Aqp8 (aquaporin 8) - Rat Genome Database

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Gene: Aqp8 (aquaporin 8) Rattus norvegicus
Symbol: Aqp8
Name: aquaporin 8
RGD ID: 2146
Description: Enables ammonium channel activity; methylammonium channel activity; and water channel activity. Involved in several processes, including ammonium import across plasma membrane; canalicular bile acid transport; and hydrogen peroxide transmembrane transport. Located in several cellular components, including basolateral plasma membrane; brush border membrane; and intracellular canaliculus. Biomarker of brain ischemia. Orthologous to human AQP8 (aquaporin 8); PARTICIPATES IN bile acid transport pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 17beta-estradiol 17-glucosiduronic acid.
Type: protein-coding
Previously known as: AQP-8; aquaporin-8; MGC93492
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81187,424,314 - 187,430,243 (+)NCBIGRCr8
mRatBN7.21177,993,313 - 177,999,158 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,993,305 - 177,999,158 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1186,329,480 - 186,335,292 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01193,515,484 - 193,521,296 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01186,193,169 - 186,198,970 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01193,424,818 - 193,430,665 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1193,424,812 - 193,430,676 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01200,483,584 - 200,489,432 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,331,494 - 182,337,291 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,471,745 - 182,477,543 (+)NCBI
Celera1175,681,663 - 175,687,460 (+)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Boldine  (EXP)
cadmium sulfate  (ISO)
capecitabine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dextran sulfate  (ISO)
dibenzofurans  (ISO)
diprotium oxide  (EXP,ISO)
diquat  (ISO)
epoxiconazole  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP)
glucose  (ISO)
graphene oxide  (ISO)
herbicide  (ISO)
hydrogen peroxide  (ISO)
leflunomide  (ISO)
leupeptin  (EXP)
lipopolysaccharide  (ISO)
mercury atom  (EXP)
mercury dichloride  (ISO)
mercury(0)  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
ochratoxin A  (EXP)
paracetamol  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
resveratrol  (ISO)
senecionine  (ISO)
sodium dichromate  (ISO)
tauroursodeoxycholic acid  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
water  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function
ammonium channel activity  (IDA,IEA,ISO,ISS)
channel activity  (IEA)
methylammonium channel activity  (IDA,IEA,ISO)
protein binding  (ISO)
urea channel activity  (IEA,ISO,ISS)
water channel activity  (IBA,IDA,IEA,IMP,ISO,TAS)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Expression and regulation of aquaporins 1, 8, and 9 in the testis, efferent ducts, and epididymis of adult rats and during postnatal development. Badran HH and Hermo LS, J Androl 2002 May-Jun;23(3):358-73.
2. Possible involvement of aquaporin-7 and -8 in rat testis development and spermatogenesis. Calamita G, etal., Biochem Biophys Res Commun 2001 Nov 2;288(3):619-25.
3. Expression and immunolocalization of the aquaporin-8 water channel in rat gastrointestinal tract. Calamita G, etal., Eur J Cell Biol 2001 Nov;80(11):711-9.
4. The inner mitochondrial membrane has aquaporin-8 water channels and is highly permeable to water. Calamita G, etal., J Biol Chem. 2005 Apr 29;280(17):17149-53. doi: 10.1074/jbc.C400595200. Epub 2005 Mar 4.
5. Data of H2O2 release from AQP8-knockdown rat hepatocyte mitochondria. Danielli M, etal., Data Brief. 2019 Mar 6;23:103722. doi: 10.1016/j.dib.2019.103722. eCollection 2019 Apr.
6. Immunolocalization of aquaporin-8 in rat kidney, gastrointestinal tract, testis, and airways. Elkjaer ML, etal., Am J Physiol Renal Physiol 2001 Dec;281(6):F1047-57.
7. The water channel aquaporin-8 is mainly intracellular in rat hepatocytes, and its plasma membrane insertion is stimulated by cyclic AMP. Garcia F, etal., J Biol Chem 2001 Apr 13;276(15):12147-52.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Glucagon induces the plasma membrane insertion of functional aquaporin-8 water channels in isolated rat hepatocytes. Gradilone SA, etal., Hepatology 2003 Jun;37(6):1435-41.
11. NH3 and NH4+ permeability in aquaporin-expressing Xenopus oocytes. Holm LM, etal., Pflugers Arch. 2005 Sep;450(6):415-28. doi: 10.1007/s00424-005-1399-1. Epub 2005 Jun 30.
12. Expression and localization of aquaporin water channels in rat hepatocytes. Evidence for a role in canalicular bile secretion. Huebert RC, etal., J Biol Chem 2002 Jun 21;277(25):22710-7.
13. Cloning and functional expression of a second new aquaporin abundantly expressed in testis. Ishibashi K, etal., Biochem Biophys Res Commun 1997 Aug 28;237(3):714-8.
