Arg1 (arginase 1) - Rat Genome Database

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Gene: Arg1 (arginase 1) Rattus norvegicus
Analyze
Symbol: Arg1
Name: arginase 1
RGD ID: 2150
Description: Enables arginase activity; identical protein binding activity; and manganese ion binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to glucagon stimulus; and collagen biosynthetic process. Located in extracellular space and neuronal cell body. Used to study acute necrotizing pancreatitis and hypertension. Biomarker of several diseases, including acute kidney failure; cholestasis; silicosis; ureteral obstruction; and uveitis. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1); PARTICIPATES IN urea cycle pathway; AGAT deficiency pathway; arginine and proline metabolic pathway; INTERACTS WITH (S)-colchicine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-bromopropane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI type I arginase; AI, type I arginase; arginase 1 liver; Arginase 1, liver; arginase, liver; arginase-1; liver-type arginase; type I arginase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8122,295,093 - 22,307,720 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl122,295,322 - 22,307,713 (+)EnsemblGRCr8
mRatBN7.2120,475,878 - 20,488,422 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl120,475,968 - 20,488,422 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx120,252,638 - 20,265,091 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0126,252,577 - 26,265,080 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0120,452,538 - 20,464,985 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0121,525,421 - 21,537,872 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,525,421 - 21,537,863 (+)Ensemblrn6Rnor6.0
Rnor_5.0123,005,260 - 23,017,714 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4120,998,894 - 21,011,275 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera119,228,309 - 19,241,078 (+)NCBICelera
RGSC_v3.1120,999,006 - 21,011,333 (+)NCBI
Cytogenetic Map1p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E)-thiamethoxam  (ISO)
(S)-colchicine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1-bromopropane  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-hexanedione  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aminoimidazole-4-carboxamide  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
acetamide  (EXP)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
agathisflavone  (EXP)
AICA ribonucleotide  (EXP)
all-trans-retinoic acid  (EXP,ISO)
AM6545  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
amlexanox  (ISO)
ammonium chloride  (EXP)
ampicillin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astaxanthin  (ISO)
azithromycin  (ISO)
Azoxymethane  (ISO)
azoxystrobin  (ISO)
baicalein  (ISO)
Bardoxolone methyl  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-amyrin  (ISO)
bexarotene  (EXP)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbendazim  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
cortisol  (EXP)
coumarin  (EXP)
crocidolite asbestos  (ISO)
Cyclopamine  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cyproconazole  (EXP)
cyprodinil  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (ISO)
dextran sulfate  (ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenzofurans  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP,ISO)
dicyclanil  (ISO)
diethylstilbestrol  (EXP,ISO)
difenoconazole  (ISO)
dimethomorph  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
diuron  (EXP)
donepezil hydrochloride  (ISO)
dopamine  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP,ISO)
enilconazole  (ISO)
epoxiconazole  (ISO)
erastin  (ISO)
ethoprophos  (ISO)
excitatory amino acid agonist  (EXP)
fasudil  (EXP)
fenhexamid  (ISO)
fenpyroximate  (ISO)
fipronil  (EXP,ISO)
flavonoids  (EXP,ISO)
fludioxonil  (ISO)
flurbiprofen  (ISO)
flusilazole  (EXP,ISO)
flutamide  (EXP)
fluxapyroxad  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glyburide  (EXP,ISO)
glycidol  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
graphene oxide  (ISO)
graphite  (EXP)
GSK-J4  (ISO)
hexadecanoic acid  (EXP,ISO)
HU-308  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
imipramine  (ISO)
indometacin  (EXP)
iodide salt  (EXP)
isoliquiritigenin  (ISO)
ketoconazole  (EXP)
L-ethionine  (EXP)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
limonene  (EXP)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
Luteolin 7-methyl ether  (ISO)
malvidin  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mechlorethamine  (EXP)
MeIQx  (ISO)
melatonin  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
mifepristone  (EXP)
MitoTEMPO  (ISO)
Morroniside  (ISO)
N,N-dimethylformamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
