Btg2 (BTG anti-proliferation factor 2) - Rat Genome Database

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Gene: Btg2 (BTG anti-proliferation factor 2) Rattus norvegicus
Analyze
Symbol: Btg2
Name: BTG anti-proliferation factor 2
RGD ID: 2225
Description: Enables transcription corepressor activity. Involved in several processes, including cellular response to phorbol 13-acetate 12-myristate; negative regulation of neuron apoptotic process; and response to electrical stimulus. Acts upstream of or within negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; and neuron differentiation. Predicted to be active in cytoplasm and nucleus. Biomarker of acute necrotizing pancreatitis and brain ischemia. Orthologous to human BTG2 (BTG anti-proliferation factor 2); PARTICIPATES IN RNA degradation pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 1-nitropropane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Agl; An; an-1; B-cell translocation gene 2; B-cell translocation gene 2 anti-proliferative; B-cell translocation gene 2, anti-proliferative; BTG family, member 2; cell surface alloantigen; Early induced gene B-cell translocation gene 2; NGF-inducible anti-proliferative protein PC3; NGF-inducible anti-proliferative putative secreted protein; PC3; Tis21
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Btg2em11Mcwi   Btg2em13Mcwi   Btg2em7Mcwi   Btg2em21Mcwi   Btg2em24Mcwi  
Genetic Models: SS.BN-(D13Rat25-rs106935835)-Btg2em11Mcwi SS.BN-(D13Rat25-rs106935835)-Btg2em13Mcwi SS.BN-(D13Rat25-rs198199323)-Btg2em24Mcwi SS.BN-(D13Rat25-rs198199323)-Btg2em21Mcwi SS.BN-(D13Rat25-rs106935835)-Btg2em7Mcwi
Candidate Gene For: Bp398
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81348,083,931 - 48,087,690 (-)NCBIGRCr8
mRatBN7.21345,531,881 - 45,535,642 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1345,531,925 - 45,535,628 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1348,140,195 - 48,143,949 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01349,428,246 - 49,432,002 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01346,692,987 - 46,696,744 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01350,913,185 - 50,916,944 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,913,180 - 50,916,982 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01355,966,299 - 55,970,058 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41347,026,986 - 47,030,745 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11347,041,028 - 47,044,788 (-)NCBI
Celera1345,860,186 - 45,864,450 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-demecolcine  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dioxane  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropropane  (EXP)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-diaminotoluene  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one  (EXP)
2-acetamidofluorene  (EXP,ISO)
2-arachidonoylglycerol  (ISO)
2-nitro-p-phenylenediamine  (EXP)
2-nitrofluorene  (EXP)
2-nitropropane  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-acetylaminofluorene  (EXP)
4-nitro-1,2-phenylenediamine  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-fluorouracil  (ISO)
6-O-methylguanine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
adenine  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
alpha-phellandrene  (ISO)
alvocidib  (ISO)
AM-251  (ISO)
ammonium chloride  (EXP)
antimonite  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brevetoxin B  (ISO)
bromoacetate  (ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
carbachol  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
cefaloridine  (EXP)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chloroform  (EXP,ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium(3+) trichloride  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper(II) chloride  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
cytarabine  (ISO)
DDE  (ISO)
DDT  (EXP)
delphinidin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorvos  (EXP)
dieldrin  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethyl sulfoxide  (EXP)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenamidone  (ISO)
fenofibrate  (EXP)
fentin chloride  (EXP)
fluoranthene  (ISO)
flusilazole  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycidol  (EXP)
glyphosate  (ISO)
Goe 6976  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
ifosfamide  (ISO)
indometacin  (ISO)
inulin  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
leptomycin B  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
melatonin  (ISO)
melphalan  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metacetamol  (ISO)
metformin  (EXP)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
myristicin  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalenes  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
Nutlin-3  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorobutyric acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenethyl isothiocyanate  (EXP)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium chloride  (ISO)
progesterone  (EXP)
propanal  (ISO)
quercetin  (ISO)
quinomethionate  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
sotorasib  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tacrolimus hydrate  (EXP)
tamibarotene  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trametinib  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (ISO)
undecane  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
nucleus  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Differential induction of primary-response (TIS) genes in PC12 pheochromocytoma cells and the unresponsive variant PC12nnr5. Altin JG, etal., J Biol Chem. 1991 Mar 25;266(9):5401-6.
2. Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization. Bradbury A, etal., Proc Natl Acad Sci U S A 1991 Apr 15;88(8):3353-7.
