Casp1 (caspase 1) - Rat Genome Database

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Gene: Casp1 (caspase 1) Rattus norvegicus
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Symbol: Casp1
Name: caspase 1
RGD ID: 2274
Description: Enables scaffold protein binding activity. Involved in several processes, including microglial cell activation; positive regulation of circadian sleep/wake cycle, non-REM sleep; and positive regulation of interleukin-1 beta production. Part of protein-containing complex. Used to study acute kidney failure. Biomarker of myocardial infarction. Orthologous to several human genes including CASP1 (caspase 1); PARTICIPATES IN interleukin-1 signaling pathway; type II interferon signaling pathway; amyotrophic lateral sclerosis pathway; INTERACTS WITH (S)-colchicine; (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CASP-1; caspase 1 apoptosis-related cysteine protease (interleukin 1 beta convertase); caspase-1; Ice; IL-1 beta-converting enzyme; IL-1BC; Il1bc; interleukin 1 beta convertase; interleukin 1, beta, convertase; Interleukin 1beta converting enzyme; interleukin-1 beta convertase; interleukin-1 beta-converting enzyme; p45
RGD Orthologs
Human
Mouse
Bonobo
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8810,746,338 - 10,882,295 (+)NCBIGRCr8
mRatBN7.282,587,812 - 2,597,403 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl82,587,831 - 2,597,383 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx86,559,379 - 6,568,854 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.084,857,147 - 4,866,622 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.082,840,611 - 2,850,083 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.082,605,743 - 2,614,637 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl82,604,962 - 2,614,631 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.082,627,976 - 2,636,870 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.482,027,976 - 2,036,872 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.182,027,975 - 2,036,866 (+)NCBI
Celera82,455,483 - 2,464,376 (+)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(-)-acanthoic acid  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP,ISO)
(S)-ropivacaine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-D  (EXP,ISO)
2,5-hexanedione  (EXP)
2,6-dimethoxyphenol  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-mercaptopropanoic acid  (ISO)
3-methyladenine  (EXP,ISO)
3-phenylprop-2-enal  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxybenzoic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
4-nonylphenol  (EXP)
4-phenylbutyric acid  (EXP,ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
7-ketocholesterol  (ISO)
acetamide  (EXP)
acetic acid  (EXP)
aclacinomycin A  (ISO)
aconitine  (EXP,ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
allicin  (ISO)
allopurinol  (EXP,ISO)
allyl methyl disulfide  (ISO)
alpha-pinene  (ISO)
aluminium hydroxide  (ISO)
aluminium sulfate (anhydrous)  (ISO)
AM-251  (ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
apocynin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atorvastatin calcium  (EXP)
ATP  (EXP,ISO)
atrazine  (ISO)
aucubin  (ISO)
aurantio-obtusin  (ISO)
baicalin  (ISO)
BAPTA  (ISO)
Bavachinin  (ISO)
bellidifolin  (ISO)
Belnacasan  (EXP,ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
Bergenin  (EXP)
beta-cyclodextrin  (ISO)
beta-eudesmol  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
bosutinib  (ISO)
buspirone  (EXP)
cadmium acetate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
cadmium telluride  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
CARBENOXOLONE  (ISO)
carbon nanotube  (ISO)
Carnosol  (ISO)
CCCP  (ISO)
celastrol  (EXP)
CGP 52608  (ISO)
chloroethene  (ISO)
chlorpyrifos  (ISO)
chlorquinaldol  (ISO)
cholesterol  (EXP,ISO)
choline  (ISO)
chrysin  (EXP,ISO)
cimetidine  (ISO)
cisplatin  (EXP,ISO)
clozapine  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corylin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