nefazodone  (EXP)
nickel dichloride  (EXP)
nitrofen  (EXP)
NS-398  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
omeprazole  (EXP)
ozone  (EXP,ISO)
paeoniflorin  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perindopril  (ISO)
Picein  (ISO)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
PRIM-O-GLUCOSYLCIMIFUGIN  (ISO)
prochloraz  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quartz  (EXP)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
salicylic acid  (EXP)
SB 203580  (ISO)
selenium atom  (ISO)
sevoflurane  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
Sinomenine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium lactate  (ISO)
Soman  (EXP)
streptozocin  (EXP,ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
tauroursodeoxycholic acid  (EXP)
tebuconazole  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thiamethoxam  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trans-caffeic acid  (ISO)
tremolite asbestos  (ISO)
triadimefon  (EXP)
trimethyltin  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
trypanothione  (ISO)
trypanothione disulfide  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
ursolic acid  (ISO)
valproic acid  (ISO)
VX nerve agent  (ISO)
WIN 55212-2  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
arginine metabolic process  (IDA,IEA)
cellular response to dexamethasone stimulus  (IEP)
cellular response to glucagon stimulus  (IEP)
cellular response to hydrogen peroxide  (IEP)
cellular response to interleukin-4  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
collagen biosynthetic process  (IMP)
defense response to protozoan  (IEA,ISO)
female pregnancy  (IEP)
immune system process  (IEA)
innate immune response  (IEA)
liver development  (IEP)
lung development  (IEP)
mammary gland involution  (IEP)
maternal process involved in female pregnancy  (IEP)
negative regulation of activated T cell proliferation  (IEA,ISO)
negative regulation of T cell proliferation  (IEA,ISO)
negative regulation of T-helper 2 cell cytokine production  (IEA,ISO)
negative regulation of type II interferon-mediated signaling pathway  (IEA,ISO)
positive regulation of endothelial cell proliferation  (IDA)
positive regulation of neutrophil mediated killing of fungus  (IEA,ISO)
regulation of cell population proliferation  (IEA)
regulation of L-arginine import across plasma membrane  (IDA)
response to amine  (IEP)
response to amino acid  (IEP)
response to axon injury  (IEP)
response to cadmium ion  (IEP)
response to herbicide  (IEP)
response to lipopolysaccharide  (IEP)
response to manganese ion  (IEP)
response to methylmercury  (IEP)
response to nematode  (IEA,ISO)
response to peptide hormone  (IEP)
response to selenium ion  (IEP)
response to steroid hormone  (IEP)
response to vitamin A  (IEP)
response to vitamin E  (IEP)
response to xenobiotic stimulus  (IEP)
response to zinc ion  (IEP)
urea cycle  (IDA,IEA)

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (IBA)
extracellular space  (IDA,IEA,ISO)
neuronal cell body  (IDA)

References

References - curated
# Reference Title Reference Citation
1. Archivos latinoamericanos de nutrición Alarcon-Corredor OM and Alfonso R, Arch Latinoam Nutr. 2007 Sep;57(3):224-30.
2. Treatment with the arginase inhibitor N(omega)-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat. Bagnost T, etal., J Hypertens. 2008 Jun;26(6):1110-8.
3. Decreased urea synthesis in cafeteria-diet-induced obesity in the rat. Barber T, etal., Biochem J. 1985 Sep 15;230(3):675-81.
4. The activity of ornithine transcarbamoylase and arginase during mechanical jaundice in the rat model. Beck B, etal., J Surg Res. 2005 Jun 1;126(1):19-26.
5. Developmental changes in arginase expression and activity in the lung. Belik J, etal., Am J Physiol Lung Cell Mol Physiol. 2008 Mar;294(3):L498-504. Epub 2008 Jan 11.
6. Chronic hypercapnia downregulates arginase expression and activity and increases pulmonary arterial smooth muscle relaxation in the newborn rat. Belik J, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L777-84. Epub 2009 Aug 7.
7. Inhibition of arginase activity ameliorates L-arginine-induced acute pancreatitis in rats. Biczo G, etal., Pancreas. 2010 Aug;39(6):868-74.
8. Structural and functional importance of first-shell metal ligands in the binuclear manganese cluster of arginase I. Cama E, etal., Biochemistry. 2003 Jul 1;42(25):7748-58.
9. Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion. Cao Y, etal., J Proteome Res. 2019 May 3;18(5):2032-2044. doi: 10.1021/acs.jproteome.8b00921. Epub 2019 Mar 29.
10. Pegylated recombinant human arginase (rhArg-peg5,000mw) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion. Cheng PN, etal., Cancer Res. 2007 Jan 1;67(1):309-17.
