Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | RGD:735912 | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | JMP syndrome | | ISO | RGD:735912 | 8554872 | ClinVar Annotator: match by term: Proteasome-associated autoinflammatory syndrome 1 | ClinVar | PMID:28492532 | megacolon | | ISO | RGD:735912 | 8554872 | ClinVar Annotator: match by term: Megacolon | ClinVar | PMID:21681106 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 |
Welcome {{ username}}
Message Center
{{ messageCount }} Messages
Watched Genes
{{$index + 1}}. {{ watchedObject.symbol }} (RGD ID:{{watchedObject.rgdId}})
Watched Ontology Terms
{{gene.symbol}}: {{ gene.description }}
|
| Save what matters to you |
| {{ loginError }} |
| Sign in with your RGD account |
| Create New Account | Recover Password |
Analyze GeneStrainQTL List |
 Gene Annotator (Functional Annotation) unavailable |
 Gene Annotator (Annotation Distribution) unavailable |
 Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable |
Gene Annotator (Functional Annotation) |
Gene Annotator (Annotation Distribution) |
Variant Visualizer (Genomic Variants) |
 InterViewer (Protein-Protein Interactions) unavailable |
 Gviewer (Genome Viewer) unavailable |
 Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable |
InterViewer (Protein-Protein Interactions) |
GViewer (Genome Viewer) |
Variant Visualizer (Damaging Variants) |
 Gene Annotator (Annotation Comparison) unavailable |
 OLGA (Gene List Generator) unavailable |
 |
Gene Annotator (Annotation Comparison) |
OLGA (Gene List Generator) |
Excel (Download) |
 MOET (Multi-Ontology Enrichement) unavailable |
 GOLF (Gene-Ortholog Location Finder) unavailable |
|
MOET (Multi-Ontology Enrichement) |
GOLF (Gene-Ortholog Location Finder) |
|
||||||||
Imported Disease Annotations - CTD
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
Cellular Component
Molecular Function
Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Disease Annotations
Click to see Annotation Detail View
|
|
|
Gene-Chemical Interaction Annotations
Click to see Annotation Detail View
Gene Ontology Annotations
Click to see Annotation Detail View
Biological Process
|
|
|
Cellular Component
|
|
Molecular Function
|
|
|
Phenotype Annotations
Click to see Annotation Detail View
References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Anticancer Effects of Mesothelin-Targeted Immunotoxin Therapy Are Regulated by Tyrosine Kinase DDR1. | Ali-Rahmani F, etal., Cancer Res. 2016 Mar 15;76(6):1560-8. doi: 10.1158/0008-5472.CAN-15-2401. Epub 2015 Dec 30. |
| 2. | Regulation of neuronal type genes in congestive heart failure rats. | Andersson KB, etal., Acta Physiol (Oxf). 2006 Jan;186(1):17-27. |
| 3. | Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors. | Canning P, etal., J Mol Biol. 2014 Jun 26;426(13):2457-70. doi: 10.1016/j.jmb.2014.04.014. Epub 2014 Apr 23. |
| 4. | NSD2 circular RNA promotes metastasis of colorectal cancer by targeting miR-199b-5p-mediated DDR1 and JAG1 signalling. | Chen LY, etal., J Pathol. 2019 May;248(1):103-115. doi: 10.1002/path.5238. Epub 2019 Feb 20. |
| 5. | Discoidin domain receptors and their ligand, collagen, are temporally regulated in fetal rat fibroblasts in vitro. | Chin GS, etal., Plast Reconstr Surg. 2001 Mar;107(3):769-76. |
| 6. | The Extracellular Matrix Receptor Discoidin Domain Receptor 1 Regulates Collagen Transcription by Translocating to the Nucleus. | Chiusa M, etal., J Am Soc Nephrol. 2019 Sep;30(9):1605-1624. doi: 10.1681/ASN.2018111160. Epub 2019 Aug 5. |
