Atp1a1 (ATPase Na+/K+ transporting subunit alpha 1) - Rat Genome Database

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Gene: Atp1a1 (ATPase Na+/K+ transporting subunit alpha 1) Rattus norvegicus
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Symbol: Atp1a1
Name: ATPase Na+/K+ transporting subunit alpha 1
RGD ID: 2167
Description: Enables several functions, including adenyl ribonucleotide binding activity; alkali metal ion binding activity; and ankyrin binding activity. Involved in several processes, including cellular response to mechanical stimulus; membrane hyperpolarization; and monoatomic cation transmembrane transport. Located in several cellular components, including T-tubule; basolateral plasma membrane; and intercalated disc. Part of sodium:potassium-exchanging ATPase complex. Used to study hypertension. Biomarker of hyperhomocysteinemia and sensorineural hearing loss. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2DD. Orthologous to human ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; INTERACTS WITH (+)-catechin; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATPase, Na+K+ transporting, alpha 1; na(+)/K(+) ATPase alpha-1 subunit; Nkaa1b; sodium pump subunit alpha-1; sodium/potassium-transporting ATPase subunit alpha-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SS.MNS-(Mme-Gca)/Ayd   SS.MNS-(Mme-D2Mit14)/Ayd   SS.MNS-(D2Mit6-Adh1)/Ayd  
QTLs:   Bp10   Bp158   Bp366  
Candidate Gene For: Bp16 Bp132 Bp366
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82191,709,311 - 191,737,414 (-)NCBIGRCr8
GRCr8 Ensembl2191,709,311 - 191,737,425 (-)EnsemblGRCr8 Ensembl
mRatBN7.22189,020,722 - 189,048,826 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2189,020,722 - 189,048,837 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2196,653,579 - 196,681,622 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02194,505,708 - 194,533,839 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02189,331,424 - 189,359,536 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02204,003,742 - 204,032,023 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2204,003,742 - 204,032,023 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02223,440,514 - 223,469,880 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42196,657,749 - 196,687,242 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2181,455,492 - 181,483,650 (-)NCBICelera
RGSC_v3.12196,620,502 - 196,649,996 (-)NCBI
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alendronic acid  (EXP)
amiloride  (EXP)
amiodarone  (EXP)
amitrole  (EXP)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
ampicillin  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcidiol  (EXP)
calcitriol  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chloroquine  (EXP,ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cocaine  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
DDT  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dioxygen  (EXP)
dipentyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enniatin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
etoposide  (ISO)
farglitazar  (EXP)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
haloperidol  (EXP)
inulin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
lactacystin  (EXP)
lead diacetate  (ISO)
lead(0)  (EXP,ISO)
limonene  (EXP)
lithium atom  (EXP,ISO)
lithium hydride  (EXP,ISO)
losartan  (EXP)
lycopene  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dichloride  (EXP)
methamphetamine  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
metronidazole  (EXP)
mitomycin C  (ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-D-aspartic acid  (ISO)
N-nitrosodiethylamine  (EXP)
neomycin  (EXP)
nitric oxide  (EXP)
ouabain  (EXP,ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
progesterone  (EXP,ISO)
propranolol  (EXP)
prostaglandin F2alpha  (EXP)
quercetin  (EXP,ISO)
raloxifene  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
sarin  (EXP)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP)
sodium chloride  (EXP,ISO)
sodium dichromate  (ISO)
sulfadimethoxine  (EXP)
T-2 toxin  (EXP)
terbutaline  (EXP)
tetracarbonylnickel  (EXP)
thallium atom  (EXP)
thallium sulfate  (EXP)
thapsigargin  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (EXP)
zearalenone  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac muscle contraction  (TAS)
cellular response to mechanical stimulus  (IDA)
