C2 (complement C2) - Rat Genome Database

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Gene: C2 (complement C2) Rattus norvegicus
Analyze
Symbol: C2 (Ensembl: Cfb)
Name: complement C2 (Ensembl:complement factor B)
RGD ID: 2231
Description: Predicted to enable serine-type endopeptidase activity. Involved in response to nutrient. Human ortholog(s) of this gene implicated in Alzheimer's disease; age related macular degeneration 14; complement component 2 deficiency; macular degeneration; and psoriasis. Orthologous to human C2 (complement C2); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: complement component 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Pur27 Pur30
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,944,722 - 3,975,006 (+)NCBIGRCr8
mRatBN7.2203,951,474 - 3,970,376 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,951,474 - 3,976,505 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,651,385 - 4,670,381 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,013,128 - 4,032,129 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,550,327 - 4,569,295 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,542,340 - 4,561,152 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,542,340 - 4,561,152 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,622,139 - 6,641,139 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,051,146 - 4,071,909 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,051,372 - 4,072,135 (+)NCBI
Celera204,060,318 - 4,078,802 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-Zearalanol  (EXP)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
cyclosporin A  (EXP,ISO)
decabromodiphenyl ether  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diuron  (EXP)
epoxiconazole  (ISO)
fenthion  (ISO)
flutamide  (EXP)
fulvestrant  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
irinotecan  (EXP)
ketamine  (EXP)
lead diacetate  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methylphenidate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenytoin  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
tacrolimus hydrate  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Susceptibility to advanced age-related macular degeneration and alleles of complement factor H, complement factor B, complement component 2, complement component 3, and age-related maculopathy susceptibility 2 genes in a Mexican population. Buentello-Volante B, etal., Mol Vis. 2012;18:2518-25. Epub 2012 Oct 11.
2. Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases. Chen CB and Wallis R, J Biol Chem. 2004 Jun 18;279(25):26058-65. Epub 2004 Apr 1.
3. HLA-linked complement polymorphisms (C2, BF) in psoriasis. Dewald G, etal., Arch Dermatol Res. 1983;275(5):301-4.
4. Variations in five genes and the severity of age-related macular degeneration: results from the Muenster aging and retina study. Farwick A, etal., Eye (Lond). 2009 Dec;23(12):2238-44. doi: 10.1038/eye.2008.426. Epub .
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Gold B, etal., Nat Genet. 2006 Apr;38(4):458-62. Epub 2006 Mar 5.
7. Association of polymorphisms in C2, CFB and C3 with exudative age-related macular degeneration in a Korean population. Kim SJ, etal., Exp Eye Res. 2012 Mar;96(1):42-7. doi: 10.1016/j.exer.2012.01.005. Epub 2012 Jan 18.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population. Nakata I, etal., Invest Ophthalmol Vis Sci. 2012 Feb 16;53(2):794-8. doi: 10.1167/iovs.11-8468.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Protein Malnutrition and complement activity in guinea pigs, germ-free and conventional rats. Petersen BH, etal., J Nutr. 1980 Nov;110(11):2159-65.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation. Proitsi P, etal., Neurobiol Aging. 2012 Aug;33(8):1843.e9-17. doi: 10.1016/j.neurobiolaging.2011.12.036. Epub 2012 Feb 1.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. Analysis of rare variants in the complement component 2 (C2) and factor B (BF) genes refine association for age-related macular degeneration (AMD). Richardson AJ, etal., Invest Ophthalmol Vis Sci. 2009 Feb;50(2):540-3. doi: 10.1167/iovs.08-2423. Epub 2008 Sep 20.
19. Breakdown product of factor B as an index of complement activation in lepromatous leprosy and its relation with bacillary load. Saha K, etal., Scand J Immunol. 1983 Jan;17(1):37-43.
20. Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration. Spencer KL, etal., Hum Mol Genet. 2007 Aug 15;16(16):1986-92. Epub 2007 Jun 18.
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. Enhanced susceptibility to acute pneumococcal otitis media in mice deficient in complement C1qa, factor B, and factor B/C2. Tong HH, etal., Infect Immun. 2010 Mar;78(3):976-83. doi: 10.1128/IAI.01012-09. Epub 2010 Jan 11.
23. Determination of the second component of complement (C2) by electroimmunoassay in sera from patients with systemic lupus erythematosus. Ueda A, etal., Clin Exp Immunol. 1983 Jul;53(1):217-24.
