Bcl2 (BCL2, apoptosis regulator) - Rat Genome Database

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Gene: Bcl2 (BCL2, apoptosis regulator) Rattus norvegicus
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Symbol: Bcl2
Name: BCL2, apoptosis regulator
RGD ID: 2199
Description: Enables BH domain binding activity. Involved in several processes, including cellular response to L-glutamate; central nervous system development; and response to monosaccharide. Located in mitochondrial crista and perinuclear region of cytoplasm. Used to study several diseases, including brain ischemia (multiple); end stage renal disease; gastric ulcer; intestinal disease (multiple); and status epilepticus. Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); carcinoma (multiple); intrinsic cardiomyopathy (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; prostate cancer; and urinary bladder cancer. Orthologous to human BCL2 (BCL2 apoptosis regulator); PARTICIPATES IN intrinsic apoptotic pathway; ceramide signaling pathway; erythropoietin signaling pathway; INTERACTS WITH (+)-catechin; (+)-pilocarpine; (+)-sesamin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: apoptosis regulator Bcl-2; B cell leukemia/lymphoma 2; B cell lymphoma 2 associated oncogene; B-cell CLL/lymphoma 2; B-cell leukemia/lymphoma 2; Bcl-2; Bcl-2alpha; Bcl2-like protein; ENSRNOG00000067693
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Iddm12
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81323,204,464 - 23,366,900 (-)NCBIGRCr8
mRatBN7.21322,689,783 - 22,853,920 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1322,684,989 - 22,853,743 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1322,684,989 - 22,853,743 (-)NCBImRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1323,013,354 - 23,175,038 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01324,297,817 - 24,459,509 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01322,983,528 - 23,145,223 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01326,605,426 - 26,769,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1326,605,426 - 26,769,374 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01331,758,213 - 31,920,775 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41312,730,736 - 12,905,108 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11312,730,735 - 12,905,108 (-)NCBI
Celera1322,550,362 - 22,711,143 (-)NCBICelera
Cytogenetic Map13p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome 1  (IEP)
acute kidney failure  (IEP)
Acute Lung Injury  (IEP)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adenoma  (ISO)
Adrenal Insufficiency  (IEP)
AIDS-Related Kaposi Sarcoma  (ISO)
alcoholic liver cirrhosis  (ISO)
allergic contact dermatitis  (ISO)
allergic rhinitis  (IEP)
Alzheimer's disease  (IDA,IEP,ISO)
amyotrophic lateral sclerosis  (ISO)
anti-basement membrane glomerulonephritis  (IEP)
asthma  (ISO)
atherosclerosis  (IEP)
autistic disorder  (ISO)
azoospermia  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bilirubin metabolic disorder  (IEP)
brain glioma  (IDA,IEP)
Brain Hypoxia-Ischemia  (IEP)
Brain Injuries  (IEP,IMP)
brain ischemia  (IDA)
Breast Neoplasms  (ISO)
Burns  (IEP)
carcinoma  (ISO)
Cerebral Hemorrhage  (ISO)
cervix uteri carcinoma in situ  (ISO)
chromosome 18q deletion syndrome  (ISO)
Chronic Intermittent Hypoxia  (IDA)
clear cell adenocarcinoma  (ISO)
colon adenocarcinoma  (ISO)
colon cancer  (IDA)
Colonic Neoplasms  (IEP,ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (IEP)
contact dermatitis  (ISO)
dementia  (IEP)
Diabetic Cardiomyopathies  (IDA,ISO)
diffuse large B-cell lymphoma  (ISO)
dilated cardiomyopathy  (IEP)
Disease Progression  (ISO)
ductal carcinoma in situ  (ISO)
end stage renal disease  (IDA)
Endometrial Neoplasms  (ISO)
endometriosis  (IDA,ISO)
Endotoxemia  (IEP)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Allergic Asthma  (IEP)
Experimental Arthritis  (IEP)
Experimental Colitis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IDA,IEP)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (IDA)
Familial Prostate Cancer  (ISO)
Fetal Growth Retardation  (IEP)
follicular lymphoma  (ISO)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (IDA)
glaucoma  (IEP)
Head and Neck Neoplasms  (ISO)
Hemorrhagic Shock  (IEP)
hepatocellular carcinoma  (IEP,ISO)
Huntington's disease  (IEP)
hypertension  (IEP,ISO)
hypertrophic cardiomyopathy  (IEP,ISO)
Hypothermia  (IEP)
impotence  (IDA,IEP,ISO)
intestinal disease  (IDA)
Intestinal Neoplasms  (ISO)
intracranial aneurysm  (ISO)
Kashin-Beck Disease  (ISO)
Kidney Reperfusion Injury  (IEP)
Knee Osteoarthritis  (IEP)
learning disability  (ISO)
leiomyoma  (IEP,ISO)
Liver Reperfusion Injury  (IDA,IEP,ISO)
Lung Injury  (IEP)
Lung Reperfusion Injury  (IEP)
lung small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
male infertility  (ISO)
malignant mesothelioma  (ISO)
melanoma  (ISO)
Memory Disorders  (ISO)
mesenchymal chondrosarcoma  (ISO)
Metaplasia  (ISO)
middle cerebral artery infarction  (IEP)
morphine dependence  (IEP)
Multi-Infarct Dementia  (IEP)
multiple congenital anomalies-hypotonia-seizures syndrome 1  (ISO)
multiple myeloma  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (IEP)
Myocardial Reperfusion Injury  (IDA,IEP)
nasopharynx carcinoma  (ISO)
Necrosis  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
Nerve Degeneration  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (IEP)
oligomeganephronia  (ISS)
Optic Nerve Injuries  (IEP)
oral mucosa leukoplakia  (IEP)
osteoarthritis  (ISO)
osteochondrodysplasia  (ISO)
osteoporosis  (IEP)
Ovarian Neoplasms  (ISO)
Oxygen-Induced Retinopathy  (ISO)
plasmacytoma  (ISO)
polycystic ovary syndrome  (IEP,ISO)
post-traumatic stress disorder  (IEP)
Postoperative Cognitive Dysfunction  (IEP)
Premature Aging  (ISO)
priapism  (IEP)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (IEP)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (IDA)
retinal degeneration  (IEP,ISO)
Sarcopenia  (IEP)
Soft Tissue Neoplasms  (ISO)
Spinal Cord Injuries  (IEP)
squamous cell carcinoma  (IEP)
status epilepticus  (IDA,IEP)
stomach cancer  (ISO)
Subarachnoid Hemorrhage  (IEP)
synovial sarcoma  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
Testis Reperfusion Injury  (IEP)
Tongue Neoplasms  (IEP)
tongue squamous cell carcinoma  (ISO)
transient cerebral ischemia  (IDA,IEP)
transitional cell carcinoma  (ISO)
Transplant Rejection  (IEP)
type 2 diabetes mellitus  (IEP,ISO)
urinary bladder cancer  (ISO)
Ventricular Remodeling  (ISO)
Viral Bronchiolitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (EXP)
(+)-sesamin  (EXP,ISO)
(+)-taxifolin  (EXP)
(+)-Tetrandrine  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-anisomycin  (EXP)
(-)-citrinin  (ISO)
(-)-ephedrine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-gambogic acid  (ISO)
(-)-noscapine  (ISO)
(-)-selegiline  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(20S)-ginsenoside Rh2  (ISO)
(6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one  (ISO)
(E)-roxithromycin  (ISO)
(E)-thiamethoxam  (ISO)
(E,E)-germacrone  (ISO)
(R)-adrenaline  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP)
(R)-salsolinol  (EXP)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(R,S)-Scoulerine  (ISO)
(S)-(-)-perillyl alcohol  (ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (EXP,ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
(S)-ropivacaine  (EXP,ISO)
(Z)-ligustilide  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-dichloropropan-2-ol  (ISO)
1,3-dinitrobenzene  (EXP,ISO)
1,3-thiazolidine-2,4-dione  (ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1,4-naphthoquinone  (ISO)
1-(4'-hydroxy-3'-methoxyphenyl)-7-phenyl-3-heptanone  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
10-Hydroxycamptothecin  (ISO)
11-deoxycorticosterone  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-pyrazole  (ISO)
2''-galloylhyperin  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,5-hexanedione  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (ISO)
2-acetamidofluorene  (EXP)
2-acetamidophenol  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-aminoethoxydiphenylborane  (EXP)
2-chloroethanol  (EXP)
2-deoxy-D-glucose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (EXP,ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP,ISO)
2-tert-butylhydroquinone  (EXP,ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
20-hydroxyecdysone  (ISO)
20-hydroxypregn-4-en-3-one  (ISO)
25-hydroxycholesterol  (ISO)
3',4'-dimethoxyflavone  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-Dichlorobenzidine  (ISO)
3,3'-diindolylmethane  (ISO)
3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine  (ISO)
3,4-dihydroxybenzoic acid  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (EXP,ISO)
3-methylcholanthrene  (EXP,ISO)
3-methylthiopropanal  (ISO)
3-nitropropanoic acid  (EXP,ISO)
3-phenylprop-2-enal  (EXP,ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-amino-1,8-naphthalimide  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
4-nitroaniline  (ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (EXP,ISO)
4-octylphenol  (ISO)
4-phenylbutyric acid  (EXP,ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-Geranyloxy-7-methoxycoumarin  (ISO)
5-Hydroxycapric acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
5alpha-pregnane-3,20-dione  (ISO)
6-anilino-5,8-quinolinedione  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-oxocampestanol  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-dihydroxycoumarin  (ISO)
7-ketocholesterol  (EXP)
8-Br-cAMP  (ISO)
8-OH-DPAT  (ISO)
9,10-anthraquinone  (ISO)
9,10-phenanthroquinone  (ISO)
9,11,13-octadecatrienoic acid  (ISO)
9-cis-retinoic acid  (ISO)
9-Methoxycamptothecin  (ISO)
[6]-Shogaol  (ISO)
abamectin  (EXP)
ABT-737  (ISO)
acadesine  (EXP,ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acetamiprid  (EXP,ISO)
acetic acid  (EXP)
acetylsalicylic acid  (EXP,ISO)
acifluorfen  (ISO)
aconitine  (EXP)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
actinomycin D  (ISO)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
agomelatine  (EXP)
AH23848  (ISO)
alachlor  (ISO)
alantolactone  (ISO)
alborixin  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alendronic acid  (ISO)
alginic acid  (ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
allethrin  (EXP,ISO)
allicin  (ISO)
allopurinol  (EXP)
alloxan  (EXP)
Allyl chloride  (EXP)
Aloe emodin  (ISO)
Aloperine  (EXP)
alpha-amanitin  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-mangostin  (ISO)
alpha-phellandrene  (ISO)
alpha-Zearalanol  (ISO)
Alpinetin  (ISO)
alpinumisoflavone  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
alvocidib  (ISO)
AM-251  (ISO)
amentoflavone  (ISO)
amidotrizoic acid  (ISO)
amifostine  (ISO)
amino acid  (ISO)
aminoguanidine  (ISO)
aminophylline  (ISO)
amiodarone  (EXP,ISO)
amitriptyline  (EXP)
amitrole  (EXP)
amlexanox  (ISO)
amlodipine  (EXP,ISO)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
amodiaquine  (ISO)
amphetamine  (EXP,ISO)
amsacrine  (ISO)
andrographolide  (ISO)
Anemoside B4  (ISO)
anethole  (EXP)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony(0)  (EXP,ISO)
antimycin A  (ISO)
Antrocin  (ISO)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
aprepitant  (ISO)
arachidonic acid  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
arecoline  (EXP,ISO)
aristolochic acid A  (EXP,ISO)
arjunolic acid  (EXP,ISO)
Aroclor 1254  (EXP,ISO)
arotinoid acid  (ISO)
arsane  (EXP,ISO)
arsenic acid  (ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
artesunate  (EXP,ISO)
asarone  (ISO)
asbestos  (ISO)
asiatic acid  (EXP,ISO)
aspartame  (EXP,ISO)
Aspidin  (ISO)
astemizole  (EXP)
astilbin  (ISO)
astragaloside IV  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
Atranorin  (ISO)
atrasentan  (EXP)
atrazine  (EXP,ISO)
auranofin  (ISO)
aurantio-obtusin  (ISO)
aureusidin  (ISO)
Auriculasin  (ISO)
avermectin  (ISO)
azadirachtin A  (ISO)
azide  (ISO)
aziridines  (ISO)
Azoxymethane  (EXP,ISO)
bafilomycin A1  (EXP,ISO)
baicalein  (ISO)
baicalin  (EXP,ISO)
bathocuproine disulfonic acid  (ISO)
Bavachinin  (ISO)
Bay-K-8644  (ISO)
beauvericin  (ISO)
belinostat  (ISO)
benazepril  (EXP)
benomyl  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzoates  (ISO)
benzoic acid  (ISO)
benzophenanthridine  (ISO)
benzothiazoles  (ISO)
berberine  (EXP,ISO)
Berberrubine  (ISO)
Bergenin  (EXP,ISO)
Besigomsin  (ISO)
beta-aminopropionitrile  (ISO)
beta-carotene  (ISO)
beta-Elemonic acid  (ISO)
beta-ionone  (ISO)
beta-naphthoflavone  (EXP)
Beta-Solamarine  (ISO)
Betanin  (EXP)
betaxolol  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
Betulonic acid  (ISO)
bezafibrate  (EXP)
bicalutamide  (ISO)
bifenthrin  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP,ISO)
boric acid  (EXP,ISO)
boron atom  (EXP)
borrelidin  (ISO)
bortezomib  (ISO)
BQ 123  (EXP,ISO)
BQ 485  (EXP)
brassinin  (ISO)
brassinolide  (ISO)
brazilin  (ISO)
bromuconazole  (EXP)
brucine  (ISO)
Brusatol  (ISO)
bucladesine  (ISO)
budesonide  (ISO)
bufalin  (ISO)
bupivacaine  (ISO)
buprofezin  (ISO)
butanal  (ISO)
butane-2,3-dione  (ISO)
butein  (ISO)
Butralin  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
Butylphthalide  (EXP)
butyric acid  (ISO)
C.I. Natural Red 20  (EXP,ISO)
cabazitaxel  (ISO)
cadmium acetate  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium nitrate  (EXP)
cadmium sulfide  (ISO)
cadmium telluride  (ISO)
cafestol  (ISO)
caffeine  (EXP)
cajanol  (ISO)
calcidiol  (ISO)
Calcimycin  (ISO)
calciol  (ISO)
calcitriol  (EXP,ISO)
calcium oxalate  (ISO)
calycosin-7-O-beta-D-glucoside  (ISO)
camalexin  (ISO)
camptothecin  (ISO)
Candesartan cilexetil  (EXP)
cannabidiol  (EXP,ISO)
cantharidin  (EXP,ISO)
capillarisin  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
captan  (ISO)
carbachol  (EXP,ISO)
carbamate ester  (ISO)
carbamazepine  (EXP)
carbendazim  (EXP)
CARBENOXOLONE  (EXP,ISO)
carbidopa  (ISO)
carbofuran  (EXP)
carbon dioxide  (EXP)
carbon disulfide  (ISO)
carbon nanotube  (EXP,ISO)
carboplatin  (ISO)
carboxy-PTIO  (ISO)
Cardamonin  (EXP)
Cardanol  (ISO)
carmustine  (ISO)
carnosic acid  (EXP,ISO)
carnosine  (EXP,ISO)
Carnosol  (ISO)
carvacrol  (EXP)
carvedilol  (EXP)