11. In-depth identification of pathways related to cisplatin-induced hepatotoxicity through an integrative method based on an informatics-assisted label-free protein quantitation and microarray gene expression approach. Cho YE, etal., Mol Cell Proteomics. 2012 Jan;11(1):M111.010884. doi: 10.1074/mcp.M111.010884. Epub 2011 Oct 24.
12. Time course of vascular arginase expression and activity in spontaneously hypertensive rats. Demougeot C, etal., Life Sci. 2007 Feb 27;80(12):1128-34. Epub 2006 Dec 14.
13. Development of the ornithine cycle in rat liver: zonation of a metabolic pathway. Dingemanse MA, etal., Hepatology. 1996 Aug;24(2):407-11.
14. Reducing arginase activity via dietary manganese deficiency enhances endothelium-dependent vasorelaxation of rat aorta. Ensunsa JL, etal., Exp Biol Med (Maywood). 2004 Dec;229(11):1143-53.
15. Effects of N-acetylcysteine on arginase, ornithine and nitric oxide in renal ischemia-reperfusion injury. Erbas H, etal., Pharmacol Res. 2004 Nov;50(5):523-7.
16. Effects of dietary vitamin E and selenium on arginase activity in the liver, kidneys, and heart of rats treated with high doses of glucocorticoid. Erisir M, etal., Cell Biochem Funct. 2003 Dec;21(4):331-5.
17. Arginase 1 regulation of nitric oxide production is key to survival of trophic factor-deprived motor neurons. Estevez AG, etal., J Neurosci. 2006 Aug 16;26(33):8512-6.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. Arginase upregulation and eNOS uncoupling contribute to impaired endothelium-dependent vasodilation in a rat model of intrauterine growth restriction. Grandvuillemin I, etal., Am J Physiol Regul Integr Comp Physiol. 2018 Sep 1;315(3):R509-R520. doi: 10.1152/ajpregu.00354.2017. Epub 2018 May 9.
20. Effects of growth hormone on steroid-induced increase in ability of urea synthesis and urea enzyme mRNA levels. Grofte T, etal., Am J Physiol. 1998 Jul;275(1 Pt 1):E79-86.
21. Involvement of arginase in regulating myometrial contractions during gestation in the rat. Hirata M, etal., Mol Hum Reprod. 2006 Aug;12(8):513-8. Epub 2006 May 30.
22. AT(1) receptor activation regulates the mRNA expression of CAT1, CAT2, arginase-1, and DDAH2 in preglomerular vessels from angiotensin II hypertensive rats. Hultstrom M, etal., Am J Physiol Renal Physiol. 2009 Jul;297(1):F163-8. Epub 2009 Apr 22.
23. Cloning and characterization of the mouse and rat type II arginase genes. Iyer RK, etal., Mol Genet Metab 1998 Mar;63(3):168-75.
24. Reduction of arginase I activity and manganese levels in the liver during exposure of rats to methylmercury: a possible mechanism. Kanda H, etal., Arch Toxicol. 2008 Nov;82(11):803-8. Epub 2008 May 17.
25. Crystallization and oligomeric structure of rat liver arginase. Kanyo ZF, etal., J Mol Biol. 1992 Apr 20;224(4):1175-7.
26. Complete nucleotide sequence of cDNA and deduced amino acid sequence of rat liver arginase. Kawamoto S, etal., J Biol Chem 1987 May 5;262(13):6280-3.
27. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
28. Effect of adrenomedullin on hepatic damage in hepatic ischaemia/reperfusion injury in rats. Kerem M, etal., Liver Int. 2008 Aug;28(7):972-81. Epub 2008 Apr 23.
29. Middle East Respiratory Syndrome-Coronavirus Infection into Established hDPP4-Transgenic Mice Accelerates Lung Damage Via Activation of the Pro-Inflammatory Response and Pulmonary Fibrosis. Kim J, etal., J Microbiol Biotechnol. 2020 Mar 28;30(3):427-438. doi: 10.4014/jmb.1910.10055.
30. Glucocorticoids inhibit lipopolysaccharide-induced up-regulation of arginase in rat alveolar macrophages. Klasen S, etal., Br J Pharmacol. 2001 Mar;132(6):1349-57.