cellular response to steroid hormone stimulus  (IEA,ISO)
energy coupled proton transmembrane transport, against electrochemical gradient  (TAS)
establishment or maintenance of transmembrane electrochemical gradient  (IC,IEA)
heart contraction  (IEA,ISO)
intracellular potassium ion homeostasis  (IBA,IEA,ISO)
intracellular sodium ion homeostasis  (IBA,IEA,ISO)
membrane hyperpolarization  (IMP)
membrane repolarization  (IEA,ISO)
monoatomic ion transport  (IEA)
negative regulation of glucocorticoid biosynthetic process  (IEA,ISO)
negative regulation of heart contraction  (IEA,ISO)
osmosensory signaling pathway  (IEA,ISO)
positive regulation of heart contraction  (IEA,ISO)
positive regulation of striated muscle contraction  (IEA,ISO)
potassium ion import across plasma membrane  (IBA,IDA,IEA,ISO)
potassium ion transmembrane transport  (IEA,ISO)
potassium ion transport  (IDA,IEA)
proton transmembrane transport  (IBA)
regulation of blood pressure  (IEA,ISO)
regulation of cardiac muscle cell contraction  (IMP)
regulation of sodium ion transport  (IDA)
regulation of the force of heart contraction  (IEA,ISO)
relaxation of cardiac muscle  (TAS)
response to glycoside  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)
sodium ion export across plasma membrane  (IBA,IDA,IEA,ISO)
sodium ion homeostasis  (IEA,ISO)
sodium ion transmembrane transport  (IEA,ISO)
sodium ion transport  (IDA,IEA)
transmembrane transport  (IDA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway   (ISO)
aldosterone signaling pathway  (IEA)
alfentanil pharmacodynamics pathway  (ISO)
amiloride pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
bendroflumethiazide pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bile acid transport pathway  (IEA)
bisoprolol pharmacodynamics pathway  (ISO)
bumetanide pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
chlorothiazide pharmacodynamics pathway  (ISO)
chlorthalidone pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
cystinuria pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
eplerenone pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
etacrynic acid pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
furosemide pharmacodynamics pathway  (ISO)
Hartnup disease pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrochlorothiazide pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydroflumethiazide pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
iminoglycinuria pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
lactose degradation pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lysinuric protein intolerance pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metolazone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
spironolactone pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
torasemide pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
trehalose degradation pathway  (ISO)
triamterene pharmacodynamics pathway  (ISO)
trichlormethiazide pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Neither the New Zealand genetically hypertensive strain nor Dahl salt-sensitive strain has an A1079T transversion in the alpha1 isoform of the Na(+),K(+)-ATPase gene. Barnard R, etal., Hypertension 2001 Oct;38(4):786-92.
2. FXYD7 is a brain-specific regulator of Na,K-ATPase alpha 1-beta isozymes. Beguin P, etal., EMBO J 2002 Jul 1;21(13):3264-73.
3. Na+-K+-ATPase is involved in the sustained ACh-induced hyperpolarization of endothelial cells from rat aorta. Bondarenko A and Sagach V, Br J Pharmacol. 2006 Dec;149(7):958-65. Epub 2006 Sep 25.
4. Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. Deng AY, etal., J Clin Invest 1994 Jul;94(1):431-6
5. Mapping of rat chromosome 2 markers generated from chromosome-sorted DNA. Deng AY, etal., Mamm Genome 1997 Oct;8(10):731-5.
6. Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats. Deng Y and Rapp JP, Nat Genet 1992 Jul;1(4):267-72
7. Ankyrin binds to two distinct cytoplasmic domains of Na,K-ATPase alpha subunit. Devarajan P, etal., Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):2965-9.
8. K+-Cl- Cotransporter-3a Up-regulates Na+,K+-ATPase in Lipid Rafts of Gastric Luminal Parietal Cells. Fujii T, etal., J Biol Chem. 2008 Mar 14;283(11):6869-77. Epub 2008 Jan 4.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Proteomic analysis of TRPC5- and TRPC6-binding partners reveals interaction with the plasmalemmal Na(+)/K(+)-ATPase. Goel M, etal., Pflugers Arch. 2005 Oct;451(1):87-98. Epub 2005 Jul 16.
