Cav1 (caveolin 1) - Rat Genome Database

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Gene: Cav1 (caveolin 1) Rattus norvegicus
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Symbol: Cav1
Name: caveolin 1
RGD ID: 2280
Description: Enables several functions, including enzyme binding activity; syntaxin binding activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of cation transmembrane transport; positive regulation of cellular component organization; and regulation of endothelial cell proliferation. Located in several cellular components, including basal plasma membrane; focal adhesion; and peroxisomal membrane. Part of protein-containing complex. Biomarker of several diseases, including artery disease (multiple); brain ischemia (multiple); obesity; osteoarthritis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); lipodystrophy (multiple); primary open angle glaucoma; primary pulmonary hypertension; and systemic scleroderma (multiple). Orthologous to human CAV1 (caveolin 1); PARTICIPATES IN transforming growth factor-beta signaling pathway; insulin signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-ethoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cav; caveolin; caveolin 1, caveolae protein; Caveolin caveolae protein 22 kDa; caveolin, caveolae protein 1; Caveolin, caveolae protein, 22 kDa; caveolin-1; caveolin-like; LOC100362870; MGC187299
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   BB/OK  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8446,606,538 - 46,639,616 (+)NCBIGRCr8
mRatBN7.2445,640,624 - 45,673,708 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl445,634,918 - 45,673,705 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx450,634,317 - 50,667,383 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0446,555,310 - 46,588,376 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0444,969,814 - 45,002,892 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0444,597,123 - 44,630,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl444,597,123 - 44,630,200 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0445,203,494 - 45,236,461 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4442,956,102 - 42,989,057 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1443,098,177 - 43,130,873 (+)NCBI
Celera440,918,628 - 40,949,677 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
acoustic neuroma  (ISO)
Acute Lung Injury  (IEP)
Alcoholic Liver Diseases  (IEP)
Alzheimer's disease  (ISS)
atherosclerosis  (IEP)
atrial fibrillation  (ISO)
basal cell carcinoma  (ISO)
brain ischemia  (IEP)
breast cancer  (ISO,ISS)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
Carcinogenesis  (ISO)
Cardiomegaly  (IEP,ISO)
congenital generalized lipodystrophy type 3  (ISO)
cystic fibrosis  (ISO)
Dermal Fibrosis  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diffuse scleroderma  (ISO)
exfoliation syndrome  (ISO)
Experimental Autoimmune Myocarditis  (IEP)
Experimental Autoimmune Neuritis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
familial partial lipodystrophy  (ISO)
Familial Partial Lipodystrophy Type 7  (ISO)
genetic disease  (ISO)
Hemorrhage  (IEP)
high grade glioma  (IEP)
Hyperplasia  (ISO)
hypertension  (IEP,ISO)
hypertrophic cardiomyopathy  (ISS)
hypothyroidism  (IEP)
invasive ductal carcinoma  (ISO)
leiomyoma  (ISO)
limited scleroderma  (ISO)
low tension glaucoma  (ISO)
Lung Neoplasms  (ISO)
Lymphatic Metastasis  (ISO)
melanoma  (ISO)
multiple sclerosis  (ISO)
Neoplasm Metastasis  (ISO)
Nephrogenic Fibrosing Dermopathy  (ISO)
obesity  (IEP)
open-angle glaucoma  (ISO)
osteoarthritis  (IEP)
ovarian carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
primary open angle glaucoma  (ISO)
primary pulmonary hypertension  (ISO)
primary pulmonary hypertension 3  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IEP,ISO)
Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia 2  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IEP)
Sarcopenia  (ISO)
sciatic neuropathy  (IEP)
silicosis  (ISO)
Spinal Cord Injuries  (IEP)
squamous cell carcinoma  (ISO)
Stevens-Johnson syndrome  (ISO)
Stomach Neoplasms  (ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (IEP,ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Weight Gain  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (ISO)
1,2-dimethylhydrazine  (ISO)
13-HPODE  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylcholine  (ISO)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
aminoguanidine  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphibole asbestos  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-carotene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