24. Physical mapping of the major histocompatibility complex class II and class III regions of the rat. Walter L, etal., Immunogenetics 2002 Jul;54(4):268-75. Epub 2002 Jun 14.
25. Association between polymorphisms of complement pathway genes and age-related macular degeneration in a Chinese population. Wu L, etal., Invest Ophthalmol Vis Sci. 2013 Jan 7;54(1):170-4. doi: 10.1167/iovs.12-10453.
26. Association of C2 and CFB polymorphisms with anterior uveitis. Yang MM, etal., Invest Ophthalmol Vis Sci. 2012 Jul 27;53(8):4969-74. doi: 10.1167/iovs.12-9478.
27. Rare inborn errors associated with chronic hepatitis B virus infection. Zhao Q, etal., Hepatology. 2012 Nov;56(5):1661-70. doi: 10.1002/hep.25850. Epub 2012 Oct 14.
Additional References at PubMed
PMID:9688553   PMID:17204478   PMID:19302245   PMID:23533145   PMID:24006456  


Genomics

Comparative Map Data
C2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,944,722 - 3,975,006 (+)NCBIGRCr8
mRatBN7.2203,951,474 - 3,970,376 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,951,474 - 3,976,505 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,651,385 - 4,670,381 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,013,128 - 4,032,129 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,550,327 - 4,569,295 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,542,340 - 4,561,152 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,542,340 - 4,561,152 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,622,139 - 6,641,139 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,051,146 - 4,071,909 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,051,372 - 4,072,135 (+)NCBI
Celera204,060,318 - 4,078,802 (-)NCBICelera
Cytogenetic Map20p12NCBI
C2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,897,783 - 31,945,672 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,897,785 - 31,945,673 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,865,560 - 31,913,449 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,003,473 - 32,021,427 (+)NCBINCBI36Build 36hg18NCBI36
Build 34632,003,472 - 32,021,427NCBI
Celera633,495,068 - 33,513,211 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,651,618 - 31,700,418 (+)NCBIHuRef
CHM1_1631,867,703 - 31,915,530 (+)NCBICHM1_1
T2T-CHM13v2.0631,751,025 - 31,798,877 (+)NCBIT2T-CHM13v2.0
C2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,081,578 - 35,101,076 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,081,580 - 35,117,241 (-)EnsemblGRCm39 Ensembl
GRCm381734,862,602 - 34,882,100 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,862,604 - 34,898,265 (-)EnsemblGRCm38mm10GRCm38
MGSCv371734,999,547 - 35,019,045 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,470,663 - 34,490,103 (-)NCBIMGSCv36mm8
Celera1737,957,910 - 37,977,407 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.41NCBI
C2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437448,672 - 460,519 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955437449,171 - 460,898 (+)NCBIChiLan1.0ChiLan1.0
C2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,376,853 - 46,422,221 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,367,483 - 42,383,704 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,590,135 - 31,606,368 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,476,791 - 32,492,982 (+)NCBIpanpan1.1PanPan1.1panPan2
C2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,363,656 - 1,399,732 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,363,803 - 1,399,728 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,493,696 - 1,534,930 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,500,603 - 1,542,031 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,500,627 - 1,542,028 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,358,291 - 1,399,309 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,426,238 - 1,467,677 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,491,715 - 1,533,005 (+)NCBIUU_Cfam_GSD_1.0
C2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,913,518 - 35,958,946 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367271,602,398 - 1,616,060 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367271,602,400 - 1,615,974 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl724,020,290 - 24,034,039 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1724,020,590 - 24,034,042 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,778,160 - 27,791,919 (-)NCBISscrofa10.2Sscrofa10.2susScr3
C2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,069,852 - 40,094,478 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1740,069,909 - 40,094,207 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604431,844,362 - 31,862,408 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
C2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,317,058 - 24,322,656 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,316,778 - 24,327,065 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in C2
