Asgr1 (asialoglycoprotein receptor 1) - Rat Genome Database

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Gene: Asgr1 (asialoglycoprotein receptor 1) Rattus norvegicus
Analyze
Symbol: Asgr1
Name: asialoglycoprotein receptor 1
RGD ID: 2160
Description: Enables asialoglycoprotein receptor activity. Predicted to be involved in endocytosis. Predicted to act upstream of or within cellular response to extracellular stimulus. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Orthologous to human ASGR1 (asialoglycoprotein receptor 1); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ASGP-R 1; ASGPR 1; ASGR; asialoglycoprotein receptor (RHL1); asialoglycoprotein receptor 1 (hepatic lectin); asialoglycoprotein receptor RHL1; hepatic lectin 1; hepatic lectin 1 RHL1; hepatic lectin 1, RHL1; HL-1; MGC108731; rat hepatic lectin 1, RHL1; RATRHL1; RHL-1; RHL1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Is Marker For: Strains:   WKY.SHRSP-(Asgr1-Vamp2)/Bbb  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21054,775,727 - 54,779,642 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,776,024 - 54,779,631 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,437,984 - 59,441,840 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,926,564 - 58,930,426 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,433,827 - 54,437,683 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,662,188 - 56,666,086 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,662,242 - 56,666,086 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,407,361 - 56,411,205 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,899,266 - 56,903,173 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11056,912,888 - 56,916,796 (+)NCBI
Celera1053,929,331 - 53,933,180 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
buspirone  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
ciprofibrate  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dibenz[a,h]anthracene  (ISO)
disulfiram  (ISO)
ethanol  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
graphene oxide  (ISO)
GW 4064  (ISO)
Kukoamine B  (ISO)
methidathion  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
PCB138  (EXP)
perfluorooctanoic acid  (ISO)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. Deng AY and Rapp JP, J Clin Invest 1995 May;95(5):2170-7
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat liver asialoglycoprotein receptor lacks a cleavable NH2-terminal signal sequence. Holland EC, etal., Proc Natl Acad Sci U S A 1984 Dec;81(23):7338-42.
5. Characterization of the gene encoding the major rat liver asialoglycoprotein receptor. Leung JO, etal., J Biol Chem 1985 Oct 15;260(23):12523-7.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:2945599   PMID:3215517   PMID:3600647   PMID:7961705   PMID:12477932   PMID:12949020   PMID:15489334   PMID:16286643   PMID:34131415  


Genomics

Comparative Map Data
Asgr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21054,775,727 - 54,779,642 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,776,024 - 54,779,631 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,437,984 - 59,441,840 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,926,564 - 58,930,426 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,433,827 - 54,437,683 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,662,188 - 56,666,086 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,662,242 - 56,666,086 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,407,361 - 56,411,205 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,899,266 - 56,903,173 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11056,912,888 - 56,916,796 (+)NCBI
Celera1053,929,331 - 53,933,180 (+)NCBICelera
Cytogenetic Map10q24NCBI
ASGR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,173,431 - 7,179,370 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,173,431 - 7,179,564 (-)EnsemblGRCh38hg38GRCh38
GRCh37177,076,750 - 7,082,689 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,017,474 - 7,023,386 (-)NCBINCBI36Build 36hg18NCBI36
Build 34177,017,473 - 7,023,386NCBI
Celera177,101,987 - 7,107,556 (-)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef176,970,042 - 6,974,571 (-)NCBIHuRef
CHM1_1177,085,514 - 7,091,656 (-)NCBICHM1_1
T2T-CHM13v2.0177,074,344 - 7,080,281 (-)NCBIT2T-CHM13v2.0
Asgr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,939,735 - 69,948,721 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,944,911 - 69,948,720 (+)EnsemblGRCm39 Ensembl
GRCm381170,048,909 - 70,057,895 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,054,085 - 70,057,894 (+)EnsemblGRCm38mm10GRCm38
MGSCv371169,867,871 - 69,871,396 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361169,870,610 - 69,874,081 (+)NCBIMGSCv36mm8
Celera1177,603,053 - 77,606,577 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.98NCBI
Asgr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,729,345 - 9,732,355 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554679,728,918 - 9,732,548 (+)NCBIChiLan1.0ChiLan1.0
ASGR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11716,732,125 - 16,737,847 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,203,387 - 7,209,602 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,191,076 - 7,196,984 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,191,076 - 7,196,992 (-)Ensemblpanpan1.1panPan2
LOC489461
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,156,746 - 32,159,927 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,089,454 - 32,159,866 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,295,516 - 32,298,705 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,262,603 - 32,265,792 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,262,610 - 32,265,736 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,228,081 - 32,231,268 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,187,171 - 32,190,355 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,364,041 - 32,367,230 (-)NCBIUU_Cfam_GSD_1.0
LOC101966831
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560246,999,464 - 47,005,701 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936595476,438 - 479,030 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936595475,816 - 479,180 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASGR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,536,738 - 52,544,791 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,536,738 - 52,540,636 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23139,811,186 - 139,815,058 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ASGR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,546,173 - 6,553,213 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,546,404 - 6,551,456 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605914,864,806 - 14,870,274 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Asgr1
17 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:249
Count of miRNA genes:190
Interacting mature miRNAs:210
Transcripts:ENSRNOT00000025254
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105220003059378278Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105379738558445852Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat

Markers in Region
D10Wox14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,775,807 - 54,775,965 (+)MAPPERmRatBN7.2
Rnor_6.01056,662,253 - 56,662,410NCBIRnor6.0
Rnor_5.01056,407,372 - 56,407,529UniSTSRnor5.0
RGSC_v3.41056,899,277 - 56,899,434UniSTSRGSC3.4
RGSC_v3.41056,899,276 - 56,899,434RGDRGSC3.4
Celera1053,929,342 - 53,929,499UniSTS
Cytogenetic Map10q24UniSTS
D10Mgh22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,775,745 - 54,776,015 (+)MAPPERmRatBN7.2
Rnor_6.01056,662,191 - 56,662,460NCBIRnor6.0
Rnor_5.01056,407,310 - 56,407,579UniSTSRnor5.0
RGSC_v3.41056,899,214 - 56,899,484RGDRGSC3.4
RGSC_v3.41056,899,215 - 56,899,484UniSTSRGSC3.4
RGSC_v3.11056,912,837 - 56,913,107RGD
Celera1053,929,280 - 53,929,549UniSTS
Cytogenetic Map10q24UniSTS
D10Rat77  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,774,291 - 54,774,503 (+)MAPPERmRatBN7.2
Rnor_6.01056,660,737 - 56,660,948NCBIRnor6.0
Rnor_5.01056,405,856 - 56,406,067UniSTSRnor5.0
RGSC_v3.41056,897,760 - 56,897,972RGDRGSC3.4
RGSC_v3.41056,897,761 - 56,897,972UniSTSRGSC3.4
RGSC_v3.11056,911,383 - 56,911,595RGD
Celera1053,927,826 - 53,928,037UniSTS
SHRSP x BN Map1046.18UniSTS
SHRSP x BN Map1046.18RGD
FHH x ACI Map1045.8799RGD
Cytogenetic Map10q24UniSTS
D10Arb6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,775,791 - 54,776,014 (+)MAPPERmRatBN7.2
Rnor_6.01056,662,237 - 56,662,459NCBIRnor6.0
Rnor_5.01056,407,356 - 56,407,578UniSTSRnor5.0
RGSC_v3.41056,899,260 - 56,899,483RGDRGSC3.4
RGSC_v3.41056,899,261 - 56,899,483UniSTSRGSC3.4
RGSC_v3.11056,912,883 - 56,913,106RGD
Celera1053,929,326 - 53,929,548UniSTS
FHH x ACI Map1046.39UniSTS
FHH x ACI Map1046.39RGD
Cytogenetic Map10q24UniSTS