butan-1-ol  (ISO)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium nitrate  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camptothecin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboxy-PTIO  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chlorohydrocarbon  (EXP)
chloropicrin  (ISO)
cholesterol  (EXP,ISO)
chromium atom  (EXP)
chrysene  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cordycepin  (ISO)
corosolic acid  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cumene  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
depsipeptide  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP,ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
equol  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
fipronil  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
furfural  (ISO)
gefitinib  (ISO)
genistein  (ISO)
geranylgeraniol  (ISO)
glucose  (ISO)
Glutathione ethyl ester  (ISO)
glycidyl methacrylate  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
lysophosphatidylcholine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl beta-cyclodextrin  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP)
mifepristone  (ISO)
miquelianin  (ISO)
monocrotaline  (EXP)
N-[3-(aminomethyl)benzyl]acetamidine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-D-aspartic acid  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nicotinic acid  (EXP)
nimesulide  (ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
nitroprusside  (ISO)
NS-398  (ISO)
nystatin  (ISO)
octanoic acid  (ISO)
okadaic acid  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(I:C)  (EXP)
potassium chloride  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
raloxifene  (EXP,ISO)
reactive oxygen species  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
saracatinib  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sulfasalazine  (ISO)
tamoxifen  (ISO)
taurocholic acid  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tolfenamic acid  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
triadimefon  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
troglitazone  (EXP)
trovafloxacin  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
wogonin  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
angiotensin-activated signaling pathway  (IEA,ISO)
animal organ regeneration  (IEP)
apoptotic signaling pathway  (IEA,ISO)
basement membrane organization  (IEA,ISO)
calcium ion homeostasis  (IEA,ISO)
calcium ion transport  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
caveola assembly  (IBA,IEA,ISO)
caveolin-mediated endocytosis  (IEA,ISO)
cell differentiation  (IBA)
cell population proliferation  (IEA,ISO)
cellular response to exogenous dsRNA  (IEA,ISO)
cellular response to hyperoxia  (IEA,ISO)
cellular response to hypoxia  (IEP)
cellular response to mechanical stimulus  (IDA)
cellular response to misfolded protein  (IEA,ISO)
cellular response to peptide hormone stimulus  (IEA,ISO)
cellular response to starvation  (ISO)
cellular response to transforming growth factor beta stimulus  (IEA,ISO)
cellular senescence  (IMP)
cholesterol efflux  (IMP)
cholesterol homeostasis  (IEA,ISO)
cytokine-mediated signaling pathway  (IEA,ISO)
endothelial cell proliferation  (IEA,ISO)
establishment of localization in cell  (IEA,ISO)
fibroblast proliferation  (IEA,ISO)
glandular epithelial cell differentiation  (IEA,ISO)
insulin receptor internalization  (IEA,ISO)
intracellular calcium ion homeostasis  (IEA,IMP,ISO)
intracellular nitric oxide homeostasis  (IEA,ISO)
lactation  (IEA,ISO)
lipid storage  (IEA,ISO)
maintenance of protein location in cell  (IMP)
mammary gland development  (IEA,ISO)
mammary gland involution  (IEA,ISO)
MAPK cascade  (IEA,ISO)
membrane depolarization  (IEA,ISO)
microtubule polymerization  (IMP)
muscle cell cellular homeostasis  (IEA,ISO)
negative regulation of anoikis  (IEA,ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of calcium ion import across plasma membrane  (IMP)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO,ISS)
negative regulation of cation channel activity  (IDA)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of cytokine-mediated signaling pathway  (IEA,ISO)
negative regulation of endothelial cell proliferation  (IBA,IEA,IMP,ISO)
negative regulation of epithelial cell differentiation  (IEA,ISO)
negative regulation of ERK1 and ERK2 cascade  (IDA)
negative regulation of fibroblast proliferation  (IEA,ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of MAPK cascade  (IEA,ISO)
negative regulation of muscle cell apoptotic process  (IMP)
