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# | Reference Title | Reference Citation |
1. | alpha1-adrenoceptors regulate only the caveolae-located subpopulation of cardiac K(V)4 channels. | Alday A, etal., Channels (Austin). 2010 May-Jun;4(3):168-78. |
2. | Caveolae modulate excitation-contraction coupling and beta2-adrenergic signalling in adult rat ventricular myocytes. | Calaghan S and White E, Cardiovasc Res. 2006 Mar 1;69(4):816-24. Epub 2005 Nov 28. |
3. | Concentration of caveolin-3 at the neuromuscular junction in young and old rat skeletal muscle fibers. | Carlson BM, etal., J Histochem Cytochem. 2003 Sep;51(9):1113-8. |
4. | 17 beta-estradiol attenuates pressure overload-induced myocardial hypertrophy through regulating caveolin-3 protein in ovariectomized female rats. | Cui YH, etal., Mol Biol Rep. 2011 Nov;38(8):4885-92. Epub 2010 Dec 18. |
5. | Generation of survival signal by differential interaction of p38MAPKalpha and p38MAPKbeta with caveolin-1 and caveolin-3 in the adapted heart. | Das M, etal., J Mol Cell Cardiol. 2007 Jan;42(1):206-13. Epub 2006 Oct 25. |
6. | Regulation of ATP-sensitive K+ channels by caveolin-enriched microdomains in cardiac myocytes. | Garg V, etal., Cardiovasc Res. 2009 Apr 1;82(1):51-8. doi: 10.1093/cvr/cvp039. Epub 2009 Jan 30. |
7. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
8. | Cell surface expression of human ether-a-go-go-related gene (hERG) channels is regulated by caveolin-3 protein via the ubiquitin ligase Nedd4-2. | Guo J, etal., J Biol Chem. 2012 Sep 28;287(40):33132-41. Epub 2012 Aug 9. |
9. | G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. | Head BP, etal., J Biol Chem. 2005 Sep 2;280(35):31036-44. Epub 2005 Jun 16. |
10. | Caveolin 3-mediated integrin beta1 signaling is required for the proliferation of folliculostellate cells in rat anterior pituitary gland under the influence of extracellular matrix. | Horiguchi K, etal., J Endocrinol. 2011 Jul;210(1):29-36. Epub 2011 Apr 20. |
11. | Caveolin-3 expression and caveolae are required for isoflurane-induced cardiac protection from hypoxia and ischemia/reperfusion injury. | Horikawa YT, etal., J Mol Cell Cardiol. 2008 Jan;44(1):123-30. Epub 2007 Oct 11. |
12. | Cathepsin B localizes to plasma membrane caveolae of differentiating myoblasts and is secreted in an active form at physiological pH. | Jane DT, etal., Biol Chem. 2006 Feb;387(2):223-34. |
13. | Caveolin regulates microtubule polymerization in the vascular smooth muscle cells. | Kawabe J, etal., Biochem Biophys Res Commun. 2006 Mar 31;342(1):164-9. Epub 2006 Feb 3. |
14. | Behavior of caveolae and caveolin-3 during the development of myocyte hypertrophy. | Kikuchi T, etal., J Cardiovasc Pharmacol. 2005 Mar;45(3):204-10. |
15. | REDOX REGULATION OF ISCHEMIC PRECONDITIONING IS MEDIATED BY THE DIFFERENTIAL ACTIVATION OF CAVEOLINS AND THEIR ASSOCIATION WITH eNOS AND GLUT-4. | Koneru S, etal., Am J Physiol Heart Circ Physiol. 2007 Feb 2;. |
16. | Caveolin-3 and eNOS colocalize and interact in ciliated airway epithelial cells in the rat. | Krasteva G, etal., Int J Biochem Cell Biol. 2007;39(3):615-25. Epub 2006 Oct 29. |
17. | Evidence for cyclooxygenase-2 association with caveolin-3 in primary cultured rat chondrocytes. | Kwak JO, etal., J Korean Med Sci. 2006 Feb;21(1):100-6. |
18. | Beta-subunit of cardiac Na+-K+-ATPase dictates the concentration of the functional enzyme in caveolae. | Liu L and Askari A, Am J Physiol Cell Physiol. 2006 Oct;291(4):C569-78. Epub 2006 Apr 19. |
19. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
20. | Mutations in the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy. | Minetti C, etal., Nat Genet. 1998 Apr;18(4):365-8. |
21. | The coiled-coil domain of MURC/cavin-4 is involved in membrane trafficking of caveolin-3 in cardiomyocytes. | Naito D, etal., Am J Physiol Heart Circ Physiol. 2015 Dec 15;309(12):H2127-36. doi: 10.1152/ajpheart.00446.2015. Epub 2015 Oct 23. |
22. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
23. | OMIM Disease Annotation Pipeline | OMIM Disease Annotation Pipeline |
24. | Nitric oxide inhibition of adenylyl cyclase type 6 activity is dependent upon lipid rafts and caveolin signaling complexes. | Ostrom RS, etal., J Biol Chem. 2004 May 7;279(19):19846-53. Epub 2004 Mar 8. |
25. | Protection of adult rat cardiac myocytes from ischemic cell death: role of caveolar microdomains and delta-opioid receptors. | Patel HH, etal., Am J Physiol Heart Circ Physiol. 2006 Jul;291(1):H344-50. Epub 2006 Feb 24. |
26. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
27. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
28. | Caveolin-3 is associated with the T-tubules of mature skeletal muscle fibers. | Ralston E and Ploug T, Exp Cell Res. 1999 Feb 1;246(2):510-5. |
29. | Caveolin-1 and -3 dissociations from caveolae to cytosol in the heart during aging and after myocardial infarction in rat. | Ratajczak P, etal., Cardiovasc Res. 2003 Feb;57(2):358-69. |
