C5 (complement C5) - Rat Genome Database

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Gene: C5 (complement C5) Rattus norvegicus
Analyze
Symbol: C5
Name: complement C5
RGD ID: 2237
Description: Enables C5a anaphylatoxin chemotactic receptor binding activity. Involved in several processes, including intracellular calcium ion homeostasis; leukocyte migration involved in inflammatory response; and negative regulation of catecholamine secretion. Located in extracellular space. Used to study adult respiratory distress syndrome; asthma; and neutropenia. Biomarker of brain edema. Human ortholog(s) of this gene implicated in several diseases, including complement component 5 deficiency; liver cirrhosis; neutropenia; paroxysmal nocturnal hemoglobinuria; and pneumonia. Orthologous to human C5 (complement C5); PARTICIPATES IN coagulation cascade pathway; complement system pathway; prion disease pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: anaphylatoxin; C5a; complement component 5; Hc; RGD1561905
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Candidate Gene For: Cia11
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8338,668,174 - 38,759,468 (-)NCBIGRCr8
mRatBN7.2318,270,696 - 18,361,994 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl318,270,696 - 18,361,994 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx321,338,177 - 21,436,625 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0329,923,207 - 30,021,653 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0328,177,076 - 28,275,525 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0314,049,993 - 14,113,931 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0314,206,466 - 14,229,141 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl314,049,995 - 14,229,080 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0319,525,468 - 19,547,636 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0319,369,981 - 19,432,948 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4314,011,115 - 14,102,744 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1313,962,273 - 13,963,756 (-)NCBI
Celera312,987,748 - 13,080,508 (-)NCBICelera
Cytogenetic Map3p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
Actein  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chondroitin sulfate  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cytochalasin B  (ISO)
D-glucose  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dithionite(2-)  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylene glycol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenthion  (ISO)
flutamide  (EXP)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
glafenine  (EXP)
glucose  (ISO)
glutathione  (EXP)
heparin  (ISO)
herbicide  (ISO)
indometacin  (ISO)
inulin  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
leukotriene B4  (ISO)
levofloxacin  (EXP)
manganese(II) chloride  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
N,N-dimethylsphingosine  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
olanzapine  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parthenolide  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
poly(styrene)  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
T-2 toxin  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
tributylstannane  (EXP)
trichloroethene  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Contribution of anaphylatoxin C5a to late airway responses after repeated exposure of antigen to allergic rats. Abe M, etal., J Immunol. 2001 Oct 15;167(8):4651-60.
2. cDNA cloning and characterization of rat C5a anaphylatoxin receptor. Akatsu H, etal., Microbiol Immunol 1997;41(7):575-80.
3. Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. Arumugam TV, etal., J Hepatol. 2004 Jun;40(6):934-41.
4. Complement factor C5a exerts an anti-inflammatory effect in acute pancreatitis and associated lung injury. Bhatia M, etal., Am J Physiol Gastrointest Liver Physiol. 2001 May;280(5):G974-8.
5. Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H. Bora NS, etal., J Immunol. 2006 Aug 1;177(3):1872-8.
6. Correlation of plasma complement split product levels with allergic respiratory disease activity and relation to allergen immunotherapy. Bowser C, etal., Ann Allergy Asthma Immunol. 2010 Jan;104(1):42-9.
7. Increased activation of the alternative complement pathway in sickle cell disease. Chudwin DS, etal., Clin Immunol Immunopathol. 1985 Oct;37(1):93-7.
8. Complement activation in patients with COVID-19: A novel therapeutic target. Cugno M, etal., J Allergy Clin Immunol. 2020 May 14. pii: S0091-6749(20)30650-3. doi: 10.1016/j.jaci.2020.05.006.
9. Primary structure and functional characterization of rat C5a: an anaphylatoxin with unusually high potency. Cui L, etal., Protein Sci. 1994 Aug;3(8):1169-77.
10. Expression of a functional C5a receptor in regenerating hepatocytes and its involvement in a proliferative signaling pathway in rat. Daveau M, etal., J Immunol. 2004 Sep 1;173(5):3418-24.
11. Role of IgG and complement component C5 in the initial course of experimental cryptococcosis. Dromer F, etal., Clin Exp Immunol. 1989 Dec;78(3):412-7.