dapagliflozin  (EXP)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
dextran sulfate  (EXP,ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
dibutylstannane  (ISO)
dichloromethane  (ISO)
dichlorvos  (EXP)
diclofenac  (EXP)
dicrotophos  (ISO)
diethyldithiocarbamic acid  (ISO)
diethylstilbestrol  (ISO)
dimethyl fumarate  (EXP,ISO)
dimethylarsinous acid  (ISO)
dimethyldithiocarbamate  (ISO)
diosmetin  (EXP)
dioxygen  (EXP,ISO)
diprotium oxide  (ISO)
dipyridamole  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
emodin  (ISO)
endosulfan  (ISO)
ergosterol  (EXP)
Erionite  (ISO)
eritoran  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylenediaminetetraacetic acid  (ISO)
Evodiamine  (EXP)
fenpropathrin  (EXP)
ferulic acid  (EXP)
fluoxetine  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
Fraxinellone  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP,ISO)
furfural  (ISO)
furosemide  (EXP)
Fusaric acid  (ISO)
galangin  (EXP,ISO)
gefitinib  (ISO)
genistein  (ISO)
genkwanin  (ISO)
gentamycin  (EXP)
ginsenoside Rb1  (EXP,ISO)
glucose  (EXP,ISO)
glyburide  (EXP,ISO)
glycerol  (EXP)
glycidol  (EXP)
glycine betaine  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP,ISO)
homocysteine  (ISO)
HU-308  (ISO)
hyaluronic acid  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (EXP)
hydroquinone  (ISO)
hydroxysafflor yellow A  (ISO)
ibuprofen  (ISO)
icariin  (EXP,ISO)
ifosfamide  (ISO)
imiquimod  (ISO)
immunological adjuvant  (ISO)
indometacin  (EXP,ISO)
insulin  (EXP)
iohexol  (ISO)
irinotecan  (EXP,ISO)
iron dextran  (EXP)
isobavachalcone  (ISO)
Isobavachin  (ISO)
isoflurane  (ISO)
isoprenaline  (ISO)
kaempferol  (ISO)
L-1,4-dithiothreitol  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
lenalidomide  (EXP)
leptomycin B  (ISO)
Liensinine  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium carbonate  (ISO)
lithocholic acid  (ISO)
loganin  (ISO)
lonidamine  (ISO)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
magnesium dihydroxide  (ISO)
malvidin  (ISO)
maneb  (ISO)
melatonin  (ISO)
memantine  (ISO)
mercaptoethanol  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
mesalamine  (ISO)
metformin  (EXP,ISO)
methamphetamine  (ISO)
methotrexate  (EXP)
methyl beta-cyclodextrin  (ISO)
methyl methanesulfonate  (ISO)
microcystin-LR  (ISO)
minocycline  (EXP,ISO)
Mitoquinone  (ISO)
Mitotane  (EXP)
MitoTEMPO  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (EXP)
Morroniside  (ISO)
muramyl dipeptide  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-dimethylformamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-5'-carboxamidoadenosine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
Neoisoliquiritin  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nigericin  (EXP,ISO)
nimustine  (ISO)
nitrates  (EXP)
nitric oxide  (ISO)
nitroflurbiprofen  (ISO)
nitroglycerin  (ISO)
NMN zwitterion  (EXP,ISO)
Nonidet P-40  (ISO)
Nonylphenol  (EXP,ISO)
ochratoxin A  (ISO)
octanoic acid  (ISO)
Ondansetron  (EXP)
oxidopamine  (EXP)
oxybenzone  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paeoniflorin  (ISO)
Palbinone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
Pentoxifylline  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
PF-3758309  (ISO)
phencyclidine  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (EXP)
phosphoramide mustard  (EXP)
pirinixic acid  (EXP)
Polpunonic acid  (ISO)
ponatinib  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
potassium atom  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
PRIM-O-GLUCOSYLCIMIFUGIN  (ISO)
probenecid  (ISO)
procyanidin B2  (EXP)
propylparaben  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
pyrethrins  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
rifampicin  (ISO)
rimonabant  (ISO)
ritonavir  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
Ruscogenin  (ISO)
rutin  (EXP)
S-allylcysteine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
salicylic acid  (ISO)
Salidroside  (EXP,ISO)
salvianolic acid B  (ISO)