3. Mediators of ischemic preconditioning identified by microarray analysis of rat spinal cord. Carmel JB, etal., Exp Neurol. 2004 Jan;185(1):81-96.
4. Noise overstimulation induces immediate early genes in the rat cochlea. Cho Y, etal., Brain Res Mol Brain Res. 2004 Nov 4;130(1-2):134-48.
5. PC3 potentiates NGF-induced differentiation and protects neurons from apoptosis. Corrente G, etal., Neuroreport 2002 Mar 25;13(4):417-22.
6. BTG2(TIS21/PC3) induces neuronal differentiation and prevents apoptosis of terminally differentiated PC12 cells. el-Ghissassi F, etal., Oncogene. 2002 Oct 3;21(44):6772-78.
7. Impaired terminal differentiation of hippocampal granule neurons and defective contextual memory in PC3/Tis21 knockout mice. Farioli-Vecchioli S, etal., PLoS One. 2009 Dec 17;4(12):e8339. doi: 10.1371/journal.pone.0008339.
8. Antiproliferative B cell translocation gene 2 protein is down-regulated post-transcriptionally as an early event in prostate carcinogenesis. Ficazzola MA, etal., Carcinogenesis. 2001 Aug;22(8):1271-9.
9. Overexpression of the PC3/TIS21/BTG2 mRNA is part of the stress response induced by acute pancreatitis in rats. Fiedler F, etal., Biochem Biophys Res Commun. 1998 Aug 19;249(2):562-5.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription. Guardavaccaro D, etal., Mol Cell Biol 2000 Mar;20(5):1797-815.
12. Immediate early gene induction after neonatal hypoxia-ischemia. Gubits RM, etal., Brain Res Mol Brain Res. 1993 May;18(3):228-38.
13. Female-specific hypertension loci on rat chromosome 13. Hoffman MJ, etal., Hypertension. 2013 Sep;62(3):557-63. doi: 10.1161/HYPERTENSIONAHA.113.01708. Epub 2013 Jul 1.
14. Induction of tetradecanoyl phorbol acetate-inducible sequence (TIS) genes by electroconvulsive shock in rat brain. Jung HY, etal., Biol Psychiatry. 1996 Sep 15;40(6):503-7.
15. Loss of B-cell translocation gene-2 in estrogen receptor-positive breast carcinoma is associated with tumor grade and overexpression of cyclin d1 protein. Kawakubo H, etal., Cancer Res. 2006 Jul 15;66(14):7075-82.
16. Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1. Lin WJ, etal., Biochem J 2001 Mar 15;354(Pt 3):635-43.
17. Gene expression analysis points to hemostasis in livers of rats cotreated with lipopolysaccharide and ranitidine. Luyendyk JP, etal., Toxicol Sci. 2004 Jul;80(1):203-13. Epub 2004 Apr 14.
18. Overexpression of the nerve growth factor-inducible PC3 immediate early gene is associated with growth inhibition. Montagnoli A, etal., Cell Growth Differ 1996 Oct;7(10):1327-36.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. GOA pipeline RGD automated data pipeline
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Comprehensive gene review and curation RGD comprehensive gene curation
24. Phosphatidylcholine-specific phospholipase C/heat shock protein 70 (Hsp70)/transcription factor B-cell translocation gene 2 signaling in rat bone marrow stromal cell differentiation to cholinergic neuron-like cells. Shao J, etal., Int J Biochem Cell Biol. 2012 Dec;44(12):2253-60. doi: 10.1016/j.biocel.2012.09.013. Epub 2012 Sep 20.
25. Brief episode of ischemia activates protective genetic program in rat heart: a gene chip study. Simkhovich BZ, etal., Cardiovasc Res. 2003 Aug 1;59(2):450-9.
26. Genetics of the rat CT system: its apparent complexity is a consequence of cross-reactivity between the distinct MHC class I antigens RT1.C and RT1.A. Stephenson SP, etal., J Immunogenet 1985 Apr;12(2):101-14.
27. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
28. Impaired expression of the cell cycle regulator BTG2 is common in clear cell renal cell carcinoma. Struckmann K, etal., Cancer Res. 2004 Mar 1;64(5):1632-8.
29. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
30. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
31. The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair? Tirone F J Cell Physiol 2001 May;187(2):155-65.
32. Synthesis, degradation, and subcellular localization of proteins encoded by the primary response genes TIS7/PC4 and TIS21/PC3. Varnum BC, etal., J Cell Physiol. 1994 Jan;158(1):205-13.
