Cav1 (caveolin 1) - Rat Genome Database

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Gene: Cav1 (caveolin 1) Rattus norvegicus
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Symbol: Cav1
Name: caveolin 1
RGD ID: 2280
Description: Enables several functions, including enzyme binding activity; syntaxin binding activity; and transmembrane transporter binding activity. Involved in several processes, including positive regulation of cellular component organization; regulation of endothelial cell proliferation; and regulation of signal transduction. Located in several cellular components, including basal plasma membrane; focal adhesion; and peroxisomal membrane. Part of protein-containing complex. Biomarker of several diseases, including artery disease (multiple); brain ischemia (multiple); obesity; osteoarthritis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); lipodystrophy (multiple); primary open angle glaucoma; primary pulmonary hypertension; and systemic scleroderma (multiple). Orthologous to human CAV1 (caveolin 1); PARTICIPATES IN transforming growth factor-beta signaling pathway; insulin signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-ethoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cav; caveolin; caveolin 1, caveolae protein; Caveolin caveolae protein 22 kDa; caveolin, caveolae protein 1; Caveolin, caveolae protein, 22 kDa; caveolin-1; caveolin-like; LOC100362870; MGC187299
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   BB/OK  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8446,606,538 - 46,639,616 (+)NCBIGRCr8
mRatBN7.2445,640,624 - 45,673,708 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl445,634,918 - 45,673,705 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx450,634,317 - 50,667,383 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0446,555,310 - 46,588,376 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0444,969,814 - 45,002,892 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0444,597,123 - 44,630,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl444,597,123 - 44,630,200 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0445,203,494 - 45,236,461 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4442,956,102 - 42,989,057 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1443,098,177 - 43,130,873 (+)NCBI
Celera440,918,628 - 40,949,677 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
acoustic neuroma  (ISO)
Acute Lung Injury  (IEP)
Alcoholic Liver Diseases  (IEP)
Alzheimer's disease  (ISS)
atherosclerosis  (IEP)
atrial fibrillation  (ISO)
brain ischemia  (IEP)
breast cancer  (ISO,ISS)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
Carcinogenesis  (ISO)
Cardiomegaly  (IEP,ISO)
congenital generalized lipodystrophy type 3  (ISO)
Dermal Fibrosis  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diffuse scleroderma  (ISO)
exfoliation syndrome  (ISO)
Experimental Autoimmune Myocarditis  (IEP)
Experimental Autoimmune Neuritis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
familial partial lipodystrophy  (ISO)
Familial Partial Lipodystrophy Type 7  (ISO)
genetic disease  (ISO)
Hemorrhage  (IEP)
high grade glioma  (IEP)
Hyperplasia  (ISO)
hypertension  (IEP,ISO)
hypertrophic cardiomyopathy  (ISS)
hypothyroidism  (IEP)
invasive ductal carcinoma  (ISO)
leiomyoma  (ISO)
limited scleroderma  (ISO)
low tension glaucoma  (ISO)
Lung Neoplasms  (ISO)
Lymphatic Metastasis  (ISO)
melanoma  (ISO)
multiple sclerosis  (ISO)
Neoplasm Metastasis  (ISO)
Nephrogenic Fibrosing Dermopathy  (ISO)
obesity  (IEP)
open-angle glaucoma  (ISO)
osteoarthritis  (IEP)
ovarian carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
primary open angle glaucoma  (ISO)
primary pulmonary hypertension  (ISO)
Primary Pulmonary Hypertension, 3  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IEP,ISO)
Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia 2  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IEP)
Sarcopenia  (ISO)
sciatic neuropathy  (IEP)
silicosis  (ISO)
Spinal Cord Injuries  (IEP)
squamous cell carcinoma  (ISO)
Stevens-Johnson syndrome  (ISO)
Stomach Neoplasms  (ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (IEP,ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Weight Gain  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (ISO)
1,2-dimethylhydrazine  (ISO)
13-HPODE  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylcholine  (ISO)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
aminoguanidine  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphibole asbestos  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-carotene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
butan-1-ol  (ISO)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium nitrate  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camptothecin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboxy-PTIO  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chlorohydrocarbon  (EXP)
chloropicrin  (ISO)
cholesterol  (EXP,ISO)
chromium atom  (EXP)
chrysene  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cordycepin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cumene  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
depsipeptide  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP,ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
equol  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
fipronil  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
gefitinib  (ISO)
genistein  (ISO)
geranylgeraniol  (ISO)
glucose  (ISO)
Glutathione ethyl ester  (ISO)
glycidyl methacrylate  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
lysophosphatidylcholine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl beta-cyclodextrin  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP)
mifepristone  (ISO)
miquelianin  (ISO)
monocrotaline  (EXP)
N-[3-(aminomethyl)benzyl]acetamidine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-D-aspartic acid  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nicotinic acid  (EXP)
nimesulide  (ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
nitroprusside  (ISO)
NS-398  (ISO)
nystatin  (ISO)
octanoic acid  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(I:C)  (EXP)
potassium chloride  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
raloxifene  (EXP,ISO)
reactive oxygen species  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
saracatinib  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
streptozocin  (EXP)
sulfasalazine  (ISO)
tamoxifen  (ISO)
taurocholic acid  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolfenamic acid  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
triadimefon  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
troglitazone  (EXP)
trovafloxacin  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
