A structural constituent of bone. Involved in several processes, including cellular response to zinc ion starvation; osteoblast development; and response to vitamin. Located in several cellular components, including dendrite; extracellular space; and perikaryon. Used to study congenital hypothyroidism and osteoporosis. Biomarker of autosomal dominant hypocalcemia; end stage renal disease; and polycystic kidney disease. Human ortholog(s) of this gene implicated in osteoarthritis; osteoporosis; prostate cancer; rheumatoid arthritis; and vitamin K deficiency bleeding. Orthologous to human BGLAP (bone gamma-carboxyglutamate protein); PARTICIPATES IN fibroblast growth factor signaling pathway; INTERACTS WITH (20S)-ginsenoside Rg3; (S)-nicotine; 17alpha-ethynylestradiol.
Bglap2; Bgp; BGPR; BGPRA; bone gamma-carboxyglutamate (gla) protein; bone gamma-carboxyglutamate (gla) protein (osteocalcin); bone gamma-carboxyglutamate protein 2; bone gamma-carboxyglutamic acid (Gla) protein (osteocalcin); bone Gla protein; bone Gla-protein; gamma-carboxyglutamic acid-containing protein; osteocalcin
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of BGLAP protein]] more ...
morroniside inhibits the reaction [Glucose results in decreased expression of BGLAP mRNA], morroniside inhibits the reaction [Glucose results in decreased expression of BGLAP protein]
[Tretinoin co-treated with Cholecalciferol] results in increased expression of BGLAP, Tretinoin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]
Allethrins inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]
Aluminum inhibits the reaction [Calcitriol results in increased secretion of BGLAP protein], Calcitriol inhibits the reaction [Aluminum results in decreased secretion of BGLAP protein]
Aluminum inhibits the reaction [Calcitriol results in increased secretion of BGLAP protein], Calcitriol inhibits the reaction [Aluminum results in decreased secretion of BGLAP protein]
Ammonium Chloride inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of BGLAP mRNA]
[pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased expression of BGLAP protein], pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of BGLAP protein]
bafilomycin A1 inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of BGLAP mRNA]
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of BGLAP protein], DKK1 protein inhibits the reaction [Berberine results in increased expression of BGLAP protein]
bexarotene inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of BGLAP protein]] more ...
Aluminum inhibits the reaction [Calcitriol results in increased secretion of BGLAP protein], Calcitriol inhibits the reaction [Aluminum results in decreased secretion of BGLAP protein]
Chloroquine inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of BGLAP mRNA]
[cobaltous chloride co-treated with BMP2 protein] results in increased expression of BGLAP protein, cobaltous chloride affects the reaction [BMP2 protein results in increased expression of BGLAP mRNA]
Cycloheximide inhibits the reaction [[Genistein co-treated with Zinc Sulfate] results in increased expression of BGLAP mRNA], Cycloheximide inhibits the reaction [[Genistein co-treated with Zinc] results in increased expression of BGLAP mRNA]
morroniside inhibits the reaction [Glucose results in decreased expression of BGLAP mRNA], morroniside inhibits the reaction [Glucose results in decreased expression of BGLAP protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of BGLAP protein]] more ...
[daidzein co-treated with ESR1 protein] results in increased expression of BGLAP mRNA, [daidzein co-treated with ESR2 protein] results in increased expression of BGLAP mRNA
[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA more ...
Quercetin inhibits the reaction [Doxorubicin results in increased expression of BGLAP protein], Vitamin E inhibits the reaction [Doxorubicin results in increased expression of BGLAP protein]
Enalapril inhibits the reaction [Corticosterone results in decreased expression of BGLAP mRNA], Enalapril inhibits the reaction [Ethanol results in decreased expression of BGLAP mRNA]
[Genistein co-treated with Ethanol] results in increased expression of BGLAP mRNA, Vitamin D affects the reaction [Ethanol results in decreased expression of BGLAP mRNA]
Enalapril inhibits the reaction [Ethanol results in decreased expression of BGLAP mRNA], Ethanol promotes the reaction [lead acetate results in decreased expression of BGLAP protein]
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of BGLAP mRNA] more ...
triphenyltin hydroxide inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]
[Genistein co-treated with ESR1 protein] results in increased expression of BGLAP mRNA, [Genistein co-treated with ESR2 protein] results in increased expression of BGLAP mRNA
morroniside inhibits the reaction [Glucose results in decreased expression of BGLAP mRNA], morroniside inhibits the reaction [Glucose results in decreased expression of BGLAP protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of BGLAP protein]] more ...
[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA more ...
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of BGLAP mRNA] more ...
Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of BGLAP mRNA], Quercetin affects the reaction [Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of BGLAP mRNA]]
chrysoeriol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BGLAP protein], myricitrin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BGLAP mRNA]
NOG protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA], SMAD6 protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] co-treated with fasudil] results in increased expression of BGLAP mRNA] more ...
[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA more ...
[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of BGLAP mRNA more ...
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of BGLAP protein]]
Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of BGLAP mRNA], Melatonin inhibits the reaction [Cadmium Chloride results in decreased secretion of BGLAP protein]
NR3C1 protein promotes the reaction [methylparaben results in decreased expression of BGLAP mRNA], PPARG protein promotes the reaction [methylparaben results in decreased expression of BGLAP mRNA]
morroniside inhibits the reaction [Glucose results in decreased expression of BGLAP mRNA], morroniside inhibits the reaction [Glucose results in decreased expression of BGLAP protein]
Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP mRNA], Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP protein]
Nicotinamide Mononucleotide inhibits the reaction [Aluminum Chloride results in decreased activity of BGLAP protein], Nicotinamide Mononucleotide inhibits the reaction [Aluminum Chloride results in decreased expression of BGLAP protein]
DKK1 protein affects the reaction [perfluorooctane sulfonic acid affects the expression of BGLAP mRNA], Lithium Chloride affects the reaction [perfluorooctane sulfonic acid affects the expression of BGLAP mRNA]
Pioglitazone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]
d, d-T80-prallethrin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]
quinoxyfen inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]
[Rutin co-treated with Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased secretion of BGLAP protein
[pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased expression of BGLAP protein] more ...
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BGLAP mRNA
CTNNB1 mutant form inhibits the reaction [Simvastatin results in increased expression of BGLAP protein], DKK1 inhibits the reaction [Simvastatin results in increased expression of BGLAP mRNA]
Sirolimus inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of BGLAP mRNA]
[Streptozocin co-treated with Dietary Fats] results in decreased expression of BGLAP protein, Calcitriol inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of BGLAP protein]
[Dietary Fats co-treated with Streptozocin] results in decreased expression of BGLAP protein modified form, Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of BGLAP protein modified form]
tributyltin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BGLAP mRNA
[Warfarin co-treated with Vitamin K] results in increased expression of BGLAP mRNA, Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of BGLAP mRNA]
[Genistein co-treated with Zinc] results in increased expression of BGLAP mRNA, Cycloheximide inhibits the reaction [[Genistein co-treated with Zinc] results in increased expression of BGLAP mRNA]
[Genistein co-treated with Zinc Sulfate] results in increased expression of BGLAP mRNA, Cycloheximide inhibits the reaction [[Genistein co-treated with Zinc Sulfate] results in increased expression of BGLAP mRNA]
[Genistein co-treated with Zinc] results in increased expression of BGLAP mRNA, Cycloheximide inhibits the reaction [[Genistein co-treated with Zinc] results in increased expression of BGLAP mRNA]
Comparative study of quantitative ultrasonography and dual-energy X-ray absorptiometry for evaluating renal osteodystrophy in children with chronic kidney disease.
1,25-Dihydroxyvitamin D3 stimulates the synthesis of matrix gamma-carboxyglutamic acid protein by osteosarcoma cells. Mutually exclusive expression of vitamin K-dependent bone proteins by clonal osteoblastic cell lines.
Increased expression of the receptor for activation of NF-kappaB and decreased runt-related transcription factor 2 expression in bone of rats with streptozotocin-induced diabetes.
Impaired gamma carboxylation of osteocalcin in elderly women with type II diabetes mellitus: relationship between increase in undercarboxylated osteocalcin levels and low bone mineral density.
Bone metabolic abnormalities associated with well-controlled type 1 diabetes (IDDM) in young adult women: a disease complication often ignored or neglected.
Interaction of the 1alpha,25-dihydroxyvitamin D3 receptor at the distal promoter region of the bone-specific osteocalcin gene requires nucleosomal remodelling.
Bone-specific transcription factor Runx2 interacts with the 1alpha,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells.
Synergistic role of hydroxyapatite nanoparticles and pulsed electromagnetic field therapy to prevent bone loss in rats following exposure to simulated microgravity.
Studies on gene expression in calvaria and serum levels of insulin-like growth factor-I and bone Gla protein in the methimazole-induced congenital hypothyroid rat.
Association between osteoporosis and polymorphisms of the bone Gla protein, estrogen receptor 1, collagen 1-A1 and calcitonin receptor genes in Turkish postmenopausal women.
The dichotomy in the effects of 1,25 dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 on bone gamma-carboxyglutamic acid-containing protein in serum and bone in vitamin D-deficient rats.