sanguinarine  (ISO)
SB 203580  (EXP,ISO)
scutellarin  (EXP)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Sodium salicylate  (EXP)
sorafenib  (ISO)
sotorasib  (ISO)
sphingosine 1-phosphate  (EXP)
staurosporine  (ISO)
sterigmatocystin  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulfasalazine  (EXP,ISO)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
suramin  (EXP)
taurine  (EXP,ISO)
tellurium atom  (EXP)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thiamine(1+) chloride  (EXP)
thioacetamide  (EXP,ISO)
thiram  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
toyocamycin  (ISO)
trametinib  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
tungsten  (EXP)
tunicamycin  (EXP)
ubiquinone-0  (ISO)
urethane  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
verapamil  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
VX nerve agent  (ISO)
water  (ISO)
wortmannin  (ISO)
Y-27632  (ISO)
zearalenone  (EXP,ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc pyrithione  (ISO)
zinc(0)  (ISO)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
AIM2 inflammasome complex assembly  (ISO)
animal organ development  (IEA)
apoptotic process  (IEA)
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to type II interferon  (ISO)
ceramide biosynthetic process  (ISO)
cytokine precursor processing  (ISO)
defense response to bacterium  (ISO)
defense response to Gram-negative bacterium  (ISO)
lung development  (IEP)
membrane hyperpolarization  (ISO)
memory  (IMP)
microglial cell activation  (IMP)
midgut development  (IEP)
mitochondrial depolarization  (ISO)
myoblast fusion  (IMP)
plasma membrane repair  (ISO)
positive regulation of apoptotic process  (IEA,IMP)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of circadian sleep/wake cycle, non-REM sleep  (IMP)
positive regulation of cytokine production  (IMP,ISO,ISS)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-1 alpha production  (ISO)
positive regulation of interleukin-1 beta production  (IMP,ISO,ISS)
positive regulation of interleukin-18 production  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
programmed necrotic cell death  (ISO)
protein autoprocessing  (ISO,ISS)
protein maturation  (ISO)
protein processing  (ISO)
protein secretion  (ISO)
proteolysis  (IEA,ISO)
pyroptotic inflammatory response  (ISO,ISS)
regulation of apoptotic process  (IEA)
regulation of autophagy  (ISO)
regulation of inflammatory response  (IBA,ISO,ISS)
response to ATP  (ISO)
response to bacterium  (ISO)
response to hypoxia  (IDA,ISO)
response to lipopolysaccharide  (IMP,ISO)
response to paraquat  (IDA)
response to toxic substance  (IEP)
response to xenobiotic stimulus  (IDA)
signaling receptor ligand precursor processing  (ISO)
system development  (IEA)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Caspase-1-induced calpastatin degradation in myoblast differentiation and fusion: cross-talk between the caspase and calpain systems. Barnoy S and Kosower NS, FEBS Lett 2003 Jul 10;546(2-3):213-7.
2. Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21(waf1/cip1). Bhanoori M, etal., Oncogene 2003 Jan 9;22(1):117-30.
3. Targeting caspase-1 by inhalation-therapy: effects of Ac-YVAD-CHO on IL-1 beta, IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia. Boost KA, etal., Intensive Care Med. 2007 May;33(5):863-71. Epub 2007 Mar 24.
4. Caspase-1 inhibitor Ac-YVAD-CHO attenuates quinolinic acid-induced increases in p53 and apoptosis in rat striatum. Cao Y, etal., Acta Pharmacol Sin. 2005 Feb;26(2):150-4.
5. AKT1 drives endothelial cell membrane asymmetry and microglial activation through Bcl-xL and caspase 1, 3, and 9. Chong ZZ, etal., Exp Cell Res. 2004 Jun 10;296(2):196-207.
6. Rapid co-release of interleukin 1beta and caspase 1 in spinal cord inflammation. Clark AK, etal., J Neurochem. 2006 Nov;99(3):868-80. Epub 2006 Aug 29.
7. Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury. de Rivero Vaccari JP, etal., J Cereb Blood Flow Metab. 2009 Jul;29(7):1251-61. Epub 2009 Apr 29.