31. Coinduction of nitric oxide synthase and arginine metabolic enzymes in endotoxin-induced uveitis rats. Koga T, etal., Exp Eye Res 2002 Dec;75(6):659-67.
32. Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells. Li H, etal., Am J Physiol Endocrinol Metab. 2001 Jan;280(1):E75-82.
33. Activities of arginase I and II are limiting for endothelial cell proliferation. Li H, etal., Am J Physiol Regul Integr Comp Physiol. 2002 Jan;282(1):R64-9.
34. Genetic polymorphisms in arginase I and II and childhood asthma and atopy. Li H, etal., J Allergy Clin Immunol. 2006 Jan;117(1):119-26. Epub 2005 Nov 28.
35. Glucocorticoid inhibition of interleukin-4 (IL-4) and interleukin-13 (IL-13) induced up-regulation of arginase in rat airway fibroblasts. Lindemann D and Racke K, Naunyn Schmiedebergs Arch Pharmacol. 2003 Dec;368(6):546-50. Epub 2003 Nov 15.
36. Pirfenidone inhibits lung allograft fibrosis through L-arginine-arginase pathway. Liu H, etal., Am J Transplant. 2005 Jun;5(6):1256-63.
37. Nitric oxide synthase and arginase expression changes in the rat perirhinal and entorhinal cortices following unilateral vestibular damage: a link to deficits in object recognition? Liu P, etal., J Vestib Res. 2004;14(6):411-7.
38. Inhibition of NADPH oxidase by apocynin inhibits lipopolysaccharide (LPS) induced up-regulation of arginase in rat alveolar macrophages. Matthiesen S, etal., Eur J Pharmacol. 2008 Jan 28;579(1-3):403-10. Epub 2007 Oct 25.
39. Spermine increases arginase activity in the liver after carbon tetrachloride-induced hepatic injury in Long-Evans rats. Mendez JD, etal., Biomed Pharmacother. 2006 Feb;60(2):82-5. Epub 2005 Dec 27.
40. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
41. Effect of paraquat exposure on nitric oxide-responsive genes in rat mesencephalic cells. Moran JM, etal., Nitric Oxide. 2010 Apr 11.
42. Regulation of the urea cycle enzyme genes in nitric oxide synthesis. Mori M, etal., J Inherit Metab Dis. 1998;21 Suppl 1:59-71.
43. Advantage of serum type-I arginase and ornithine carbamoyltransferase in the evaluation of acute and chronic liver damage induced by thioacetamide in rats. Murayama H, etal., Clin Chim Acta. 2007 Jan;375(1-2):63-8. Epub 2006 Jun 21.
44. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
45. The role of mitochondrially bound arginase in the regulation of urea synthesis: studies with [U-15N4]arginine, isolated mitochondria, and perfused rat liver. Nissim I, et al., J Biol Chem. 2005 May 6;280(18):17715-24. Epub 2005 Mar 7.
46. Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across species. O'Brien J, etal., Am J Pathol. 2010 Mar;176(3):1241-55. Epub 2010 Jan 28.
47. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
48. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
49. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
50. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
51. Cell- and isoform-specific increases in arginase expression in acute silica-induced pulmonary inflammation. Poljakovic M, etal., J Toxicol Environ Health A. 2007 Jan 15;70(2):118-27.
52. Insulin resistance induced by a high-fructose diet potentiates thioacetamide hepatotoxicity. Pooranaperundevi M, etal., Singapore Med J. 2010 May;51(5):389-98.
53. Induction of arginase isoforms in the lung during hyperoxia. Que LG, etal., Am J Physiol. 1998 Jul;275(1 Pt 1):L96-102.
54. Effects of arginase isoforms on NO Production by nNOS. Que LG, etal., Nitric Oxide 2002 Feb;6(1):1-8.
55. Liver I/R injury is improved by the arginase inhibitor, N(omega)-hydroxy-nor-L-arginine (nor-NOHA). Reid KM, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Feb;292(2):G512-7. Epub 2006 Oct 5.
56. GOA pipeline RGD automated data pipeline
57. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
58. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
59. Diabetes-induced coronary vascular dysfunction involves increased arginase activity. Romero MJ, etal., Circ Res. 2008 Jan 4;102(1):95-102. Epub 2007 Oct 25.