12. Primary structures of two types of alpha-subunit of rat brain Na+,K+,-ATPase deduced from cDNA sequences. Hara Y, etal., J Biochem (Tokyo) 1987 Jul;102(1):43-58.
13. Training-induced changes in skeletal muscle Na+-K+ pump number and isoform expression in rats with chronic heart failure. Helwig B, etal., J Appl Physiol 2003 Jun;94(6):2225-36.
14. Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications. Herrera VL, etal., J Cell Biol 1987 Oct;105(4):1855-65.
15. ATP-induced conformational changes of the nucleotide-binding domain of Na,K-ATPase. Hilge M, etal., Nat Struct Biol. 2003 Jun;10(6):468-74.
16. Induction of mRNAs and proteins for Na/K ATPase alpha1 and beta1 subunits following hypoxia/reoxygenation in astrocytes. Kasai K, etal., Brain Res Mol Brain Res 2003 Jan 31;110(1):38-44.
17. An extracellular loop of the human non-gastric H,K-ATPase alpha-subunit is involved in apical plasma membrane polarization. Lerner M, etal., Cell Physiol Biochem. 2006;18(1-3):75-84. doi: 10.1159/000095169. Epub 2006 Aug 15.
18. Role of the transmembrane domain of FXYD7 in structural and functional interactions with Na,K-ATPase. Li C, etal., J Biol Chem. 2005 Dec 30;280(52):42738-43. Epub 2005 Nov 3.
19. Structural interactions between FXYD proteins and Na+,K+-ATPase: alpha/beta/FXYD subunit stoichiometry and cross-linking. Lindzen M, etal., J Biol Chem. 2006 Mar 3;281(9):5947-55. Epub 2005 Dec 21.
20. Beta-subunit of cardiac Na+-K+-ATPase dictates the concentration of the functional enzyme in caveolae. Liu L and Askari A, Am J Physiol Cell Physiol. 2006 Oct;291(4):C569-78. Epub 2006 Apr 19.
21. Association of PI3K-Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes. Liu L, etal., Am J Physiol Cell Physiol. 2007 Nov;293(5):C1489-97. Epub 2007 Aug 29.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Crystal structure of the sodium-potassium pump. Morth JP, etal., Nature. 2007 Dec 13;450(7172):1043-9.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Structure/function analysis of Na(+)-K(+)-ATPase central isoform-specific region: involvement in PKC regulation. Pierre SV, etal., Am J Physiol Renal Physiol 2002 Nov;283(5):F1066-74.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Confirmation of mutant alpha 1 Na,K-ATPase gene and transcript in Dahl salt-sensitive/JR rats. Ruiz-Opazo N, etal., Hypertension. 1994 Sep;24(3):260-70.
32. Analysis of quantitative trait loci for blood pressure on rat chromosomes 2 and 13. Age-related differences in effect. Samani NJ, etal., Hypertension 1996 Dec;28(6):1118-22
33. Mild hyperhomocysteinemia reduces the activity and immunocontent, but does not alter the gene expression, of catalytic a subunits of cerebral Na+,K+-ATPase. Scherer EB, etal., Mol Cell Biochem. 2013 Jun;378(1-2):91-7. doi: 10.1007/s11010-013-1598-6. Epub 2013 Mar 7.
34. Molecular cloning of three distinct forms of the Na+,K+-ATPase alpha-subunit from rat brain. Shull GE, etal., Biochemistry 1986 Dec 16;25(25):8125-32.
35. SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process. Sjostrom M, etal., Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16922-7. Epub 2007 Oct 15.
36. Ankyrin facilitates intracellular trafficking of alpha1-Na+-K+-ATPase in polarized cells. Stabach PR, etal., Am J Physiol Cell Physiol. 2008 Nov;295(5):C1202-14. doi: 10.1152/ajpcell.00273.2008. Epub 2008 Sep 3.
37. The α2β2 isoform combination dominates the astrocytic Na+ /K+ -ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation. Stoica A, etal., Glia. 2017 Nov;65(11):1777-1793. doi: 10.1002/glia.23194. Epub 2017 Aug 8.
38. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
39. The Na+/K+-ATPase alpha2-isoform regulates cardiac contractility in rat cardiomyocytes. Swift F, etal., Cardiovasc Res. 2007 Jul 1;75(1):109-17. Epub 2007 Mar 24.
40. Long-lasting changes in the cochlear K recycling structures after acute energy failure. Takiguchi Y, etal., Neurosci Res. 2013 Jul 1. pii: S0168-0102(13)00159-4. doi: 10.1016/j.neures.2013.06.003.
41. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
42. Importance of conserved Thr214 in domain A of the Na+,K+ -ATPase for stabilization of the phosphoryl transition state complex in E2P dephosphorylation. Toustrup-Jensen M and Vilsen B, J Biol Chem 2003 Mar 28;278(13):11402-10.
43. Evidence that the H1-H2 domain of alpha1 subunit of (Na++K+)-ATPase participates in the regulation of cardiac contraction. Xu KY, etal., FASEB J. 2005 Jan;19(1):53-61.
44. Cloning and analysis of the 5'-flanking region of rat Na+/K(+)-ATPase alpha 1 subunit gene. Yagawa Y, etal., Biochim Biophys Acta 1990 Jul 30;1049(3):286-92.
45. Cyclic stretch translocates the alpha2-subunit of the Na pump to plasma membrane in skeletal muscle cells in vitro. Yuan X, etal., Biochem Biophys Res Commun. 2006 Sep 22;348(2):750-7. Epub 2006 Jul 31.
46. Effects of different magnitudes of cyclic stretch on Na+-K+-ATPase in skeletal muscle cells in vitro. Yuan X, etal., J Cell Physiol. 2007 Aug;212(2):509-18.
Additional References at PubMed
PMID:1655743   PMID:2994074   PMID:7510709   PMID:7711835   PMID:7775468   PMID:8144700   PMID:10360172   PMID:10468580   PMID:10473631   PMID:10636900   PMID:10823893   PMID:10837135  
PMID:11139403   PMID:11193188   PMID:11507009   PMID:11546672   PMID:11926353   PMID:12511576   PMID:12519789   PMID:12527732   PMID:12631124   PMID:12631730   PMID:12637991   PMID:12884521  
PMID:12972417   PMID:14522987   PMID:14593108   PMID:14742675   PMID:15342623   PMID:15485817   PMID:15489334   PMID:15563542   PMID:15574410   PMID:15743908   PMID:15755730   PMID:15764602  
PMID:15775778   PMID:16051601   PMID:16123128   PMID:16153614   PMID:16243970   PMID:16292983   PMID:16293684   PMID:16723354   PMID:16791210   PMID:16861705   PMID:16949583   PMID:17008770  
PMID:17114649   PMID:17234593   PMID:17392375   PMID:17468335   PMID:17507069   PMID:17532187   PMID:17634366   PMID:17673438   PMID:17880911   PMID:17881356   PMID:18052210   PMID:18058007  
PMID:18285611   PMID:18420589   PMID:18504258   PMID:18522992   PMID:18581035   PMID:18669634   PMID:18693246   PMID:18701625   PMID:18794328   PMID:19082858   PMID:19164762   PMID:19199708  
PMID:19202345   PMID:19363037   PMID:19380482   PMID:19476441   PMID:19542013   PMID:19553454   PMID:19560439   PMID:19619588   PMID:19751721   PMID:19808891   PMID:20131911   PMID:20332111  
PMID:20427472   PMID:20458337   PMID:20691666   PMID:20801885   PMID:20817950   PMID:20883770   PMID:21354298   PMID:21478253   PMID:21705333   PMID:21730292   PMID:22145807   PMID:22237155  
PMID:22242112   PMID:22333836   PMID:22610379   PMID:22759964   PMID:22797923   PMID:22798075   PMID:22810802   PMID:22871113   PMID:23086991   PMID:23106098   PMID:23195960   PMID:23229519  
PMID:23288841   PMID:23327671   PMID:23376485   PMID:23532853   PMID:23829947   PMID:23857379   PMID:24218169   PMID:24275648   PMID:24277826   PMID:24391932   PMID:24614174   PMID:24625528  
PMID:24769233   PMID:24903141   PMID:25274047   PMID:25283821   PMID:25583115   PMID:25652450   PMID:25988879   PMID:26296893   PMID:26316108   PMID:26582472   PMID:26702050   PMID:27563007  
PMID:27586561   PMID:27613772   PMID:27845894   PMID:27903584   PMID:28131823   PMID:28181111   PMID:28515088   PMID:29101646   PMID:29118027   PMID:29351422   PMID:29476059   PMID:30746862  
PMID:31208048   PMID:32357304   PMID:33450132   PMID:33805551   PMID:33920198   PMID:34315852   PMID:36919600  


Genomics

Comparative Map Data