30. | GOA pipeline | RGD automated data pipeline |
31. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
32. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
33. | Caveolae-associated proteins in cardiomyocytes: caveolin-2 expression and interactions with caveolin-3. | Rybin VO, etal., Am J Physiol Heart Circ Physiol 2003 Jul;285(1):H325-32. Epub 2003 Mar 20. |
34. | Caveolin-3 is adjacent to a group of extradyadic ryanodine receptors. | Scriven DR, etal., Biophys J. 2005 Sep;89(3):1893-901. Epub 2005 Jun 24. |
35. | Expression of caveolin-1, -2, and -3 in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis. | Shin T, etal., J Neuroimmunol. 2005 Aug;165(1-2):11-20. |
36. | Caveolin isoform expression during differentiation of C6 glioma cells. | Silva WI, etal., Int J Dev Neurosci. 2005 Nov;23(7):599-612. Epub 2005 Aug 30. |
37. | Caveolin-3 directly interacts with the C-terminal tail of beta -dystroglycan. Identification of a central WW-like domain within caveolin family members. | Sotgia F, etal., J Biol Chem. 2000 Dec 1;275(48):38048-58. |
38. | Role for SUR2A in coupling cardiac K(ATP) channels to caveolin-3. | Sun W and Hu K, Cell Physiol Biochem. 2010;25(4-5):409-18. doi: 10.1159/000303045. Epub 2010 Mar 23. |
39. | Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle. | Tang Z, etal., J Biol Chem 1996 Jan 26;271(4):2255-61. |
40. | Tentative Sequence Identification Numbers | Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
41. | Localization of caveolin-3 in the sinus endothelial cells of the rat spleen. | Uehara K and Miyoshi M, Cell Tissue Res 2002 Mar;307(3):329-36. Epub 2002 Feb 23. |
42. | Caveolin-1 and caveolin-3 form heterooligomeric complexes in atrial cardiac myocytes that are required for doxorubicin-induced apoptosis. | Volonte D, etal., Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H392-401. Epub 2007 Nov 2. |
43. | Estrogen modulation of eNOS activity and its association with caveolin-3 and calmodulin in rat hearts. | Wang X and Abdel-Rahman AA, Am J Physiol Heart Circ Physiol 2002 Jun;282(6):H2309-15. |
44. | Localization of cardiac sodium channels in caveolin-rich membrane domains: regulation of sodium current amplitude. | Yarbrough TL, etal., Circ Res. 2002 Mar 8;90(4):443-9. |
45. | Membrane localization, Caveolin-3 association and rapid actions of vitamin D receptor in cardiac myocytes. | Zhao G and Simpson RU, Steroids. 2010 Aug-Sep;75(8-9):555-9. Epub 2009 Dec 14. |
46. | FAT10 attenuates hypoxia-induced cardiomyocyte apoptosis by stabilizing caveolin-3. | Zhou Q, etal., J Mol Cell Cardiol. 2018 Mar;116:115-124. doi: 10.1016/j.yjmcc.2018.02.008. Epub 2018 Feb 10. |
PMID:8663016 | PMID:9008709 | PMID:9353265 | PMID:10835421 | PMID:11115849 | PMID:11159934 | PMID:11259414 | PMID:12138167 | PMID:12477932 | PMID:12705878 | PMID:12847114 | PMID:14517320 |
PMID:14600260 | PMID:15155732 | PMID:15277200 | PMID:15314230 | PMID:15466641 | PMID:15489334 | PMID:15499025 | PMID:15541368 | PMID:16319126 | PMID:16455755 | PMID:16565301 | PMID:16648270 |
PMID:16676355 | PMID:17060380 | PMID:17164264 | PMID:17200204 | PMID:17275750 | PMID:17337601 | PMID:17524427 | PMID:18286598 | PMID:18552160 | PMID:18720574 | PMID:18936328 | PMID:18956885 |
PMID:19101541 | PMID:19164602 | PMID:19238754 | PMID:19299911 | PMID:19380584 | PMID:19523531 | PMID:19535499 | PMID:19544087 | PMID:19800018 | PMID:19923424 | PMID:20304057 | PMID:20472890 |
PMID:20953984 | PMID:21084288 | PMID:21182936 | PMID:21296051 | PMID:22374691 | PMID:22792322 | PMID:23058350 | PMID:23620341 | PMID:24040945 | PMID:24066022 | PMID:24412535 | PMID:25211146 |
PMID:25257915 | PMID:25450954 | PMID:25661386 | PMID:25849791 | PMID:26071359 | PMID:26191152 | PMID:26313243 | PMID:27733157 | PMID:28825318 | PMID:29101175 | PMID:29486470 | PMID:31050077 |
Cav3 (Rattus norvegicus - Norway rat) |
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CAV3 (Homo sapiens - human) |
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Cav3 (Mus musculus - house mouse) |
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Cav3 (Chinchilla lanigera - long-tailed chinchilla) |
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CAV3 (Pan paniscus - bonobo/pygmy chimpanzee) |
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CAV3 (Canis lupus familiaris - dog) |
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Cav3 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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CAV3 (Sus scrofa - pig) |
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CAV3 (Chlorocebus sabaeus - green monkey) |
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Cav3 (Heterocephalus glaber - naked mole-rat) |
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Variants in Cav3
104 total Variants ![]() |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