8. A molecular platform in neurons regulates inflammation after spinal cord injury. de Rivero Vaccari JP, etal., J Neurosci. 2008 Mar 26;28(13):3404-14.
9. [Expression and significance of caspase-1 in benign hyperplastic prostate tissues] Deng CH, etal., Zhonghua Nan Ke Xue. 2005 Nov;11(11):810-2.
10. Immunological and inflammatory functions of the interleukin-1 family. Dinarello CA Annu Rev Immunol. 2009;27:519-50.
11. Sodium salicylate prevents paraquat-induced apoptosis in the rat lung. Dinis-Oliveira RJ, etal., Free Radic Biol Med. 2007 Jul 1;43(1):48-61. Epub 2007 Mar 24.
12. Interleukin-1 beta-converting enzyme-related proteases (IRPs) and mammalian cell death: dissociation of IRP-induced oligonucleosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle. Flaws JA, etal., Endocrinology 1995 Nov;136(11):5042-53.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Improvement of memory for context by inhibition of caspase-1 in aged rats. Gemma C, etal., Eur J Neurosci. 2005 Oct;22(7):1751-6.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Increased apoptosis of peripheral blood mononuclear cells in patients with perennial allergic asthma/rhinitis: relation to serum markers of apoptosis. Grzegorczyk J, etal., Mediators Inflamm. 2002 Aug;11(4):225-33.
17. Inflammatory markers in nondiabetic and diabetic rat retinas exposed to ischemia followed by reperfusion. Gustavsson C, etal., Retina. 2008 Apr;28(4):645-52.
18. LncRNA H19 suppresses pyroptosis of cardiomyocytes to attenuate myocardial infarction in a PBX3/CYP1B1-dependent manner. Han Y, etal., Mol Cell Biochem. 2021 Mar;476(3):1387-1400. doi: 10.1007/s11010-020-03998-y. Epub 2021 Jan 3.
19. Role of caspases on cell death, inflammation, and cell cycle in glycerol-induced acute renal failure. Homsi E, etal., Kidney Int. 2006 Apr;69(8):1385-92.
20. Role of proinflammatory cytokines IL-18 and IL-1beta in bleomycin-induced lung injury in humans and mice. Hoshino T, etal., Am J Respir Cell Mol Biol. 2009 Dec;41(6):661-70. Epub 2009 Mar 5.
21. Inhibition of caspase-1 in rat brain reduces spontaneous nonrapid eye movement sleep and nonrapid eye movement sleep enhancement induced by lipopolysaccharide. Imeri L, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Jul;291(1):R197-204. Epub 2006 Feb 2.
22. Castration-induced expression of caspase-1 in epithelia of accessory sex organs in male rats. Izawa M, etal., Asian J Androl 2001 Jun;3(2):105-8.
23. Cloning, tissue expression and regulation of rat interleukin 1 beta converting enzyme. Keane KM, etal., Cytokine 1995 Feb;7(2):105-10.
24. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
25. Hypoxic induction of caspase-11/caspase-1/interleukin-1beta in brain microglia. Kim NG, etal., Brain Res Mol Brain Res. 2003 Jun 10;114(2):107-14.
26. Role of epigenetic regulatory mechanisms in neonatal hypoxic-ischemic brain injury. Kumral A, etal., Early Hum Dev. 2013 Mar;89(3):165-73. doi: 10.1016/j.earlhumdev.2012.09.016. Epub 2012 Oct 6.
27. The NALP1 inflammasome controls cytokine production and nociception in a rat fracture model of complex regional pain syndrome. Li WW, etal., Pain. 2009 Dec 15;147(1-3):277-86. Epub 2009 Oct 22.
28. A role for caspase-1 in heart failure. Merkle S, etal., Circ Res. 2007 Mar 16;100(5):645-53. Epub 2007 Feb 15.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
31. Anthrax lethal toxin activates the inflammasome in sensitive rat macrophages. Newman ZL, etal., Biochem Biophys Res Commun. 2010 Aug 6;398(4):785-9. Epub 2010 Jul 16.