Atp1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82191,709,311 - 191,737,414 (-)NCBIGRCr8
GRCr8 Ensembl2191,709,311 - 191,737,425 (-)EnsemblGRCr8 Ensembl
mRatBN7.22189,020,722 - 189,048,826 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2189,020,722 - 189,048,837 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2196,653,579 - 196,681,622 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02194,505,708 - 194,533,839 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02189,331,424 - 189,359,536 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02204,003,742 - 204,032,023 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2204,003,742 - 204,032,023 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02223,440,514 - 223,469,880 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42196,657,749 - 196,687,242 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2181,455,492 - 181,483,650 (-)NCBICelera
RGSC_v3.12196,620,502 - 196,649,996 (-)NCBI
Cytogenetic Map2q34NCBI
ATP1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381116,373,244 - 116,404,774 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1116,372,668 - 116,410,261 (+)EnsemblGRCh38hg38GRCh38
GRCh371116,915,866 - 116,947,396 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361116,717,359 - 116,748,919 (+)NCBINCBI36Build 36hg18NCBI36
Build 341116,627,877 - 116,659,436NCBI
Celera1115,144,421 - 115,176,022 (+)NCBICelera
Cytogenetic Map1p13.1NCBI
HuRef1114,773,961 - 114,805,562 (+)NCBIHuRef
CHM1_11117,030,620 - 117,062,221 (+)NCBICHM1_1
T2T-CHM13v2.01116,381,314 - 116,412,844 (+)NCBIT2T-CHM13v2.0
Atp1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393101,483,535 - 101,512,023 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3101,483,535 - 101,512,000 (-)EnsemblGRCm39 Ensembl
GRCm383101,576,219 - 101,604,707 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3101,576,219 - 101,604,684 (-)EnsemblGRCm38mm10GRCm38
MGSCv373101,380,146 - 101,408,580 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363101,705,284 - 101,733,721 (-)NCBIMGSCv36mm8
Celera3103,788,093 - 103,816,528 (-)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map344.3NCBI
Atp1a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543519,536,634 - 19,564,580 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543519,537,224 - 19,563,631 (+)NCBIChiLan1.0ChiLan1.0
ATP1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21109,022,509 - 109,054,043 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11108,622,152 - 108,653,661 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0186,162,401 - 86,193,883 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11121,212,161 - 121,232,876 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1121,212,488 - 121,243,099 (-)Ensemblpanpan1.1panPan2
ATP1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11753,828,482 - 53,847,043 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1753,813,976 - 53,847,167 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1753,476,043 - 53,494,904 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01754,699,283 - 54,728,846 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1754,699,543 - 54,728,855 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11753,747,272 - 53,766,129 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01753,783,159 - 53,802,012 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01754,356,732 - 54,375,594 (+)NCBIUU_Cfam_GSD_1.0
Atp1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505812,904,636 - 12,933,790 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366271,554,873 - 1,584,638 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366271,555,151 - 1,584,370 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4104,353,506 - 104,384,680 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14104,353,506 - 104,384,321 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24114,431,993 - 114,451,892 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap4q1.6-q2.3NCBI