12. Complement activation in cystic fibrosis respiratory fluids: in vivo and in vitro generation of C5a and chemotactic activity. Fick RB Jr, etal., Pediatr Res. 1986 Dec;20(12):1258-68.
13. The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis. Flierl MA, etal., PLoS One. 2008 Jul 2;3(7):e2560.
14. Induction of acute pulmonary inflammation. A differential effect of C5 and the 200,000 molecular weight form of trypsin-activated C5 (C5'). Fowler SR, etal., Am Rev Respir Dis. 1987 Sep;136(3):691-7.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis. Griffiths MM, etal., Arthritis Rheum 2000 Jun;43(6):1278-89
17. Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma. Hasegawa K, etal., Hum Genet. 2004 Sep;115(4):295-301.
18. Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Hillebrandt S, etal., Nat Genet. 2005 Aug;37(8):835-43. Epub 2005 Jul 3.
19. Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. Karp CL, etal., Nat Immunol. 2000 Sep;1(3):221-6.
20. Renal C3 complement component: feed forward to diabetic kidney disease. Kelly KJ, etal., Am J Nephrol. 2015;41(1):48-56. doi: 10.1159/000371426. Epub 2015 Jan 30.
21. The role of C5a in the development of thrombotic glomerulonephritis in rats. Kondo C, etal., Clin Exp Immunol. 2001 May;124(2):323-9.
22. Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. Lajoie S, etal., Nat Immunol. 2010 Oct;11(10):928-35. Epub 2010 Aug 29.
23. Accentuated formation of the terminal C5b-9 complement complex in patient plasma precedes development of the adult respiratory distress syndrome. Langlois PF and Gawryl MS, Am Rev Respir Dis. 1988 Aug;138(2):368-75.
24. Complement factor C5a in acute exacerbation of Chronic Obstructive Pulmonary Disease. Marc MM, etal., Scand J Immunol. 2010 May;71(5):386-91.
25. C5 modulates airway hyperreactivity and pulmonary eosinophilia during enhanced respiratory syncytial virus disease by decreasing C3a receptor expression. Melendi GA, etal., J Virol. 2007 Jan;81(2):991-9. Epub 2006 Nov 1.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. Requirement and role of C5a in acute lung inflammatory injury in rats. Mulligan MS, etal., J Clin Invest. 1996 Jul 15;98(2):503-12.
28. A recombinant vaccine effectively induces c5a-specific neutralizing antibodies and prevents arthritis. Nandakumar KS, etal., PLoS One. 2010 Oct 20;5(10):e13511.
29. The membrane attack complex of complement induces caspase activation and apoptosis. Nauta AJ, etal., Eur J Immunol 2002 Mar;32(3):783-92.
30. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
31. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
32. Chemotactic mediator requirements in lung injury following skin burns in rats. Piccolo MT, etal., Exp Mol Pathol. 1999 Aug;66(3):220-6.
33. Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia. Pierangeli SS, etal., Arthritis Rheum. 2005 Jul;52(7):2120-4.
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. GOA pipeline RGD automated data pipeline
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. FcgammaRIII is protective against Pseudomonas aeruginosa pneumonia. Rhein LM, etal., Am J Respir Cell Mol Biol. 2008 Apr;38(4):401-6. Epub 2007 Nov 1.
39. Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis. Riedemann NC, etal., FASEB J. 2004 Feb;18(2):370-2. Epub 2003 Dec 19.
40. Expression and function of the C5a receptor in rat alveolar epithelial cells. Riedemann NC, etal., J Immunol 2002 Feb 15;168(4):1919-25.
41. Activation of the complement system in the adult respiratory distress syndrome. Robbins RA, etal., Am Rev Respir Dis. 1987 Mar;135(3):651-8.
42. Nucleotide and corrected amino acid sequence of the functional recombinant rat anaphylatoxin C5a. Rothermel E, etal., Biochim Biophys Acta 1997 Mar 20;1351(1-2):9-12.
43. Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumonia. Rubins JB, etal., J Clin Invest. 1995 Jan;95(1):142-50.