negative regulation of necroptotic process  (IEA,ISO)
negative regulation of neuron differentiation  (IMP)
negative regulation of nitric oxide biosynthetic process  (IEA,ISO)
negative regulation of nitric-oxide synthase activity  (ISO)
negative regulation of pinocytosis  (IEA,ISO)
negative regulation of potassium ion transmembrane transport  (IEA,ISO)
negative regulation of protein ubiquitination  (IEA,ISO)
negative regulation of receptor signaling pathway via JAK-STAT  (IEA,ISO)
negative regulation of signal transduction  (IEA,ISO)
negative regulation of smooth muscle cell migration  (IMP)
negative regulation of smooth muscle cell proliferation  (IMP)
negative regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
negative regulation of tyrosine phosphorylation of STAT protein  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (IMP)
nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of calcium ion transport into cytosol  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell adhesion molecule production  (IEA,ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cholesterol efflux  (IEA,ISO)
positive regulation of cold-induced thermogenesis  (IEA,ISO,ISS)
positive regulation of endocytosis  (IMP)
positive regulation of endothelial cell proliferation  (IMP)
positive regulation of ERAD pathway  (IEA,ISO)
positive regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of gap junction assembly  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of intrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of microtubule polymerization  (IMP)
positive regulation of protein ubiquitination  (IEA,ISO)
positive regulation of signal transduction  (IMP)
positive regulation of toll-like receptor 3 signaling pathway  (IEA,ISO)
positive regulation of vasoconstriction  (IEA,IMP,ISO)
post-transcriptional regulation of gene expression  (IEA,ISO)
protein localization  (IEA,ISO)
protein localization to basolateral plasma membrane  (ISO)
protein localization to plasma membrane raft  (ISO)
protein transport  (IEA,ISO)
receptor internalization  (IEA,ISO,ISS)
receptor-mediated endocytosis of virus by host cell  (IEA,ISO)
regulation of blood coagulation  (IEA,ISO)
regulation of cell communication by electrical coupling involved in cardiac conduction  (IEA,ISO)
regulation of cytosolic calcium ion concentration  (IBA,IEA,ISO)
regulation of entry of bacterium into host cell  (IEA,ISO)
regulation of fatty acid metabolic process  (IEA,ISO)
regulation of heart rate by cardiac conduction  (IEA,ISO)
regulation of membrane repolarization during action potential  (IEA,ISO)
regulation of peptidase activity  (ISO)
regulation of ruffle assembly  (IEA,ISO)
regulation of smooth muscle contraction  (IEA,ISO)
regulation of the force of heart contraction  (IEA,ISO)
regulation of the force of heart contraction by chemical signal  (IEA,ISO)
regulation of ventricular cardiac muscle cell action potential  (IEA,ISO)
response to bacterium  (IEA,ISO)
response to calcium ion  (IEA,ISO)
response to estrogen  (IEA,ISO)
response to gamma radiation  (IEP)
response to glucocorticoid  (IEP)
response to hypoxia  (IEA,ISO)
response to ischemia  (IEA,ISO)
response to mechanical stimulus  (IMP)
response to nutrient  (IEP)
response to progesterone  (IEA,ISO)
response to xenobiotic stimulus  (IEP)
skeletal muscle tissue development  (IEA,ISO)
T cell costimulation  (IEA,ISO,ISS)
triglyceride metabolic process  (IEA,ISO)
tyrosine phosphorylation of STAT protein  (ISO)
vasculogenesis  (IEA,ISO)
vasoconstriction  (IEA,ISO)
vesicle organization  (ISO)

Cellular Component
acrosomal membrane  (IEA,ISO)
apical plasma membrane  (ISO)
basal plasma membrane  (IDA)
basolateral plasma membrane  (ISO)
caveola  (IDA,IEA,ISO,ISS)
caveolar macromolecular signaling complex  (IEA,ISO)
cell cortex  (IEA,ISO)
cell surface  (IDA)
cilium  (IEA,ISO)
cytoplasmic vesicle  (IBA,IEA,ISO)
endoplasmic reticulum  (IEA,ISO,ISS)
endosome  (IEA,ISO,ISS)
exocytic vesicle  (ISO)
focal adhesion  (IDA,IEA,ISO)
Golgi apparatus  (IBA,IDA,IEA,ISO)
Golgi membrane  (IEA,ISO,ISS)
lipid droplet  (IDA)
membrane  (IEA,ISO)
membrane raft  (IDA,IEA,ISO)
perinuclear region of cytoplasm  (IBA,IDA,IEA,ISO)
peroxisomal membrane  (IDA)
plasma membrane  (IDA,IEA,ISO)
protein-containing complex  (IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Global gene expression profiling and tissue microarray reveal novel candidate genes and down-regulation of the tumor suppressor gene CAV1 in sporadic vestibular schwannomas. Aarhus M, etal., Neurosurgery. 2010 Oct;67(4):998-1019; discussion 1019. doi: 10.1227/NEU.0b013e3181ec7b71.