casticin  (EXP,ISO)
catalpol  (ISO)
CEDRELONE  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
ceric oxide  (ISO)
ceritinib  (ISO)
ceruletide  (ISO)
cetrorelix  (EXP,ISO)
chalcones  (ISO)
chelerythrine  (EXP,ISO)
chelidonine  (ISO)
Chikusetsusaponin-IV  (ISO)
Chikusetsusaponin-V  (ISO)
CHIR 99021  (ISO)
chitosan  (EXP,ISO)
chlorambucil  (ISO)
chlordecone  (ISO)
chloroacetic acid  (ISO)
chlorogenic acid  (EXP,ISO)
chloroprene  (ISO)
chloroquine  (EXP,ISO)
chlorothalonil  (ISO)
chlorpyrifos  (EXP,ISO)
Cholestane-3,5,6-triol  (EXP)
cholesterol  (EXP,ISO)
choline  (ISO)
chromium(3+) trichloride  (ISO)
chromium(6+)  (EXP,ISO)
chrysazin  (ISO)
chrysene  (ISO)
chrysin  (EXP,ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
cilnidipine  (EXP,ISO)
cilostazol  (EXP,ISO)
cimetidine  (ISO)
Cinobufagin  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
Citreoviridin  (EXP,ISO)
citric acid  (ISO)
citronellal  (EXP)
cladribine  (ISO)
clofibrate  (ISO)
clonazepam  (EXP)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clorgyline  (ISO)
clozapine  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
codeinone  (ISO)
coenzyme Q10  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
colistin  (EXP,ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
coptisine  (ISO)
cordycepin  (EXP,ISO)
corilagin  (EXP)
corosolic acid  (EXP,ISO)
corticosterone  (EXP)
Corynoxine B  (ISO)
coumarin  (ISO)
coumarins  (ISO)
coumermycin A1  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP,ISO)
crocin-1  (EXP,ISO)
crotonaldehyde  (EXP)
crystal violet  (ISO)
CU-O LINKAGE  (ISO)
cucurbitacin B  (ISO)
cucurbitacin E  (EXP,ISO)
cudraflavone B  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyanamide  (EXP)
Cyanoginosin  (EXP)
cyclizine  (ISO)
cycloheximide  (ISO)
Cyclopamine  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
cylindrospermopsin  (EXP,ISO)
cypermethrin  (EXP,ISO)
cytarabine  (ISO)
cytochalasin B  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (EXP)
D-penicillamine  (ISO)
daidzein  (ISO)
dantrolene  (EXP)
dapagliflozin  (EXP)
dapoxetine  (EXP)
DAPT  (EXP)
daunorubicin  (EXP,ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
deferiprone  (ISO)
deguelin  (ISO)
dehydrocostus lactone  (ISO)
dehydroepiandrosterone  (EXP)
dehydroepiandrosterone sulfate  (EXP)
delphinidin  (ISO)
demethoxycurcumin  (ISO)
demethoxyfumitremorgin C  (ISO)
Dendrobine  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
Deoxyschizandrin  (ISO)
desferrioxamine B  (EXP,ISO)
desipramine  (EXP)
desloratadine  (ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
dextran sulfate  (ISO)
dextromethorphan  (EXP)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP,ISO)
diazoxide  (EXP,ISO)
dibenziodolium  (ISO)
dibenzoylmethane  (ISO)
dibromoacetic acid  (ISO)
Dibromoacetonitrile  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
dichromium trioxide  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
Didymin  (ISO)
dieckol  (ISO)
dieldrin  (ISO)
diepoxybutane  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (EXP,ISO)
diethyl sulfate  (ISO)
diethylstilbestrol  (EXP,ISO)
dihydroactinidiolide  (ISO)
diiodine  (ISO)
diisobutyl phthalate  (EXP,ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (EXP,ISO)
dimethomorph  (ISO)
Dimethyl phthalate  (EXP)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dioscin  (ISO)
diosgenin  (EXP,ISO)
diosmin  (EXP,ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP,ISO)
diprotium oxide  (ISO)
diquat  (EXP,ISO)
disodium cromoglycate  (EXP)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
dithionite(2-)  (EXP,ISO)
dizocilpine maleate  (EXP,ISO)
dobutamine  (ISO)
Dodecyl gallate  (ISO)
domoic acid  (ISO)
donepezil hydrochloride  (EXP,ISO)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
drimenol  (ISO)
dronedarone  (EXP)
ebselen  (EXP)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP)
echinacoside  (ISO)
Echinocystic acid  (EXP)
edaravone  (EXP)
edelfosine  (ISO)
elemental boron  (EXP)
elemental selenium  (EXP,ISO)
ellagic acid  (EXP,ISO)
ellipticine  (ISO)
embelin  (ISO)
emodin  (EXP,ISO)
enalapril  (EXP)
enalaprilat dihydrate  (ISO)
endosulfan  (EXP,ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epichlorohydrin  (ISO)
epoxomicin  (ISO)
erdosteine  (EXP)
eriocitrin  (ISO)
eritoran  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin estolate  (EXP)
esculetin  (ISO)
esketamine  (ISO)
estramustine  (ISO)
ethanol  (EXP,ISO)
ethidium  (ISO)
ethylbenzene  (EXP)
ethylene glycol  (EXP)
Ethylenethiourea  (ISO)
etodolac  (ISO)
etoposide  (ISO)
eugenol  (ISO)
EUK-134  (ISO)
everolimus  (EXP)
Evodiamine  (ISO)
excitatory amino acid agonist  (ISO)
farrerol  (ISO)
fasudil  (EXP)
favipiravir  (EXP)
febuxostat  (EXP)
fenbendazole  (ISO)
fenhexamid  (ISO)
fenitrothion  (EXP,ISO)
fenofibrate  (EXP,ISO)
fenpyroximate  (ISO)
fenvalerate  (EXP,ISO)
ferric oxide  (EXP,ISO)
ferrosoferric oxide  (ISO)
ferrostatin-1  (EXP,ISO)
ferulic acid  (EXP)
finasteride  (EXP)
fingolimod hydrochloride  (ISO)
fipronil  (EXP,ISO)
fisetin  (EXP,ISO)
flavanones  (ISO)
flavokawain B  (ISO)
flavones  (EXP,ISO)
flavonoids  (ISO)
flavonols  (ISO)
fluazinam  (ISO)
flubendazole  (ISO)
flucytosine  (ISO)
fludioxonil  (ISO)
flumethrin  (ISO)
fluoxetine  (EXP,ISO)
flutamide  (EXP)
flutriafol  (EXP)
fluvastatin  (EXP)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (EXP,ISO)
formononetin  (EXP,ISO)
formoterol fumarate  (ISO)
Forsythiaside  (ISO)
fraxetin  (ISO)
fructose  (EXP,ISO)
fucoxanthin  (ISO)
fulvestrant  (EXP,ISO)
fumagillin  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
furosemide  (EXP)
Fusarenone X  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (ISO)
galactose  (EXP,ISO)
galangin  (ISO)
galanthamine  (EXP)
galanthamine Trifluoroacetic acid  (EXP)
Galbanic acid  (ISO)
gallein  (EXP)
gallic acid  (EXP,ISO)
gamma-aminobutyric acid  (EXP)
gamma-hexachlorocyclohexane  (EXP,ISO)
gamma-tocopherol  (ISO)
ganciclovir  (ISO)
Ganoderic acid A  (ISO)
Garcinol  (ISO)
gardenin B  (ISO)
Gastrodin  (EXP,ISO)
gefitinib  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
Genipin  (ISO)
Geniposide  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
Gentiopicrin  (ISO)
Geraniin  (ISO)
geraniol  (EXP,ISO)
geranyl acetate  (ISO)
gingerol  (ISO)
ginkgetin  (ISO)
Ginkgoic acid  (ISO)
Ginkgolide C  (EXP)
ginsenoside Rd  (EXP)
ginsenoside Re  (ISO)
ginsenoside Rg1  (EXP,ISO)
ginsenoside Rg2  (EXP)
glabridin  (ISO)
gliclazide  (ISO)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glyburide  (EXP)
glycerol  (EXP)
glycidol  (EXP)
glycine betaine  (EXP,ISO)
glycyrrhetinate  (EXP,ISO)
glycyrrhetinic acid  (EXP,ISO)
glycyrrhizinic acid  (ISO)
glyoxylic acid  (ISO)
glyphosate  (EXP,ISO)
gold atom  (EXP,ISO)
gold(0)  (EXP,ISO)
Goserelin  (ISO)
gossypol  (ISO)
graphene oxide  (ISO)
graphite  (ISO)
Grifolin  (ISO)
GSK690693  (ISO)
guanidines  (ISO)
guggulsterone  (ISO)
Gyrophoric acid  (ISO)
haloperidol  (EXP)
hemin  (EXP,ISO)
heparin  (ISO)
heptachlor  (EXP)
herbacetin  (EXP)
hesperetin  (EXP,ISO)
hesperidin  (EXP,ISO)
hexachlorophene  (EXP)
hexadecanoic acid  (EXP,ISO)
hexaflumuron  (EXP)
hexane  (EXP)
hinokiflavone  (ISO)
histamine  (EXP)
homocysteine  (EXP,ISO)
homoeriodictyol  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxamic acid  (ISO)
hydroxychloroquine  (ISO)
hydroxytyrosol  (EXP,ISO)
hymexazol  (EXP)
hyperforin  (EXP,ISO)
hypoxanthine  (ISO)
icariin  (EXP,ISO)
icariside II  (ISO)
ICI 118551  (ISO)
icosanoid  (EXP)
idarubicin  (ISO)
idelalisib  (ISO)
Idoxifene  (EXP)
ifosfamide  (EXP,ISO)
Ilimaquinone  (ISO)
imidacloprid  (EXP)
Imipenem-cilastatin  (EXP)
imiquimod  (ISO)
indirubin  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
inositol  (ISO)
Inotodiol  (ISO)
iodoacetic acid  (ISO)
iohexol  (EXP,ISO)
Ioversol  (EXP)
iprodione  (EXP)
irbesartan  (EXP,ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron dextran  (EXP,ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (EXP,ISO)
isocarbophos  (ISO)
isoflavones  (EXP,ISO)
isoflurane  (EXP,ISO)
Isoliensinine  (ISO)
isoliquiritigenin  (ISO)
isoniazide  (ISO)
isoorientin  (EXP)
isoprenaline  (EXP,ISO)
isoquinoline-1,5-diol  (ISO)
isorhamnetin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
JBIR-99  (ISO)
juglone  (ISO)
Jujuboside A  (EXP,ISO)
kaempferol  (EXP,ISO)
kahweol  (ISO)
kainic acid  (EXP,ISO)
ketamine  (EXP,ISO)
ketoconazole  (ISO)
KN-93  (ISO)
Kukoamine B  (ISO)
L-1,4-dithiothreitol  (ISO)
L-arginine  (ISO)
L-ascorbic acid  (EXP,ISO)
L-dehydroascorbic acid  (ISO)
L-gamma-glutamyl-L-cysteine  (EXP)
L-glutamic acid  (EXP,ISO)
L-methionine  (EXP,ISO)
L-mimosine  (ISO)
lactacystin  (EXP,ISO)
lactucin  (ISO)
lamivudine  (ISO)
lamotrigine  (EXP)
lansoprazole  (EXP)
lapatinib  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (ISO)
leptomycin B  (ISO)
letrozole  (EXP)
leuprolide  (EXP)
levamisole  (ISO)
levetiracetam  (EXP)
levonorgestrel  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP,ISO)
lignan  (ISO)
limonene  (ISO)
limonin  (ISO)
linalool  (ISO)
linoleic acid  (EXP)
linsidomine  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
liraglutide  (EXP,ISO)
lisinopril dihydrate  (ISO)
lithium atom  (EXP,ISO)
lithium chloride  (EXP,ISO)
lithium hydride  (EXP,ISO)
loganin  (ISO)
lonafarnib  (ISO)
Longikaurin A  (ISO)
lonidamine  (ISO)
loperamide  (ISO)
losartan  (EXP)
lovastatin  (EXP,ISO)
Lupalbigenin  (ISO)
lupeol  (EXP,ISO)
Lupiwighteone  (ISO)
lupulone  (ISO)
lutein  (ISO)
luteolin  (ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
LY294002  (EXP,ISO)
lycopene  (EXP,ISO)
maculosin  (ISO)
madecassoside  (ISO)
magnesium atom  (EXP)
magnesium oxide  (ISO)
Magnolol  (ISO)
malaoxon  (ISO)
malathion  (EXP,ISO)
malonic acid  (EXP)
malvidin  (ISO)
mancozeb  (EXP,ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
mebendazole  (ISO)
Mecamylamine  (ISO)
mechlorethamine  (ISO)
mefenamic acid  (ISO)
meglumine amidotrizoate  (EXP,ISO)
MeIQx  (ISO)
melamine  (ISO)
Melarsoprol  (ISO)
melatonin  (EXP,ISO)
melittin  (EXP,ISO)
melphalan  (ISO)
memantine  (EXP,ISO)
menadione  (EXP,ISO)
menaquinone  (EXP)
mercaptopurine  (ISO)
mercury atom  (EXP)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP)
mesalamine  (EXP)
metaproterenol  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methimazole  (EXP)
methomyl  (ISO)
methotrexate  (EXP,ISO)
methoxsalen  (ISO)
methoxychlor  (EXP,ISO)
methyl caffeate  (ISO)
methyl methanesulfonate  (ISO)
methylene blue  (EXP)
methylglyoxal  (EXP,ISO)
methylisothiazolinone  (ISO)
methyllycaconitine  (EXP)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
methylseleninic acid  (EXP)
metipranolol  (EXP)
metiram  (ISO)
metrafenone  (ISO)
mevalonic acid  (EXP,ISO)
mevinphos  (EXP)
microcystin  (EXP)
microcystin RR  (ISO)
microcystin-LR  (EXP,ISO)
midazolam  (EXP)
mifepristone  (ISO)
miglustat  (ISO)
minocycline  (EXP,ISO)
mirtazapine  (ISO)
mitomycin C  (ISO)
Mitotane  (EXP,ISO)
MitoTEMPO  (ISO)
mitoxantrone  (ISO)
MK-2206  (ISO)
ML-7  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (EXP,ISO)
monocrotophos  (EXP)
monoethyl phthalate  (ISO)
monosodium L-glutamate  (EXP,ISO)
montelukast  (ISO)
morin  (EXP,ISO)
morphine  (EXP,ISO)
Morroniside  (EXP,ISO)
morusin  (ISO)
mycophenolic acid  (ISO)
myricetin  (ISO)
myricitrin  (ISO)
myristicin  (ISO)
Myrtucommulone A  (ISO)
N'-Nitrosonornicotine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N,N-dimethylsphingosine  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-[2-amino-6-[(4-fluorophenyl)methylamino]-3-pyridinyl]carbamic acid ethyl ester  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-methylnicotinate  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-phosphocreatine  (EXP,ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
nabumetone  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
naloxone  (EXP,ISO)
naphthalene  (ISO)
naphthalenes  (ISO)
naringin  (EXP,ISO)
Neferine  (EXP)
neoastilbin  (ISO)
Neoisoliquiritin  (ISO)
neomycin  (ISO)
nerolidol  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel ferrite  (ISO)
nickel subsulfide  (ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (ISO)
nicorandil  (EXP)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nifedipine  (EXP,ISO)
nigericin  (ISO)
nilotinib  (ISO)
nimesulide  (EXP,ISO)
nimodipine  (EXP,ISO)
Nitidine  (ISO)
nitrendipine  (EXP)
nitric oxide  (ISO)
nitrofen  (EXP)
nitroglycerin  (EXP)
nitroprusside  (EXP,ISO)
nitroxoline  (ISO)
NMS-873  (ISO)
nobiletin  (EXP,ISO)
nocodazole  (ISO)
Nodularin  (ISO)
Nonylphenol  (EXP,ISO)
Norbinaltorphimine  (ISO)
NORCANTHARIDIN  (ISO)
Norethindrone enanthate  (EXP)
norfloxacin  (ISO)
norwogonin  (EXP,ISO)
notoginsenoside R1  (EXP,ISO)
NS 1619  (ISO)
NS-398  (ISO)
Nutlin-3  (ISO)
o-anisidine  (ISO)
o-cresol  (EXP)
Obacunone  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
octyl gallate  (ISO)
okadaic acid  (ISO)
olanzapine  (EXP)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oleuropein  (EXP,ISO)
oligomycin A  (ISO)
oligopeptide  (ISO)
Olmesartan medoxomil  (EXP)
omacetaxine mepesuccinate  (ISO)
omeprazole  (ISO)
Ophiopogonin D  (ISO)
orciprenaline  (ISO)
organoselenium compound  (EXP)
oridonin  (EXP,ISO)
orlistat  (EXP)
oroxylin A  (ISO)
osthole  (ISO)
ouabain  (ISO)
oxalic acid  (ISO)
oxaliplatin  (EXP,ISO)
oxidopamine  (EXP,ISO)
oxomalononitrile  (ISO)
oxytocin  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
Pachymic acid  (ISO)
paclitaxel  (EXP,ISO)
paeoniflorin  (EXP,ISO)
Paeonol  (EXP,ISO)
palmatine  (ISO)
Palmitic acid(d3)  (ISO)
pamidronate  (ISO)
Panaxynol  (EXP)
Panduratin A  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
paricalcitol  (ISO)
parthenolide  (ISO)
pefloxacin  (ISO)
pemetrexed  (ISO)
pendimethalin  (EXP)
Pendulone  (ISO)
pentanal  (ISO)
pentobarbital  (EXP)
Pentoxifylline  (EXP)
perfluoroheptanoic acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (EXP)
perillyl alcohol  (ISO)
permethrin  (EXP,ISO)
peroxynitrous acid  (EXP)
pevonedistat  (ISO)
PF-3758309  (ISO)
Phellopterin  (ISO)
phenazine-1-carboxylic acid  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP,ISO)
phenylhydrazine  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
phloretin  (EXP)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphatidylcholine  (ISO)