wogonin  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
angiotensin-activated signaling pathway  (IEA,ISO)
animal organ regeneration  (IEP)
apoptotic signaling pathway  (IEA,ISO)
basement membrane organization  (IEA,ISO)
calcium ion homeostasis  (ISO)
calcium ion transport  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
caveola assembly  (IBA,IEA,ISO)
caveolin-mediated endocytosis  (IEA,ISO)
cell differentiation  (IBA,IEA)
cell population proliferation  (ISO)
cellular response to exogenous dsRNA  (IEA,ISO)
cellular response to hyperoxia  (IEA,ISO)
cellular response to hypoxia  (IEP)
cellular response to mechanical stimulus  (IDA)
cellular response to misfolded protein  (IEA,ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to starvation  (ISO)
cellular response to transforming growth factor beta stimulus  (IEA,ISO)
cellular senescence  (IMP)
cholesterol efflux  (IMP)
cholesterol homeostasis  (IEA,ISO)
cytokine-mediated signaling pathway  (IEA,ISO)
endothelial cell proliferation  (IEA,ISO)
establishment of localization in cell  (IEA,ISO)
fibroblast proliferation  (IEA,ISO)
glandular epithelial cell differentiation  (IEA,ISO)
insulin receptor internalization  (IEA,ISO)
intracellular calcium ion homeostasis  (IMP,ISO)
intracellular nitric oxide homeostasis  (IEA,ISO)
lactation  (IEA,ISO)
lipid storage  (IEA,ISO)
maintenance of protein location in cell  (IMP)
mammary gland development  (ISO)
mammary gland involution  (IEA,ISO)
MAPK cascade  (IEA,ISO)
membrane depolarization  (IEA,ISO)
microtubule polymerization  (IMP)
muscle cell cellular homeostasis  (IEA,ISO)
negative regulation of anoikis  (IEA,ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of calcium ion import across plasma membrane  (IMP)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO,ISS)
negative regulation of cation channel activity  (IDA)
negative regulation of cell population proliferation  (ISO)
negative regulation of cytokine-mediated signaling pathway  (IEA,ISO)
negative regulation of endothelial cell proliferation  (IBA,IEA,IMP,ISO)
negative regulation of epithelial cell differentiation  (IEA,ISO)
negative regulation of ERK1 and ERK2 cascade  (IDA)
negative regulation of fibroblast proliferation  (IEA,ISO)
negative regulation of MAPK cascade  (IEA,ISO)
negative regulation of muscle cell apoptotic process  (IMP)
negative regulation of necroptotic process  (IEA,ISO)
negative regulation of neuron differentiation  (IMP)
negative regulation of nitric oxide biosynthetic process  (IEA,ISO)
negative regulation of peptidyl-serine phosphorylation  (IEA,ISO)
negative regulation of peptidyl-tyrosine autophosphorylation  (IEA,ISO)
negative regulation of pinocytosis  (IEA,ISO)
negative regulation of potassium ion transmembrane transport  (IEA,ISO)
negative regulation of protein ubiquitination  (IEA,ISO)
negative regulation of receptor signaling pathway via JAK-STAT  (ISO)
negative regulation of signal transduction  (ISO)
negative regulation of smooth muscle cell migration  (IMP)
negative regulation of smooth muscle cell proliferation  (IMP)
negative regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
negative regulation of tyrosine phosphorylation of STAT protein  (IEA,ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (IMP)
nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of calcium ion transport into cytosol  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of cell adhesion molecule production  (IEA,ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cholesterol efflux  (IEA,ISO)
positive regulation of cold-induced thermogenesis  (IEA,ISO,ISS)
positive regulation of endocytosis  (IMP)
positive regulation of endothelial cell proliferation  (IMP)
positive regulation of ERAD pathway  (IEA,ISO)
positive regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of gap junction assembly  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of intrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of microtubule polymerization  (IMP)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of protein ubiquitination  (IEA,ISO)
positive regulation of signal transduction  (IMP)
positive regulation of toll-like receptor 3 signaling pathway  (IEA,ISO)
positive regulation of vasoconstriction  (IEA,IMP,ISO)
post-transcriptional regulation of gene expression  (IEA,ISO)
protein localization  (ISO)
protein localization to basolateral plasma membrane  (ISO)
protein localization to plasma membrane raft  (ISO)
protein transport  (IEA,ISO)
receptor internalization  (ISO,ISS)
receptor-mediated endocytosis of virus by host cell  (IEA,ISO)
regulation of blood coagulation  (IEA,ISO)
regulation of cell communication by electrical coupling involved in cardiac conduction  (IEA,ISO)
regulation of cytosolic calcium ion concentration  (IBA,IEA,ISO)
regulation of entry of bacterium into host cell  (IEA,ISO)
regulation of fatty acid metabolic process  (IEA,ISO)
regulation of heart rate by cardiac conduction  (IEA,ISO)
regulation of membrane repolarization during action potential  (IEA,ISO)
regulation of ruffle assembly  (IEA,ISO)
regulation of smooth muscle contraction  (IEA,ISO)
regulation of the force of heart contraction  (ISO)
regulation of the force of heart contraction by chemical signal  (IEA,ISO)
regulation of ventricular cardiac muscle cell action potential  (IEA,ISO)
response to bacterium  (IEA,ISO)
response to calcium ion  (IEA,ISO)
response to estrogen  (IEA,ISO)
response to gamma radiation  (IEP)
response to glucocorticoid  (IEP)
response to hypoxia  (IEA,ISO)
response to ischemia  (IEA,ISO)
response to mechanical stimulus  (IMP)
response to nutrient  (IEP)
response to progesterone  (IEA,ISO)
response to xenobiotic stimulus  (IEP)
skeletal muscle tissue development  (IEA,ISO)
T cell costimulation  (IEA,ISO,ISS)
triglyceride metabolic process  (IEA,ISO)
vasculogenesis  (IEA,ISO)
vasoconstriction  (IEA,ISO)
vesicle organization  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Global gene expression profiling and tissue microarray reveal novel candidate genes and down-regulation of the tumor suppressor gene CAV1 in sporadic vestibular schwannomas. Aarhus M, etal., Neurosurgery. 2010 Oct;67(4):998-1019; discussion 1019. doi: 10.1227/NEU.0b013e3181ec7b71.
2. Lack of association of SNP rs4236601 near CAV1 and CAV2 with POAG in a Saudi cohort. Abu-Amero KK, etal., Mol Vis. 2012;18:1960-5. Epub 2012 Jul 18.
3. Caveolin-1 assembles type 1 inositol 1,4,5-trisphosphate receptors and canonical transient receptor potential 3 channels into a functional signaling complex in arterial smooth muscle cells. Adebiyi A, etal., J Biol Chem. 2011 Feb 11;286(6):4341-8. Epub 2010 Nov 23.
4. Increased expression of caveolin-1 and -2 in the hearts of Lewis rats with experimental autoimmune myocarditis. Ahn M, etal., Autoimmunity. 2006 Sep;39(6):489-95.
