Casq2 (calsequestrin 2) - Rat Genome Database

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Gene: Casq2 (calsequestrin 2) Rattus norvegicus
Analyze
Symbol: Casq2
Name: calsequestrin 2
RGD ID: 2276
Description: Enables protein homodimerization activity and protein kinase C binding activity. Involved in negative regulation of ryanodine-sensitive calcium-release channel activity; regulation of cardiac muscle cell contraction; and regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion. Located in Z disc and sarcoplasmic reticulum. Biomarker of congestive heart failure and supravalvular aortic stenosis. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia 2. Orthologous to human CASQ2 (calsequestrin 2); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calsequestrin 2 (cardiac muscle); calsequestrin, cardiac muscle isoform; calsequestrin-2; cardCSQ; SR calcium binding protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82192,214,556 - 192,270,821 (+)NCBIGRCr8
mRatBN7.22189,526,003 - 189,582,276 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2189,525,960 - 189,582,267 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2197,154,083 - 197,210,463 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02195,012,238 - 195,067,913 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02189,839,671 - 189,896,025 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02204,512,361 - 204,568,643 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2204,512,302 - 204,568,656 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02223,945,611 - 224,001,893 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42197,182,938 - 197,239,201 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12197,145,718 - 197,201,199 (+)NCBI
Celera2181,958,395 - 182,014,660 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The catecholaminergic polymorphic ventricular tachycardia mutation R33Q disrupts the N-terminal structural motif that regulates reversible calsequestrin polymerization. Bal NC, etal., J Biol Chem. 2010 May 28;285(22):17188-96. doi: 10.1074/jbc.M109.096354. Epub 2010 Mar 30.
2. Sildenafil and FDP-Sr attenuate diabetic cardiomyopathy by suppressing abnormal expression of myocardial CASQ2, FKBP12.6, and SERCA2a in rats. Cheng YS, etal., Acta Pharmacol Sin. 2011 Apr;32(4):441-8. Epub 2011 Mar 28.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. A missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel. Lahat H, etal., Am J Hum Genet 2001 Dec;69(6):1378-84. Epub 2001 Oct 25.
6. Membrane associated Ca2+ buffers in the heart. Lee D and Michalak M, BMB Rep. 2010 Mar;43(3):151-7.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Characterization of the binding and phosphorylation of cardiac calsequestrin by epsilon protein kinase C. Rodriguez MM, etal., FEBS Lett 1999 Jul 9;454(3):240-6.
16. Distribution of proteins implicated in excitation-contraction coupling in rat ventricular myocytes. Scriven DR, etal., Biophys J. 2000 Nov;79(5):2682-91.
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. Age-related differences in the expression of proto-oncogene and contractile protein genes in response to pressure overload in the rat myocardium. Takahashi T, etal., J Clin Invest. 1992 Mar;89(3):939-46.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Protein protein interactions between triadin and calsequestrin are involved in modulation of sarcoplasmic reticulum calcium release in cardiac myocytes. Terentyev D, etal., J Physiol. 2007 Aug 15;583(Pt 1):71-80. Epub 2007 Jun 14.
21. Changes in ion channel gene expression underlying heart failure-induced sinoatrial node dysfunction. Yanni J, etal., Circ Heart Fail. 2011 Jul;4(4):496-508. Epub 2011 May 12.
Additional References at PubMed
PMID:8042990   PMID:9287354   PMID:9525981   PMID:15041652   PMID:15485681   PMID:15486014   PMID:15489334   PMID:15698842   PMID:16601229   PMID:16908766   PMID:16932808   PMID:17881003  
PMID:18399795   PMID:19103607   PMID:19383796   PMID:19920148   PMID:20525644   PMID:21063088   PMID:21431367   PMID:22123818   PMID:23876860   PMID:25931508   PMID:26316108   PMID:28169003  