phosphoramide mustard  (EXP)
phylloquinone  (EXP,ISO)
phytol  (ISO)
phytosphingosine  (ISO)
piclamilast  (EXP)
picoxystrobin  (ISO)
pifithrin-alpha hydrobromide  (EXP,ISO)
pimozide  (ISO)
pinostrobin  (EXP,ISO)
pioglitazone  (EXP)
piperazine  (ISO)
piperidine  (ISO)
piperine  (ISO)
Pirarubicin  (ISO)
pirinixic acid  (EXP,ISO)
PK-11195  (EXP,ISO)
platinum  (ISO)
platinum(0)  (ISO)
platycodin D  (ISO)
plumbagin  (EXP)
poly(I:C)  (ISO)
Polygodial  (ISO)
polysulfur  (ISO)
ponatinib  (ISO)
Ponicidin  (ISO)
porphyrins  (ISO)
potassium bromate  (EXP)
potassium cyanide  (EXP)
potassium dichromate  (EXP,ISO)
potassium iodide  (EXP)
Pramanicin  (ISO)
Pranoprofen  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
proanthocyanidin  (EXP,ISO)
probenecid  (ISO)
probucol  (EXP)
procyanidin  (ISO)
procyanidin B2  (ISO)
prodigiosin  (EXP)
progesterone  (EXP,ISO)
promethazine  (ISO)
propionic acid  (EXP)
propofol  (EXP,ISO)
propranolol  (EXP,ISO)
propylparaben  (ISO)
prostaglandin E2  (ISO)
Protolichesterinic acid  (ISO)
psoralen  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
Punicalagin  (EXP,ISO)
purine-6-thiol  (ISO)
purmorphamine  (EXP)
puromycin  (ISO)
putrescine  (EXP)
pyrethrins  (EXP,ISO)
pyridaben  (ISO)
Pyridostigmine bromide  (ISO)
pyridoxal 5'-phosphate  (EXP)
pyrroles  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
pyrroloquinoline quinone  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (EXP)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quercetin 4'-O-beta-D-glucopyranoside  (ISO)
quinazolines  (ISO)
quinolinic acid  (EXP)
quinoxyfen  (ISO)
quizartinib  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ramipril  (EXP)
ranitidine  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
remdesivir  (ISO)
reserpine  (EXP)
resolvin D1  (EXP)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
rifampicin  (ISO)
Riluzole  (EXP)
rimonabant  (ISO)
ritonavir  (ISO)
rivastigmine  (EXP)
Ro 31-8220  (EXP)
rocaglamide  (ISO)
roflumilast  (EXP,ISO)
rolipram  (EXP)
ropinirole  (ISO)
rosmarinic acid  (ISO)
rosuvastatin calcium  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
royal jelly  (EXP,ISO)
RU 58668  (ISO)
rubitecan  (ISO)
ruthenium atom  (EXP)
rutin  (EXP,ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-allylcysteine  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
S-nitrosoglutathione  (ISO)
saccharin  (EXP)
safrole  (ISO)
Salidroside  (EXP,ISO)
Salinomycin  (ISO)
Salmeterol xinafoate  (ISO)
salubrinal  (EXP,ISO)
Salvianolic acid A  (EXP)
salvianolic acid B  (EXP)
Sanggenon C  (EXP,ISO)
sanguinarine  (EXP,ISO)
sappanchalcone  (ISO)
sarin  (EXP)
sarpogrelate  (ISO)
saxagliptin  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SB-239063  (EXP)
SCH 23390  (EXP,ISO)
SCH772984  (ISO)
sclareol  (ISO)
scoparone  (ISO)
scopolamine  (EXP,ISO)
scopoletin  (EXP)
scutellarin  (ISO)
Se-methyl-L-selenocysteine  (EXP,ISO)
Se-methylselenocysteine  (EXP,ISO)
selenium atom  (EXP,ISO)
selenocystine  (ISO)
selenomethionine  (ISO)
semaglutide  (EXP,ISO)
semilicoisoflavone B  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
Sesamol  (ISO)
sevoflurane  (EXP,ISO)
Shikonin  (EXP,ISO)
sibutramine  (ISO)
sildenafil citrate  (EXP,ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simazine  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (EXP)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
SNX-2112  (ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium azide  (EXP)
sodium chloride  (EXP,ISO)
sodium cholate  (ISO)
sodium chromate  (ISO)
sodium dichromate  (EXP,ISO)
sodium disulfite  (ISO)
sodium fluoride  (EXP,ISO)
sodium nitrite  (EXP)
sodium silicate  (EXP)
Sophoricoside  (ISO)
sorafenib  (ISO)
soybean oil  (EXP)
spermine  (EXP,ISO)
sphingosine 1-phosphate  (ISO)
spironolactone  (EXP)
Spiroquinazoline  (ISO)
squalene  (EXP)
stattic  (ISO)
staurosporine  (ISO)
stavudine  (ISO)
sterigmatocystin  (ISO)
stilbenoid  (ISO)
streptozocin  (EXP,ISO)
styrene  (ISO)
styrene oxide  (EXP,ISO)
succimer  (EXP)
sulfadimethoxine  (EXP)
sulfaphenazole  (ISO)
sulfasalazine  (EXP,ISO)
sulforaphane  (ISO)
sulfur atom  (ISO)
sulfur dioxide  (ISO)
sulindac  (EXP,ISO)
sulindac sulfide  (ISO)
sulpiride  (ISO)
sunitinib  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
Swertiamarin  (EXP,ISO)
syringic acid  (ISO)
syringin  (ISO)
T-2 toxin  (EXP,ISO)
tacrine  (ISO)
tacrolimus hydrate  (EXP,ISO)
tadalafil  (EXP,ISO)
taiwanin C  (ISO)
talazoparib  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
Tanshinone I  (ISO)
Tariquidar  (ISO)
taurine  (EXP)
taurocholic acid  (ISO)
tauroursodeoxycholic acid  (EXP,ISO)
tazarotene  (ISO)
tebuconazole  (EXP,ISO)
telmisartan  (EXP)
temozolomide  (ISO)
TEMPO  (ISO)
Temsirolimus  (ISO)
terazosin  (ISO)
Terfenadine  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
tetrachloroethene  (ISO)
tetrachlorohydroquinone  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydropalmatine  (ISO)
tetramethylpyrazine  (EXP)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (EXP,ISO)
thapsigargin  (EXP,ISO)
theaflavin  (ISO)
Theaflavin 3,3'-digallate  (EXP,ISO)
theophylline  (ISO)
thiamethoxam  (ISO)
thiamine(1+) chloride  (EXP,ISO)
thioacetamide  (EXP,ISO)
thiostrepton  (ISO)
Thiotepa  (ISO)
thymol  (EXP,ISO)
thymol sulfate(1-)  (EXP,ISO)
thymoquinone  (EXP,ISO)
thyroxine  (EXP)
tigecycline  (EXP)
tin(II) chloride (anhydrous)  (EXP)
Tiron  (ISO)
titanium dioxide  (EXP,ISO)
tocopherol  (ISO)
Tomentosin  (ISO)
toosendanin  (ISO)
topotecan  (ISO)
trametinib  (ISO)
tranexamic acid  (ISO)
trans-anethole  (EXP)
trans-cinnamic acid  (EXP)
trans-piceid  (ISO)
tranylcypromine  (EXP)
triacetin  (ISO)
triazoles  (ISO)
tributylstannane  (EXP,ISO)
Tributyltin oxide  (EXP)
tributyrin  (ISO)
tricetin  (ISO)
trichlorfon  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (EXP,ISO)
triclosan  (ISO)
trifluoperazine  (ISO)
trilobatin  (EXP)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tropisetron  (EXP)
Tubeimoside I  (ISO)
tubocurarine  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
umbelliferone  (EXP,ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (ISO)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vanadyl sulfate  (ISO)
vancomycin  (EXP)
vemurafenib  (ISO)
venetoclax  (ISO)
venlafaxine hydrochloride  (EXP)
venom  (ISO)
verapamil  (ISO)
Vernodalin  (ISO)
verteporfin  (EXP)
Vicanicin  (ISO)
vildagliptin  (EXP)
vinclozolin  (ISO)
vincristine  (EXP,ISO)
vindesine  (ISO)
Vinpocetine  (EXP)
vismodegib  (ISO)
vitamin D  (ISO)
vitamin E  (EXP,ISO)
vitexin  (ISO)
vorinostat  (EXP,ISO)
warfarin  (EXP)
water  (ISO)
wedelolactone  (ISO)
WIN 55212-2  (ISO)
withaferin A  (EXP,ISO)
wogonin  (ISO)
wortmannin  (EXP,ISO)
xanthohumol  (EXP,ISO)
Xanthorrhizol  (ISO)
xenon atom  (EXP)
xenon(0)  (EXP)
XMU-MP-1  (ISO)
Y-27632  (EXP,ISO)
ytterbium  (ISO)
zearalenone  (EXP,ISO)
zebularine  (ISO)
zerumbone  (EXP,ISO)
zidovudine  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc molecular entity  (ISO)
zinc oxide  (EXP,ISO)
zinc protoporphyrin  (EXP,ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP,ISO)
zingiberene  (EXP)
ziram  (EXP)
zoledronic acid  (ISO)
zolmitriptan  (EXP)
zoxamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (ISO)
animal organ morphogenesis  (ISO)
apoptotic mitochondrial changes  (ISO)
apoptotic process  (IEA,ISO)
autophagy  (IEA,ISO)
axon regeneration  (ISO)
axonogenesis  (ISO)
B cell apoptotic process  (ISO)
B cell differentiation  (ISO)
B cell homeostasis  (ISO)
B cell lineage commitment  (ISO)
B cell proliferation  (ISO)
B cell receptor signaling pathway  (ISO)
behavioral fear response  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
calcium ion transport into cytosol  (ISO)
CD8-positive, alpha-beta T cell lineage commitment  (ISO)
cell migration  (ISO)
cell morphogenesis  (ISO)
cell population proliferation  (ISO)
cell-cell adhesion  (ISO)
cellular response to fluoride  (IEP)
cellular response to glucose starvation  (ISO)
cellular response to glucose stimulus  (IEP)
cellular response to hydrogen peroxide  (IEP)
cellular response to hypoxia  (IEP,ISO)
cellular response to L-glutamate  (IEP)
cerebral cortex development  (IEP)
cochlear nucleus development  (ISO)
defense response to virus  (ISO)
dendritic cell apoptotic process  (ISO)
developmental growth  (ISO)
developmental pigmentation  (ISO)
digestive tract morphogenesis  (ISO)
DNA damage response  (ISO)
ear development  (ISO)
endoplasmic reticulum calcium ion homeostasis  (ISO)
epithelial cell apoptotic process  (ISO)
establishment of localization in cell  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA,ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
focal adhesion assembly  (ISO)
G1/S transition of mitotic cell cycle  (ISO)
gland morphogenesis  (ISO)
glial cell apoptotic process  (IEP)
glomerulus development  (ISO)
gonad development  (IEA)
hair follicle morphogenesis  (ISO)
hematopoietic stem cell differentiation  (ISO)
hemopoiesis  (ISO)
homeostasis of number of cells within a tissue  (ISO)
immune system development  (ISO)
intracellular calcium ion homeostasis  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IBA,ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
intrinsic apoptotic signaling pathway in response to oxidative stress  (ISO)
kidney development  (ISO)
leukocyte homeostasis  (ISO)
liver regeneration  (IEP)
lymphocyte apoptotic process  (ISO)
lymphocyte homeostasis  (ISO)
lymphoid progenitor cell differentiation  (ISO)
male gonad development  (ISO)
melanin metabolic process  (ISO)
melanocyte differentiation  (ISO)
mesenchymal cell development  (ISO)
metanephros development  (ISO)
mitotic cell cycle  (ISO)
motor neuron apoptotic process  (ISO)
myeloid cell apoptotic process  (ISO)
negative regulation of anoikis  (ISO)
negative regulation of apoptotic process  (IDA,IEA,IMP,ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of autophagy  (ISO,ISS)
negative regulation of B cell apoptotic process  (ISO)
negative regulation of calcium ion transport into cytosol  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of cell growth  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cellular pH reduction  (ISO)
negative regulation of dendritic cell apoptotic process  (ISO)
negative regulation of epithelial cell apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (ISO)
negative regulation of lymphocyte apoptotic process  (ISO)
negative regulation of mitotic cell cycle  (ISO)
negative regulation of motor neuron apoptotic process  (ISO)
negative regulation of myeloid cell apoptotic process  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of ossification  (ISO)
negative regulation of osteoblast proliferation  (ISO)
negative regulation of retinal cell programmed cell death  (ISO)
negative regulation of T cell apoptotic process  (ISO)
neuron apoptotic process  (ISO)
neuron maturation  (ISO)
oligodendrocyte differentiation  (IEP)
oocyte development  (ISO)
organ growth  (ISO)
ossification  (ISO)
osteoblast proliferation  (ISO)
ovarian follicle development  (IEP,ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
pigment granule organization  (ISO)
pigmentation  (ISO)
positive regulation of apoptotic process  (IBA)
positive regulation of B cell proliferation  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of developmental pigmentation  (ISO)
positive regulation of melanocyte differentiation  (ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of neuron maturation  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of skeletal muscle fiber development  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
post-embryonic development  (ISO)
protein dephosphorylation  (ISO)
protein polyubiquitination  (ISO)
reactive oxygen species metabolic process  (ISO)
regulation of apoptotic process  (IEA,ISO)
regulation of autophagy  (ISO)
regulation of calcium ion transport  (ISO)
regulation of catalytic activity  (ISO)
regulation of cell cycle  (ISO)
regulation of cell-matrix adhesion  (ISO)
regulation of developmental pigmentation  (ISO)
regulation of gene expression  (ISO)
regulation of glycoprotein biosynthetic process  (ISO)
regulation of growth  (ISO)
regulation of mitochondrial membrane permeability  (ISO,ISS)
regulation of mitochondrial membrane potential  (ISO,ISS)
regulation of neuron apoptotic process  (IEP)
regulation of nitrogen utilization  (ISO)
regulation of programmed cell death  (ISO)
regulation of protein localization  (ISO)
regulation of protein stability  (ISO)
regulation of viral genome replication  (ISO)
release of cytochrome c from mitochondria  (IBA,ISO,ISS)
renal system process  (ISO)
response to aluminum ion  (IEP)
response to amyloid-beta  (IEP)
response to anesthetic  (IEP)
response to caffeine  (IEP)
response to cAMP  (IEP)
response to copper ion  (IEP)
response to corticosterone  (IEP)
response to cytokine  (IEP,ISO)
response to electrical stimulus  (IEP)
response to erythropoietin  (IEP)
response to estrogen  (IEP)
response to ethanol  (IDA,IEP)
response to folic acid  (IEP)
response to gamma radiation  (ISO)
response to glucocorticoid  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (IEP)
response to insulin  (IEP)
response to insulin-like growth factor stimulus  (IEP)
response to iron ion  (ISO)
response to ischemia  (IEP,ISO)
response to L-ascorbic acid  (IEP)
response to monosaccharide  (IEP)
response to nicotine  (IEP,ISO)
response to nutrient  (IEP)
response to oxidative stress  (ISO)
response to peptide hormone  (IEP)
response to phenylpropanoid  (IEP)
response to steroid hormone  (ISO)
response to toxic substance  (ISO)
response to UV-B  (ISO)
response to vitamin E  (IEP)
response to xenobiotic stimulus  (IEP,ISO)
retinal cell programmed cell death  (ISO)
skeletal muscle fiber development  (ISO)
smooth muscle cell migration  (ISO)
spleen development  (ISO)
stem cell development  (ISO)
swimming behavior  (IEP)
T cell apoptotic process  (ISO)
T cell differentiation  (ISO)
T cell differentiation in thymus  (ISO)
T cell homeostasis  (ISO)
T cell lineage commitment  (ISO)
thymus development  (ISO)
ureteric bud development  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The Bcl-2 apoptotic switch in cancer development and therapy. Adams JM and Cory S, Oncogene. 2007 Feb 26;26(9):1324-37.