ATP1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12017,319,440 - 17,351,054 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2017,315,117 - 17,351,054 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603820,010,534 - 20,042,335 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp1a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477212,099,435 - 12,127,737 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477212,099,523 - 12,127,437 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atp1a1
91 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:48
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000040430
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2187663373195783351Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
D2Mgh11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22189,039,155 - 189,039,377 (+)MAPPERmRatBN7.2
Rnor_6.02204,022,334 - 204,022,555NCBIRnor6.0
Rnor_5.02223,459,806 - 223,460,027UniSTSRnor5.0
Celera2181,473,981 - 181,474,202UniSTS
RH 3.4 Map21294.1UniSTS
RH 3.4 Map21294.1RGD
RH 2.0 Map2967.0RGD
SHRSP x BN Map272.7598RGD
Cytogenetic Map2q34UniSTS
D2Wox26  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82191,727,813 - 191,727,999 (+)Marker Load Pipeline
RH 3.4 Map21294.3UniSTS
RH 3.4 Map21294.3RGD
RH 2.0 Map2969.2RGD
Cytogenetic Map2q34UniSTS
D2Arb18  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82191,727,743 - 191,728,017 (+)Marker Load Pipeline
mRatBN7.22189,039,155 - 189,039,429 (+)MAPPERmRatBN7.2
Rnor_6.02204,022,334 - 204,022,607NCBIRnor6.0
Rnor_5.02223,459,806 - 223,460,079UniSTSRnor5.0
Celera2181,473,981 - 181,474,254UniSTS
SHRSP x BN Map272.7698UniSTS
SHRSP x BN Map272.7698RGD
Cytogenetic Map2q34UniSTS
A001Z44  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22189,020,722 - 189,020,907 (+)MAPPERmRatBN7.2
Rnor_6.02204,003,743 - 204,003,927NCBIRnor6.0
Rnor_5.02223,440,515 - 223,440,699UniSTSRnor5.0
RGSC_v3.42196,657,750 - 196,657,934UniSTSRGSC3.4
RGSC_v3.42196,657,198 - 196,657,382UniSTSRGSC3.4
Celera2181,455,493 - 181,455,677UniSTS
Cytogenetic Map2q34UniSTS


Related Rat Strains
The following Strains have been annotated to Atp1a1
SS.MNS-(D2Mit6-Adh1)/Ayd     SS.MNS-(Mme-D2Mit14)/Ayd     SS.MNS-(Mme-Gca)/Ayd    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF304110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF304111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF304112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF304113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF304114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF304115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF304116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF304117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M11733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M28647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M74494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X53233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X53234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000040430   ⟹   ENSRNOP00000045650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2191,709,313 - 191,737,425 (-)Ensembl
mRatBN7.2 Ensembl2189,020,724 - 189,048,837 (-)Ensembl
Rnor_6.0 Ensembl2204,003,742 - 204,032,023 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095094   ⟹   ENSRNOP00000076543
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2191,709,311 - 191,728,167 (-)Ensembl
mRatBN7.2 Ensembl2189,020,722 - 189,039,579 (-)Ensembl
RefSeq Acc Id: NM_012504   ⟹   NP_036636
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82191,709,311 - 191,737,414 (-)NCBI
mRatBN7.22189,020,722 - 189,048,826 (-)NCBI
Rnor_6.02204,003,742 - 204,032,023 (-)NCBI
Rnor_5.02223,440,514 - 223,469,880 (-)NCBI
RGSC_v3.42196,657,749 - 196,687,242 (-)RGD
Celera2181,455,492 - 181,483,650 (-)RGD
Sequence:
RefSeq Acc Id: NP_036636   ⟸   NM_012504
- Peptide Label: precursor
- UniProtKB: Q64609 (UniProtKB/Swiss-Prot),   P06685 (UniProtKB/Swiss-Prot),   A0A8I5Y5B0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000045650   ⟸   ENSRNOT00000040430
Ensembl Acc Id: ENSRNOP00000076543   ⟸   ENSRNOT00000095094
Protein Domains
Cation-transporting P-type ATPase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06685-F1-model_v2 AlphaFold P06685 1-1023 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691615
Promoter ID:EPDNEW_R2140
Type:initiation region
Name:Atp1a1_1
Description:ATPase Na+/K+ transporting subunit alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02204,032,048 - 204,032,108EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2167 AgrOrtholog
BioCyc Gene G2FUF-51850 BioCyc
Ensembl Genes ENSRNOG00000030019 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000040430 ENTREZGENE
  ENSRNOT00000040430.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.1110.10 UniProtKB/Swiss-Prot
  3.40.50.1000 UniProtKB/Swiss-Prot
  Calcium-transporting ATPase, cytoplasmic transduction domain A UniProtKB/Swiss-Prot
  Calcium-transporting ATPase, transmembrane domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5598014 IMAGE-MGC_LOAD
InterPro ATPase_P-typ_cation-transptr_C UniProtKB/Swiss-Prot
  ATPase_P-typ_cation-transptr_N UniProtKB/Swiss-Prot
  ATPase_P-typ_cyto_dom_N UniProtKB/Swiss-Prot
  ATPase_P-typ_P_site UniProtKB/Swiss-Prot
  ATPase_P-typ_TM_dom_sf UniProtKB/Swiss-Prot
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/Swiss-Prot
  Cation_transp_ATPase_P-type UniProtKB/Swiss-Prot
  HAD-like_sf UniProtKB/Swiss-Prot
  HAD_sf UniProtKB/Swiss-Prot
  P-type_ATPase_IIC UniProtKB/Swiss-Prot
  P_typ_ATPase UniProtKB/Swiss-Prot
  P_typ_ATPase_HD_dom UniProtKB/Swiss-Prot
KEGG Report rno:24211 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72546 IMAGE-MGC_LOAD
NCBI Gene 24211 ENTREZGENE
PANTHER SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA UniProtKB/Swiss-Prot
  SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1 UniProtKB/Swiss-Prot
Pfam Cation_ATPase UniProtKB/Swiss-Prot
  Cation_ATPase_C UniProtKB/Swiss-Prot
  Cation_ATPase_N UniProtKB/Swiss-Prot
  E1-E2_ATPase UniProtKB/Swiss-Prot
PhenoGen Atp1a1 PhenoGen
PRINTS CATATPASE UniProtKB/Swiss-Prot
  NAKATPASE UniProtKB/Swiss-Prot
PROSITE ATPASE_E1_E2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000030019 RatGTEx
SMART Cation_ATPase_N UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56784 UniProtKB/Swiss-Prot
  SSF81653 UniProtKB/Swiss-Prot
  SSF81660 UniProtKB/Swiss-Prot
  SSF81665 UniProtKB/Swiss-Prot
TIGR TC216770
UniProt A0A8I5Y5B0 ENTREZGENE, UniProtKB/TrEMBL
  A6K3H7_RAT UniProtKB/TrEMBL
  AT1A1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q64609 ENTREZGENE
UniProt Secondary Q64609 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Atp1a1  ATPase Na+/K+ transporting subunit alpha 1  Atp1a1  ATPase, Na+/K+ transporting, alpha 1 polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Atp1a1  ATPase, Na+/K+ transporting, alpha 1 polypeptide    ATPase, Na+K+ transporting, alpha 1   Name updated 1299863 APPROVED
2002-06-10 Atp1a1  ATPase, Na+K+ transporting, alpha 1       Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains central isoform-specific region (ISR) mediates PKC response but not K+ deocclusion 628463
gene_expression expressed ubiquitously in fetal and adult tissues 61043
gene_function catalytic subunit of Apt1 enzyme 628463
gene_function transports Na+ from the cell and accumulates K+ 628463
gene_mutations_overexpression A1079T mutation that had been proposed to be related to hypertension was not found in any of several hypertension-prone rats 70519
gene_process required in maintaining ionic homeostasis in the kidney 70519
gene_process mediates ionic gradients across the plasma membrane 628463
gene_protein contains binding sites for ions and substrates 628463