2. Lack of association of SNP rs4236601 near CAV1 and CAV2 with POAG in a Saudi cohort. Abu-Amero KK, etal., Mol Vis. 2012;18:1960-5. Epub 2012 Jul 18.
3. Caveolin-1 assembles type 1 inositol 1,4,5-trisphosphate receptors and canonical transient receptor potential 3 channels into a functional signaling complex in arterial smooth muscle cells. Adebiyi A, etal., J Biol Chem. 2011 Feb 11;286(6):4341-8. Epub 2010 Nov 23.
4. Increased expression of caveolin-1 and -2 in the hearts of Lewis rats with experimental autoimmune myocarditis. Ahn M, etal., Autoimmunity. 2006 Sep;39(6):489-95.
5. Contribution of caveolin-1 to ventricular nitric oxide in age-related adaptation to hypovolemic state. Arreche ND, etal., Regul Pept. 2012 Nov 10;179(1-3):43-9. doi: 10.1016/j.regpep.2012.08.002. Epub 2012 Sep 3.
6. Downmodulation of caveolin-1 expression in human ovarian carcinoma is directly related to alpha-folate receptor overexpression. Bagnoli M, etal., Oncogene. 2000 Sep 28;19(41):4754-63.
7. Effect of insulin on caveolin-enriched membrane domains in rat liver. Balbis A, etal., J Biol Chem. 2004 Sep 17;279(38):39348-57. Epub 2004 Jul 12.
8. Cell selective glucocorticoid induction of caveolin-1 and caveolae in differentiating pulmonary alveolar epithelial cell cultures. Barar J, etal., Biochem Biophys Res Commun. 2007 Jul 27;359(2):360-6. Epub 2007 May 24.
9. Opposite pattern of MDR1 and caveolin-1 gene expression in human atherosclerotic lesions and proliferating human smooth muscle cells. Batetta B, etal., Cell Mol Life Sci. 2001 Jul;58(8):1113-20.
10. Integrins regulate opioid receptor signaling in trigeminal ganglion neurons. Berg KA, etal., Neuroscience. 2007 Feb 9;144(3):889-97. Epub 2006 Dec 8.
11. Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors. Bhatnagar A, etal., J Biol Chem. 2004 Aug 13;279(33):34614-23. Epub 2004 Jun 9.
12. Ruscogenin attenuates monocrotaline-induced pulmonary hypertension in rats. Bi LQ, etal., Int Immunopharmacol. 2013 May;16(1):7-16. doi: 10.1016/j.intimp.2013.03.010. Epub 2013 Mar 26.