Genomics

Comparative Map Data
Casq2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82192,214,556 - 192,270,821 (+)NCBIGRCr8
mRatBN7.22189,526,003 - 189,582,276 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2189,525,960 - 189,582,267 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2197,154,083 - 197,210,463 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02195,012,238 - 195,067,913 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02189,839,671 - 189,896,025 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02204,512,361 - 204,568,643 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2204,512,302 - 204,568,656 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02223,945,611 - 224,001,893 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42197,182,938 - 197,239,201 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12197,145,718 - 197,201,199 (+)NCBI
Celera2181,958,395 - 182,014,660 (+)NCBICelera
Cytogenetic Map2q34NCBI
CASQ2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381115,700,021 - 115,768,714 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1115,698,038 - 115,793,195 (-)EnsemblGRCh38hg38GRCh38
GRCh371116,242,642 - 116,311,335 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361116,044,147 - 116,112,929 (-)NCBINCBI36Build 36hg18NCBI36
Build 341115,954,684 - 116,023,312NCBI
Celera1114,471,445 - 114,540,231 (-)NCBICelera
Cytogenetic Map1p13.1NCBI
HuRef1114,100,712 - 114,169,492 (-)NCBIHuRef
CHM1_11116,357,421 - 116,426,262 (-)NCBICHM1_1
T2T-CHM13v2.01115,707,724 - 115,776,700 (-)NCBIT2T-CHM13v2.0
Casq2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393101,993,731 - 102,053,830 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3101,993,731 - 102,053,830 (+)EnsemblGRCm39 Ensembl
GRCm383102,086,415 - 102,146,514 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3102,086,415 - 102,146,514 (+)EnsemblGRCm38mm10GRCm38
MGSCv373101,890,433 - 101,950,437 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363102,205,026 - 102,275,310 (+)NCBIMGSCv36mm8
Celera3104,291,185 - 104,350,741 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map344.3NCBI
Casq2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543518,941,936 - 18,996,200 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543518,941,975 - 18,996,027 (-)NCBIChiLan1.0ChiLan1.0
CASQ2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21108,347,728 - 108,421,140 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11107,950,341 - 108,020,647 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0186,795,392 - 86,864,196 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11121,844,494 - 121,913,311 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1121,844,097 - 121,913,311 (+)Ensemblpanpan1.1panPan2
CASQ2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11753,233,966 - 53,299,093 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1753,224,438 - 53,299,708 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1752,883,024 - 52,948,138 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01754,114,995 - 54,180,159 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1754,115,013 - 54,180,265 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11753,153,853 - 53,218,892 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01753,188,593 - 53,253,716 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01753,761,968 - 53,827,341 (-)NCBIUU_Cfam_GSD_1.0
Casq2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505813,419,602 - 13,487,289 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366271,001,678 - 1,069,438 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366271,001,681 - 1,069,377 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASQ2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4104,918,501 - 104,983,607 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14104,918,204 - 104,984,019 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24115,007,604 - 115,070,817 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CASQ2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12017,937,089 - 18,008,433 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2017,937,524 - 18,008,786 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603820,654,546 - 20,724,412 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Casq2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477211,456,554 - 11,521,939 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477211,458,994 - 11,521,809 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Casq2
634 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:88
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000021846
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2184974550193094998Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat

Markers in Region
D2Rat235  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22189,529,583 - 189,529,737 (+)MAPPERmRatBN7.2
Rnor_6.02204,515,942 - 204,516,095NCBIRnor6.0
Rnor_5.02223,949,192 - 223,949,345UniSTSRnor5.0
RGSC_v3.42197,186,518 - 197,186,672RGDRGSC3.4
RGSC_v3.42197,186,519 - 197,186,672UniSTSRGSC3.4
RGSC_v3.12197,149,076 - 197,149,440RGD
Celera2181,961,976 - 181,962,129UniSTS
SHRSP x BN Map272.7698RGD
SHRSP x BN Map272.7698UniSTS
Cytogenetic Map2q34UniSTS
D2Got127  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22189,544,741 - 189,544,885 (+)MAPPERmRatBN7.2
Rnor_6.02204,531,003 - 204,531,146NCBIRnor6.0
Rnor_5.02223,964,253 - 223,964,396UniSTSRnor5.0
RGSC_v3.42197,201,672 - 197,201,816RGDRGSC3.4
RGSC_v3.42197,201,673 - 197,201,816UniSTSRGSC3.4
RGSC_v3.12197,164,427 - 197,164,570RGD
Celera2181,977,144 - 181,977,287UniSTS
RH 3.4 Map21287.7UniSTS
RH 3.4 Map21287.7RGD
RH 2.0 Map2972.9RGD
Cytogenetic Map2q34UniSTS
D2Got190  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22189,534,808 - 189,535,085 (+)MAPPERmRatBN7.2
Rnor_6.02204,521,167 - 204,521,443NCBIRnor6.0
Rnor_5.02223,954,417 - 223,954,693UniSTSRnor5.0
RGSC_v3.42197,191,743 - 197,192,020RGDRGSC3.4
RGSC_v3.42197,191,744 - 197,192,020UniSTSRGSC3.4
RGSC_v3.12197,154,498 - 197,154,774RGD
Celera2181,967,201 - 181,967,491UniSTS
RH 3.4 Map21290.1UniSTS
RH 3.4 Map21290.1RGD
RH 2.0 Map2973.4RGD
Cytogenetic Map2q34UniSTS
AA924985  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22189,581,999 - 189,582,203 (+)MAPPERmRatBN7.2
Rnor_6.02204,568,367 - 204,568,570NCBIRnor6.0
Rnor_5.02224,001,617 - 224,001,820UniSTSRnor5.0
RGSC_v3.42197,238,925 - 197,239,128UniSTSRGSC3.4
Celera2182,014,384 - 182,014,587UniSTS
RH 3.4 Map21288.8UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 111 62 61 30 25 30 6 189 97 91 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000021846   ⟹   ENSRNOP00000021846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2189,525,960 - 189,582,267 (+)Ensembl
Rnor_6.0 Ensembl2204,512,302 - 204,568,656 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096981   ⟹   ENSRNOP00000089016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2189,525,962 - 189,582,097 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101544   ⟹   ENSRNOP00000097042
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2189,525,986 - 189,582,263 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111697   ⟹   ENSRNOP00000086716
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2189,525,986 - 189,582,263 (+)Ensembl
RefSeq Acc Id: NM_017131   ⟹   NP_058827
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82192,214,556 - 192,270,821 (+)NCBI
mRatBN7.22189,526,003 - 189,582,276 (+)NCBI
Rnor_6.02204,512,361 - 204,568,643 (+)NCBI
Rnor_5.02223,945,611 - 224,001,893 (+)NCBI
RGSC_v3.42197,182,938 - 197,239,201 (+)RGD
Celera2181,958,395 - 182,014,660 (+)RGD
Sequence:
RefSeq Acc Id: NP_058827   ⟸   NM_017131
- Peptide Label: precursor
- UniProtKB: Q6IMX1 (UniProtKB/Swiss-Prot),   O09177 (UniProtKB/Swiss-Prot),   P51868 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021846   ⟸   ENSRNOT00000021846
Ensembl Acc Id: ENSRNOP00000097042   ⟸   ENSRNOT00000101544
Ensembl Acc Id: ENSRNOP00000089016   ⟸   ENSRNOT00000096981
Ensembl Acc Id: ENSRNOP00000086716   ⟸   ENSRNOT00000111697

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51868-F1-model_v2 AlphaFold P51868 1-413 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691618
Promoter ID:EPDNEW_R2143
Type:initiation region
Name:Casq2_1
Description:calsequestrin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02204,512,357 - 204,512,417EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2276 AgrOrtholog
BIND 133998
  134040
  134041
BioCyc Gene G2FUF-51841 BioCyc
Ensembl Genes ENSRNOG00000016243 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021846.7 UniProtKB/TrEMBL
  ENSRNOT00000096981.1 UniProtKB/TrEMBL
  ENSRNOT00000101544.1 UniProtKB/TrEMBL
  ENSRNOT00000111697.1 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7105911 IMAGE-MGC_LOAD
InterPro Calsequestrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calsequestrin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calsequestrin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calsequestrin_middle_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calsequestrin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29209 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91724 IMAGE-MGC_LOAD
NCBI Gene 29209 ENTREZGENE
PANTHER CALSEQUESTRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CALSEQUESTRIN-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Calsequestrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CASQ2 RGD
PhenoGen Casq2 PhenoGen
PRINTS CALSEQUESTRN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CALSEQUESTRIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CALSEQUESTRIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016243 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC229963
UniProt A0A8I6A1S3_RAT UniProtKB/TrEMBL
  A0A8I6A994_RAT UniProtKB/TrEMBL
  A0A8I6AS63_RAT UniProtKB/TrEMBL
  A6K3I5_RAT UniProtKB/TrEMBL
  A6K3I6_RAT UniProtKB/TrEMBL
  CASQ2_RAT UniProtKB/Swiss-Prot
  F1M944_RAT UniProtKB/TrEMBL
  O09177 ENTREZGENE
  P51868 ENTREZGENE
  Q6IMX1 ENTREZGENE
UniProt Secondary O09177 UniProtKB/Swiss-Prot
  Q6IMX1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Casq2  calsequestrin 2  Casq2  calsequestrin 2 (cardiac muscle)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Casq2  calsequestrin 2 (cardiac muscle)  Casq2  calsequestrin 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds activated epsilon protein kinase C holoenzyme 69798