60. Journal of animal physiology and animal nutrition Roth VH J Anim Physiol Anim Nutr (Berl). 2001 Feb;85(1-2):45-52.
61. Inducible NO synthase dependent S-nitrosylation and activation of arginase1 contribute to age-related endothelial dysfunction. Santhanam L, et al., Circ Res. 2007 Sep 28;101(7):692-702. Epub 2007 Aug 17.
62. Arginine transport is augmented, through modulation of cationic amino acid transporter-1, in obstructive uropathy in rats. Schwartz IF, etal., Kidney Blood Press Res. 2008;31(3):210-6. Epub 2008 Jun 14.
63. L-Arginine transport is augmented through up-regulation of tubular CAT-2 mRNA in ischemic acute renal failure in rats. Schwartz IF, etal., Kidney Int 2002 Nov;62(5):1700-6.
64. Cold acclimation reduces hepatic protein Kinase B and AMP-activated protein kinase phosphorylation and increases gluconeogenesis in Rats. Sepa-Kishi DM, etal., Physiol Rep. 2018 Mar;6(5). doi: 10.14814/phy2.13592.
65. Coinduction of nitric-oxide synthase and arginase I in cultured rat peritoneal macrophages and rat tissues in vivo by lipopolysaccharide. Sonoki T, etal., J Biol Chem. 1997 Feb 7;272(6):3689-93.
66. Regulation of genes for inducible nitric oxide synthase and urea cycle enzymes in rat liver in endotoxin shock. Tabuchi S, etal., Biochem Biophys Res Commun. 2000 Feb 5;268(1):221-4.
67. Inhibition of rat liver and kidney arginase by cadmium ion. Tormanen CD J Enzyme Inhib Med Chem. 2006 Feb;21(1):119-23.
68. IL-33-induced alternatively activated macrophage attenuates the development of TNBS-induced colitis. Tu L, etal., Oncotarget. 2017 Apr 25;8(17):27704-27714. doi: 10.18632/oncotarget.15984.
69. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
70. Molecular basis of phenotypic variation in patients with argininemia. Uchino T, etal., Hum Genet. 1995 Sep;96(3):255-60.
71. Coordinate induction of the urea cycle enzymes by glucagon and dexamethasone is accomplished by three different mechanisms. Ulbright C and Snodgrass PJ, Arch Biochem Biophys. 1993 Mar;301(2):237-43.
72. Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response. Vonk JM, etal., Pharmacogenet Genomics. 2010 Mar;20(3):179-86.
73. Species differences in expression pattern of arginase isoenzymes and differential effects of arginase inhibition on collagen synthesis in human and rat pulmonary fibroblasts. Warnken M, etal., Naunyn Schmiedebergs Arch Pharmacol. 2010 Apr;381(4):297-304. Epub 2010 Jan 28.
74. Induction of arginase II in livers of bile duct-ligated rats. Wei CL, etal., Biochem Pharmacol. 2002 Mar 15;63(6):1043-50.
75. Arginase acts as an alternative pathway of L-arginine metabolism in experimental colon anastomosis. Witte MB, etal., J Gastrointest Surg. 2003 Mar-Apr;7(3):378-85.
76. Upregulation of arginase expression in wound-derived fibroblasts. Witte MB, etal., J Surg Res 2002 Jun 1;105(1):35-42.
77. Role of KCa3.1 Channels in Macrophage Polarization and Its Relevance in Atherosclerotic Plaque Instability. Xu R, etal., Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):226-236. doi: 10.1161/ATVBAHA.116.308461. Epub 2016 Dec 29.
78. The heterogeneous distribution of argininosuccinate synthetase in the liver of type II citrullinemic patients. Its specificity and possible clinical implications. Yagi Y, etal., Am J Clin Pathol. 1988 Jun;89(6):735-41.
79. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. Zimmermann N, etal., J Clin Invest. 2003 Jun;111(12):1863-74.