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100. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
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PMID:21900688   PMID:21918362   PMID:21938483   PMID:21978755   PMID:22173826   PMID:22215724   PMID:22230296   PMID:22277751   PMID:22377966   PMID:22378877   PMID:22513464   PMID:22669893  
PMID:22683596   PMID:22792322   PMID:22871113   PMID:23007290   PMID:23049990   PMID:23225242   PMID:23262137   PMID:23269647   PMID:23319823   PMID:23576582   PMID:23583380   PMID:23665238  
PMID:23987506   PMID:24013648   PMID:24089527   PMID:24419512   PMID:24576892   PMID:24608114   PMID:24625804   PMID:24755228   PMID:24755854   PMID:24953158   PMID:25006397   PMID:25017399  
PMID:25204428   PMID:25204797   PMID:25322824   PMID:25419974   PMID:25450954   PMID:25527780   PMID:25556234   PMID:25618412   PMID:25661386   PMID:25674202   PMID:25748795   PMID:25893292  
PMID:26020612   PMID:26357463   PMID:26543049   PMID:26813466   PMID:26839631   PMID:26847875   PMID:26847917   PMID:27009876   PMID:27110488   PMID:27138644   PMID:27311393   PMID:27383193  
PMID:27470556   PMID:27708218   PMID:27747480   PMID:27771236   PMID:27886057   PMID:27956030   PMID:28729092   PMID:28751541   PMID:28957875   PMID:29039595   PMID:29199336   PMID:29462885  
PMID:29471582   PMID:29760379   PMID:30563532   PMID:30840346   PMID:30943774   PMID:31318049   PMID:31391685   PMID:31505169   PMID:31565882   PMID:31728004   PMID:31889352   PMID:31911435  
PMID:32311453   PMID:32554851   PMID:32810492   PMID:33000233   PMID:33148419   PMID:33423964   PMID:33450132   PMID:33726791   PMID:34223768   PMID:34360984   PMID:34394002   PMID:34554674  
PMID:35958678   PMID:36007380   PMID:36240973   PMID:36631446   PMID:36918760   PMID:37336147   PMID:37349971   PMID:37598879   PMID:37714275   PMID:39178948  


Genomics

Comparative Map Data
Cav1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8446,606,538 - 46,639,616 (+)NCBIGRCr8
mRatBN7.2445,640,624 - 45,673,708 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl445,634,918 - 45,673,705 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx450,634,317 - 50,667,383 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0446,555,310 - 46,588,376 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0444,969,814 - 45,002,892 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0444,597,123 - 44,630,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl444,597,123 - 44,630,200 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0445,203,494 - 45,236,461 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4442,956,102 - 42,989,057 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1443,098,177 - 43,130,873 (+)NCBI
Celera440,918,628 - 40,949,677 (+)NCBICelera
Cytogenetic Map4q22NCBI
CAV1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387116,525,009 - 116,561,185 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7116,524,994 - 116,561,179 (+)EnsemblGRCh38hg38GRCh38
GRCh377116,165,063 - 116,201,239 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367115,952,075 - 115,988,466 (+)NCBINCBI36Build 36hg18NCBI36
Build 347115,758,789 - 115,795,181NCBI
Celera7110,972,249 - 111,008,654 (+)NCBICelera
Cytogenetic Map7q31.2NCBI
HuRef7110,530,835 - 110,566,784 (+)NCBIHuRef
CHM1_17116,098,482 - 116,134,827 (+)NCBICHM1_1
T2T-CHM13v2.07117,840,041 - 117,876,175 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27115,560,275 - 115,596,679 (+)NCBI
Cav1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39617,306,387 - 17,341,323 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl617,306,334 - 17,341,451 (+)EnsemblGRCm39 Ensembl
GRCm38617,306,335 - 17,341,328 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl617,306,335 - 17,341,452 (+)EnsemblGRCm38mm10GRCm38
MGSCv37617,256,370 - 17,291,324 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36617,256,370 - 17,291,324 (+)NCBIMGSCv36mm8
Celera617,378,835 - 17,414,670 (+)NCBICelera
Cytogenetic Map6A2NCBI
cM Map67.73NCBI
Cav1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543222,258,250 - 22,292,403 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543222,258,262 - 22,292,403 (+)NCBIChiLan1.0ChiLan1.0
CAV1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26153,356,633 - 153,393,045 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan175,367,106 - 5,403,301 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07108,497,125 - 108,533,090 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17121,193,678 - 121,229,655 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7121,193,424 - 121,229,655 (+)Ensemblpanpan1.1panPan2