5. Contribution of caveolin-1 to ventricular nitric oxide in age-related adaptation to hypovolemic state. Arreche ND, etal., Regul Pept. 2012 Nov 10;179(1-3):43-9. doi: 10.1016/j.regpep.2012.08.002. Epub 2012 Sep 3.
6. Downmodulation of caveolin-1 expression in human ovarian carcinoma is directly related to alpha-folate receptor overexpression. Bagnoli M, etal., Oncogene. 2000 Sep 28;19(41):4754-63.
7. Effect of insulin on caveolin-enriched membrane domains in rat liver. Balbis A, etal., J Biol Chem. 2004 Sep 17;279(38):39348-57. Epub 2004 Jul 12.
8. Cell selective glucocorticoid induction of caveolin-1 and caveolae in differentiating pulmonary alveolar epithelial cell cultures. Barar J, etal., Biochem Biophys Res Commun. 2007 Jul 27;359(2):360-6. Epub 2007 May 24.
9. Opposite pattern of MDR1 and caveolin-1 gene expression in human atherosclerotic lesions and proliferating human smooth muscle cells. Batetta B, etal., Cell Mol Life Sci. 2001 Jul;58(8):1113-20.
10. Integrins regulate opioid receptor signaling in trigeminal ganglion neurons. Berg KA, etal., Neuroscience. 2007 Feb 9;144(3):889-97. Epub 2006 Dec 8.
11. Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors. Bhatnagar A, etal., J Biol Chem. 2004 Aug 13;279(33):34614-23. Epub 2004 Jun 9.
12. Ruscogenin attenuates monocrotaline-induced pulmonary hypertension in rats. Bi LQ, etal., Int Immunopharmacol. 2013 May;16(1):7-16. doi: 10.1016/j.intimp.2013.03.010. Epub 2013 Mar 26.
13. Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound healing in diabetes. Bitar MS, etal., Am J Physiol Endocrinol Metab. 2013 Oct 15;305(8):E951-63. doi: 10.1152/ajpendo.00189.2013. Epub 2013 Aug 13.
14. Downregulation and altered spatial pattern of caveolin-1 in chronic plaque psoriasis. Campbell L, etal., Br J Dermatol. 2002 Oct;147(4):701-9.
15. Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I. Carro E, etal., J Neurosci. 2005 Nov 23;25(47):10884-93. doi: 10.1523/JNEUROSCI.2909-05.2005.
16. Evidence for Na+/Ca2+ exchanger 1 association with caveolin-1 and -2 in C6 glioma cells. Cha SH, etal., IUBMB Life. 2004 Oct;56(10):621-7.
17. Cellular localization and interaction of ABCA1 and caveolin-1 in aortic endothelial cells after HDL incubation. Chao WT, etal., Biochem Biophys Res Commun. 2005 Jul 8;332(3):743-9.
18. Caveolae: biochemical analysis. Chatenay-Rivauday C, etal., Mol Biol Rep. 2004 Jun;31(2):67-84.
19. Mutational, epigenetic and expressional analyses of caveolin-1 gene in breast cancers. Chen ST, etal., Int J Mol Med. 2004 Oct;14(4):577-82.
20. Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization. Cogolludo A, etal., Circ Res. 2006 Apr 14;98(7):931-8. Epub 2006 Mar 9.
21. Caveolin-1 expression is essential for proper nonshivering thermogenesis in brown adipose tissue. Cohen AW, etal., Diabetes. 2005 Mar;54(3):679-86.
22. Hypermethylation of the caveolin-1 gene promoter in prostate cancer. Cui J, etal., Prostate. 2001 Feb 15;46(3):249-56.
23. Caveolin-1--a novel interacting partner of organic cation/carnitine transporter (Octn2): effect of protein kinase C on this interaction in rat astrocytes. Czeredys M, etal., PLoS One. 2013 Dec 13;8(12):e82105. doi: 10.1371/journal.pone.0082105. eCollection 2013.
24. Catabolic stress induces features of chondrocyte senescence through overexpression of caveolin 1: possible involvement of caveolin 1-induced down-regulation of articular chondrocytes in the pathogenesis of osteoarthritis. Dai SM, etal., Arthritis Rheum. 2006 Mar;54(3):818-31.
25. Interaction with caveolin-1 modulates vascular ATP-sensitive potassium (KATP) channel activity. Davies LM, etal., J Physiol. 2010 Sep 1;588(Pt 17):3255-66. Epub 2010 Jul 12.
26. Decreased expression of caveolin 1 in patients with systemic sclerosis: crucial role in the pathogenesis of tissue fibrosis. Del Galdo F, etal., Arthritis Rheum. 2008 Sep;58(9):2854-65. doi: 10.1002/art.23791.
27. Caveolin-1 is required for the upregulation of fatty acid synthase (FASN), a tumor promoter, during prostate cancer progression. Di Vizio D, etal., Cancer Biol Ther. 2007 Aug;6(8):1263-8. Epub 2007 May 17.
28. Peripheral nerve injury alters blood-spinal cord barrier functional and molecular integrity through a selective inflammatory pathway. Echeverry S, etal., J Neurosci. 2011 Jul 27;31(30):10819-28.
29. Reciprocal regulation of neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo. Implications for human breast cancer. Engelman JA, etal., J Biol Chem. 1998 Aug 7;273(32):20448-55.
30. Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation. Fong A, etal., Am J Clin Pathol. 2003 Jul;120(1):93-100.
31. Up-regulation of caveolin-1 by DJ-1 attenuates rat pulmonary arterial hypertension by inhibiting TGFβ/Smad signaling pathway. Gao W, etal., Exp Cell Res. 2017 Dec 1;361(1):192-198. doi: 10.1016/j.yexcr.2017.10.019. Epub 2017 Oct 22.
32. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
33. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
34. Caveolin-1 regulates the delivery and endocytosis of the glutamate transporter, excitatory amino acid carrier 1. Gonzalez MI, etal., J Biol Chem. 2007 Oct 12;282(41):29855-65. Epub 2007 Aug 22.
35. Vascular microarray profiling in two models of hypertension identifies Cav-1, Rgs2 and Rgs5 as antihypertensive targets. Grayson TH, etal., BMC Genomics. 2007 Nov 7;8(1):404.
36. Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury. Gu Y, etal., J Neurochem. 2012 Jan;120(1):147-56. doi: 10.1111/j.1471-4159.2011.07542.x. Epub 2011 Nov 17.
37. Association of a CAV-1 haplotype to familial aggressive prostate cancer. Haeusler J, etal., Prostate. 2005 Oct 1;65(2):171-7.
38. Invasion activating caveolin-1 mutation in human scirrhous breast cancers. Hayashi K, etal., Cancer Res. 2001 Mar 15;61(6):2361-4.
39. Influence of caveolin on constitutively activated recombinant eNOS: insights into eNOS dysfunction in BDL rat liver. Hendrickson H, etal., Am J Physiol Gastrointest Liver Physiol 2003 Sep;285(3):G652-60. Epub 2003 Jun 26.
40. Impact of caveolin-1 expression on clinicopathological parameters in renal cell carcinoma. Horiguchi A, etal., J Urol. 2004 Aug;172(2):718-22.
41. Caveolin 3-mediated integrin beta1 signaling is required for the proliferation of folliculostellate cells in rat anterior pituitary gland under the influence of extracellular matrix. Horiguchi K, etal., J Endocrinol. 2011 Jul;210(1):29-36. Epub 2011 Apr 20.
42. Caveolin-3 expression and caveolae are required for isoflurane-induced cardiac protection from hypoxia and ischemia/reperfusion injury. Horikawa YT, etal., J Mol Cell Cardiol. 2008 Jan;44(1):123-30. Epub 2007 Oct 11.
43. Dietary obesity increases NO and inhibits BKCa-mediated, endothelium-dependent dilation in rat cremaster muscle artery: association with caveolins and caveolae. Howitt L, etal., Am J Physiol Heart Circ Physiol. 2012 Jun;302(12):H2464-76. Epub 2012 Apr 6.
44. Endothelin-1 activates mesangial cell ERK1/2 via EGF-receptor transactivation and caveolin-1 interaction. Hua H, etal., Am J Physiol Renal Physiol 2003 Feb;284(2):F303-12.
45. The potential role of caveolin-1 in inhibition of aquaporins during the AVD. Jablonski EM and Hughes FM Jr, Biol Cell. 2006 Jan;98(1):33-42.
46. Caveolin-1 deficiency increases cerebral ischemic injury. Jasmin JF, etal., Circ Res. 2007 Mar 16;100(5):721-9. Epub 2007 Feb 9.
47. Caveolin-1 sensitizes rat pituitary adenoma GH3 cells to bromocriptine induced apoptosis. Jiang YN, etal., Cancer Cell Int. 2007 Mar 2;7:1.
48. Caveolin-1 and caveolin-3 regulate Ca2+ homeostasis of single smooth muscle cells from rat cerebral resistance arteries. Kamishima T, etal., Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H204-14. Epub 2007 Mar 2.
49. Association study of genetic variants on chromosome 7q31 with susceptibility to normal tension glaucoma in a Japanese population. Kato T, etal., Eye (Lond). 2013 Aug;27(8):979-83. doi: 10.1038/eye.2013.123. Epub 2013 Jun 7.
50. Caveolin regulates microtubule polymerization in the vascular smooth muscle cells. Kawabe J, etal., Biochem Biophys Res Commun. 2006 Mar 31;342(1):164-9. Epub 2006 Feb 3.
51. Increased phosphorylation of caveolin-1 in the sciatic nerves of Lewis rats with experimental autoimmune neuritis. Kim H, etal., Brain Res. 2007 Mar 16;1137(1):153-60. Epub 2006 Dec 20.
52. Increased phosphorylation of caveolin-1 in the spinal cord of irradiated rats. Kim H, etal., J Vet Sci. 2007 Dec;8(4):323-7.
53. Caveolin-1 expression by means of p38beta mitogen-activated protein kinase mediates the antiproliferative effect of carbon monoxide. Kim HP, etal., Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11319-24. Epub 2005 Jul 28.
54. Caveolin isoforms in resident and elicited rat peritoneal macrophages. Kiss AL, etal., Eur J Cell Biol. 2000 May;79(5):343-9.
55. Oestrogen-mediated tyrosine phosphorylation of caveolin-1 and its effect on the oestrogen receptor localisation: an in vivo study. Kiss AL, etal., Mol Cell Endocrinol. 2005 Dec 21;245(1-2):128-37. Epub 2005 Dec 20.
56. REDOX REGULATION OF ISCHEMIC PRECONDITIONING IS MEDIATED BY THE DIFFERENTIAL ACTIVATION OF CAVEOLINS AND THEIR ASSOCIATION WITH eNOS AND GLUT-4. Koneru S, etal., Am J Physiol Heart Circ Physiol. 2007 Feb 2;.
57. Caveolin-1 and -2 in airway epithelium: expression and in situ association as detected by FRET-CLSM. Krasteva G, etal., Respir Res. 2006 Aug 11;7:108.
58. Increased expression of endothelial nitric oxide synthase and caveolin-1 in the aorta of rats with isoproterenol-induced cardiac hypertrophy. Krenek P, etal., Can J Physiol Pharmacol. 2006 Dec;84(12):1245-50.
59. Transitional cell carcinomas and nonurothelial carcinomas of the urinary bladder differ in the promoter methylation status of the caveolin-1, hDAB2IP and p53 genes, but not in the global methylation of Alu elements. Kunze E, etal., Int J Mol Med. 2006 Jan;17(1):3-13.
60. Co-localization and interaction of b0,+-type amino acid transporter 1 (BAT1) with caveolin-1 in rat kidney. Kwak JO, etal., J Nephrol. 2005 Nov-Dec;18(6):681-9.
61. MLC1 trafficking and membrane expression in astrocytes: role of caveolin-1 and phosphorylation. Lanciotti A, etal., Neurobiol Dis. 2010 Mar;37(3):581-95. Epub 2009 Nov 26.
62. Caveolin-1 and -2 interact with connexin43 and regulate gap junctional intercellular communication in keratinocytes. Langlois S, etal., Mol Biol Cell. 2008 Mar;19(3):912-28. Epub 2007 Dec 27.