Additional References at PubMed
PMID:2026618   PMID:2892837   PMID:8849731   PMID:9179379   PMID:9265637   PMID:9502196   PMID:10542097   PMID:11883902   PMID:12020133   PMID:12194870   PMID:12477932   PMID:15013576  
PMID:15248756   PMID:15489334   PMID:15546957   PMID:16141327   PMID:16380531   PMID:16709924   PMID:16794538   PMID:17418108   PMID:19164802   PMID:19182904   PMID:19360123   PMID:19641117  
PMID:19661445   PMID:19763131   PMID:20032511   PMID:21408057   PMID:21630459   PMID:21952491   PMID:21975054   PMID:22182949   PMID:22325098   PMID:22483960   PMID:22507752   PMID:22872058  
PMID:23232640   PMID:23376485   PMID:23665321   PMID:23691079   PMID:25490411   PMID:25557182   PMID:25872571   PMID:25931508   PMID:26140333   PMID:28259758   PMID:37042199  


Genomics

Comparative Map Data
Arg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8122,295,093 - 22,307,720 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl122,295,322 - 22,307,713 (+)EnsemblGRCr8
mRatBN7.2120,475,878 - 20,488,422 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl120,475,968 - 20,488,422 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx120,252,638 - 20,265,091 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0126,252,577 - 26,265,080 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0120,452,538 - 20,464,985 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0121,525,421 - 21,537,872 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,525,421 - 21,537,863 (+)Ensemblrn6Rnor6.0
Rnor_5.0123,005,260 - 23,017,714 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4120,998,894 - 21,011,275 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera119,228,309 - 19,241,078 (+)NCBICelera
RGSC_v3.1120,999,006 - 21,011,333 (+)NCBI
Cytogenetic Map1p12NCBI
ARG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386131,573,226 - 131,584,329 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6131,470,832 - 131,584,332 (+)Ensemblhg38GRCh38
GRCh376131,894,366 - 131,905,469 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366131,936,058 - 131,947,161 (+)NCBIBuild 36Build 36hg18NCBI36
Build 346131,936,057 - 131,947,161NCBI
Celera6132,641,003 - 132,652,108 (+)NCBICelera
Cytogenetic Map6q23.2NCBI
HuRef6129,475,527 - 129,486,657 (+)NCBIHuRef
CHM1_16132,158,130 - 132,169,259 (+)NCBICHM1_1
T2T-CHM13v2.06132,767,703 - 132,778,804 (+)NCBIT2T-CHM13v2.0
Arg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391024,791,105 - 24,803,368 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1024,791,119 - 24,803,382 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381024,915,207 - 24,927,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1024,915,221 - 24,927,484 (-)Ensemblmm10GRCm38
MGSCv371024,635,013 - 24,647,276 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361024,604,637 - 24,617,896 (-)NCBIMGSCv36mm8
Celera1025,846,180 - 25,858,528 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1012.26NCBI
Arg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543612,235,767 - 12,251,972 (+)Ensembl
ChiLan1.0NW_00495543612,235,767 - 12,247,817 (+)NCBIChiLan1.0ChiLan1.0
ARG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25151,578,718 - 151,592,958 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16149,485,403 - 149,496,465 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06129,372,747 - 129,383,880 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16133,479,966 - 133,491,162 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6133,479,966 - 133,491,162 (+)EnsemblpanPan2panpan1.1
ARG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.112242,717 - 255,736 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl12242,714 - 255,305 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha12380,548 - 393,575 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.012386,327 - 399,472 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl12386,328 - 461,505 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.112243,210 - 256,371 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.012313,845 - 327,006 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.012384,828 - 398,005 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
ARG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl132,006,046 - 32,028,988 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1132,006,035 - 32,028,983 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2135,580,471 - 35,603,458 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11341,971,955 - 41,983,372 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1341,971,802 - 41,983,049 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604014,133,035 - 14,144,266 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247535,737,237 - 5,752,966 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247535,737,720 - 5,749,313 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Arg1