| 7. | MicroRNA-486-3p functions as a tumor suppressor in oral cancer by targeting DDR1. | Chou ST, etal., J Exp Clin Cancer Res. 2019 Jun 28;38(1):281. doi: 10.1186/s13046-019-1283-z. |
| 8. | Discoidin Domain Receptor 1 Mediates Myosin-Dependent Collagen Contraction. | Coelho NM, etal., Cell Rep. 2017 Feb 14;18(7):1774-1790. doi: 10.1016/j.celrep.2017.01.061. |
| 9. | Suppressing miR-199a-3p by promoter methylation contributes to tumor aggressiveness and cisplatin resistance of ovarian cancer through promoting DDR1 expression. | Deng Y, etal., J Ovarian Res. 2017 Jul 25;10(1):50. doi: 10.1186/s13048-017-0333-4. |
| 10. | Expression and mutation analysis of the discoidin domain receptors 1 and 2 in non-small cell lung carcinoma. | Ford CE, etal., Br J Cancer. 2007 Mar 12;96(5):808-14. doi: 10.1038/sj.bjc.6603614. Epub 2007 Feb 13. |
| 11. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 12. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
| 13. | Discoidin domain receptor inhibition reduces neuropathology and attenuates inflammation in neurodegeneration models. | Hebron M, etal., J Neuroimmunol. 2017 Oct 15;311:1-9. doi: 10.1016/j.jneuroim.2017.07.009. Epub 2017 Aug 12. |
| 14. | Inhibition of DDR1-BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer. | Jeitany M, etal., EMBO Mol Med. 2018 Apr;10(4). pii: emmm.201707918. doi: 10.15252/emmm.201707918. |
| 15. | Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. | Kim HG, etal., ACS Chem Biol. 2013 Oct 18;8(10):2145-50. doi: 10.1021/cb400430t. Epub 2013 Aug 13. |
| 16. | Altered Expression of DDR1 in Clear Cell Renal Cell Carcinoma Correlates With miR-199a/b-5p and Patients' Outcome. | Krazinski BE, etal., Cancer Genomics Proteomics. 2019 May-Jun;16(3):179-193. doi: 10.21873/cgp.20124. |
| 17. | Localization of discoidin domain receptors in rat kidney. | Lee R, etal., Nephron Exp Nephrol. 2004;97(2):e62-70. |
| 18. | Effect of Hypoxia on DDR1 Expression in Pituitary Adenomas. | Li S, etal., Med Sci Monit. 2015 Aug 19;21:2433-8. doi: 10.12659/MSM.894205. |
| 19. | Discoidin domain receptor 1-deletion ameliorates fibrosis and promotes adipose tissue beiging, brown fat activity, and increased metabolic rate in a mouse model of cardiometabolic disease. | Lino M, etal., Mol Metab. 2020 Sep;39:101006. doi: 10.1016/j.molmet.2020.101006. Epub 2020 Apr 28. |
| 20. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
| 21. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 22. | Migration inhibition of mammary epithelial cells by Syk is blocked in the presence of DDR1 receptors. | Neuhaus B, etal., Cell Mol Life Sci. 2011 Nov;68(22):3757-70. doi: 10.1007/s00018-011-0676-8. Epub 2011 Apr 17. |
| 23. | The Regulation of Matrix Metalloproteinase Expression and the Role of Discoidin Domain Receptor 1/2 Signalling in Zoledronate-treated PC3 Cells. | Reel B, etal., J Cancer. 2015 Aug 28;6(10):1020-9. doi: 10.7150/jca.12733. eCollection 2015. |
| 24. | Discoidin domain receptors: A promising target in melanoma. | Reger de Moura C, etal., Pigment Cell Melanoma Res. 2019 Sep;32(5):697-707. doi: 10.1111/pcmr.12809. Epub 2019 Jul 22. |
| 25. | GOA pipeline | RGD automated data pipeline |
| 26. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 27. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 28. | Comprehensive gene review and curation | RGD comprehensive gene curation |
| 29. | Silencing of sinusoidal DDR1 reduces murine liver metastasis by colon carcinoma. | Romayor I, etal., Sci Rep. 2020 Oct 27;10(1):18398. doi: 10.1038/s41598-020-75395-w. |