32. 3,4-Methylenedioxymethamphetamine increases pro-interleukin-1beta production and caspase-1 protease activity in frontal cortex, but not in hypothalamus, of Dark Agouti rats: role of interleukin-1beta in neurotoxicity. O'Shea E, etal., Neuroscience. 2005;135(4):1095-105. Epub 2005 Sep 13.
33. Beneficial effects of chelidonic acid on a model of allergic rhinitis. Oh HA, etal., Int Immunopharmacol. 2011 Jan;11(1):39-45. Epub 2010 Oct 23.
34. Synergistic inhibition of tumor growth in a murine mammary adenocarcinoma model by combinational gene therapy using IL-12, pro-IL-18, and IL-1beta converting enzyme cDNA. Oshikawa K, etal., Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13351-6.
35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
37. Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease. Pompl PN, etal., Arch Neurol. 2003 Mar;60(3):369-76.
38. MOLECULAR CLASSIFICATION OF BREAST CARCINOMA IN SITU. Raju U, etal., Curr Genomics. 2006 Dec;7(8):523-532.
39. Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy. Ravizza T, etal., Epilepsia. 2006 Jul;47(7):1160-8.
40. GOA pipeline RGD automated data pipeline
41. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
42. Lymphocyte apoptosis in acute respiratory syncytial virus bronchiolitis. Roe MF, etal., Clin Exp Immunol. 2004 Jul;137(1):139-45.
43. A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat. Ross J, etal., Neuropharmacology. 2007 Oct;53(5):638-42. Epub 2007 Aug 10.
44. The inflammasomes. Schroder K and Tschopp J, Cell. 2010 Mar 19;140(6):821-32. doi: 10.1016/j.cell.2010.01.040.
45. Activation of caspase-1 dependent interleukins in developmental brain trauma. Sifringer M, etal., Neurobiol Dis. 2007 Mar;25(3):614-22. Epub 2006 Dec 22.
46. The pannexin 1 channel activates the inflammasome in neurons and astrocytes. Silverman WR, etal., J Biol Chem. 2009 Jul 3;284(27):18143-51. Epub 2009 May 5.
47. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
48. The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Thomas PG, etal., Immunity. 2009 Apr 17;30(4):566-75. Epub 2009 Apr 9.
49. Up-regulation of microRNA-223 inhibits brain injury and hippocampal neuron apoptosis of rats after febrile seizure through the NLRP3-Caspase-1 signaling pathway. Wang B, etal., Biomed Pharmacother. 2019 Jun;114:108683. doi: 10.1016/j.biopha.2019.108683. Epub 2019 Apr 1.
50. Loss of caspase-1 and caspase-3 protein expression in human prostate cancer. Winter RN, etal., Cancer Res. 2001 Feb 1;61(3):1227-32.
51. Therapeutic effects of caspase-1 inhibitors on acute lung injury in experimental severe acute pancreatitis. Zhang XH, etal., World J Gastroenterol. 2007 Jan 28;13(4):623-7.