156 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:219
Count of miRNA genes:132
Interacting mature miRNAs:150
Transcripts:ENSRNOT00000000477, ENSRNOT00000060607, ENSRNOT00000065044
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
737973Pia21Pristane induced arthritis QTL 214.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2036216564606812Rat

Markers in Region
D20Yum57  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,965,881 - 3,966,060 (-)MAPPERmRatBN7.2
Rnor_6.0204,546,656 - 4,546,834NCBIRnor6.0
Rnor_5.0206,626,455 - 6,626,633UniSTSRnor5.0
RGSC_v3.4204,067,037 - 4,067,215UniSTSRGSC3.4
Celera204,064,634 - 4,064,812UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000000477   ⟹   ENSRNOP00000000477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,970,643 - 3,976,505 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000060607   ⟹   ENSRNOP00000057340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,951,474 - 3,970,375 (+)Ensembl
Rnor_6.0 Ensembl204,542,340 - 4,561,152 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000065044   ⟹   ENSRNOP00000059051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,951,474 - 3,970,375 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000075928   ⟹   ENSRNOP00000068499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,951,564 - 3,970,375 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092698   ⟹   ENSRNOP00000075765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,951,474 - 3,970,375 (+)Ensembl
RefSeq Acc Id: NM_172222   ⟹   NP_757376
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,956,105 - 3,975,004 (+)NCBI
mRatBN7.2203,951,474 - 3,970,376 (+)NCBI
Rnor_6.0204,542,340 - 4,561,152 (-)NCBI
Rnor_5.0206,622,139 - 6,641,139 (-)NCBI
RGSC_v3.4204,051,146 - 4,071,909 (+)RGD
Celera204,060,318 - 4,078,802 (-)RGD
Sequence:
RefSeq Acc Id: XM_063278949   ⟹   XP_063135019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,944,722 - 3,975,006 (+)NCBI
RefSeq Acc Id: NP_757376   ⟸   NM_172222
- Peptide Label: precursor
- UniProtKB: Q6MG73 (UniProtKB/TrEMBL),   D4AAK8 (UniProtKB/TrEMBL),   Q8CIP8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000057340   ⟸   ENSRNOT00000060607
Ensembl Acc Id: ENSRNOP00000059051   ⟸   ENSRNOT00000065044
Ensembl Acc Id: ENSRNOP00000000477   ⟸   ENSRNOT00000000477
Ensembl Acc Id: ENSRNOP00000068499   ⟸   ENSRNOT00000075928
Ensembl Acc Id: ENSRNOP00000075765   ⟸   ENSRNOT00000092698
RefSeq Acc Id: XP_063135019   ⟸   XM_063278949
- Peptide Label: isoform X1
Protein Domains
Peptidase S1   Sushi   VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6MG73-F1-model_v2 AlphaFold Q6MG73 1-758 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701357
Promoter ID:EPDNEW_R11880
Type:initiation region
Name:C2_1
Description:complement C2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0204,561,112 - 4,561,172EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2231 AgrOrtholog
BioCyc Gene G2FUF-4603 BioCyc
Ensembl Genes ENSRNOG00000051235 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060607.5 UniProtKB/TrEMBL
  ENSRNOT00000065044 ENTREZGENE
  ENSRNOT00000065044.5 UniProtKB/TrEMBL
  ENSRNOT00000075928 ENTREZGENE
  ENSRNOT00000075928.3 UniProtKB/TrEMBL
  ENSRNOT00000092698.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  2.40.10.120 UniProtKB/TrEMBL
  3.40.50.410 UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7096131 IMAGE-MGC_LOAD
InterPro Compl_C2_B UniProtKB/TrEMBL
  Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Ser/Cys_Pept_Trypsin-like UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
KEGG Report rno:24231 UniProtKB/TrEMBL
MGC_CLONE MGC:91431 IMAGE-MGC_LOAD
NCBI Gene 24231 ENTREZGENE
PANTHER PTHR46393 UniProtKB/TrEMBL
  PTHR46393:SF2 UniProtKB/TrEMBL
Pfam Sushi UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
PhenoGen C2 PhenoGen
PIRSF Compl_C2_B UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE SUSHI UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
  VWFA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000051235 RatGTEx
SMART CCP UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP Complement_control_module UniProtKB/TrEMBL
  Pept_Ser_Cys UniProtKB/TrEMBL
  SSF53300 UniProtKB/TrEMBL
UniProt A0A096MKF9_RAT UniProtKB/TrEMBL
  A0A0U1RRP9_RAT UniProtKB/TrEMBL
  A0A8J8XKZ6_RAT UniProtKB/TrEMBL
  A0A8J8YKQ8_RAT UniProtKB/TrEMBL
  A6KTM3_RAT UniProtKB/TrEMBL
  A6KTM4_RAT UniProtKB/TrEMBL
  A6KTM5_RAT UniProtKB/TrEMBL
  A6KTM6_RAT UniProtKB/TrEMBL
  D4AAK8 ENTREZGENE
  Q6MG73 ENTREZGENE, UniProtKB/TrEMBL
  Q8CIP8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary D4AAK8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-24 C2  complement C2  C2  complement component 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 C2  Complement component 2      Symbol and Name status set to approved 70586 APPROVED