Related Rat Strains
The following Strains have been annotated to Asgr1


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 29 29 29 4 11 1
Low 1 8 23 12 4 12 2 2 68 24 32 8 2
Below cutoff 29 5 15 4 4 2 8 3 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH002139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K02817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M16348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M16349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M16350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000025254   ⟹   ENSRNOP00000025254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,776,024 - 54,779,631 (+)Ensembl
Rnor_6.0 Ensembl1056,662,561 - 56,666,082 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086919   ⟹   ENSRNOP00000070316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,776,024 - 54,779,631 (+)Ensembl
Rnor_6.0 Ensembl1056,662,242 - 56,666,086 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107307   ⟹   ENSRNOP00000084688
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,776,024 - 54,779,631 (+)Ensembl
RefSeq Acc Id: NM_012503   ⟹   NP_036635
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21054,775,797 - 54,779,641 (+)NCBI
Rnor_6.01056,662,242 - 56,666,086 (+)NCBI
Rnor_5.01056,407,361 - 56,411,205 (+)NCBI
RGSC_v3.41056,899,266 - 56,903,173 (+)RGD
Celera1053,929,331 - 53,933,180 (+)RGD
Sequence:
RefSeq Acc Id: XM_006246579   ⟹   XP_006246641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21054,776,029 - 54,779,641 (+)NCBI
Rnor_6.01056,662,474 - 56,666,086 (+)NCBI
Rnor_5.01056,407,361 - 56,411,205 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767768   ⟹   XP_008765990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21054,776,030 - 54,779,642 (+)NCBI
Rnor_6.01056,662,479 - 56,666,086 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767769   ⟹   XP_008765991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21054,775,727 - 54,779,642 (+)NCBI
Rnor_6.01056,662,188 - 56,666,086 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085168   ⟹   XP_038941096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21054,775,801 - 54,779,642 (+)NCBI
RefSeq Acc Id: XM_039085169   ⟹   XP_038941097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21054,775,793 - 54,779,642 (+)NCBI
RefSeq Acc Id: XM_039085170   ⟹   XP_038941098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21054,777,741 - 54,779,642 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_036635   ⟸   NM_012503
- UniProtKB: P02706 (UniProtKB/Swiss-Prot),   A6HG16 (UniProtKB/TrEMBL),   A6HG15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246641   ⟸   XM_006246579
- Peptide Label: isoform X1
- UniProtKB: P02706 (UniProtKB/Swiss-Prot),   A6HG16 (UniProtKB/TrEMBL),   A6HG15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765991   ⟸   XM_008767769
- Peptide Label: isoform X2
- UniProtKB: A6HG15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765990   ⟸   XM_008767768
- Peptide Label: isoform X2
- UniProtKB: A6HG15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025254   ⟸   ENSRNOT00000025254
RefSeq Acc Id: ENSRNOP00000070316   ⟸   ENSRNOT00000086919
RefSeq Acc Id: XP_038941097   ⟸   XM_039085169
- Peptide Label: isoform X2
- UniProtKB: A6HG15 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941096   ⟸   XM_039085168
- Peptide Label: isoform X1
- UniProtKB: P02706 (UniProtKB/Swiss-Prot),   A6HG16 (UniProtKB/TrEMBL),   A6HG15 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941098   ⟸   XM_039085170
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000084688   ⟸   ENSRNOT00000107307
Protein Domains
C-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02706-F1-model_v2 AlphaFold P02706 1-284 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2160 AgrOrtholog
BioCyc Gene G2FUF-24484 BioCyc
Ensembl Genes ENSRNOG00000018693 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000025254 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000070316.2 UniProtKB/TrEMBL
  ENSRNOP00000084688.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025254 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000086919.2 UniProtKB/TrEMBL
  ENSRNOT00000107307.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7372227 IMAGE-MGC_LOAD
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CD209-like_CTLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24210 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108731 IMAGE-MGC_LOAD
NCBI Gene 24210 ENTREZGENE
PANTHER MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REGENERATING ISLET-DERIVED PROTEIN 3-GAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lectin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Asgr1 PhenoGen
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC239648
UniProt A0A8I6GAW1_RAT UniProtKB/TrEMBL
  A0A8L2R240_RAT UniProtKB/TrEMBL
  A6HG15 ENTREZGENE, UniProtKB/TrEMBL
  A6HG16 ENTREZGENE, UniProtKB/TrEMBL
  A6HG18_RAT UniProtKB/TrEMBL
  A6HG19_RAT UniProtKB/TrEMBL
  ASGR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Asgr1  asialoglycoprotein receptor 1    asialoglycoprotein receptor 1   Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Asgr1  asialoglycoprotein receptor 1       Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 631721
gene_function plasma membane receptor 631721
gene_function functions as the major rat hepatic lectin 631725
gene_protein 42 kilodaltons 631721
gene_protein 42 kilodaltons 631725
gene_transcript encoded by nine exons separated by eight introns 631721