RH130686 |
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alimentary part of gastrointestinal system
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appendage
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circulatory system
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ectoderm
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endocrine system
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endoderm
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exocrine system
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hemolymphoid system
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hepatobiliary system
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integumental system
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mesenchyme
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mesoderm
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musculoskeletal system
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nervous system
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renal system
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reproductive system
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respiratory system
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sensory system
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visual system
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9 | 11 | 49 | 96 | 51 | 55 | 24 | 25 | 24 | 6 | 173 | 92 | 10 | 81 | 40 | 45 | 31 | 6 | 6 |
RefSeq Transcripts | NM_019155 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
GenBank Nucleotide | BC084692 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
CH473957 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ215709 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ224953 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000004 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
U31968 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Ensembl Acc Id: | ENSRNOT00000007601 ⟹ ENSRNOP00000007601 | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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RefSeq Acc Id: | NM_019155 ⟹ NP_062028 | ||||||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
Protein RefSeqs | NP_062028 | (Get FASTA) | NCBI Sequence Viewer |
GenBank Protein | AAC52377 | (Get FASTA) | NCBI Sequence Viewer |
AAH84692 | (Get FASTA) | NCBI Sequence Viewer | |
EDL91498 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000007601 | ||
ENSRNOP00000007601.4 | |||
GenBank Protein | P51638 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_062028 ⟸ NM_019155 |
- UniProtKB: | P51638 (UniProtKB/Swiss-Prot), A6IBN0 (UniProtKB/TrEMBL) |
- Sequence: |
Ensembl Acc Id: | ENSRNOP00000007601 ⟸ ENSRNOT00000007601 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P51638-F1-model_v2 | AlphaFold | P51638 | 1-151 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13693287 | ||||||||
Promoter ID: | EPDNEW_R3812 | ||||||||
Type: | single initiation site | ||||||||
Name: | Cav3_1 | ||||||||
Description: | caveolin 3 | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:2281 | AgrOrtholog |
BioCyc Gene | G2FUF-43420 | BioCyc |
Ensembl Genes | ENSRNOG00000005798 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot |
Ensembl Transcript | ENSRNOT00000007601 | ENTREZGENE |
ENSRNOT00000007601.5 | UniProtKB/Swiss-Prot | |
IMAGE_CLONE | IMAGE:7103841 | IMAGE-MGC_LOAD |
InterPro | Caveolin | UniProtKB/Swiss-Prot |
Caveolin_CS | UniProtKB/Swiss-Prot | |
KEGG Report | rno:29161 | UniProtKB/Swiss-Prot |
MGC_CLONE | MGC:105449 | IMAGE-MGC_LOAD |
NCBI Gene | 29161 | ENTREZGENE |
PANTHER | PTHR10844 | UniProtKB/Swiss-Prot |
PTHR10844:SF16 | UniProtKB/Swiss-Prot | |
Pfam | Caveolin | UniProtKB/Swiss-Prot |
PhenoGen | Cav3 | PhenoGen |
PROSITE | CAVEOLIN | UniProtKB/Swiss-Prot |
RatGTEx | ENSRNOG00000005798 | RatGTEx |
TIGR | TC219233 | |
UniProt | A6IBN0 | ENTREZGENE, UniProtKB/TrEMBL |
CAV3_RAT | UniProtKB/Swiss-Prot, ENTREZGENE |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2002-06-10 | Cav3 | caveolin 3 | Symbol and Name status set to approved | 70586 | APPROVED |
Note Type | Note | Reference |
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gene_cellular_localization | integral membrane protein localized to caveolae | 69799 |
gene_expression | expressed in skeletal muscle, diaphragm, and heart | 69799 |
gene_expression | expressed in sinus endothelial cells of spleen | 1299862 |
gene_function | interacts with heterotrimeric G-proteins | 69799 |
gene_physical_interaction | binds to endothelial nitric oxide synthase (eNOS) | 1299844 |
gene_process | suppresses the basal GTPase activity of purified heterotrimeric G-proteins | 69799 |
gene_process | may play a role in stress fiber constriction in spleen sinus endothelial cells | 1299862 |
gene_process | regulates activity of endothelial nitric oxide synthase (eNOS) | 1299844 |