101 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:31
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000017911
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1592587724697545Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat

Markers in Region
RH134303  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2120,488,177 - 20,488,361 (+)MAPPERmRatBN7.2
Rnor_6.0121,537,628 - 21,537,811NCBIRnor6.0
Rnor_5.0123,017,470 - 23,017,653UniSTSRnor5.0
RGSC_v3.4121,011,031 - 21,011,214UniSTSRGSC3.4
Celera119,240,834 - 19,241,017UniSTS
RH 3.4 Map1193.0UniSTS
Cytogenetic Map1p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 155 91 90 59 79 59 6 335 179 11 132 73 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000017911   ⟹   ENSRNOP00000017911
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl122,295,322 - 22,307,713 (+)Ensembl
mRatBN7.2 Ensembl120,475,968 - 20,488,422 (+)Ensembl
Rnor_6.0 Ensembl121,525,421 - 21,537,863 (+)Ensembl
RefSeq Acc Id: NM_017134   ⟹   NP_058830
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8122,295,269 - 22,307,720 (+)NCBI
mRatBN7.2120,475,968 - 20,488,422 (+)NCBI
Rnor_6.0121,525,421 - 21,537,872 (+)NCBI
Rnor_5.0123,005,260 - 23,017,714 (+)NCBI
RGSC_v3.4120,998,894 - 21,011,275 (+)RGD
Celera119,228,309 - 19,241,078 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103358   ⟹   XP_038959286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8122,295,093 - 22,307,720 (+)NCBI
mRatBN7.2120,475,878 - 20,488,422 (+)NCBI
RefSeq Acc Id: XM_039103362   ⟹   XP_038959290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8122,295,332 - 22,307,720 (+)NCBI
mRatBN7.2120,476,044 - 20,488,422 (+)NCBI
RefSeq Acc Id: NP_058830   ⟸   NM_017134
- UniProtKB: Q5BK93 (UniProtKB/Swiss-Prot),   P07824 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017911   ⟸   ENSRNOT00000017911
RefSeq Acc Id: XP_038959286   ⟸   XM_039103358
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q8Y7 (UniProtKB/TrEMBL),   A6JUJ9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959290   ⟸   XM_039103362
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07824-F1-model_v2 AlphaFold P07824 1-323 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689524
Promoter ID:EPDNEW_R48
Type:multiple initiation site
Name:Arg1_1
Description:arginase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0121,525,474 - 21,525,534EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2150 AgrOrtholog
BioCyc Gene G2FUF-62121 BioCyc
BioCyc Pathway ARG-PRO-PWY [L-arginine degradation VI (arginase 2 pathway)] BioCyc
  ARGASEDEG-PWY [L-arginine degradation I (arginase pathway)] BioCyc
  CITRULBIO-PWY [L-citrulline biosynthesis] BioCyc
  PWY-46 [putrescine biosynthesis III] BioCyc
  PWY-4984 [urea cycle] BioCyc
BioCyc Pathway Image ARG-PRO-PWY BioCyc
  ARGASEDEG-PWY BioCyc
  CITRULBIO-PWY BioCyc
  PWY-46 BioCyc
  PWY-4984 BioCyc
Ensembl Genes ENSRNOG00000013304 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000017911 ENTREZGENE
Gene3D-CATH Ureohydrolase domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7368991 IMAGE-MGC_LOAD
InterPro Arginase UniProtKB/Swiss-Prot
  Ureohydrolase UniProtKB/Swiss-Prot
  Ureohydrolase_dom_sf UniProtKB/Swiss-Prot
  Ureohydrolase_Mn_BS UniProtKB/Swiss-Prot
KEGG Report rno:29221 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108729 IMAGE-MGC_LOAD
NCBI Gene 29221 ENTREZGENE
PANTHER ARGINASE-1 UniProtKB/Swiss-Prot
  PTHR43782 UniProtKB/Swiss-Prot
Pfam Arginase UniProtKB/Swiss-Prot
PhenoGen Arg1 PhenoGen
PIRSF Arginase UniProtKB/Swiss-Prot
PRINTS ARGINASE UniProtKB/Swiss-Prot
PROSITE ARGINASE_1 UniProtKB/Swiss-Prot
  ARGINASE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013304 RatGTEx
Superfamily-SCOP SSF52768 UniProtKB/Swiss-Prot
UniProt A0A8L2Q8Y7 ENTREZGENE, UniProtKB/TrEMBL
  A6JUJ9 ENTREZGENE, UniProtKB/TrEMBL
  A6JUK0_RAT UniProtKB/TrEMBL
  A6JUK1_RAT UniProtKB/TrEMBL
  ARGI1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5BK93 ENTREZGENE
UniProt Secondary Q5BK93 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-31 Arg1  arginase 1  Arg1  arginase, liver  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Arg1  arginase, liver  Arg1  arginase 1, liver  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-14 Arg1  arginase 1, liver  Arg1  arginase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Arg1  arginase 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function catalyzes the hydrolysis of arginine to ornithine and urea 634666
gene_process plays a role in arginine metabolism 634666
gene_process may play a role in recovery from wounding 634666
gene_process regulates nitric oxide production 634667
gene_regulation increased expression is detected in fibroblasts after wounding 634666