44. Increase by anaphylatoxin C5a of glucose output in perfused rat liver via prostanoids derived from nonparenchymal cells: direct action of prostaglandins and indirect action of thromboxane A(2) on hepatocytes. Schieferdecker HL, etal., Hepatology. 1999 Aug;30(2):454-61.
45. Differential expression of the C5a receptor on the main cell types of rat liver as demonstrated with a novel monoclonal antibody and by C5a anaphylatoxin-induced Ca2+ release. Schlaf G, etal., Lab Invest. 1999 Oct;79(10):1287-97.
46. Neutrophil chemotactic activity and C5a following systemic activation of complement in rats. Schmid E, etal., Inflammation. 1997 Jun;21(3):325-33.
47. Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat. Short A, etal., Br J Pharmacol. 1999 Feb;126(3):551-4.
48. Response-selective C5a agonists: differential effects on neutropenia and hypotension in the rat. Short AJ, etal., Br J Pharmacol. 1999 Oct;128(3):511-4.
49. A new small molecule C5a receptor antagonist inhibits the reverse-passive Arthus reaction and endotoxic shock in rats. Strachan AJ, etal., J Immunol. 2000 Jun 15;164(12):6560-5.
50. Protective effect of C5 shRNA on myocardial ischemia-reperfusion injury in rats. Tang K, etal., Can J Physiol Pharmacol. 2012 Oct;90(10):1394-402. doi: 10.1139/y2012-114. Epub 2012 Oct 15.
51. Mediators of lung injury in mice following systemic activation of complement. Tvedten HW, etal., Am J Pathol. 1985 Apr;119(1):92-100.
52. Myocardial infarction and apoptosis after myocardial ischemia and reperfusion: role of the terminal complement components and inhibition by anti-C5 therapy. Vakeva AP, etal., Circulation. 1998 Jun 9;97(22):2259-67.
53. Circulating immune complexes and complement levels in hemophilic children. Verroust F, etal., J Clin Lab Immunol. 1981 Sep;6(2):127-30.
54. Physical mapping of the major histocompatibility complex class II and class III regions of the rat. Walter L, etal., Immunogenetics 2002 Jul;54(4):268-75. Epub 2002 Jun 14.
55. Specific detection by flow cytometry of histidine-tagged ligands bound to their receptors using a tag-specific monoclonal antibody. Wilken HC, etal., J Immunol Methods. 1999 Jun 24;226(1-2):139-45.
56. Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat. Woodruff TM, etal., Arthritis Rheum. 2002 Sep;46(9):2476-85.
57. Systemic complement depletion diminishes perihematomal brain edema in rats. Xi G, etal., Stroke. 2001 Jan;32(1):162-7.
Additional References at PubMed
PMID:11877299   PMID:12218141   PMID:12637249   PMID:14566334   PMID:14732352   PMID:16452172   PMID:16769899   PMID:16780818   PMID:17068344   PMID:17389734   PMID:17621257   PMID:17703884  
PMID:18084313   PMID:18178252   PMID:18947875   PMID:19056867   PMID:19196477   PMID:19285573   PMID:21148255   PMID:22537900   PMID:22832194   PMID:23237573   PMID:23533145   PMID:24344329  
PMID:25385326   PMID:27437704   PMID:29956782   PMID:30092352   PMID:31624141   PMID:32567007   PMID:36251578   PMID:38326494  


Genomics

Comparative Map Data
C5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8338,668,174 - 38,759,468 (-)NCBIGRCr8
mRatBN7.2318,270,696 - 18,361,994 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl318,270,696 - 18,361,994 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx321,338,177 - 21,436,625 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0329,923,207 - 30,021,653 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0328,177,076 - 28,275,525 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0314,049,993 - 14,113,931 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0314,206,466 - 14,229,141 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl314,049,995 - 14,229,080 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0319,525,468 - 19,547,636 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0319,369,981 - 19,432,948 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4314,011,115 - 14,102,744 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1313,962,273 - 13,963,756 (-)NCBI
Celera312,987,748 - 13,080,508 (-)NCBICelera
Cytogenetic Map3p11NCBI
C5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389120,952,335 - 121,074,865 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9120,932,987 - 121,075,195 (-)EnsemblGRCh38hg38GRCh38
GRCh379123,714,613 - 123,837,143 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369122,754,434 - 122,852,375 (-)NCBINCBI36Build 36hg18NCBI36
Build 349120,794,168 - 120,892,108NCBI
Celera994,363,035 - 94,461,011 (-)NCBICelera
Cytogenetic Map9q33.2NCBI
HuRef993,332,095 - 93,430,452 (-)NCBIHuRef
CHM1_19123,861,740 - 123,959,592 (-)NCBICHM1_1
T2T-CHM13v2.09133,148,474 - 133,270,972 (-)NCBIT2T-CHM13v2.0
Hc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39234,873,341 - 34,958,518 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl234,873,343 - 34,951,450 (-)EnsemblGRCm39 Ensembl