33. A rat genetic linkage map and comparative maps for mouse or human homologous rat genes. Yamada J, etal., Mamm Genome 1994 Feb;5(2):63-83.
Additional References at PubMed
PMID:7811636   PMID:8663146   PMID:8944033   PMID:15056715   PMID:15489334   PMID:15542835   PMID:16191397   PMID:16335396   PMID:17032584   PMID:17371797   PMID:18337750   PMID:18773938  
PMID:19056867   PMID:19359386   PMID:19997037   PMID:22147266   PMID:23058912   PMID:23236473   PMID:23267836   PMID:23703573   PMID:27333946   PMID:32945347   PMID:35503009   PMID:36759943  
PMID:37062247   PMID:38437946  


Genomics

Comparative Map Data
Btg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81348,083,931 - 48,087,690 (-)NCBIGRCr8
mRatBN7.21345,531,881 - 45,535,642 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1345,531,925 - 45,535,628 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1348,140,195 - 48,143,949 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01349,428,246 - 49,432,002 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01346,692,987 - 46,696,744 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01350,913,185 - 50,916,944 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,913,180 - 50,916,982 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01355,966,299 - 55,970,058 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41347,026,986 - 47,030,745 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11347,041,028 - 47,044,788 (-)NCBI
Celera1345,860,186 - 45,864,450 (-)NCBICelera
Cytogenetic Map13q13NCBI
BTG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381203,305,519 - 203,309,602 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1203,305,491 - 203,309,602 (+)EnsemblGRCh38hg38GRCh38
GRCh371203,274,647 - 203,278,730 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361201,541,287 - 201,545,353 (+)NCBINCBI36Build 36hg18NCBI36
Build 341200,006,320 - 200,010,384NCBI
Celera1176,403,938 - 176,408,003 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1174,439,723 - 174,443,788 (+)NCBIHuRef
CHM1_11204,697,045 - 204,701,100 (+)NCBICHM1_1
T2T-CHM13v2.01202,568,370 - 202,572,442 (+)NCBIT2T-CHM13v2.0
Btg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391134,002,603 - 134,006,893 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1134,002,908 - 134,006,858 (-)EnsemblGRCm39 Ensembl
GRCm381134,074,865 - 134,079,155 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1134,075,170 - 134,079,120 (-)EnsemblGRCm38mm10GRCm38
MGSCv371135,971,442 - 135,975,732 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361135,891,276 - 135,895,566 (-)NCBIMGSCv36mm8
Celera1136,692,103 - 136,696,393 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map158.1NCBI
Btg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540639,303,175 - 39,308,778 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540639,303,221 - 39,307,308 (+)NCBIChiLan1.0ChiLan1.0
BTG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2146,068,366 - 46,072,485 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1146,035,354 - 46,039,474 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01178,907,317 - 178,911,410 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11183,201,297 - 183,205,404 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1183,201,297 - 183,205,404 (+)Ensemblpanpan1.1panPan2
BTG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13870,921 - 75,149 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3870,452 - 72,976 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha38161,110 - 165,136 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03867,926 - 71,934 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3867,702 - 71,934 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13860,447 - 64,469 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.038454,515 - 458,533 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.038668,563 - 672,594 (+)NCBIUU_Cfam_GSD_1.0
Btg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934472,075,888 - 72,079,831 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365671,309,658 - 1,314,515 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365671,310,525 - 1,314,469 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BTG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl964,031,832 - 64,035,837 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1964,033,853 - 64,037,795 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2970,327,454 - 70,331,396 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9q21-q25NCBI
BTG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12526,032,404 - 26,036,500 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2526,034,632 - 26,036,538 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605526,808,911 - 26,813,028 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Btg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248077,540,602 - 7,545,521 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248077,541,335 - 7,545,412 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Btg2
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:685
Count of miRNA genes:275
Interacting mature miRNAs:353
Transcripts:ENSRNOT00000004408
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