2. Neuroprotective Effect of Nanodiamond in Alzheimer's Disease Rat Model: a Pivotal Role for Modulating NF-kappaB and STAT3 Signaling. Alawdi SH, etal., Mol Neurobiol. 2016 Feb 20.
3. Lung injury after ischemia-reperfusion of small intestine in rats involves apoptosis of type II alveolar epithelial cells mediated by TNF-alpha and activation of Bid pathway. An S, etal., Apoptosis. 2007 Nov;12(11):1989-2001. doi: 10.1007/s10495-007-0125-1.
4. Combination of PTEN gene therapy and radiation inhibits the growth of human prostate cancer xenografts. Anai S, etal., Hum Gene Ther. 2006 Oct;17(10):975-84.
5. BAG-4/SODD and associated antiapoptotic proteins are linked to aggressiveness of epithelial ovarian cancer. Annunziata CM, etal., Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6585-92.
6. The AA genotype of the regulatory BCL2 promoter polymorphism ( 938C>A) is associated with a favorable outcome in lymph node negative invasive breast cancer patients. Bachmann HS, etal., Clin Cancer Res. 2007 Oct 1;13(19):5790-7.
7. Effects of sulfur dioxide on apoptosis-related gene expressions in lungs from rats. Bai J and Meng Z, Regul Toxicol Pharmacol. 2005 Dec;43(3):272-9. Epub 2005 Oct 26.
8. Elevated caspase and AIF gene expression correlate with progression of sarcopenia during aging in male F344BN rats. Baker DJ and Hepple RT, Exp Gerontol. 2006 Nov;41(11):1149-56. Epub 2006 Oct 6.
9. Cardioprotective role of growth/differentiation factor 1 in post-infarction left ventricular remodelling and dysfunction. Bao MW, etal., J Pathol. 2015 Jul;236(3):360-72. doi: 10.1002/path.4523. Epub 2015 Mar 30.
10. Altered expression of Bcl-2 and Bax in follicles within dehydroepiandrosterone-induced polycystic ovaries in rats. Bas D, etal., Cell Biol Int. 2011 May;35(5):423-9. doi: 10.1042/CBI20100542.
11. Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation. Bhattacharjee M, etal., Int Immunol. 2008 Dec;20(12):1489-505. Epub 2008 Oct 17.
12. T11TS Treatment Augments Apoptosis of Glioma Associated Brain Endothelial Cells, Hint Toward Anti-Angiogenic Action in Glioma. Bhattacharya D, etal., J Cell Physiol. 2017 Mar;232(3):526-539. doi: 10.1002/jcp.25447. Epub 2016 Jun 21.
13. Cell death is associated with reduced base excision repair during chronic alcohol administration in adult rat brain. Bhupanapadu Sunkesula SR, etal., Neurochem Res. 2008 Jun;33(6):1117-28. Epub 2008 Feb 8.
14. Double inhibition of XIAP and Bcl-2 axis is beneficial for retrieving sensitivity of renal cell cancer to apoptosis. Bilim V, etal., Br J Cancer. 2008 Mar 11;98(5):941-9. Epub 2008 Feb 19.
15. Chemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancer. Bishayee A, etal., Int J Cancer. 2013 Sep 1;133(5):1054-63. doi: 10.1002/ijc.28108. Epub 2013 Mar 29.
16. Antitumour activity of a combined treatment with PMEDAP and docetaxel in the Prague inbred Sprague-Dawley/cub rat strain bearing T-cell lymphoma. Bobkov K, etal., Anticancer Res 2001 Jul-Aug;21(4A):2725-31.
17. Optimizing chemotherapy for transitional cell carcinoma by application of bcl-2 and bcl-xL antisense oligodeoxynucleotides. Bolenz C, etal., Urol Oncol. 2007 Nov-Dec;25(6):476-82.
18. The antibiotic erythromycin induces tolerance against transient global cerebral ischemia in rats (pharmacologic preconditioning). Brambrink AM, etal., Anesthesiology. 2006 Jun;104(6):1208-15.
19. Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cai D, etal., Cell Death Dis. 2016 Mar 31;7:e2161. doi: 10.1038/cddis.2016.67.
20. Phosphoinositol 3 kinase inhibitor, LY294002 increases bcl-2 protein and inhibits okadaic acid-induced apoptosis in Bcl-2 expressing renal epithelial cells. Carbott DE, etal., Apoptosis 2002 Feb;7(1):69-76.
21. Mutant animal models of stroke and gene expression: the stroke-prone spontaneously hypertensive rat. Carswell HV, etal., Methods Mol Med 2005;104:49-74.
22. Role of p97/Valosin-containing protein (VCP) and Jab1/CSN5 in testicular ischaemia-reperfusion injury. Cayli S, etal., J Mol Histol. 2016 Feb;47(1):91-100. doi: 10.1007/s10735-016-9652-9. Epub 2016 Jan 11.
23. A purine antimetabolite attenuates toll-like receptor-2, -4, and subarachnoid hemorrhage-induced brain apoptosis. Chang CZ, etal., J Surg Res. 2015 Dec;199(2):676-87. doi: 10.1016/j.jss.2015.06.011. Epub 2015 Jun 12.
24. Cilostazol therapy attenuates monocrotaline-induced pulmonary arterial hypertension in rat model. Chang LT, etal., Circ J. 2008 May;72(5):825-31.
25. Induction of Bcl-2 and Bax was related to hyperphosphorylation of tau and neuronal death induced by okadaic acid in rat brain. Chen LQ, etal., Anat Rec A Discov Mol Cell Evol Biol. 2005 Dec;287(2):1236-45.
26. Interfering effect and mechanism of neuregulin on experimental dementia model in rats. Chen Y, etal., Behav Brain Res. 2011 Sep 23;222(2):321-5. doi: 10.1016/j.bbr.2011.03.063. Epub 2011 Apr 5.
27. Tournefolic acid B attenuates amyloid beta protein-mediated toxicity by abrogating the calcium overload in mitochondria and retarding the caspase 8-truncated Bid-cytochrome c pathway in rat cortical neurons. Chi CW, etal., Eur J Pharmacol. 2008 May 31;586(1-3):35-43. Epub 2008 Feb 29.
28. Influence of BCL2-938C>A and BAX-248G>A promoter polymorphisms in the development of AML: case-control study from South India. Cingeetham A, etal., Tumour Biol. 2015 Sep;36(10):7967-76. doi: 10.1007/s13277-015-3457-4. Epub 2015 May 10.
29. Molecular markers and mortality in prostate cancer. Concato J, etal., BJU Int. 2007 Dec;100(6):1259-63. Epub 2007 Sep 10.
30. Acute caffeine administration decreased NOS and Bcl2 expression in rat skeletal muscles. Corsetti G, etal., Pharmacol Res. 2006 Oct 10;.
31. Propofol prevents autophagic cell death following oxygen and glucose deprivation in PC12 cells and cerebral ischemia-reperfusion injury in rats. Cui D, etal., PLoS One. 2012;7(4):e35324. doi: 10.1371/journal.pone.0035324. Epub 2012 Apr 11.
32. Epoetin delta as an antifibrotic agent in the remnant kidney rat: a possible role for transforming growth factor beta and hepatocyte growth factor. De Beuf A, etal., Nephron Exp Nephrol. 2010;115(3):e46-59. doi: 10.1159/000313830. Epub 2010 Apr 24.
33. Spontaneous apoptosis and proliferation detected by BCL-2 and CD71 proteins are important progression indicators within ZAP-70 negative chronic lymphocytic leukemia. Del Poeta G, etal., Leuk Lymphoma. 2010 Jan;51(1):95-106. doi: 10.3109/10428190903350421.
34. BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner. Dluzen D, etal., J Biol Chem. 2011 Mar 4;286(9):7705-13. doi: 10.1074/jbc.M110.207639. Epub 2011 Jan 6.
35. Differential expression of cyclin-dependent kinase inhibitors and apoptosis-related proteins in endocervical lesions. El-Ghobashy AA, etal., Eur J Cancer. 2007 Sep;43(13):2011-8. Epub 2007 Aug 10.
36. Effect of erythropoietin on bcl-2 gene expression in rat cardiac myocytes after traumatic brain injury. Emir M, etal., Transplant Proc. 2004 Dec;36(10):2935-8.
37. [The changes of inducible nitric oxide synthase activity and apoptosis-related gene expression in endotoxemia-induced rat diaphragm]. Fang YY, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013 May;29(3):209-12.
38. LPS-induced neutrophilic inflammation and Bcl-2 expression in metaplastic mucous cells. Foster JE, etal., Am J Physiol Lung Cell Mol Physiol 2003 Aug;285(2):L405-14. Epub 2003 Apr 18.
39. Heat shock protein 90 protects rat mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis via the PI3K/Akt and ERK1/2 pathways. Gao F, etal., J Zhejiang Univ Sci B. 2010 Aug;11(8):608-17. doi: 10.1631/jzus.B1001007.
40. The timing of re-institution of good blood glucose control affects apoptosis and expression of Bax and Bcl-2 in the retina of diabetic rats. Gao XY, etal., Mol Biol Rep. 2008 Nov 8.
41. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
42. Altered expression of Bcl2, Bad and Bax mRNA occurs in the rat cerebellum within hours after ethanol exposure on postnatal day 4 but not on postnatal day 9. Ge Y, etal., Brain Res Mol Brain Res. 2004 Oct 22;129(1-2):124-34.
43. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
44. Retinal ganglion cells do not extend axons by default: promotion by neurotrophic signaling and electrical activity. Goldberg JL, etal., Neuron 2002 Feb 28;33(5):689-702.
45. Bcl-2 expression in malignant melanoma and its prognostic significance. Grover R and Wilson GD, Eur J Surg Oncol. 1996 Aug;22(4):347-9.
46. Mitochondrial calcium regulates rat liver regeneration through the modulation of apoptosis. Guerra MT, etal., Hepatology. 2011 Jul;54(1):296-306. doi: 10.1002/hep.24367.
47. Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer. Gupta S, etal., Sci Rep. 2015 Nov 19;5:16811. doi: 10.1038/srep16811.
48. Expression and localisation of Bcl-2 and Bax proteins in developing rat ovary. Gursoy E, etal., Res Vet Sci. 2008 Feb;84(1):56-61. Epub 2007 Jun 13.
49. Dendroaspis natriuretic peptide protects the post-ischemic myocardial injury. Ha KC, etal., Regul Pept. 2006 Jan 15;133(1-3):13-9. Epub 2005 Nov 11.
50. Bcl-XL and Bcl-2 Expression in Bilharzial Squamous Cell Carcinoma of the Urinary Bladder: Which Protein Is Prognostic? Hameed DA, etal., Urology. 2008 Mar 14;.