GRCm38234,983,329 - 35,068,506 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl234,983,331 - 35,061,438 (-)EnsemblGRCm38mm10GRCm38
MGSCv37234,838,851 - 34,916,961 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36234,805,340 - 34,883,405 (-)NCBIMGSCv36mm8
Celera234,677,654 - 34,755,968 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map223.22NCBI
C5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21118,270,718 - 18,393,732 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1918,273,303 - 18,396,082 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0992,069,574 - 92,202,513 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19120,416,256 - 120,548,366 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9120,426,354 - 120,523,856 (-)Ensemblpanpan1.1panPan2
C5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11173,953,727 - 74,029,919 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1173,953,727 - 74,029,851 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1172,364,536 - 72,439,848 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01175,089,862 - 75,165,511 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1175,089,988 - 75,165,437 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11173,598,023 - 73,673,494 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01173,629,460 - 73,704,118 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01174,367,743 - 74,443,207 (-)NCBIUU_Cfam_GSD_1.0
C5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947189,622,879 - 189,804,753 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364879,391,804 - 9,474,159 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364879,391,774 - 9,474,168 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,995,668 - 261,133,483 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,995,662 - 261,088,868 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21293,077,418 - 293,163,277 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q2.13NCBI
C5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11218,525,855 - 18,624,048 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1218,525,880 - 18,623,636 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603524,390,627 - 24,506,352 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in C5
719 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:47
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000025534
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1558657Cm43Cardiac mass QTL 436.60.0000000293heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)heart rate (CMO:0000002)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)heart rate (CMO:0000002)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145428441896Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat

Markers in Region
D3Rat52  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,311,454 - 18,311,610 (+)MAPPERmRatBN7.2
Rnor_6.0314,090,411 - 14,090,566NCBIRnor6.0
Rnor_5.0319,410,399 - 19,410,554UniSTSRnor5.0
RGSC_v3.4314,051,872 - 14,052,028RGDRGSC3.4
RGSC_v3.4314,051,873 - 14,052,028UniSTSRGSC3.4
RGSC_v3.1313,948,245 - 13,948,400RGD
Celera313,028,531 - 13,028,700UniSTS
RH 3.4 Map3157.8RGD
RH 3.4 Map3157.8UniSTS
RH 2.0 Map347.5RGD
SHRSP x BN Map34.6298RGD
Cytogenetic Map3p11UniSTS
D3Cebr7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,278,158 - 18,278,369 (+)MAPPERmRatBN7.2
Rnor_6.0314,057,455 - 14,057,665NCBIRnor6.0
Rnor_5.0319,377,443 - 19,377,653UniSTSRnor5.0
RGSC_v3.4314,018,577 - 14,018,787UniSTSRGSC3.4
Celera312,995,210 - 12,995,413UniSTS
Cytogenetic Map3p11UniSTS
RH143462  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,357,646 - 18,357,794 (+)MAPPERmRatBN7.2
Rnor_6.0314,224,793 - 14,224,940NCBIRnor6.0
Rnor_5.0319,543,310 - 19,543,457UniSTSRnor5.0
RGSC_v3.4314,098,470 - 14,098,617UniSTSRGSC3.4
Celera313,076,161 - 13,076,308UniSTS
RH 3.4 Map3164.3UniSTS
Cytogenetic Map3p11UniSTS
RH131515  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,326,070 - 18,326,264 (+)MAPPERmRatBN7.2
Rnor_6.0314,105,149 - 14,105,342NCBIRnor6.0
Rnor_5.0319,425,137 - 19,425,330UniSTSRnor5.0
RGSC_v3.4314,067,044 - 14,067,237UniSTSRGSC3.4
Celera313,044,868 - 13,045,061UniSTS
RH 3.4 Map3161.8UniSTS
Cytogenetic Map3p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 37 37 37 19 2 9
Low 2 14 2 14 2 3 3 3 16 17 2 3
Below cutoff 3 24 6 2 5 2 5 6 59 22 5

Sequence


RefSeq Acc Id: ENSRNOT00000025534   ⟹   ENSRNOP00000025534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl318,270,696 - 18,361,994 (-)Ensembl
Rnor_6.0 Ensembl314,050,357 - 14,229,067 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092736   ⟹   ENSRNOP00000076004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl314,049,995 - 14,112,851 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092865   ⟹   ENSRNOP00000075982
