnsemblGRCm39 Ensembl
GRCm386112,459,505 - 112,472,872 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6112,459,505 - 112,472,872 (+)EnsemblGRCm38mm10GRCm38
MGSCv376112,409,499 - 112,422,866 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366112,425,278 - 112,438,649 (+)NCBIMGSCv36mm8
Celera6114,297,536 - 114,310,896 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.26NCBI
Cav3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955561325,944 - 335,914 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955561326,008 - 335,911 (+)NCBIChiLan1.0ChiLan1.0
CAV3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan138,748,826 - 8,765,179 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v038,684,829 - 8,697,731 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.138,928,069 - 8,940,942 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl38,928,069 - 8,940,942 (+)Ensemblpanpan1.1panPan2
CAV3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1209,384,901 - 9,398,055 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl209,384,901 - 9,401,196 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha209,418,382 - 9,431,544 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0209,414,987 - 9,428,087 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl209,414,987 - 9,428,087 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1209,136,869 - 9,150,024 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0209,481,732 - 9,494,836 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0209,455,880 - 9,468,982 (-)NCBIUU_Cfam_GSD_1.0
Cav3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494214,631,527 - 14,644,827 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366024,264,889 - 4,278,161 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366024,264,896 - 4,278,160 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAV3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1365,117,795 - 65,131,273 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11365,117,868 - 65,130,886 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21372,400,156 - 72,412,174 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CAV3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12244,726,597 - 44,740,456 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2244,727,624 - 44,740,459 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041121,826,639 - 121,839,504 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cav3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247313,347,984 - 3,364,581 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247313,348,172 - 3,363,772 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cav3
46 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:447
Count of miRNA genes:210
Interacting mature miRNAs:263
Transcripts:ENSRNOT00000007601
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4119463257147278687Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4120260281147278687Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4120926564148090731Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat

Markers in Region
RH130686  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24145,597,285 - 145,597,676 (+)MAPPERmRatBN7.2
Rnor_6.04144,398,063 - 144,398,453NCBIRnor6.0
Rnor_5.04207,698,320 - 207,698,710UniSTSRnor5.0
RGSC_v3.44148,309,524 - 148,309,914UniSTSRGSC3.4
Celera4134,167,606 - 134,167,996UniSTS
RH 3.4 Map4931.3UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43 8 11 2 5 8
Low 3 8 6 13 6 27 2 20 6
Below cutoff 25 12 6 12 37 30 14

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007601   ⟹   ENSRNOP00000007601
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4145,582,060 - 145,598,137 (+)Ensembl
Rnor_6.0 Ensembl4144,382,945 - 144,398,917 (+)Ensembl
RefSeq Acc Id: NM_019155   ⟹   NP_062028
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24145,582,168 - 145,598,142 (+)NCBI
Rnor_6.04144,382,945 - 144,398,919 (+)NCBI
Rnor_5.04207,683,202 - 207,699,176 (+)NCBI
RGSC_v3.44148,294,428 - 148,310,380 (+)RGD
Celera4134,152,488 - 134,168,462 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062028 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52377 (Get FASTA)   NCBI Sequence Viewer  
  AAH84692 (Get FASTA)   NCBI Sequence Viewer  
  EDL91498 (Get FASTA)   NCBI Sequence Viewer  
  P51638 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_062028   ⟸   NM_019155
- UniProtKB: P51638 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007601   ⟸   ENSRNOT00000007601

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51638-F1-model_v2 AlphaFold P51638 1-151 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693287
Promoter ID:EPDNEW_R3812
Type:single initiation site
Name:Cav3_1
Description:caveolin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04144,383,006 - 144,383,066EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2281 AgrOrtholog
BioCyc Gene G2FUF-43420 BioCyc
Ensembl Genes ENSRNOG00000005798 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000007601 ENTREZGENE
  ENSRNOP00000007601.4 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007601 ENTREZGENE
  ENSRNOT00000007601.5 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7103841 IMAGE-MGC_LOAD
InterPro Caveolin UniProtKB/Swiss-Prot
  Caveolin_CS UniProtKB/Swiss-Prot
KEGG Report rno:29161 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105449 IMAGE-MGC_LOAD
NCBI Gene 29161 ENTREZGENE
PANTHER PTHR10844 UniProtKB/Swiss-Prot
  PTHR10844:SF16 UniProtKB/Swiss-Prot
Pfam Caveolin UniProtKB/Swiss-Prot
PhenoGen Cav3 PhenoGen
PROSITE CAVEOLIN UniProtKB/Swiss-Prot
TIGR TC219233
UniProt CAV3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Cav3  caveolin 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization integral membrane protein localized to caveolae 69799
gene_expression expressed in skeletal muscle, diaphragm, and heart 69799
gene_expression expressed in sinus endothelial cells of spleen 1299862
gene_function interacts with heterotrimeric G-proteins 69799
gene_physical_interaction binds to endothelial nitric oxide synthase (eNOS) 1299844
gene_process suppresses the basal GTPase activity of purified heterotrimeric G-proteins 69799
gene_process may play a role in stress fiber constriction in spleen sinus endothelial cells 1299862
gene_process regulates activity of endothelial nitric oxide synthase (eNOS) 1299844