51. The correlations between HPV16 infection and expressions of c-erbB-2 and bcl-2 in breast carcinoma. He Q, etal., Mol Biol Rep. 2008 Apr 22;.
52. Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Hsu SY, etal., Proc Natl Acad Sci U S A 1997 Nov 11;94(23):12401-6.
53. Dynamic changes of the anti- and pro-apoptotic proteins Bcl-w, Bcl-2, and Bax with Smac/Diablo mitochondrial release after photothrombotic ring stroke in rats. Hu XL, etal., Eur J Neurosci. 2004 Sep;20(5):1177-88.
54. Cytoprotective effect of American ginseng in a rat ethanol gastric ulcer model. Huang CC, etal., Molecules. 2013 Dec 27;19(1):316-26. doi: 10.3390/molecules19010316.
55. GAPDH/Siah1 cascade is involved in traumatic spinal cord injury and could be attenuated by sivelestat sodium. Huo J, etal., Neuroscience. 2016 Aug 25;330:171-80. doi: 10.1016/j.neuroscience.2016.05.054. Epub 2016 May 30.
56. Protective role of heme oxygenase 1 in the intestinal tissue injury in hemorrhagic shock in rats. Inoue K, etal., Shock. 2008 Feb;29(2):252-61.
57. Gene Data File Integration of LocusLink data, October 12, 2001
58. Bcl-2-related protein family gene expression during oligodendroglial differentiation. Itoh T, etal., J Neurochem 2003 Jun;85(6):1500-12.
59. Evaluation of insulin and ascorbic acid effects on expression of Bcl-2 family proteins and caspase-3 activity in hippocampus of STZ-induced diabetic rats. Jafari Anarkooli I, etal., Cell Mol Neurobiol. 2009 Feb;29(1):133-40. Epub 2008 Aug 30.
60. Isoflurane inhibits cardiac myocyte apoptosis during oxidative and inflammatory stress by activating Akt and enhancing Bcl-2 expression. Jamnicki-Abegg M, etal., Anesthesiology. 2005 Nov;103(5):1006-14.
61. Age-dependent cyclooxygenase-2 induction and neuronal damage after status epilepticus in the postnatal rat hippocampus. Jarvela JT, etal., Epilepsia. 2008 May;49(5):832-41. Epub 2007 Dec 10.
62. Vitamin A supplementation induces adipose tissue loss through apoptosis in lean but not in obese rats of the WNIN/Ob strain. Jeyakumar SM, etal., J Mol Endocrinol. 2005 Oct;35(2):391-8.
63. The effect of 17-methoxyl-7-hydroxy-benzene-furanchalcone isolated from Millettia pulchra on myocardial ischemia in vitro and in vivo. Jian J, etal., Planta Med. 2012 Aug;78(12):1324-31. doi: 10.1055/s-0032-1314964. Epub 2012 Jun 14.
64. [Effect of shuganjianpifang on the expression of BCL-2 and BAX in rats livers with hepatic fibrosis]. Jiang H, etal., Zhong Yao Cai. 2013 May;36(5):776-80.
65. Therapeutic effects of astragalus polysaccharides on inflammation and synovial apoptosis in rats with adjuvant-induced arthritis. Jiang JB, etal., Int J Rheum Dis. 2010 Oct;13(4):396-405. doi: 10.1111/j.1756-185X.2010.01555.x.
66. CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease. Jiao W, etal., Biochem Biophys Res Commun. 2018 Jul 2;501(4):1016-1022. doi: 10.1016/j.bbrc.2018.05.101. Epub 2018 May 18.
67. Attenuation of warm ischemia-reperfusion injury in the liver by bucillamine through decreased neutrophil activation and Bax/Bcl-2 modulation. Junnarkar SP, etal., J Gastroenterol Hepatol. 2010 Dec;25(12):1891-9. doi: 10.1111/j.1440-1746.2010.06312.x.
68. Hypothermia and rewarming induce gene expression and multiplication of cells in healthy rat prostate tissue. Kaija H, etal., PLoS One. 2015 May 21;10(5):e0127854. doi: 10.1371/journal.pone.0127854. eCollection 2015.
69. Immunohistochemical bcl-2 expression, p53 overexpression, PR and ER status in endometrial carcinoma and survival outcomes. Kalogiannidis I, etal., Eur J Gynaecol Oncol. 2008;29(1):19-25.
70. Experimental priapism is associated with increased oxidative stress and activation of protein degradation pathways in corporal tissue. Kanika ND, etal., Int J Impot Res. 2010 Nov-Dec;22(6):363-73. doi: 10.1038/ijir.2010.27. Epub 2010 Nov 18.
71. Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling. Katare R, etal., Circ Res. 2011 May 13;108(10):1238-51. doi: 10.1161/CIRCRESAHA.110.239111. Epub 2011 Apr 7.
72. Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane. Kaufmann T, etal., J Cell Biol 2003 Jan 6;160(1):53-64.
73. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
74. Heat stress induced apoptosis in BC-8 cells derived from AK-5 tumor involves downregulation of Bcl-2 and generation of reactive oxygen species. Khar A, etal., Indian J Exp Biol. 2006 Oct;44(10):802-8.
75. Treadmill exercise inhibits traumatic brain injury-induced hippocampal apoptosis. Kim DH, etal., Physiol Behav. 2010 Dec 2;101(5):660-5. doi: 10.1016/j.physbeh.2010.09.021. Epub 2010 Oct 1.
76. N-acetylcysteine attenuates glycerol-induced acute kidney injury by regulating MAPKs and Bcl-2 family proteins. Kim JH, etal., Nephrol Dial Transplant. 2010 May;25(5):1435-43. doi: 10.1093/ndt/gfp659. Epub 2009 Dec 27.
77. The neuroprotective effect of recombinant human erythropoietin via an antiapoptotic mechanism on hypoxic-ischemic brain injury in neonatal rats. Kim MS, etal., Korean J Pediatr. 2010 Oct;53(10):898-908. doi: 10.3345/kjp.2010.53.10.898. Epub 2010 Oct 31.
78. Glucose-dependent insulinotropic polypeptide-mediated up-regulation of beta-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic AMP (cAMP) response element binding protein (CREB) and cAMP-responsive CREB coactivator 2. Kim SJ, etal., Mol Cell Biol. 2008 Mar;28(5):1644-56. Epub 2007 Dec 17.
79. Angiotensin II type 1 receptor-activated caspase-3 through ras/mitogen-activated protein kinase/extracellular signal-regulated kinase in the rostral ventrolateral medulla is involved in sympathoexcitation in stroke-prone spontaneously hypertensive rats. Kishi T, etal., Hypertension. 2010 Feb;55(2):291-7. doi: 10.1161/HYPERTENSIONAHA.109.138636. Epub 2010 Jan 11.
80. Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease. Kitamura Y, etal., Brain Res. 1998 Jan 12;780(2):260-9.
81. Repeated Unpredictable Stress and Antidepressants Differentially Regulate Expression of the Bcl-2 Family of Apoptotic Genes in Rat Cortical, Hippocampal, and Limbic Brain Structures. Kosten TA, etal., Neuropsychopharmacology. 2007 Aug 15;.
82. Tumor growth fraction, expression of estrogen and progesterone receptors, p53, bcl-2 and cathepsin D activity in primary ductal invasive breast carcinoma and their axillary lymph node metastases. Kristek J, etal., Coll Antropol. 2007 Dec;31(4):1043-7.
83. Immunohistochemical and histomorphological analysis of rat mammary tumors after simvastatin treatment. Kubatka P, etal., Neoplasma. 2012;59(5):516-23. doi: 10.4149/neo_2012_066.
84. The hyperglycemia stimulated myocardial endoplasmic reticulum (ER) stress contributes to diabetic cardiomyopathy in the transgenic non-obese type 2 diabetic rats: a differential role of unfolded protein response (UPR) signaling proteins. Lakshmanan AP, etal., Int J Biochem Cell Biol. 2013 Feb;45(2):438-47. doi: 10.1016/j.biocel.2012.09.017. Epub 2012 Sep 29.
85. Granulocyte-colony stimulating factor inhibits neuronal apoptosis in a rat model of diabetic cerebral ischemia. Lan X, etal., Tohoku J Exp Med. 2008 Oct;216(2):117-26.
86. Interleukin-15 is associated with disease severity in viral bronchiolitis. Leahy TR, etal., Eur Respir J. 2016 Jan;47(1):212-22. doi: 10.1183/13993003.00642-2015. Epub 2015 Nov 5.
87. Conventional (clear cell) renal carcinoma metastases have greater bcl-2 expression than high-risk primary tumors. Lee CT, etal., Urol Oncol. 2003 May-Jun;21(3):179-84.
88. The coexistence of nocturnal sustained hypoxia and obesity additively increases cardiac apoptosis. Lee SD, etal., J Appl Physiol. 2008 Apr;104(4):1144-53. Epub 2008 Jan 17.
89. Comparison between axonal and retinal ganglion cell gene expression in various optic nerve injuries including glaucoma. Levkovitch-Verbin H, etal., Mol Vis. 2013 Dec 16;19:2526-41. eCollection 2013.
90. Edaravone attenuates neuronal apoptosis in hypoxic-ischemic brain damage rat model via suppression of TRAIL signaling pathway. Li C, etal., Int J Biochem Cell Biol. 2018 Jun;99:169-177. doi: 10.1016/j.biocel.2018.03.020. Epub 2018 Apr 7.
91. Effect of Lichong decoction on expression of Bcl-2 and Bcl-2-associated X protein mRNAs in hysteromyoma model rat. Li D, etal., J Tradit Chin Med. 2013 Apr;33(2):238-42.
92. [Effect of NG-nitro-L-arginine on pulmonary surfactant and pulmonary apoptosis in acute lung injury induced by lipopolysaccharide]. Li LP, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2010 Jul;22(7):397-400.
93. Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving beta-catenin, c-Myc and E2F1. Li Q, etal., Oncogene. 2007 Sep 13;26(42):6194-202. Epub 2007 Apr 2.
94. 7,3'-dimethoxy hesperetin inhibits inflammation by inducing synovial apoptosis in rats with adjuvant-induced arthritis. Li R, etal., Immunopharmacol Immunotoxicol. 2013 Feb;35(1):139-46. doi: 10.3109/08923973.2012.723010. Epub 2012 Sep 17.
95. Intravenous transfusion of endothelial colony-forming cells attenuates vascular degeneration after cerebral aneurysm induction. Li S, etal., Brain Res. 2014 Dec 17;1593:65-75. doi: 10.1016/j.brainres.2014.09.077. Epub 2014 Oct 12.
96. By improving regional cortical blood flow, attenuating mitochondrial dysfunction and sequential apoptosis galangin acts as a potential neuroprotective agent after acute ischemic stroke. Li S, etal., Molecules. 2012 Nov 9;17(11):13403-23. doi: 10.3390/molecules171113403.
97. PARP inhibition restores erectile function by suppressing corporal smooth muscle apoptosis in diabetic rats. Li WJ, etal., J Sex Med. 2011 Apr;8(4):1072-82. doi: 10.1111/j.1743-6109.2010.02176.x. Epub 2011 Jan 14.
98. Increased neuronal apoptosis in medial prefrontal cortex is accompanied with changes of Bcl-2 and Bax in a rat model of post-traumatic stress disorder. Li Y, etal., J Mol Neurosci. 2013 Sep;51(1):127-37. doi: 10.1007/s12031-013-9965-z. Epub 2013 Feb 5.
99. [Excessive copper induces hepatocyte apoptosis and affects Bax and Bcl-2 expression in rat live.] Li YW, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2008 Feb;10(1):42-6.
100. Ginkgolic acid (GA) suppresses gastric cancer growth by inducing apoptosis and suppressing STAT3/JAK2 signaling regulated by ROS. Liang JR and Yang H, Biomed Pharmacother. 2020 May;125:109585. doi: 10.1016/j.biopha.2019.109585. Epub 2020 Feb 25.
101. Recombinant human erythropoietin administration protects cortical neurons from traumatic brain injury in rats. Liao ZB, etal., Eur J Neurol. 2008 Feb;15(2):140-9. Epub 2007 Dec 18.
102. Anti-apoptotic and Pro-survival Effects of Food Restriction on High-Fat Diet-Induced Obese Hearts. Lin YY, etal., Cardiovasc Toxicol. 2017 Apr;17(2):163-174. doi: 10.1007/s12012-016-9370-2.
103. Defining the role of the Bcl-2 family of proteins in the nervous system. Lindsten T, etal., Neuroscientist. 2005 Feb;11(1):10-5.
104. Cellular communication network factor 1 (CCN1) knockdown exerts a protective effect for hepatic ischemia/reperfusion injury by deactivating the MEK/ERK pathway. Liu H, etal., Clin Res Hepatol Gastroenterol. 2021 Sep;45(5):101737. doi: 10.1016/j.clinre.2021.101737. Epub 2021 Jun 16.
105. Antenatal supplementation of taurine for protection of fetal rat brain with intrauterine growth restriction from injury by reducing neuronal apoptosis. Liu J, etal., Neuropediatrics. 2012 Oct;43(5):258-63. doi: 10.1055/s-0032-1324730. Epub 2012 Aug 29.
106. Liquiritigenin inhibits Abeta(25-35)-induced neurotoxicity and secretion of Abeta(1-40) in rat hippocampal neurons. Liu RT, etal., Acta Pharmacol Sin. 2009 Jul;30(7):899-906. doi: 10.1038/aps.2009.74.
107. Prolyl hydroxylase 3 interacts with Bcl-2 to regulate doxorubicin-induced apoptosis in H9c2 cells. Liu Y, etal., Biochem Biophys Res Commun. 2010 Oct 15;401(2):231-7. doi: 10.1016/j.bbrc.2010.09.037. Epub 2010 Sep 16.
108. Ghrelin protects against obesity-induced myocardial injury by regulating the lncRNA H19/miR-29a/IGF-1 signalling axis. Liu Y, etal., Exp Mol Pathol. 2020 Jun;114:104405. doi: 10.1016/j.yexmp.2020.104405. Epub 2020 Feb 19.
109. Effects of apigenin on the expression levels of B-cell lymphoma-2, Fas and Fas ligand in renal ischemia-reperfusion injury in rats. Liu Y, etal., Exp Ther Med. 2017 Dec;14(6):5345-5354. doi: 10.3892/etm.2017.5241. Epub 2017 Oct 2.
110. Ponicidin induces apoptosis via JAK2 and STAT3 signaling pathways in gastric carcinoma. Liu YF, etal., Int J Mol Sci. 2015 Jan 12;16(1):1576-89. doi: 10.3390/ijms16011576.
111. MicroRNA-145 Protects against Myocardial Ischemia Reperfusion Injury via CaMKII-Mediated Antiapoptotic and Anti-Inflammatory Pathways. Liu Z, etal., Oxid Med Cell Longev. 2019 Sep 10;2019:8948657. doi: 10.1155/2019/8948657. eCollection 2019.