Additional References at PubMed
PMID:11016935   PMID:11432859   PMID:11536016   PMID:11684016   PMID:11821383   PMID:12191486   PMID:12477932   PMID:12761501   PMID:12888622   PMID:14663141   PMID:15030775   PMID:15190255  
PMID:15383541   PMID:15882992   PMID:16301672   PMID:16429160   PMID:16573645   PMID:16585594   PMID:16920334   PMID:17036048   PMID:17431085   PMID:18490713   PMID:18632279   PMID:18980715  
PMID:19158676   PMID:19158679   PMID:19317852   PMID:19593445   PMID:20025855   PMID:20595632   PMID:21832250   PMID:21874021   PMID:22002608   PMID:22267217   PMID:22297845   PMID:23028046  
PMID:23395675   PMID:23716698   PMID:24548080   PMID:24581500   PMID:24630722   PMID:24695748   PMID:24699513   PMID:25132762   PMID:25501827   PMID:26061900   PMID:26438340   PMID:27043298  
PMID:27289225   PMID:28823375   PMID:29101761   PMID:31195405   PMID:32186399   PMID:32461137   PMID:35775127   PMID:35995981   PMID:37549514   PMID:38221531  


Genomics

Comparative Map Data
Casp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8810,746,338 - 10,882,295 (+)NCBIGRCr8
mRatBN7.282,587,812 - 2,597,403 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl82,587,831 - 2,597,383 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx86,559,379 - 6,568,854 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.084,857,147 - 4,866,622 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.082,840,611 - 2,850,083 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.082,605,743 - 2,614,637 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl82,604,962 - 2,614,631 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.082,627,976 - 2,636,870 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.482,027,976 - 2,036,872 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.182,027,975 - 2,036,866 (+)NCBI
Celera82,455,483 - 2,464,376 (+)NCBICelera
Cytogenetic Map8q11NCBI
CASP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811105,025,443 - 105,036,686 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11105,025,397 - 105,035,250 (-)EnsemblGRCh38hg38GRCh38
GRCh3711104,896,170 - 104,905,871 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611104,401,445 - 104,411,067 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411104,401,448 - 104,411,067NCBI
Celera11102,060,400 - 102,070,022 (-)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11100,827,223 - 100,836,872 (-)NCBIHuRef
CHM1_111104,779,164 - 104,788,813 (-)NCBICHM1_1
T2T-CHM13v2.011105,029,522 - 105,040,777 (-)NCBIT2T-CHM13v2.0
Casp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3995,298,517 - 5,307,281 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl95,298,508 - 5,307,290 (+)EnsemblGRCm39 Ensembl
GRCm3895,298,517 - 5,307,281 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl95,298,508 - 5,307,290 (+)EnsemblGRCm38mm10GRCm38
MGSCv3795,298,517 - 5,307,281 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3695,298,517 - 5,307,281 (+)NCBIMGSCv36mm8
Celera3117,396,675 - 117,405,459 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
CASP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29105,815,530 - 105,827,153 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111106,903,793 - 106,914,716 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01199,965,964 - 99,975,640 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111103,448,497 - 103,468,367 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11103,467,368 - 103,468,288 (-)Ensemblpanpan1.1panPan2
PanPan1.1 Ensembl11103,448,497 - 103,458,149 (-)Ensemblpanpan1.1panPan2
CASP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl935,186,420 - 35,200,328 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1935,188,066 - 35,199,364 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2939,210,251 - 39,221,559 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103248365
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1196,389,697 - 96,400,610 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl196,389,657 - 96,400,849 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604329,497,194 - 29,506,147 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Casp1
34 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:54
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000009993
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)813402289Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat

Markers in Region
RH141870  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.282,596,234 - 2,597,352 (+)MAPPERmRatBN7.2