CAV1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11455,458,934 - 55,494,563 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1455,461,048 - 55,492,935 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1454,856,462 - 54,888,069 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01455,500,946 - 55,536,541 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1455,503,040 - 55,536,538 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11455,530,973 - 55,562,566 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01455,219,411 - 55,251,015 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01455,590,528 - 55,622,125 (+)NCBIUU_Cfam_GSD_1.0
Cav1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511844,152,891 - 44,185,619 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365892,504,224 - 2,537,170 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365892,504,235 - 2,536,778 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAV1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1829,649,992 - 29,682,465 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11829,648,120 - 29,682,451 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21831,745,664 - 31,778,987 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CAV1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12185,222,724 - 85,258,562 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2185,222,879 - 85,258,627 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604218,474,866 - 18,510,943 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cav1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248272,844,115 - 2,879,179 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248272,844,855 - 2,878,367 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cav1
98 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:179
Count of miRNA genes:135
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000009253
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41794699962946999Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
11530004Niddm71Non-insulin dependent diabetes mellitus QTL 710.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43258419952754138Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat

Markers in Region
RH142797  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2445,672,046 - 45,672,280 (+)MAPPERmRatBN7.2
Rnor_6.0444,628,545 - 44,628,778NCBIRnor6.0
Rnor_5.0445,234,800 - 45,235,033UniSTSRnor5.0
RGSC_v3.4442,987,400 - 42,987,633UniSTSRGSC3.4
Celera440,948,019 - 40,948,252UniSTS
RH 3.4 Map4284.1UniSTS
Cytogenetic Map4q21UniSTS
AA946480  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2445,673,157 - 45,673,362 (+)MAPPERmRatBN7.2
Rnor_6.0444,629,656 - 44,629,860NCBIRnor6.0
Rnor_5.0445,235,911 - 45,236,115UniSTSRnor5.0
Celera440,949,130 - 40,949,334UniSTS
RH 3.4 Map4282.8UniSTS
Cytogenetic Map4q21UniSTS


Related Rat Strains
The following Strains have been annotated to Cav1
BB/OK    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_133651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC087102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC110102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF439778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF439779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF489529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC104689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC161826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB698936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK364516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DP000027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM039194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z46614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000078250   ⟹   ENSRNOP00000073712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl445,640,546 - 45,673,705 (+)Ensembl
Rnor_6.0 Ensembl444,597,123 - 44,630,200 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105620   ⟹   ENSRNOP00000087572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl445,634,918 - 45,673,700 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111645   ⟹   ENSRNOP00000097222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl445,641,877 - 45,673,700 (+)Ensembl