112. [Effect of "Xiusanzhen"on expression of hippocampal Bcl-2 and Bax proteins in Alzheimer disease rats]. Liu ZB, etal., Zhen Ci Yan Jiu. 2011 Feb;36(1):7-11.
113. In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration. Loberg RD, etal., Neoplasia. 2007 Dec;9(12):1030-7.
114. Expression of p53, bcl-2 and Ki-67 in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix. Looi ML, etal., Anal Quant Cytol Histol. 2008 Apr;30(2):63-70.
115. Expression of Epstein-Barr virus latent membrane protein 1 and B-cell leukemia-lymphoma 2 gene in nasopharyngeal carcinoma tissues. Lu JJ, etal., J Microbiol Immunol Infect. 2002 Jun;35(2):136-40.
116. NFAT-1 hyper-activation by methionine enkephalin (MENK) significantly induces cell apoptosis of rats C6 glioma in vivo and in vitro. Lu WC, etal., Int Immunopharmacol. 2018 Mar;56:1-8. doi: 10.1016/j.intimp.2018.01.005. Epub 2018 Jan 9.
117. The effect of the Ginkgo biloba extract in the expression of Bax, Bcl-2 and bone mineral content of Wistar rats with glucocorticoid-induced osteoporosis. Lucinda LM, etal., Phytother Res. 2013 Apr;27(4):515-20. doi: 10.1002/ptr.4747. Epub 2012 May 31.
118. [Intensive insulin treatment protected the cardiac myocytes against apoptosis in severely scalded rats]. Lv GF, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2011 Dec;23(12):714-7.
119. Metallothionein 3 attenuated the apoptosis of neurons in the CA1 region of the hippocampus in the senescence-accelerated mouse/PRONE8 (SAMP8). Ma F, etal., Arq Neuropsiquiatr. 2011 Feb;69(1):105-11.
120. Hypoxia-reoxygenation-induced apoptosis in cultured neonatal rat cardiomyocyets and the protective effect of prostaglandin E. Ma XQ, etal., Clin Exp Pharmacol Physiol. 2005 Dec;32(12):1124-30.
121. BCL2 expression in chronic lymphocytic leukemia: lack of association with the BCL2 938A>C promoter single nucleotide polymorphism. Majid A, etal., Blood. 2008 Jan 15;111(2):874-7. Epub 2007 Oct 24.
122. Moderately high folic acid supplementation exacerbates experimentally induced liver fibrosis in rats. Marsillach J, etal., Exp Biol Med (Maywood). 2008 Jan;233(1):38-47.
123. Changes in the expression of genes related to apoptosis and fibrosis pathways in CCl4-treated rats. Marsillach J, etal., Mol Cell Biochem. 2008 Jan;308(1-2):101-9. Epub 2007 Oct 16.
124. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
125. Effects of voluntary and treadmill exercise on spontaneous withdrawal signs, cognitive deficits and alterations in apoptosis-associated proteins in morphine-dependent rats. Mokhtari-Zaer A, etal., Behav Brain Res. 2014 Sep 1;271:160-70. doi: 10.1016/j.bbr.2014.05.061. Epub 2014 Jun 4.
126. BCL2 gene polymorphism could predict the treatment outcomes in acute myeloid leukemia patients. Moon JH, etal., Leuk Res. 2010 Feb;34(2):166-72. doi: 10.1016/j.leukres.2009.05.009. Epub 2009 Jun 10.
127. Bcl-2 is located predominantly in the inner membrane and crista of mitochondria in rat liver. Motoyama S, etal., Biochem Biophys Res Commun. 1998 Aug 28;249(3):628-36. doi: 10.1006/bbrc.1998.9205.
128. Expression patterns and prognostic value of Bag-1 and Bcl-2 in breast cancer. Nadler Y, etal., Breast Cancer Res. 2008 Apr 22;10(2):R35.
129. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Narita M, etal., Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14681-6.
130. Unconjugated Bilirubin exerts Pro-Apoptotic Effect on Platelets via p38-MAPK activation. NaveenKumar SK, etal., Sci Rep. 2015 Oct 13;5:15045. doi: 10.1038/srep15045.
131. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
132. Expression in non-Hodgkin's lymphoma of the bcl-2 protein associated with the t(14;18) chromosomal translocation. Ngan BY, etal., N Engl J Med 1988 Jun 23;318(25):1638-44.
133. Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate. Nilsen J and Brinton RD, Endocrinology 2002 Jan;143(1):205-12.
134. Expression of Bcl-2 protects against photoreceptor degeneration in retinal degeneration slow (rds) mice. Nir I, etal., J Neurosci. 2000 Mar 15;20(6):2150-4.
135. The relationship between Bcl-gene expression and learning and memory impairment in chronic aluminum-exposed rats. Niu Q, etal., Neurotox Res. 2007 Oct;12(3):163-9.
136. Propofol protects the autophagic cell death induced by the ischemia/reperfusion injury in rats. Noh HS, etal., Mol Cells. 2010 Nov;30(5):455-60. doi: 10.1007/s10059-010-0130-z. Epub 2010 Sep 2.
137. Association of a novel regulatory polymorphism (-938C>A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia. Nuckel H, etal., Blood. 2007 Jan 1;109(1):290-7. Epub 2006 Sep 7.
138. Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia. O'Brien S, etal., J Clin Oncol. 2007 Mar 20;25(9):1114-20. Epub 2007 Feb 12.
139. Investigation of environmental factors for diagnosing malignant potential in oral epithelial dysplasia. Okazaki Y, etal., Oral Oncol. 2002 Sep;38(6):562-73.
140. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
141. Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression. Onoue S, etal., FEBS J. 2008 Nov;275(22):5542-51.
142. Effect of superoxide anion scavenger on rat hearts with chronic intermittent hypoxia. Pai P, etal., J Appl Physiol (1985). 2016 Apr 15;120(8):982-90. doi: 10.1152/japplphysiol.01109.2014. Epub 2016 Jan 14.
143. Cytochrome c release from mitochondria in the aging heart: a possible mechanism for apoptosis with age. Phaneuf S and Leeuwenburgh C, Am J Physiol Regul Integr Comp Physiol 2002 Feb;282(2):R423-30.
144. Immunohistochemical analysis with multiple antibodies in search of prognostic markers for clear cell renal cell carcinoma. Phuoc NB, etal., Urology. 2007 May;69(5):843-8.
145. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
146. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
147. Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains. Pravenec M, etal., J Clin Invest 1995 Oct;96(4):1973-8
148. Biological markers that predict clinical recurrence in ductal carcinoma in situ of the breast. Provenzano E, etal., Eur J Cancer. 2003 Mar;39(5):622-30.
149. Neuroprotective effects of microRNA-210 on hypoxic-ischemic encephalopathy. Qiu J, etal., Biomed Res Int. 2013;2013:350419. doi: 10.1155/2013/350419. Epub 2013 Sep 9.
150. Fraxetin inhibits the growth of colon adenocarcinoma cells via the Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway. Ren S, etal., Int J Biochem Cell Biol. 2020 Aug;125:105777. doi: 10.1016/j.biocel.2020.105777. Epub 2020 Jun 3.
151. GOA pipeline RGD automated data pipeline
152. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
153. Abnormal expression of bcl-2 and bax in rat tongue mucosa during the development of squamous cell carcinoma induced by 4-nitroquinoline 1-oxide. Ribeiro DA, etal., Int J Exp Pathol. 2005 Dec;86(6):375-81.
154. FISH detection of t(14;18) in follicular lymphoma on Papanicolaou-stained archival cytology slides. Richmond J, etal., Cancer. 2006 Jun 25;108(3):198-204.
155. Bcl-2/Bax protein expression in heart, slow-twitch and fast-twitch muscles in young rats growing under chronic hypoxia conditions. Riva C, etal., Mol Cell Biochem 2001 Oct;226(1-2):9-16.
156. Licochalcone B Ameliorates Liver Cancer via Targeting of Apoptotic Genes, DNA Repair Systems, and Cell Cycle Control. Sadek K, etal., Iran J Pharm Res. 2020 Fall;19(4):372-386. doi: 10.22037/ijpr.2020.1101292.
157. Cloning and sequencing of a cDNA encoding the rat Bcl-2 protein. Sato T, etal., Gene 1994 Mar 25;140(2):291-2.
158. Subcellular distribution of Bcl-2 family proteins and 14-3-3 within the hippocampus during seizure-induced neuronal death in the rat. Schindler CK, etal., Neurosci Lett. 2004 Feb 19;356(3):163-6.
159. High energy shock waves and 5-aminolevulinic for sonodynamic therapy: effects in a syngeneic model of colon cancer. Serpe L, etal., Technol Cancer Res Treat. 2011 Feb;10(1):85-93.
160. Involvement of caspases and their upstream regulators in myocardial apoptosis in a rat model of selenium deficiency-induced dilated cardiomyopathy. Shan H, etal., J Trace Elem Med Biol. 2015;31:85-91. doi: 10.1016/j.jtemb.2015.03.005. Epub 2015 Apr 16.
161. High receptor tyrosine kinase (FLT3, KIT) transcript versus anti-apoptotic (BCL2) transcript ratio independently predicts inferior outcome in pediatric acute myeloid leukemia. Sharawat SK, etal., Blood Cells Mol Dis. 2015 Jan;54(1):56-64. doi: 10.1016/j.bcmd.2014.07.019. Epub 2014 Sep 15.
162. beta-receptor antagonist treatment prevents activation of cell death signaling in the diabetic heart independent of its metabolic actions. Sharma V, etal., Eur J Pharmacol. 2011 Apr 25;657(1-3):117-25. doi: 10.1016/j.ejphar.2011.01.044. Epub 2011 Feb 4.
163. Nuclear Translocation of Calpain-2 Mediates Apoptosis of Hypertrophied Cardiomyocytes in Transverse Aortic Constriction Rat. Sheng JJ, etal., J Cell Physiol. 2015 Nov;230(11):2743-54. doi: 10.1002/jcp.24999.
164. Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice. Shi SY, etal., J Biol Chem. 2017 Mar 3;292(9):3789-3799. doi: 10.1074/jbc.M116.752519. Epub 2017 Jan 18.
165. Pretreatment with sildenafil alleviates early lung ischemia-reperfusion injury in a rat model. Shih PK, etal., J Surg Res. 2013 Dec;185(2):e77-83. doi: 10.1016/j.jss.2013.07.010. Epub 2013 Jul 31.
166. Differential expression of rat brain bcl-2 family proteins in development and aging. Shimohama S, etal., Biochem Biophys Res Commun. 1998 Nov 9;252(1):92-6.
167. Suppression of NFkappaB and its Regulated Gene Products by Oral Administration of Green Tea Polyphenols in an Autochthonous Mouse Prostate Cancer Model. Siddiqui IA, etal., Pharm Res. 2008 Mar 4;.
168. BCL2 accelerates inflammation-induced BALB/c plasmacytomas and promotes novel tumors with coexisting T(12;15) and T(6;15) translocations. Silva S, etal., Cancer Res. 2003 Dec 15;63(24):8656-63.
169. Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria. Soane L, etal., J Neurosci Res. 2008 May 1;86(6):1267-76.
170. MiR-451 is decreased in hypertrophic cardiomyopathy and regulates autophagy by targeting TSC1. Song L, etal., J Cell Mol Med. 2014 Nov;18(11):2266-74. doi: 10.1111/jcmm.12380. Epub 2014 Sep 11.
171. Ethanol extract from Epimedium brevicornum attenuates left ventricular dysfunction and cardiac remodeling through down-regulating matrix metalloproteinase-2 and -9 activity and myocardial apoptosis in rats with congestive heart failure. Song YH, etal., Int J Mol Med. 2008 Jan;21(1):117-24.
172. A novel angiogenesis inhibitor bevacizumab induces apoptosis in the rat endometriosis model. Soysal D, etal., Balkan J Med Genet. 2015 Apr 10;17(2):73-80. doi: 10.2478/bjmg-2014-0077. eCollection 2014 Dec.
173. Overexpression of BCL2 and BAX following BFM induction therapy predicts ch-ALL patients' poor response to treatment and short-term relapse. Stamati L, etal., J Cancer Res Clin Oncol. 2015 Nov;141(11):2023-36. doi: 10.1007/s00432-015-1982-6. Epub 2015 May 16.
174. Apoptosis and its pathway in early post-implantation embryos of diabetic rats. Sun F, etal., Diabetes Res Clin Pract. 2005 Feb;67(2):110-8.
175. The effects of simvastatin on hippocampal caspase-3 and Bcl-2 expression following kainate-induced seizures in rats. Sun J, etal., Int J Mol Med. 2012 Oct;30(4):739-46. doi: 10.3892/ijmm.2012.1076. Epub 2012 Jul 25.
176. Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway. Sun Q, etal., Biochem Biophys Res Commun. 2018 Mar 25;498(1):164-170. doi: 10.1016/j.bbrc.2018.02.009. Epub 2018 Mar 5.
177. Protective effects of nicotine against glutamate-induced neurotoxicity in PC12 cells. Sun X, etal., Cell Mol Biol Lett. 2004;9(3):409-22.
178. [Expression of Bcl-2 mRNA and Bcl-2 protein in nasal mucusa of rat in allergic rhinitis model]. Suo L, etal., Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2004 Feb;18(2):105-7.
179. Primary breast cancer phenotypes associated with propensity for central nervous system metastases. Tham YL, etal., Cancer. 2006 Aug 15;107(4):696-704.
180. Immunohistochemical study of the apoptosis process in epidermal epithelial cells of rats under a physiological condition. Udayanga KG, etal., Histol Histopathol. 2011 Jul;26(7):811-20. doi: 10.14670/HH-26.811.
181. Argon inhalation attenuates retinal apoptosis after ischemia/reperfusion injury in a time- and dose-dependent manner in rats. Ulbrich F, etal., PLoS One. 2014 Dec 23;9(12):e115984. doi: 10.1371/journal.pone.0115984. eCollection 2014.
182. Segmental heterogeneity in Bcl-2, Bcl-xL and Bax expression in rat tubular epithelium after ischemia-reperfusion. Valdes F, etal., Nephrology (Carlton). 2008 Jan 23;.
183. The mitochondrial toxin 3-nitropropionic acid induces differential expression patterns of apoptosis-related markers in rat striatum. Vis JC, etal., Neuropathol Appl Neurobiol. 2001 Feb;27(1):68-76.
184. Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis. Vukosavic S, etal., J Neurochem. 1999 Dec;73(6):2460-8.
185. Protective effects of Carthamus tinctorius injection on isoprenaline-induced myocardial injury in rats. Wan LH, etal., Pharm Biol. 2011 Nov;49(11):1204-9. doi: 10.3109/13880209.2011.576348.
186. Insulin-like growth factor-1 improves postoperative cognitive dysfunction following splenectomy in aged rats. Wang B, etal., Exp Ther Med. 2021 Mar;21(3):215. doi: 10.3892/etm.2021.9647. Epub 2021 Jan 15.
187. Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria. Wang J, etal., J Biol Chem. 2004 May 7;279(19):19948-54. Epub 2004 Mar 5.