Rnor_6.082,613,473 - 2,614,590NCBIRnor6.0
Rnor_5.082,635,706 - 2,636,823UniSTSRnor5.0
RGSC_v3.482,035,705 - 2,036,825UniSTSRGSC3.4
Celera82,463,212 - 2,464,329UniSTS
Cytogenetic Map8q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 45 113 91 90 59 25 59 6 214 93 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000009993   ⟹   ENSRNOP00000009993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl82,587,938 - 2,597,383 (+)Ensembl
Rnor_6.0 Ensembl82,604,962 - 2,614,631 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098719   ⟹   ENSRNOP00000086752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl82,587,831 - 2,597,383 (+)Ensembl
RefSeq Acc Id: NM_012762   ⟹   NP_036894
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8810,872,830 - 10,882,295 (+)NCBI
mRatBN7.282,587,938 - 2,597,403 (+)NCBI
Rnor_6.082,605,743 - 2,614,637 (+)NCBI
Rnor_5.082,627,976 - 2,636,870 (+)NCBI
RGSC_v3.482,027,976 - 2,036,872 (+)RGD
Celera82,455,483 - 2,464,376 (+)RGD
Sequence:
RefSeq Acc Id: XM_063264944   ⟹   XP_063121014
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8810,746,338 - 10,882,291 (+)NCBI
RefSeq Acc Id: XR_005487743
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8810,872,704 - 10,881,165 (+)NCBI
mRatBN7.282,587,812 - 2,596,273 (+)NCBI
RefSeq Acc Id: NP_036894   ⟸   NM_012762
- UniProtKB: P43527 (UniProtKB/Swiss-Prot),   F1LQZ4 (UniProtKB/TrEMBL),   A6KQJ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009993   ⟸   ENSRNOT00000009993
Ensembl Acc Id: ENSRNOP00000086752   ⟸   ENSRNOT00000098719
RefSeq Acc Id: XP_063121014   ⟸   XM_063264944
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ACX6 (UniProtKB/TrEMBL),   A6KQJ9 (UniProtKB/TrEMBL)
Protein Domains
CARD   Caspase family p10   Caspase family p20

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43527-F1-model_v2 AlphaFold P43527 1-402 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695727
Promoter ID:EPDNEW_R6250
Type:multiple initiation site
Name:Casp1_1
Description:caspase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.082,605,157 - 2,605,217EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2274 AgrOrtholog
BioCyc Gene G2FUF-31821 BioCyc
Ensembl Genes ENSRNOG00000007372 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000009993 ENTREZGENE
  ENSRNOT00000098719 ENTREZGENE
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot
  3.40.50.1460 UniProtKB/Swiss-Prot
InterPro CARD UniProtKB/Swiss-Prot
  Caspase-like_dom_sf UniProtKB/Swiss-Prot
  Caspase_cys_AS UniProtKB/Swiss-Prot
  Caspase_his_AS UniProtKB/Swiss-Prot
  DEATH-like_dom_sf UniProtKB/Swiss-Prot
  Pept_C14 UniProtKB/Swiss-Prot
  Pept_C14_caspase UniProtKB/Swiss-Prot
  Pept_C14_p10 UniProtKB/Swiss-Prot
  Pept_C14_p20 UniProtKB/Swiss-Prot
  Pept_C14A UniProtKB/Swiss-Prot
NCBI Gene 25166 ENTREZGENE
PANTHER CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18 UniProtKB/Swiss-Prot
  CASPASE-1 UniProtKB/Swiss-Prot
Pfam CARD UniProtKB/Swiss-Prot
  Peptidase_C14 UniProtKB/Swiss-Prot
PhenoGen Casp1 PhenoGen
PIRSF Caspase_ICE UniProtKB/Swiss-Prot
PRINTS IL1BCENZYME UniProtKB/Swiss-Prot
PROSITE CARD UniProtKB/Swiss-Prot
  CASPASE_CYS UniProtKB/Swiss-Prot
  CASPASE_HIS UniProtKB/Swiss-Prot
  CASPASE_P10 UniProtKB/Swiss-Prot
  CASPASE_P20 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007372 RatGTEx
SMART CARD UniProtKB/Swiss-Prot
  CASc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot
  SSF52129 UniProtKB/Swiss-Prot
TIGR TC210778
UniProt A0A8I6ACX6 ENTREZGENE, UniProtKB/TrEMBL
  A6KQJ8 ENTREZGENE, UniProtKB/TrEMBL
  A6KQJ9 ENTREZGENE, UniProtKB/TrEMBL
  CASP1_RAT UniProtKB/Swiss-Prot
  F1LQZ4 ENTREZGENE, UniProtKB/TrEMBL
  P43527 ENTREZGENE
  Q91W32_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Casp1  caspase 1      Symbol and Name status set to approved 70586 APPROVED
2001-07-23 Casp1  Interleukin 1beta converting enzyme      Name withdrawn 67952 WITHDRAWN
2001-07-23 Casp1  caspase 1      Name withdrawn 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_expression expression upregulated in epithelial cells of ventral prostate and seminal vesicle in castrated rats 631309
gene_process may play a role in inflammation 634698
gene_process may play a role in apoptosis in male accessory sex organs 631309
gene_protein 402 amino acid protein 634698
gene_regulation expression upregulated by lipopolysaccharide 634698
gene_regulation active protein increased upon thiol alkylation in vascular smooth muscle cells 1299059