12879436Bp395Blood pressure QTL 395arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134463918245700190Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134343790447841255Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471945536711Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
12879472Bp399Blood pressure QTL 399arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134522835847841255Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat

Markers in Region
AA819837  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21345,533,782 - 45,533,932 (+)MAPPERmRatBN7.2
Rnor_6.01350,915,087 - 50,915,236NCBIRnor6.0
Rnor_5.01355,968,201 - 55,968,350UniSTSRnor5.0
RGSC_v3.41347,028,888 - 47,029,037UniSTSRGSC3.4
Celera1345,862,088 - 45,862,237UniSTS
RH 3.4 Map13178.1UniSTS
Cytogenetic Map13q13-q31UniSTS
PMC156147P12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21345,533,920 - 45,534,013 (+)MAPPERmRatBN7.2
Rnor_6.01350,915,225 - 50,915,317NCBIRnor6.0
Rnor_5.01355,968,339 - 55,968,431UniSTSRnor5.0
RGSC_v3.41347,029,026 - 47,029,118UniSTSRGSC3.4
Celera1345,862,226 - 45,862,318UniSTS
Cytogenetic Map13q13-q31UniSTS



Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000004408   ⟹   ENSRNOP00000004408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1345,531,925 - 45,535,628 (-)Ensembl
Rnor_6.0 Ensembl1350,913,180 - 50,916,982 (-)Ensembl
RefSeq Acc Id: NM_017259   ⟹   NP_058955
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81348,083,931 - 48,087,690 (-)NCBI
mRatBN7.21345,531,881 - 45,535,642 (-)NCBI
Rnor_6.01350,913,185 - 50,916,944 (-)NCBI
Rnor_5.01355,966,299 - 55,970,058 (-)NCBI
RGSC_v3.41347,026,986 - 47,030,745 (-)RGD
Celera1345,860,186 - 45,864,450 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058955 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB49567 (Get FASTA)   NCBI Sequence Viewer  
  AAH72493 (Get FASTA)   NCBI Sequence Viewer  
  EDM09744 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004408.1
  ENSRNOP00055030613
  ENSRNOP00060024290
  ENSRNOP00065026249
GenBank Protein P27049 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058955   ⟸   NM_017259
- UniProtKB: P27049 (UniProtKB/Swiss-Prot),   A6ICA3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004408   ⟸   ENSRNOT00000004408
Protein Domains
Anti-proliferative protein

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27049-F1-model_v2 AlphaFold P27049 1-158 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698825
Promoter ID:EPDNEW_R9350
Type:single initiation site
Name:Btg2_1
Description:BTG anti-proliferation factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01350,916,944 - 50,917,004EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2225 AgrOrtholog
BIND 130432
  130434
BioCyc Gene G2FUF-18254 BioCyc
Ensembl Genes ENSRNOG00000003300 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055021880 UniProtKB/Swiss-Prot
  ENSRNOG00060017613 UniProtKB/Swiss-Prot
  ENSRNOG00065019487 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004408.4 UniProtKB/Swiss-Prot
  ENSRNOT00055037530 UniProtKB/Swiss-Prot
  ENSRNOT00060030093 UniProtKB/Swiss-Prot
  ENSRNOT00065032838 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.640.90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7097327 IMAGE-MGC_LOAD
InterPro Anti_prolifrtn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTG-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29619 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91753 IMAGE-MGC_LOAD
NCBI Gene 29619 ENTREZGENE
PANTHER B-CELL TRANSLOCATION GENE UniProtKB/TrEMBL
  PROTEIN BTG2 UniProtKB/TrEMBL
  PTHR22978 UniProtKB/Swiss-Prot
  PTHR22978:SF29 UniProtKB/Swiss-Prot
Pfam BTG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Btg2 PhenoGen
PRINTS ANTIPRLFBTG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BTG_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTG_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003300 RatGTEx
  ENSRNOG00055021880 RatGTEx
  ENSRNOG00060017613 RatGTEx
  ENSRNOG00065019487 RatGTEx
SMART btg1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP BTG domain-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC217033
UniProt A6ICA3 ENTREZGENE, UniProtKB/TrEMBL
  BTG2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-13 Btg2  BTG anti-proliferation factor 2  Btg2  BTG family, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-04 Btg2  BTG family, member 2  Btg2  B-cell translocation gene 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-11-05 Btg2  B-cell translocation gene 2  Btg2  B-cell translocation gene 2, anti-proliferative  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Btg2  B-cell translocation gene 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutations in mouse homolog result in symptoms of mild to severe anemia 1300183
gene_function interacts with Pick1, a protein kinase C-alpha-binding protein 68719
gene_process may be involved in mitogenic responses, differentiation, and cell death 68719
gene_process has a role in cellular differentiation 1298588
gene_process may act as a transcriptional co-regulator 1298712
gene_product member of a novel family of antiproliferative genes 1298588
gene_regulation a p53-inducible gene 1298713