188. Neuroprotective effects of caffeic acid phenethyl ester against sevoflurane‑induced neuronal degeneration in the hippocampus of neonatal rats involve MAPK and PI3K/Akt signaling pathways. Wang LY, etal., Mol Med Rep. 2016 Oct;14(4):3403-12. doi: 10.3892/mmr.2016.5586. Epub 2016 Aug 4.
189. Chondrocyte apoptosis and expression of Bcl-2, Bax, Fas, and iNOS in articular cartilage in patients with Kashin-Beck disease. Wang SJ, etal., J Rheumatol. 2006 Mar;33(3):615-9.
190. [Mechanism of chondrocyte apoptosis in Kashin-Beck disease and primary osteoarthritis: a comparative study]. Wang SJ, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2006 Jul;26(7):927-30.
191. Acupuncture protected cerebral multi-infarction rats from memory impairment by regulating the expression of apoptosis related genes Bcl-2 and Bax in hippocampus. Wang T, etal., Physiol Behav. 2009 Jan 8;96(1):155-61. doi: 10.1016/j.physbeh.2008.09.024. Epub 2008 Oct 9.
192. LncRNA TUG1 Promotes Apoptosis, Invasion, and Angiogenesis of Retinal Endothelial Cells in Retinopathy of Prematurity via MiR-145-5p. Wang Y, etal., Front Med (Lausanne). 2022 Apr 4;9:803214. doi: 10.3389/fmed.2022.803214. eCollection 2022.
193. Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p-AKT/Bcl-2 pathways. Wazea SA, etal., Sci Rep. 2018 Mar 23;8(1):5110. doi: 10.1038/s41598-018-23359-6.
194. Activation of autophagy in ischemic postconditioning contributes to cardioprotective effects against ischemia/reperfusion injury in rat hearts. Wei C, etal., J Cardiovasc Pharmacol. 2013 May;61(5):416-22. doi: 10.1097/FJC.0b013e318287d501.
195. Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees. Weng LH, etal., Arthritis Rheum. 2010 May;62(5):1393-402.
196. Inflammation induction of Dickkopf-1 mediates chondrocyte apoptosis in osteoarthritic joint. Weng LH, etal., Osteoarthritis Cartilage. 2009 Jul;17(7):933-43. doi: 10.1016/j.joca.2008.12.008. Epub 2008 Dec 30.
197. Lentiviral-mediated delivery of Bcl-2 or GDNF protects against excitotoxicity in the rat hippocampus. Wong LF, etal., Mol Ther. 2005 Jan;11(1):89-95.
198. Aberrant expression of apoptosis proteins and ultrastructural aberrations in uterine leiomyomas from patients with hereditary leiomyomatosis and renal cell carcinoma. Wortham NC, etal., Fertil Steril. 2006 Oct;86(4):961-71. Epub 2006 Sep 7.
199. rhEPO affects apoptosis in hippocampus of aging rats by upregulating SIRT1. Wu H, etal., Int J Clin Exp Pathol. 2015 Jun 1;8(6):6870-80. eCollection 2015.
200. Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. Wu IC, etal., Neoplasia. 2011 Apr;13(4):386-92. doi: 10.1593/neo.101722.
201. 17Beta-estradiol induced Ca2+ influx via L-type calcium channels activates the Src/ERK/cyclic-AMP response element binding protein signal pathway and BCL-2 expression in rat hippocampal neurons: a potential initiation mechanism for estrogen-induced neuroprotection. Wu TW, etal., Neuroscience. 2005;135(1):59-72.
202. [Effect of letrozole on endometrosis and apoptosis of ectopic endometrial cells in rats]. Xia X, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Jan;38(1):54-9. doi: 10.3969/j.issn.1672-7347.2013.01.010.
203. Effect of sodium fluoride on the expression of bcl-2 family and osteopontin in rat renal tubular cells. Xu H, etal., Biol Trace Elem Res. 2006 Jan;109(1):55-60.
204. Bajijiasu Ameliorates ß-Amyloid-Triggered Endoplasmic Reticulum Stress and Related Pathologies in an Alzheimer's Disease Model. Xu TT, etal., Cell Physiol Biochem. 2018;46(1):107-117. doi: 10.1159/000488414. Epub 2018 Mar 20.
205. Upregulation of CREM-1 relates to retinal ganglion cells apoptosis after light-induced damage in vivo. Xu Y, etal., J Mol Neurosci. 2014 Mar;52(3):331-8. doi: 10.1007/s12031-013-0153-y. Epub 2013 Oct 30.
206. Protective effects of ebselen, a seleno-organic antioxidant on neurodegeneration induced by hypoxia and reperfusion in stroke-prone spontaneously hypertensive rat. Yamagata K, etal., Neuroscience. 2008 May 2;153(2):428-35. Epub 2008 Feb 29.
207. Loss of anti-apoptotic genes in aging rat crura. Yamanaka M, etal., J Urol. 2002 Nov;168(5):2296-300.
208. Shenfu Formula reduces cardiomyocyte apoptosis in heart failure rats by regulating microRNAs. Yan X, etal., J Ethnopharmacol. 2018 May 8;227:105-112. doi: 10.1016/j.jep.2018.05.006.
209. Wentong decoction cures allergic bronchial asthma by regulating the apoptosis imbalance of EOS. Yan Y, etal., Chin Med. 2018 Apr 18;13:21. doi: 10.1186/s13020-018-0180-2. eCollection 2018.
210. A shift in the Bax/Bcl-2 balance may activate caspase-3 and modulate apoptosis in experimental glomerulonephritis. Yang B, etal., Kidney Int. 2002 Oct;62(4):1301-13.
211. Association of the functional BCL-2 rs2279115 genetic variant and small cell lung cancer. Yang X, etal., Tumour Biol. 2016 Feb;37(2):1693-8. doi: 10.1007/s13277-015-3934-9. Epub 2015 Aug 27.
212. Rho-kinase-dependent pathway mediates the hepatoprotective effects of sorafenib against ischemia/reperfusion liver injury in rats with nonalcoholic steatohepatitis. Yang YY, etal., Liver Transpl. 2012 Nov;18(11):1371-83. doi: 10.1002/lt.23520.
213. Hydrogen peroxide predisposes neonatal rat ventricular myocytes to Fas-mediated apoptosis. Yaniv G, etal., Biochem Biophys Res Commun. 2005 Oct 28;336(3):740-6. doi: 10.1016/j.bbrc.2005.08.167.
214. Protective effect of curcumin on chemotherapy-induced intestinal dysfunction. Yao Q, etal., Int J Clin Exp Pathol. 2013 Oct 15;6(11):2342-9. eCollection 2013.
215. Neuroprotective effects of breviscapine against apoptosis induced by transient focal cerebral ischaemia in rats. Yiming L, etal., J Pharm Pharmacol. 2008 Mar;60(3):349-55.
216. Influence of age or circadian time on Bcl-2 and Bax mRNA expression in the rat hippocampus after corticosterone exposure. Yoshimura A, etal., Brain Res Bull. 2007 Jul 12;73(4-6):254-8. Epub 2007 Apr 10.
217. A novel set of DNA methylation markers in urine sediments for sensitive/specific detection of bladder cancer. Yu J, etal., Clin Cancer Res. 2007 Dec 15;13(24):7296-304.
218. Changes of inflammation and apoptosis in adrenal gland after experimental injury in rats with acute necrotizing pancreatitis. Yu J, etal., Inflammation. 2012 Feb;35(1):11-22.
219. [Effects of TX0201 abstracted from heart-regulating formula on spatial learning and regulation of Bax mRNA, Bcl-2 mRNA level in brain of rat with Alzheimer's disease] Yu ZH, etal., Zhongguo Zhong Yao Za Zhi. 2007 May;32(9):839-42.
220. Gastrodin Ameliorates Acute Rejection via IRE1α/TRAF2/NF-κB in Rats Receiving Liver Allografts. Yuan F, etal., Biomed Res Int. 2019 Nov 20;2019:9276831. doi: 10.1155/2019/9276831. eCollection 2019.
221. Inhibition of microRNA-1 attenuates hypoxia/re-oxygenation-induced apoptosis of cardiomyocytes by directly targeting Bcl-2 but not GADD45Beta. Zhai C, etal., Am J Transl Res. 2015 Oct 15;7(10):1952-62. eCollection 2015.
222. Gingerol ameliorates neuronal damage induced by hypoxia-reoxygenation via the miR-210/brain-derived neurotrophic factor axis. Zhai Y, etal., Kaohsiung J Med Sci. 2022 Apr;38(4):367-377. doi: 10.1002/kjm2.12486. Epub 2021 Dec 28.
223. nNOS Translocates into the Nucleus and Interacts with Sox2 to Protect Neurons Against Early Excitotoxicity via Promotion of Shh Transcription. Zhang D, etal., Mol Neurobiol. 2016 Nov;53(9):6444-6458. doi: 10.1007/s12035-015-9545-z. Epub 2015 Nov 25.
224. Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia. Zhang G, etal., J Ethnopharmacol. 2008 Feb 12;115(3):441-8. Epub 2007 Oct 25.
225. [Lipid peroxidation affects serum T and Bcl-2 expression in the testis of aging male rats] Zhang ZB, etal., Zhonghua Nan Ke Xue. 2007 Jan;13(1):46-9.
226. Elevated retinol binding protein 4 levels are associated with atherosclerosis in diabetic rats via JAK2/STAT3 signaling pathway. Zhou W, etal., World J Diabetes. 2021 Apr 15;12(4):466-479. doi: 10.4239/wjd.v12.i4.466.
Additional References at PubMed
PMID:36599   PMID:1373874   PMID:1502141   PMID:7472523   PMID:7546744   PMID:7563251   PMID:7595537   PMID:7628407   PMID:7650367   PMID:7650488   PMID:7675327   PMID:7751019  
PMID:7772249   PMID:7812968   PMID:7828536   PMID:7834747   PMID:7834748   PMID:7840250   PMID:7896880   PMID:7945396   PMID:7953633   PMID:7969891   PMID:8022822   PMID:8030757  
PMID:8050499   PMID:8080725   PMID:8084613   PMID:8170972   PMID:8313913   PMID:8358790   PMID:8372353   PMID:8402648   PMID:8402909   PMID:8623928   PMID:8625820   PMID:8663032  
PMID:8755480   PMID:8758925   PMID:8760259   PMID:8788039   PMID:8918887   PMID:9008714   PMID:9009190   PMID:9027314   PMID:9028316   PMID:9098922   PMID:9111042   PMID:9153592  
PMID:9184696   PMID:9202146   PMID:9215624   PMID:9219694   PMID:9241272   PMID:9252127   PMID:9374413   PMID:9463381   PMID:9547242   PMID:9560217   PMID:9660918   PMID:9681465  
PMID:9731710   PMID:9950951   PMID:10193316   PMID:10200548   PMID:10321489   PMID:10488913   PMID:10506221   PMID:10597216   PMID:10602483   PMID:10620603   PMID:10674380   PMID:10726970  
PMID:10762311   PMID:10815637   PMID:11027399   PMID:11146504   PMID:11226327   PMID:11264898   PMID:11530860   PMID:11546872   PMID:11684014   PMID:11709185   PMID:11980919   PMID:11983915  
PMID:11997180   PMID:12009022   PMID:12050152   PMID:12082633   PMID:12086670   PMID:12107157   PMID:12198774   PMID:12231259   PMID:12420306   PMID:12421364   PMID:12421819   PMID:12510149  
PMID:12531534   PMID:12568497   PMID:12591359   PMID:12599216   PMID:12603823   PMID:12606450   PMID:12616533   PMID:12617961   PMID:12716434   PMID:12769190   PMID:12855558   PMID:14527929  
PMID:14532118   PMID:14551195   PMID:14580719   PMID:14608004   PMID:14651853   PMID:14660795   PMID:14699151   PMID:14707049   PMID:14754538   PMID:14759493   PMID:15006356   PMID:15051517  
PMID:15126120   PMID:15140194   PMID:15184368   PMID:15194869   PMID:15208316   PMID:15292044   PMID:15545017   PMID:15613488   PMID:15719136   PMID:15733859   PMID:15776018   PMID:15796810  
PMID:15808558   PMID:15818405   PMID:15877958   PMID:15922606   PMID:15975921   PMID:15983387   PMID:16004788   PMID:16085054   PMID:16095731   PMID:16121936   PMID:16133871   PMID:16282979  
PMID:16307838   PMID:16344898   PMID:16427619   PMID:16443602   PMID:16446153   PMID:16459353   PMID:16481323   PMID:16535832   PMID:16535844   PMID:16551891   PMID:16571718   PMID:16604387  
PMID:16642033   PMID:16672320   PMID:16717086   PMID:16733793   PMID:16950491   PMID:16996745   PMID:17005564   PMID:17026529   PMID:17031671   PMID:17068116   PMID:17080656   PMID:17123509  
PMID:17184147   PMID:17262823   PMID:17267035   PMID:17289999   PMID:17318810   PMID:17330752   PMID:17382917   PMID:17478584   PMID:17546582   PMID:17591857   PMID:17690097   PMID:17875758  
PMID:17897919   PMID:17965419   PMID:18056966   PMID:18160625   PMID:18201675   PMID:18279996   PMID:18337831   PMID:18346784   PMID:18367586   PMID:18407748   PMID:18497705   PMID:18563323  
PMID:18614015   PMID:18614344   PMID:18625500   PMID:18637984   PMID:18649423   PMID:18655204   PMID:18723055   PMID:18724894   PMID:18768150   PMID:18785877   PMID:18835031   PMID:18852517  
PMID:18923682   PMID:18930091   PMID:19111121   PMID:19125405   PMID:19228691   PMID:19229825   PMID:19258038   PMID:19265712   PMID:19267062   PMID:19399403   PMID:19481735   PMID:19483283  
PMID:19506341   PMID:19565656   PMID:19568971   PMID:19576024   PMID:19696693   PMID:19702087   PMID:19723098   PMID:19763897   PMID:19774672   PMID:19788070   PMID:19806804   PMID:19936637  
PMID:19938943   PMID:19951548   PMID:19996924   PMID:20021812   PMID:20021825   PMID:20041405   PMID:20092675   PMID:20097879   PMID:20128384   PMID:20139280   PMID:20189983   PMID:20209634  
PMID:20448358   PMID:20465949   PMID:20465951   PMID:20483005   PMID:20495005   PMID:20651836   PMID:20684272   PMID:20850791   PMID:20889974   PMID:20933054   PMID:20965838   PMID:20968180  
PMID:21120620   PMID:21126425   PMID:21148565   PMID:21158042   PMID:21158059   PMID:21161433   PMID:21223820   PMID:21300124   PMID:21391123   PMID:21474673   PMID:21483632   PMID:21500593  
PMID:21672380   PMID:21710144   PMID:21818658   PMID:21845871   PMID:21858143   PMID:21868309   PMID:21903151   PMID:21916846   PMID:22001368   PMID:22023760   PMID:22094093   PMID:22115789  
PMID:22145321   PMID:22258505   PMID:22260021   PMID:22306244   PMID:22341695   PMID:22357517   PMID:22424444   PMID:22461702   PMID:22521772   PMID:22564541   PMID:22611939   PMID:22650024  
PMID:22819929   PMID:22978712   PMID:22982225   PMID:22999929   PMID:23150431   PMID:23225311   PMID:23324128   PMID:23354397   PMID:23469855   PMID:23984821   PMID:24096434   PMID:24178239  
PMID:24240096   PMID:24287037   PMID:24364912   PMID:24551276   PMID:24606213   PMID:24633814   PMID:24763879   PMID:24938610   PMID:24957688   PMID:24984066   PMID:24986006   PMID:24986327  
PMID:25035058   PMID:25063066   PMID:25220584   PMID:25282819   PMID:25403402   PMID:25480575   PMID:25744447   PMID:25820554   PMID:25861655   PMID:26003800   PMID:26012958   PMID:26035971  
PMID:26125843   PMID:26252661   PMID:26319553   PMID:26400280   PMID:26400308   PMID:26456506   PMID:26697948   PMID:26886004   PMID:27166426   PMID:27526155   PMID:27590063   PMID:27645924  
PMID:27666568   PMID:27690136   PMID:27919736   PMID:28093932   PMID:28176371   PMID:28257878   PMID:28280358   PMID:28369910   PMID:28379541   PMID:28388366   PMID:28486954   PMID:28814571  
PMID:29057768   PMID:29243771   PMID:29325994   PMID:29412156   PMID:29518790   PMID:29658076   PMID:29760303   PMID:30287344   PMID:30488170   PMID:31081107   PMID:31485886   PMID:31493044  