63. Fibrosis-associated single-nucleotide polymorphisms in TGFB1 and CAV1 are not associated with the development of nephrogenic systemic fibrosis. Le LP, etal., Am J Dermatopathol. 2013 May;35(3):351-6. doi: 10.1097/DAD.0b013e31826c5508.
64. Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia. Lee H, etal., Am J Pathol. 2002 Oct;161(4):1357-69.
65. Upregulation of caveolin-1 contributes to aggravated high-salt diet-induced endothelial dysfunction and hypertension in type 1 diabetic rats. Li X, etal., Life Sci. 2014 Sep 15;113(1-2):31-9. doi: 10.1016/j.lfs.2014.07.027. Epub 2014 Jul 30.
66. Caveolin-1 plays a crucial role in inhibiting neuronal differentiation of neural stem/progenitor cells via VEGF signaling-dependent pathway. Li Y, etal., PLoS One. 2011;6(8):e22901. Epub 2011 Aug 3.
67. Caveolin-1 expression in benign and malignant lesions of the breast. Liedtke C, etal., World J Surg Oncol. 2007 Oct 3;5:110.
68. A novel caveolin-1 biomarker for clinical outcome of sarcopenia. Lin CH, etal., In Vivo. 2014 May-Jun;28(3):383-9.
69. The regulation of the cardiac potassium channel (HERG) by caveolin-1. Lin J, etal., Biochem Cell Biol. 2008 Oct;86(5):405-15. doi: 10.1139/o08-118.
70. Molecular interaction between caveolin-1 and ABCA1 on high-density lipoprotein-mediated cholesterol efflux in aortic endothelial cells. Lin YC, etal., Cardiovasc Res. 2007 Aug 1;75(3):575-83. Epub 2007 Apr 21.
71. Significant association of caveolin-1 (CAV1) genotypes with breast cancer in Taiwan. Liu LC, etal., Anticancer Res. 2011 Oct;31(10):3511-5.
72. Caveolin 1 and G-Protein-Coupled Receptor Kinase-2 Coregulate Endothelial Nitric Oxide Synthase Activity in Sinusoidal Endothelial Cells. Liu S, etal., Am J Pathol. 2017 Apr;187(4):896-907. doi: 10.1016/j.ajpath.2016.11.017. Epub 2017 Feb 3.
73. Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss. Loomis SJ, etal., Ophthalmology. 2014 Feb;121(2):508-16. doi: 10.1016/j.ophtha.2013.09.012. Epub 2013 Oct 25.
74. High-fat feeding period affects gene expression in rat white adipose tissue. Lopez IP, etal., Mol Cell Biochem. 2005 Jul;275(1-2):109-15.
75. ATP dependence of the SNARE/caveolin 1 interaction in the hippocampus. Magga JM, etal., Biochem Biophys Res Commun 2002 Mar 15;291(5):1232-8.
76. 14-Deoxyandrographolide targets adenylate cyclase and prevents ethanol-induced liver injury through constitutive NOS dependent reduced redox signaling in rats. Mandal S, etal., Food Chem Toxicol. 2013 Sep;59:236-48. doi: 10.1016/j.fct.2013.05.056. Epub 2013 Jun 10.
77. Evidence for caveolin-1 as a new susceptibility gene regulating tissue fibrosis in systemic sclerosis. Manetti M, etal., Ann Rheum Dis. 2012 Jun;71(6):1034-41. doi: 10.1136/annrheumdis-2011-200986. Epub 2012 Mar 8.
78. Sonic hedgehog ligand partners with caveolin-1 for intracellular transport. Mao H, etal., Lab Invest. 2009 Mar;89(3):290-300. Epub 2009 Jan 12.
79. Caveolin-1 and mitochondrial alterations in regenerating rat liver. Mastrodonato M, etal., Microsc Res Tech. 2012 Aug;75(8):1026-32. doi: 10.1002/jemt.22027. Epub 2012 Mar 19.
80. Disruption of endothelial-cell caveolin-1alpha/raft scaffolding during development of monocrotaline-induced pulmonary hypertension. Mathew R, etal., Circulation. 2004 Sep 14;110(11):1499-506. Epub 2004 Sep 7.
81. Caveolin-1 and altered neuregulin signaling contribute to the pathophysiological progression of diabetic peripheral neuropathy. McGuire JF, etal., Diabetes. 2009 Nov;58(11):2677-86. doi: 10.2337/db09-0594. Epub 2009 Aug 12.
82. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
83. Comparative effect of fish oil feeding and other dietary fatty acids on plasma lipoproteins, biliary lipids, and hepatic expression of proteins involved in reverse cholesterol transport in the rat. Morgado N, etal., Ann Nutr Metab. 2005 Nov-Dec;49(6):397-406. Epub 2005 Oct 14.
84. Decreased endothelial nitric-oxide synthase (eNOS) activity resulting from abnormal interaction between eNOS and its regulatory proteins in hypoxia-induced pulmonary hypertension. Murata T, etal., J Biol Chem 2002 Nov 15;277(46):44085-92. Epub 2002 Aug 15.
85. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
86. Association of the low-density lipoprotein receptor with caveolae in hamster and rat liver. Ness GC, etal., Biochem Biophys Res Commun 2003 Mar 28;303(1):177-81.
87. Reverse cholesterol transport and cholesterol efflux in atherosclerosis. Ohashi R, etal., QJM. 2005 Dec;98(12):845-56. Epub 2005 Oct 28.
88. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
89. Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. Ostrom RS, etal., J Biol Chem. 2003 Jul 4;278(27):24461-8. Epub 2003 Apr 23.
90. Non-existence of caveolin-1 gene mutations in human breast cancer. Patani N, etal., Breast Cancer Res Treat. 2012 Jan;131(1):307-10. doi: 10.1007/s10549-011-1761-2. Epub 2011 Sep 11.
91. Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension. Patel HH, etal., FASEB J. 2007 Apr 30;.
92. Growth hormone activity in mitochondria depends on GH receptor Box 1 and involves caveolar pathway targeting. Perret-Vivancos C, etal., Exp Cell Res. 2006 Feb 1;312(3):215-32.
93. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
94. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
95. Dynamic and regulated association of caveolin with lipid bodies: modulation of lipid body motility and function by a dominant negative mutant. Pol A, etal., Mol Biol Cell. 2004 Jan;15(1):99-110. Epub 2003 Oct 3.
96. In situ prostate cancer gene therapy using a novel adenoviral vector regulated by the caveolin-1 promoter. Pramudji C, etal., Clin Cancer Res. 2001 Dec;7(12):4272-9.
97. Prognostic significance of tumor/stromal caveolin-1 expression in breast cancer patients. Qian N, etal., Cancer Sci. 2011 Aug;102(8):1590-6. doi: 10.1111/j.1349-7006.2011.01985.x. Epub 2011 Jun 27.
98. Caveolin-1 and -3 dissociations from caveolae to cytosol in the heart during aging and after myocardial infarction in rat. Ratajczak P, etal., Cardiovasc Res. 2003 Feb;57(2):358-69.
99. Hexose transporters GLUT1 and GLUT3 are colocalized with hexokinase I in caveolae microdomains of rat spermatogenic cells. Rauch MC, etal., J Cell Physiol. 2006 May;207(2):397-406.
100. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
101. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
102. Caveolin-1 Down-Regulation Inhibits Insulin-Like Growth Factor-I Receptor Signal Transduction in H9C2 Rat Cardiomyoblasts. Salani B, etal., Endocrinology. 2008 Feb;149(2):461-5. Epub 2007 Nov 26.
103. Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels. Sampson LJ, etal., Circ Res. 2004 Nov 12;95(10):1012-8. Epub 2004 Oct 21.
104. Decline in caveolin-1 expression and scaffolding of G protein receptor kinase-2 with age in Fischer 344 aortic vascular smooth muscle. Schutzer WE, etal., Am J Physiol Heart Circ Physiol. 2005 May;288(5):H2457-64. Epub 2004 Dec 30.
105. Caveolin-1 facilitates mechanosensitive protein kinase B (Akt) signaling in vitro and in vivo. Sedding DG, etal., Circ Res. 2005 Apr 1;96(6):635-42. Epub 2005 Feb 24.
106. Expression of sex hormone-binding globulin, oxytocin receptor, caveolin-1 and p21 in leiomyoma. Sendemir A, etal., Gynecol Endocrinol. 2008 Feb;24(2):105-12.
107. Nitric oxide down-regulates caveolin-1 expression in rat brains during focal cerebral ischemia and reperfusion injury. Shen J, etal., J Neurochem. 2006 Feb;96(4):1078-89. Epub 2006 Jan 17.
108. Increases in the phosphorylated form of caveolin-1 in the spinal cord of rats with clip compression injury. Shin T Brain Res. 2007 Apr 13;1141:228-34. Epub 2007 Jan 9.
109. Expression of caveolin-1, -2, and -3 in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis. Shin T, etal., J Neuroimmunol. 2005 Aug;165(1-2):11-20.
110. Caveolin-1 inhibits breast cancer growth and metastasis. Sloan EK, etal., Oncogene. 2004 Oct 14;23(47):7893-7.
111. Focal adhesions in (myo)fibroblasts scaffold adenylyl cyclase with phosphorylated caveolin. Swaney JS, etal., J Biol Chem. 2006 Jun 23;281(25):17173-9. Epub 2006 Apr 17.
112. Development of an immunoassay for serum caveolin-1: a novel biomarker for prostate cancer. Tahir SA, etal., Clin Cancer Res. 2003 Sep 1;9(10 Pt 1):3653-9.
113. Caveolin 1 is critical for abdominal aortic aneurysm formation induced by angiotensin II and inhibition of lysyl oxidase. Takayanagi T, etal., Clin Sci (Lond). 2014 Jun;126(11):785-94. doi: 10.1042/CS20130660.
114. Nerve growth factor blocks the glucose-induced down-regulation of caveolin-1 expression in Schwann cells via p75 neurotrophin receptor signaling. Tan W, etal., J Biol Chem 2003 Jun 20;278(25):23151-62. Epub 2003 Apr 5.
115. Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma. Thorleifsson G, etal., Nat Genet. 2010 Oct;42(10):906-9. doi: 10.1038/ng.661. Epub 2010 Sep 12.
116. Cav1 suppresses tumor growth and metastasis in a murine model of cutaneous SCC through modulation of MAPK/AP-1 activation. Trimmer C, etal., Am J Pathol. 2013 Mar;182(3):992-1004. doi: 10.1016/j.ajpath.2012.11.008. Epub 2012 Dec 22.
117. Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization. Walentinsson A, etal., Cancer Res 2001 Nov 15;61(22):8263-73.
118. A dual-color FISH gene map of the proximal region of rat Chromosome 4 and comparative analysis in human and mouse. Walentinsson A, etal., Mamm Genome 2001 Dec;12(12):900-8.
119. Caveolin-1 regulates neural differentiation of rat bone mesenchymal stem cells into neurons by modulating Notch signaling. Wang S, etal., Int J Dev Neurosci. 2013 Feb;31(1):30-5. doi: 10.1016/j.ijdevneu.2012.09.004. Epub 2012 Sep 29.
120. A role for caveolin-1 in mechanotransduction of fetal type II epithelial cells. Wang Y, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Jun;298(6):L775-83. Epub 2010 Feb 19.
121. Developmental iodine deficiency and hypothyroidism impair neural development, upregulate caveolin-1, and downregulate synaptotagmin-1 in the rat cerebellum. Wang Y, etal., Biol Trace Elem Res. 2011 Dec;144(1-3):1039-49. Epub 2011 May 25.
122. Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion. Williams TM, etal., J Biol Chem. 2004 Dec 3;279(49):51630-46. Epub 2004 Sep 7.
123. Caveolin-1 is enriched in the peroxisomal membrane of rat hepatocytes. Woudenberg J, etal., Hepatology. 2010 May;51(5):1744-53.
124. Loss of stromal caveolin-1 expression in malignant melanoma metastases predicts poor survival. Wu KN, etal., Cell Cycle. 2011 Dec 15;10(24):4250-5. doi: 10.4161/cc.10.24.18551. Epub 2011 Dec 15.