RefSeq Acc Id: NM_031556   ⟹   NP_113744
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8446,606,538 - 46,639,616 (+)NCBI
mRatBN7.2445,640,624 - 45,673,705 (+)NCBI
Rnor_6.0444,597,123 - 44,630,203 (+)NCBI
Rnor_5.0445,203,494 - 45,236,461 (+)NCBI
RGSC_v3.4442,956,102 - 42,989,057 (+)RGD
Celera440,918,628 - 40,949,677 (+)NCBI
Sequence:
RefSeq Acc Id: NM_133651   ⟹   NP_598412
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8446,607,972 - 46,639,616 (+)NCBI
mRatBN7.2445,642,058 - 45,673,705 (+)NCBI
Rnor_6.0444,598,557 - 44,630,203 (+)NCBI
Rnor_5.0445,203,494 - 45,236,461 (+)NCBI
RGSC_v3.4442,956,102 - 42,989,057 (+)RGD
Celera440,920,068 - 40,949,677 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236130   ⟹   XP_006236192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8446,607,268 - 46,639,616 (+)NCBI
mRatBN7.2445,641,347 - 45,673,708 (+)NCBI
Rnor_6.0444,597,846 - 44,630,206 (+)NCBI
Rnor_5.0445,203,494 - 45,236,461 (+)NCBI
Sequence:
RefSeq Acc Id: NP_113744   ⟸   NM_031556
- Peptide Label: isoform alpha
- UniProtKB: Q8VIK9 (UniProtKB/Swiss-Prot),   Q8VIK8 (UniProtKB/Swiss-Prot),   P41350 (UniProtKB/Swiss-Prot),   Q2IBC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_598412   ⟸   NM_133651
- Peptide Label: isoform beta
- UniProtKB: B1WBN8 (UniProtKB/TrEMBL),   Q3MHT6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236192   ⟸   XM_006236130
- Peptide Label: isoform X1
- UniProtKB: B1WBN8 (UniProtKB/TrEMBL),   Q3MHT6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073712   ⟸   ENSRNOT00000078250
Ensembl Acc Id: ENSRNOP00000087572   ⟸   ENSRNOT00000105620
Ensembl Acc Id: ENSRNOP00000097222   ⟸   ENSRNOT00000111645

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41350-F1-model_v2 AlphaFold P41350 1-178 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692892
Promoter ID:EPDNEW_R3416
Type:initiation region
Name:Cav1_1
Description:caveolin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0444,597,216 - 44,597,276EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2280 AgrOrtholog
BIND 134453
  134455
  134456
  134458
BioCyc Gene G2FUF-45566 BioCyc
Ensembl Genes ENSRNOG00000056836 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000078250 ENTREZGENE
  ENSRNOT00000157538 ENTREZGENE
InterPro Caveolin UniProtKB/Swiss-Prot
  Caveolin_CS UniProtKB/Swiss-Prot
NCBI Gene 25404 ENTREZGENE
PANTHER PTHR10844 UniProtKB/Swiss-Prot
  PTHR10844:SF18 UniProtKB/Swiss-Prot
Pfam Caveolin UniProtKB/Swiss-Prot
PharmGKB CAV1 RGD
PhenoGen Cav1 PhenoGen
PROSITE CAVEOLIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000056836 RatGTEx
UniProt A0A0G2K682_RAT UniProtKB/TrEMBL
  A0A8I6A884_RAT UniProtKB/TrEMBL
  A0A8I6AS98_RAT UniProtKB/TrEMBL
  A2VCW2_RAT UniProtKB/TrEMBL
  B1WBN8 ENTREZGENE, UniProtKB/TrEMBL
  CAV1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q2IBC6 ENTREZGENE, UniProtKB/TrEMBL
  Q3MHT6 ENTREZGENE, UniProtKB/TrEMBL
  Q8VIK8 ENTREZGENE
  Q8VIK9 ENTREZGENE
UniProt Secondary Q8VIK8 UniProtKB/Swiss-Prot
  Q8VIK9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Cav1  caveolin 1  Cav1  caveolin 1, caveolae protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-29 Cav1  caveolin 1, caveolae protein  LOC100362870  caveolin-like  Data merged from RGD:2323909 737654 PROVISIONAL
2012-08-14 Cav1  caveolin 1, caveolae protein  Cav1  caveolin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-08-13 Cav1  caveolin 1  Cav1  caveolin 1, caveolae protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100362870  caveolin-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-18 Cav1  caveolin 1, caveolae protein  Cav1  caveolin, caveolae protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-10-01 Cav1  caveolin, caveolae protein 1  Cav  caveolin  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2003-04-09 Cav  caveolin      Symbol and Name updated 629477 APPROVED
2003-03-10 Cav  caveolin  Cav1    Data merged from RGD:620347 628472 PROVISIONAL
2002-08-07 Cav1        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Cav  Caveolin, caveolae protein, 22 kDa      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in uterine tumors 70348
gene_disease upregulated in uterine tumors 70557
gene_expression expressed in uterus 70348
gene_expression expressed in uterus 70557
gene_function binds cholesterol and acts as a cholesterol shuttling protein 1298592
gene_process inhibits the activity of the Erb B2 tyrosine kinase receptor for neuregulins 1298592