PMID:31549850   PMID:31603252   PMID:31784847   PMID:32307774   PMID:32714078   PMID:32735924   PMID:32920758   PMID:33856081   PMID:34123712   PMID:34411492   PMID:34617183   PMID:34716503  
PMID:37813166   PMID:38344831   PMID:38396011  


Genomics

Comparative Map Data
Bcl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81323,204,464 - 23,366,900 (-)NCBIGRCr8
mRatBN7.21322,689,783 - 22,853,920 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1322,684,989 - 22,853,743 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1322,684,989 - 22,853,743 (-)NCBImRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1323,013,354 - 23,175,038 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01324,297,817 - 24,459,509 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01322,983,528 - 23,145,223 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01326,605,426 - 26,769,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1326,605,426 - 26,769,374 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01331,758,213 - 31,920,775 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41312,730,736 - 12,905,108 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11312,730,735 - 12,905,108 (-)NCBI
Celera1322,550,362 - 22,711,143 (-)NCBICelera
Cytogenetic Map13p11NCBI
BCL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381863,123,346 - 63,320,090 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1863,123,346 - 63,320,128 (-)EnsemblGRCh38hg38GRCh38
GRCh371860,790,579 - 60,987,002 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361858,941,559 - 59,137,593 (-)NCBINCBI36Build 36hg18NCBI36
Build 341858,941,558 - 59,136,910NCBI
Celera1857,509,356 - 57,706,116 (-)NCBICelera
Cytogenetic Map18q21.33NCBI
HuRef1857,487,199 - 57,684,751 (-)NCBIHuRef
CHM1_11860,786,149 - 60,982,536 (-)NCBICHM1_1
T2T-CHM13v2.01863,326,497 - 63,525,122 (-)NCBIT2T-CHM13v2.0
Bcl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391106,465,906 - 106,642,020 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1106,465,908 - 106,642,004 (-)EnsemblGRCm39 Ensembl
GRCm381106,538,176 - 106,714,290 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1106,538,178 - 106,714,274 (-)EnsemblGRCm38mm10GRCm38
MGSCv371108,434,756 - 108,610,867 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361108,365,740 - 108,541,849 (-)NCBIMGSCv36mm8
Celera1109,386,734 - 109,563,656 (-)NCBICelera
Cytogenetic Map1E2.1NCBI
cM Map149.76NCBI
Bcl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540246,916,266 - 47,084,485 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540246,911,125 - 47,084,214 (-)NCBIChiLan1.0ChiLan1.0
BCL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21780,632,173 - 80,830,186 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11866,324,787 - 66,522,695 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01856,481,212 - 56,679,012 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11859,797,184 - 59,993,298 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1859,802,443 - 59,992,100 (-)Ensemblpanpan1.1panPan2
BCL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1113,733,849 - 13,900,653 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl113,731,406 - 13,900,658 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha114,699,877 - 14,866,689 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0113,595,394 - 13,762,294 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl113,595,394 - 13,762,292 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1113,633,483 - 13,799,972 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0113,562,764 - 13,729,319 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0113,811,587 - 13,978,482 (+)NCBIUU_Cfam_GSD_1.0
Bcl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494426,970,171 - 27,134,608 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364972,210,334 - 2,210,921 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364972,209,136 - 2,373,580 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1158,337,522 - 158,518,879 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11158,337,403 - 158,518,214 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21175,824,218 - 175,994,403 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BCL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11816,440,560 - 16,643,187 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1816,441,733 - 16,637,895 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660609,049,043 - 9,247,859 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247928,859,522 - 9,031,344 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247928,854,345 - 9,032,727 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bcl2
782 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir16-2rno-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19232449
Mir1rno-miR-1-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI19506341
Mir15brno-miR-15b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19232449

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:24
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000003768
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317027Aia22Adjuvant induced arthritis QTL 222.29joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)13134266636Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317034Aia9Adjuvant induced arthritis QTL 94.62joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131176653532331607Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
631672Iddm12Insulin dependent diabetes mellitus QTL 122.20.0032blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)13599466834535351Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2303031Bp326Blood pressure QTL 326arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131176653523001904Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317044Aia23Adjuvant induced arthritis QTL 232.3joint integrity trait (VT:0010548)ankle joint diameter (CMO:0002148)131176653532331607Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat

Markers in Region
D13Kyo4   No map positions available.
RH142296  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81323,366,677 - 23,366,834 (+)Marker Load Pipeline
mRatBN7.21322,852,015 - 22,852,172 (+)MAPPERmRatBN7.2
Rnor_6.01326,769,152 - 26,769,308NCBIRnor6.0
Rnor_5.01331,919,628 - 31,919,784UniSTSRnor5.0
RGSC_v3.41312,904,886 - 12,905,042UniSTSRGSC3.4
Celera1322,710,921 - 22,711,077UniSTS
Cytogenetic Map13p13UniSTS
PMC150726P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21322,851,683 - 22,851,977 (+)MAPPERmRatBN7.2
Rnor_6.01326,768,820 - 26,769,113NCBIRnor6.0
Rnor_5.01331,919,296 - 31,919,589UniSTSRnor5.0
RGSC_v3.41312,904,554 - 12,904,847UniSTSRGSC3.4
Celera1322,710,589 - 22,710,882UniSTS
Cytogenetic Map13p13UniSTS
PMC16825P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21322,851,425 - 22,852,128 (+)MAPPERmRatBN7.2
Rnor_6.01326,768,562 - 26,769,264NCBIRnor6.0
Rnor_5.01331,919,038 - 31,919,740UniSTSRnor5.0
RGSC_v3.41312,904,296 - 12,904,998UniSTSRGSC3.4
Celera1322,710,331 - 22,711,033UniSTS
Cytogenetic Map13p13UniSTS
RH131732  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21322,737,170 - 22,737,383 (+)MAPPERmRatBN7.2
Rnor_6.01326,653,324 - 26,653,536NCBIRnor6.0
Rnor_5.01331,805,570 - 31,805,782UniSTSRnor5.0
RGSC_v3.41312,778,905 - 12,779,117UniSTSRGSC3.4
Celera1322,597,379 - 22,597,591UniSTS
Cytogenetic Map13p13UniSTS
PMC104155P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21322,851,427 - 22,851,695 (+)MAPPERmRatBN7.2
Rnor_6.01326,768,564 - 26,768,831NCBIRnor6.0
Rnor_5.01331,919,040 - 31,919,307UniSTSRnor5.0
RGSC_v3.41312,904,298 - 12,904,565UniSTSRGSC3.4
Celera1322,710,333 - 22,710,600UniSTS
Cytogenetic Map13p13UniSTS
PMC125347P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21322,851,488 - 22,851,935 (+)MAPPERmRatBN7.2
Rnor_6.01326,768,625 - 26,769,071NCBIRnor6.0
Rnor_5.01331,919,101 - 31,919,547UniSTSRnor5.0
RGSC_v3.41312,904,359 - 12,904,805UniSTSRGSC3.4
Celera1322,710,394 - 22,710,840UniSTS
Cytogenetic Map13p13UniSTS
UniSTS:461954  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21322,851,514 - 22,851,862 (+)MAPPERmRatBN7.2
Rnor_6.01326,768,651 - 26,768,998NCBIRnor6.0
Rnor_5.01331,919,127 - 31,919,474UniSTSRnor5.0
RGSC_v3.41312,904,385 - 12,904,732UniSTSRGSC3.4
Celera1322,710,420 - 22,710,767UniSTS
Cytogenetic Map13p13UniSTS
PMC316415P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21322,851,944 - 22,852,544 (+)MAPPERmRatBN7.2
Rnor_6.01326,769,081 - 26,769,680NCBIRnor6.0
Rnor_5.01331,919,557 - 31,920,156UniSTSRnor5.0
RGSC_v3.41312,904,815 - 12,905,414UniSTSRGSC3.4
Celera1322,710,850 - 22,711,449UniSTS
Cytogenetic Map13p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000003768   ⟹   ENSRNOP00000003768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1326,605,426 - 26,769,374 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092763   ⟹   ENSRNOP00000075954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1326,767,685 - 26,768,708 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099529   ⟹   ENSRNOP00000093136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1322,684,989 - 22,853,743 (-)Ensembl
RefSeq Acc Id: NM_016993   ⟹   NP_058689
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81323,204,464 - 23,366,900 (-)NCBI
mRatBN7.21322,689,783 - 22,852,238 (-)NCBI
Rnor_6.01326,605,426 - 26,769,374 (-)NCBI
Rnor_5.01331,758,213 - 31,920,775 (-)NCBI
RGSC_v3.41312,730,736 - 12,905,108 (-)RGD
Celera1322,550,362 - 22,711,143 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058689 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA53662 (Get FASTA)   NCBI Sequence Viewer  
  AAA77687 (Get FASTA)   NCBI Sequence Viewer  
  AAD48410 (Get FASTA)   NCBI Sequence Viewer  
  AAP47159 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000106668
GenBank Protein P49950 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058689   ⟸   NM_016993
- UniProtKB: Q64032 (UniProtKB/Swiss-Prot),   Q62837 (UniProtKB/Swiss-Prot),   P49950 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075954   ⟸   ENSRNOT00000092763
Ensembl Acc Id: ENSRNOP00000003768   ⟸   ENSRNOT00000003768
Ensembl Acc Id: ENSRNOP00000093136   ⟸   ENSRNOT00000099529

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49950-F1-model_v2 AlphaFold P49950 1-236 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2199 AgrOrtholog
BioCyc Gene G2FUF-18606 BioCyc
Ensembl Genes ENSRNOG00000002791 Ensembl
  ENSRNOG00000067693 Ensembl
  ENSRNOG00000077679 ENTREZGENE
Ensembl Transcript ENSRNOT00000156655 ENTREZGENE
Gene3D-CATH 1.10.437.10 UniProtKB/Swiss-Prot
InterPro Apop_reg_Bcl2 UniProtKB/Swiss-Prot
  Bcl-2_BH1-3 UniProtKB/Swiss-Prot
  Bcl2-like UniProtKB/Swiss-Prot
  Bcl2/BclX UniProtKB/Swiss-Prot
  Bcl2_BH1_motif_CS UniProtKB/Swiss-Prot
  Bcl2_BH2_motif_CS UniProtKB/Swiss-Prot
  Bcl2_BH3_motif_CS UniProtKB/Swiss-Prot
  Bcl2_BH4 UniProtKB/Swiss-Prot
  Bcl2_BH4_motif_CS UniProtKB/Swiss-Prot
  Blc2-like_sf UniProtKB/Swiss-Prot
  Blc2_fam UniProtKB/Swiss-Prot
KEGG Report rno:24224 UniProtKB/Swiss-Prot
NCBI Gene 24224 ENTREZGENE
PANTHER APOPTOSIS REGULATOR BCL-2 UniProtKB/Swiss-Prot
  PTHR11256 UniProtKB/Swiss-Prot
Pfam Bcl-2 UniProtKB/Swiss-Prot
  BH4 UniProtKB/Swiss-Prot
PharmGKB BCL2 RGD
PhenoGen Bcl2 PhenoGen
PRINTS APOPREGBCL2 UniProtKB/Swiss-Prot
  BCL2FAMILY UniProtKB/Swiss-Prot
PROSITE BCL2_FAMILY UniProtKB/Swiss-Prot
  BH1 UniProtKB/Swiss-Prot
  BH2 UniProtKB/Swiss-Prot
  BH3 UniProtKB/Swiss-Prot
  BH4_1 UniProtKB/Swiss-Prot
  BH4_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002791 RatGTEx
  ENSRNOG00000067693 RatGTEx
  ENSRNOG00000077679 RatGTEx
SMART BCL UniProtKB/Swiss-Prot
  BH4 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56854 UniProtKB/Swiss-Prot
UniProt A0A8I6AJ02_RAT UniProtKB/TrEMBL
  BCL2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q62837 ENTREZGENE
  Q64032 ENTREZGENE
UniProt Secondary Q62837 UniProtKB/Swiss-Prot
  Q64032 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Bcl2  BCL2, apoptosis regulator  Bcl2  B cell leukemia/lymphoma 2  Data merged from RGD:150341388 737654 PROVISIONAL
2022-01-06 Bcl2  B cell leukemia/lymphoma 2  ENSRNOG00000067693    Symbol and/or name change 19259462 PROVISIONAL
2021-08-31 ENSRNOG00000067693        Symbol and Name status set to provisional 45752 PROVISIONAL
2016-06-22 Bcl2  BCL2, apoptosis regulator  Bcl2  B-cell CLL/lymphoma 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Bcl2  B-cell CLL/lymphoma 2  Bcl2  B-cell leukemia/lymphoma 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Bcl2  B-cell leukemia/lymphoma 2      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Bcl2  B-cell leukemia/lymphoma 2      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease combined DTX and PMEDAP treatment inhibited or significantly reduced lymphomas 70255
gene_expression mitochondrial level decreased with age 70304
gene_expression protein expression was greatest in fast-twitch glycolytic muscles than in slow-twitch or oxidative muscles 1298696
gene_expression expression is decreased neuronally after hypoxia in SHRSP rat strain compared with WKY rat strain 1553895
gene_mutations_overexpression overexpression is sufficient for survival of retinal ganglion cells (RGCs) without glial or trophic support 70671
gene_process anti-apoptotic 70304
gene_regulation expression increased by progesterone (and 19-norprogesterone) alone or in combination with estrogen 625452