125. Low-Frequency Ultrasound Irradiation Increases Blood-Tumor Barrier Permeability by Transcellular Pathway in a Rat Glioma Model. Xia CY, etal., J Mol Neurosci. 2012 Apr 20.
126. The role of caveolin1 and sprouty1 in genistein's regulation of vascular smooth muscle cell and endothelial cell proliferation. Xiang Q, etal., Eur J Pharmacol. 2010 Dec 1;648(1-3):153-61. Epub 2010 Sep 7.
127. Pretreatment with andrographolide pills((R)) attenuates lipopolysaccharide-induced pulmonary microcirculatory disturbance and acute lung injury in rats. Yang N, etal., Microcirculation. 2014 Nov;21(8):703-16. doi: 10.1111/micc.12152.
128. Skew in the human caveolin 1 gene upstream purine complex homozygote haplotype compartment in multiple sclerosis. Zarif Yeganeh M, etal., J Neuroimmunol. 2009 Nov 30;216(1-2):103-7. doi: 10.1016/j.jneuroim.2009.09.007. Epub 2009 Oct 13.
129. Caveolin-1 phosphorylation is required for stretch-induced EGFR and Akt activation in mesangial cells. Zhang B, etal., Cell Signal. 2007 Aug;19(8):1690-700. Epub 2007 Mar 19.
130. Integrated Analysis of Multiple Microarray Studies to Identify Core Gene-Expression Signatures Involved in Tubulointerstitial Injury in Diabetic Nephropathy. Zhou H, etal., Biomed Res Int. 2022 May 10;2022:9554658. doi: 10.1155/2022/9554658. eCollection 2022.
131. Xuezhikang, extract of red yeast rice, improved abnormal hemorheology, suppressed caveolin-1 and increased eNOS expression in atherosclerotic rats. Zhu XY, etal., PLoS One. 2013 May 10;8(5):e62731. doi: 10.1371/journal.pone.0062731. Print 2013.
132. Caveolin and GLT-1 gene expression is reciprocally regulated in primary astrocytes: association of GLT-1 with non-caveolar lipid rafts. Zschocke J, etal., Glia. 2005 Jan 15;49(2):275-87.
Additional References at PubMed
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Genomics

Comparative Map Data
Cav1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8446,606,538 - 46,639,616 (+)NCBIGRCr8
mRatBN7.2445,640,624 - 45,673,708 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl445,634,918 - 45,673,705 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx450,634,317 - 50,667,383 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0446,555,310 - 46,588,376 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0444,969,814 - 45,002,892 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0444,597,123 - 44,630,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl444,597,123 - 44,630,200 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0445,203,494 - 45,236,461 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4442,956,102 - 42,989,057 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1443,098,177 - 43,130,873 (+)NCBI
Celera440,918,628 - 40,949,677 (+)NCBICelera
Cytogenetic Map4q22NCBI
CAV1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387116,525,009 - 116,561,185 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7116,524,994 - 116,561,179 (+)EnsemblGRCh38hg38GRCh38
GRCh377116,165,063 - 116,201,239 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367115,952,075 - 115,988,466 (+)NCBINCBI36Build 36hg18NCBI36
Build 347115,758,789 - 115,795,181NCBI
Celera7110,972,249 - 111,008,654 (+)NCBICelera
Cytogenetic Map7q31.2NCBI
HuRef7110,530,835 - 110,566,784 (+)NCBIHuRef
CHM1_17116,098,482 - 116,134,827 (+)NCBICHM1_1
T2T-CHM13v2.07117,840,041 - 117,876,175 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27115,560,275 - 115,596,679 (+)NCBI
Cav1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39617,306,387 - 17,341,323 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl617,306,334 - 17,341,451 (+)EnsemblGRCm39 Ensembl
GRCm38617,306,335 - 17,341,328 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl617,306,335 - 17,341,452 (+)EnsemblGRCm38mm10GRCm38
MGSCv37617,256,370 - 17,291,324 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36617,256,370 - 17,291,324 (+)NCBIMGSCv36mm8
Celera617,378,835 - 17,414,670 (+)NCBICelera
Cytogenetic Map6A2NCBI
cM Map67.73NCBI
Cav1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543222,258,250 - 22,292,403 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543222,258,262 - 22,292,403 (+)NCBIChiLan1.0ChiLan1.0
CAV1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26153,356,633 - 153,393,045 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan175,367,106 - 5,403,301 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07108,497,125 - 108,533,090 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17121,193,678 - 121,229,655 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7121,193,424 - 121,229,655 (+)Ensemblpanpan1.1panPan2
CAV1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11455,458,934 - 55,494,563 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1455,461,048 - 55,492,935 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1454,856,462 - 54,888,069 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01455,500,946 - 55,536,541 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1455,503,040 - 55,536,538 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11455,530,973 - 55,562,566 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01455,219,411 - 55,251,015 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01455,590,528 - 55,622,125 (+)NCBIUU_Cfam_GSD_1.0
Cav1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511844,152,891 - 44,185,619 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365892,504,224 - 2,537,170 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365892,504,235 - 2,536,778 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAV1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1829,649,992 - 29,682,465 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11829,648,120 - 29,682,451 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21831,745,664 - 31,778,987 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CAV1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12185,222,724 - 85,258,562 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2185,222,879 - 85,258,627 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604218,474,866 - 18,510,943 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cav1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248272,844,115 - 2,879,179 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248272,844,855 - 2,878,367 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cav1
93 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:179
Count of miRNA genes:135
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000009253
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
11530004Niddm71Non-insulin dependent diabetes mellitus QTL 710.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43258419952754138Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat

Markers in Region