| 30. | Multiple tyrosine protein kinases in rat hippocampal neurons: isolation of Ptk-3, a receptor expressed in proliferative zones of the developing brain. | Sanchez MP, etal., Proc Natl Acad Sci U S A 1994 Mar 1;91(5):1819-23. |
| 31. | Discoidin domain receptor 1 (DDR1), a promising biomarker, induces epithelial to mesenchymal transition in renal cancer cells. | Song J, etal., Tumour Biol. 2016 Aug;37(8):11509-21. doi: 10.1007/s13277-016-5021-2. Epub 2016 Mar 28. |
| 32. | Tumor-extrinsic discoidin domain receptor 1 promotes mammary tumor growth by regulating adipose stromal interleukin 6 production in mice. | Sun X, etal., J Biol Chem. 2018 Feb 23;293(8):2841-2849. doi: 10.1074/jbc.RA117.000672. Epub 2018 Jan 3. |
| 33. | Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers. | Takai K, etal., Genes Dev. 2018 Feb 1;32(3-4):244-257. doi: 10.1101/gad.301366.117. Epub 2018 Feb 26. |
| 34. | Inhibition of EP300 and DDR1 synergistically alleviates pulmonary fibrosis in vitro and in vivo. | Tao J, etal., Biomed Pharmacother. 2018 Oct;106:1727-1733. doi: 10.1016/j.biopha.2018.07.132. Epub 2018 Jul 30. |
| 35. | Tentative Sequence Identification Numbers | Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 36. | Novel role of sorting nexin 5 in renal D(1) dopamine receptor trafficking and function: implications for hypertension. | Villar VA, etal., FASEB J. 2013 May;27(5):1808-19. doi: 10.1096/fj.12-208439. Epub 2012 Nov 29. |
| 37. | E2F1 silencing inhibits migration and invasion of osteosarcoma cells via regulating DDR1 expression. | Wang Z, etal., Int J Oncol. 2017 Dec;51(6):1639-1650. doi: 10.3892/ijo.2017.4165. Epub 2017 Oct 16. |
| 38. | Fate and functional roles of Prominin 1+ cells in liver injury and cancer. | Wu R, etal., Sci Rep. 2020 Nov 10;10(1):19412. doi: 10.1038/s41598-020-76458-8. |
| 39. | Identification of expressed genes characterizing long-term survival in malignant glioma patients. | Yamanaka R, etal., Oncogene. 2006 Sep 28;25(44):5994-6002. doi: 10.1038/sj.onc.1209585. Epub 2006 May 1. |
| 40. | DDR1 promotes breast tumor growth by suppressing antitumor immunity. | Zhong X, etal., Oncol Rep. 2019 Dec;42(6):2844-2854. doi: 10.3892/or.2019.7338. Epub 2019 Sep 27. |
| 41. | 2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy. | Zhu D, etal., J Med Chem. 2019 Aug 22;62(16):7431-7444. doi: 10.1021/acs.jmedchem.9b00365. Epub 2019 Aug 2. |
Additional References at PubMed
| PMID:9659899 | PMID:10970885 | PMID:11283268 | PMID:12065315 | PMID:12397034 | PMID:12477932 | PMID:16472941 | PMID:16502470 | PMID:16806867 | PMID:19199708 | PMID:21044884 | PMID:23376485 |
| PMID:23382219 | PMID:24018687 | PMID:25630038 |
Genomics
Comparative Map Data
| Ddr1 (Rattus norvegicus - Norway rat) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DDR1 (Homo sapiens - human) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ddr1 (Mus musculus - house mouse) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ddr1 (Chinchilla lanigera - long-tailed chinchilla) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DDR1 (Pan paniscus - bonobo/pygmy chimpanzee) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DDR1 (Canis lupus familiaris - dog) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ddr1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DDR1 (Sus scrofa - pig) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DDR1 (Chlorocebus sabaeus - green monkey) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ddr1 (Heterocephalus glaber - naked mole-rat) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Variants
.
Variants in Ddr1
98 total Variants 
|