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl314,207,044 - 14,229,080 (-)Ensembl
RefSeq Acc Id: NM_053020   ⟹   NP_444179
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8338,668,174 - 38,759,468 (-)NCBI
mRatBN7.2318,270,696 - 18,361,994 (-)NCBI
Protein Sequences
Protein RefSeqs NP_444179 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA62994 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025534
  ENSRNOP00000025534.8
GenBank Protein P08650 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: ENSRNOP00000076004   ⟸   ENSRNOT00000092736
RefSeq Acc Id: ENSRNOP00000075982   ⟸   ENSRNOT00000092865
RefSeq Acc Id: ENSRNOP00000025534   ⟸   ENSRNOT00000025534
RefSeq Acc Id: NP_444179   ⟸   NM_053020
- Peptide Label: precursor
- UniProtKB: Q63078 (UniProtKB/Swiss-Prot),   P08650 (UniProtKB/Swiss-Prot),   A0A096P6L9 (UniProtKB/Swiss-Prot),   A0A8I5ZDN9 (UniProtKB/TrEMBL)
Protein Domains
Anaphylatoxin-like   NTR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08650-F1-model_v2 AlphaFold P08650 1-1681 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692014
Promoter ID:EPDNEW_R2538
Type:initiation region
Name:C5_1
Description:complement C5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0314,229,122 - 14,229,182EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2237 AgrOrtholog
BioCyc Gene G2FUF-50067 BioCyc
Ensembl Genes ENSRNOG00000018899 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025534 ENTREZGENE
  ENSRNOT00000025534.8 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.20.130.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.50.120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.1540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1930 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1940 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.20.50.160 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anaphylotoxins (complement system) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A-macroglobulin_rcpt-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A-macroglobulin_rcpt-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_N_BRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha-macroglobulin_TED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anaphylatoxin/fibulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anaphylatoxin_comp_syst UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C3/4/5_MG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C5_CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Macroglobln_a2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Netrin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Netrin_module_non-TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Terpenoid_cyclase/PrenylTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene C5 ENTREZGENE
PANTHER MACROGLOBULIN / COMPLEMENT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11412:SF83 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam A2M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_BRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANATO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C5_CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TED_complement UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen C5 PhenoGen
PROSITE ANAPHYLATOXIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANAPHYLATOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018899 RatGTEx
SMART A2M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANATO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C345C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47686 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50242 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A096P6L9 ENTREZGENE
  A0A8I5ZDN9 ENTREZGENE, UniProtKB/TrEMBL
  CO5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63078 ENTREZGENE
UniProt Secondary A0A096P6L9 UniProtKB/Swiss-Prot
  Q63078 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 C5  complement C5  C5  complement component 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 C5  Complement component 5      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds to alveolar epithelial cells 61066
gene_function binds to alveolar epithelial cells 70320
gene_process enhances inflamatory response in lung by increasing expression of C5a receptor and pro-inflamatory mediators 61066
gene_process enhances inflamatory response in lung by increasing expression of C5a receptor and pro-inflamatory mediators 70320
gene_regulation binding to alveolar epithelial cells is increased by LPS, Il-6, and Tnf 61066
gene_regulation binding to alveolar epithelial cells is increased by LPS, Il-6, and Tnf 70320