RH142797  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2445,672,046 - 45,672,280 (+)MAPPERmRatBN7.2
Rnor_6.0444,628,545 - 44,628,778NCBIRnor6.0
Rnor_5.0445,234,800 - 45,235,033UniSTSRnor5.0
RGSC_v3.4442,987,400 - 42,987,633UniSTSRGSC3.4
Celera440,948,019 - 40,948,252UniSTS
RH 3.4 Map4284.1UniSTS
Cytogenetic Map4q21UniSTS
AA946480  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2445,673,157 - 45,673,362 (+)MAPPERmRatBN7.2
Rnor_6.0444,629,656 - 44,629,860NCBIRnor6.0
Rnor_5.0445,235,911 - 45,236,115UniSTSRnor5.0
Celera440,949,130 - 40,949,334UniSTS
RH 3.4 Map4282.8UniSTS
Cytogenetic Map4q21UniSTS


Related Rat Strains
The following Strains have been annotated to Cav1
BB/OK    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 3
Medium 3 43 28 12 19 12 8 11 64 35 37 8 8
Low 29 29 29 10 4
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_133651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC087102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC110102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF439778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF439779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF489529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC104689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC161826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB698936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK364516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DP000027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM039194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z46614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000078250   ⟹   ENSRNOP00000073712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl445,640,546 - 45,673,705 (+)Ensembl
Rnor_6.0 Ensembl444,597,123 - 44,630,200 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105620   ⟹   ENSRNOP00000087572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl445,634,918 - 45,673,700 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111645   ⟹   ENSRNOP00000097222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl445,641,877 - 45,673,700 (+)Ensembl
RefSeq Acc Id: NM_031556   ⟹   NP_113744
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8446,606,538 - 46,639,616 (+)NCBI
mRatBN7.2445,640,624 - 45,673,705 (+)NCBI
Rnor_6.0444,597,123 - 44,630,203 (+)NCBI
Rnor_5.0445,203,494 - 45,236,461 (+)NCBI
RGSC_v3.4442,956,102 - 42,989,057 (+)RGD
Celera440,918,628 - 40,949,677 (+)NCBI
Sequence:
RefSeq Acc Id: NM_133651   ⟹   NP_598412
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8446,607,972 - 46,639,616 (+)NCBI
mRatBN7.2445,642,058 - 45,673,705 (+)NCBI
Rnor_6.0444,598,557 - 44,630,203 (+)NCBI
Rnor_5.0445,203,494 - 45,236,461 (+)NCBI
RGSC_v3.4442,956,102 - 42,989,057 (+)RGD
Celera440,920,068 - 40,949,677 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236130   ⟹   XP_006236192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8446,607,268 - 46,639,616 (+)NCBI
mRatBN7.2445,641,347 - 45,673,708 (+)NCBI
Rnor_6.0444,597,846 - 44,630,206 (+)NCBI
Rnor_5.0445,203,494 - 45,236,461 (+)NCBI
Sequence:
RefSeq Acc Id: NP_113744   ⟸   NM_031556
- Peptide Label: isoform alpha
- UniProtKB: Q8VIK9 (UniProtKB/Swiss-Prot),   Q8VIK8 (UniProtKB/Swiss-Prot),   P41350 (UniProtKB/Swiss-Prot),   Q2IBC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_598412   ⟸   NM_133651
- Peptide Label: isoform beta
- UniProtKB: B1WBN8 (UniProtKB/TrEMBL),   Q3MHT6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236192   ⟸   XM_006236130
- Peptide Label: isoform X1
- UniProtKB: B1WBN8 (UniProtKB/TrEMBL),   Q3MHT6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073712   ⟸   ENSRNOT00000078250
RefSeq Acc Id: ENSRNOP00000087572   ⟸   ENSRNOT00000105620
RefSeq Acc Id: ENSRNOP00000097222   ⟸   ENSRNOT00000111645

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41350-F1-model_v2 AlphaFold P41350 1-178 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692892
Promoter ID:EPDNEW_R3416
Type:initiation region
Name:Cav1_1
Description:caveolin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0444,597,216 - 44,597,276EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2280 AgrOrtholog
BIND 134453
  134455
  134456
  134458
BioCyc Gene G2FUF-45566 BioCyc
Ensembl Genes ENSRNOG00000056836 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078250 ENTREZGENE
  ENSRNOT00000078250.2 UniProtKB/TrEMBL
  ENSRNOT00000105620.1 UniProtKB/TrEMBL
  ENSRNOT00000111645.1 UniProtKB/TrEMBL
InterPro Caveolin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Caveolin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25404 UniProtKB/TrEMBL
NCBI Gene 25404 ENTREZGENE
PANTHER PTHR10844 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10844:SF18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Caveolin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CAV1 RGD
PhenoGen Cav1 PhenoGen
PROSITE CAVEOLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000056836 RatGTEx
UniProt A0A0G2K682_RAT UniProtKB/TrEMBL
  A0A8I6A884_RAT UniProtKB/TrEMBL
  A0A8I6AS98_RAT UniProtKB/TrEMBL
  A2VCW2_RAT UniProtKB/TrEMBL
  B1WBN8 ENTREZGENE, UniProtKB/TrEMBL
  CAV1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q2IBC6 ENTREZGENE, UniProtKB/TrEMBL
  Q3MHT6 ENTREZGENE, UniProtKB/TrEMBL
  Q8VIK8 ENTREZGENE
  Q8VIK9 ENTREZGENE
UniProt Secondary Q8VIK8 UniProtKB/Swiss-Prot
  Q8VIK9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Cav1  caveolin 1  Cav1  caveolin 1, caveolae protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-29 Cav1  caveolin 1, caveolae protein  LOC100362870  caveolin-like  Data merged from RGD:2323909 737654 PROVISIONAL
2012-08-14 Cav1  caveolin 1, caveolae protein  Cav1  caveolin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-08-13 Cav1  caveolin 1  Cav1  caveolin 1, caveolae protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100362870  caveolin-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-18 Cav1  caveolin 1, caveolae protein  Cav1  caveolin, caveolae protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-10-01 Cav1  caveolin, caveolae protein 1  Cav  caveolin  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2003-04-09 Cav  caveolin      Symbol and Name updated 629477 APPROVED
2003-03-10 Cav  caveolin  Cav1    Data merged from RGD:620347 628472 PROVISIONAL
2002-08-07 Cav1        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Cav  Caveolin, caveolae protein, 22 kDa      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in uterine tumors 70348
gene_disease upregulated in uterine tumors 70557
gene_expression expressed in uterus 70348
gene_expression expressed in uterus 70557
gene_function binds cholesterol and acts as a cholesterol shuttling protein 1298592
gene_process inhibits the activity of the Erb B2 tyrosine kinase receptor for neuregulins 1298592