14. AQP8 is a crucial H2O2 transporter in insulin-producing RINm5F cells. Kr├╝ger C, etal., Redox Biol. 2021 Jul;43:101962. doi: 10.1016/j.redox.2021.101962. Epub 2021 Apr 1.
15. Aquaporin-8 is involved in water transport in isolated superficial colonocytes from rat proximal colon. Laforenza U, etal., J Nutr. 2005 Oct;135(10):2329-36. doi: 10.1093/jn/135.10.2329.
16. Purification and functional characterization of aquaporin-8. Liu K, etal., Biol Cell. 2006 Mar;98(3):153-61.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. GOA pipeline RGD automated data pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Fast and selective ammonia transport by aquaporin-8. Saparov SM, etal., J Biol Chem. 2007 Feb 23;282(8):5296-301. doi: 10.1074/jbc.M609343200. Epub 2006 Dec 21.
23. Aquaporin-8-facilitated mitochondrial ammonia transport. Soria LR, etal., Biochem Biophys Res Commun. 2010 Mar 5;393(2):217-21. doi: 10.1016/j.bbrc.2010.01.104. Epub 2010 Feb 2.
24. Ammonia detoxification via ureagenesis in rat hepatocytes involves mitochondrial aquaporin-8 channels. Soria LR, etal., Hepatology. 2013 May;57(5):2061-71. doi: 10.1002/hep.26236.
25. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
26. Immunolocalization of aquaporin-8 in rat digestive organs and testis. Tani T, etal., Arch Histol Cytol. 2001 May;64(2):159-68. doi: 10.1679/aohc.64.159.
27. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
28. Osmotic water permeability of rat intestinal brush border membrane vesicles: involvement of aquaporin-7 and aquaporin-8 and effect of metal ions. Tritto S, etal., Biochem Cell Biol. 2007 Dec;85(6):675-84. doi: 10.1139/o07-142.
29. Evidence that aquaporin-8 is located in the basolateral membrane of rat submandibular gland acinar cells. Wellner RB, etal., Pflugers Arch. 2000 Nov;441(1):49-56. doi: 10.1007/s004240000396.
30. Evidence from knockout mice against physiologically significant aquaporin 8-facilitated ammonia transport. Yang B, etal., Am J Physiol Cell Physiol. 2006 Sep;291(3):C417-23. doi: 10.1152/ajpcell.00057.2006. Epub 2006 Apr 19.
31. Temporal changes in expression of aquaporin-3, -4, -5 and -8 in rat brains after permanent focal cerebral ischemia. Yang M, etal., Brain Res. 2009 Sep 22;1290:121-32. Epub 2009 Jul 16.
Additional References at PubMed
PMID:1373524   PMID:1510932   PMID:7530250   PMID:9369468   PMID:9374520   PMID:9405233   PMID:9806845   PMID:9829975   PMID:10318966   PMID:10510269   PMID:10564231   PMID:11001937  
PMID:11034202   PMID:11076974   PMID:11573934   PMID:12084581   PMID:12717383   PMID:12801959   PMID:14701836   PMID:15489334   PMID:15647389   PMID:15682487   PMID:16311720   PMID:16596446  
PMID:17110522   PMID:17178220   PMID:17636236   PMID:18202181   PMID:18501347   PMID:18511455   PMID:18662282   PMID:18683753   PMID:18762715   PMID:19193945   PMID:20958229   PMID:21251984  
PMID:21713710   PMID:22622463   PMID:24286754   PMID:24642373   PMID:26194146   PMID:28525373   PMID:30579780   PMID:32115689  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81187,424,314 - 187,430,243 (+)NCBIGRCr8
mRatBN7.21177,993,313 - 177,999,158 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,993,305 - 177,999,158 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1186,329,480 - 186,335,292 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01193,515,484 - 193,521,296 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01186,193,169 - 186,198,970 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01193,424,818 - 193,430,665 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1193,424,812 - 193,430,676 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01200,483,584 - 200,489,432 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,331,494 - 182,337,291 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,471,745 - 182,477,543 (+)NCBI
Celera1175,681,663 - 175,687,460 (+)NCBICelera
Cytogenetic Map1q36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381625,216,947 - 25,228,932 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1625,215,731 - 25,228,932 (+)EnsemblGRCh38hg38GRCh38
GRCh371625,228,268 - 25,240,253 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361625,135,786 - 25,147,754 (+)NCBINCBI36Build 36hg18NCBI36
Build 341625,135,785 - 25,147,753NCBI
Celera1624,008,196 - 24,020,163 (+)NCBICelera
Cytogenetic Map16p12.1NCBI
HuRef1623,321,042 - 23,333,010 (+)NCBIHuRef
CHM1_11626,242,508 - 26,254,476 (+)NCBICHM1_1
T2T-CHM13v2.01625,496,437 - 25,508,423 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm397123,061,517 - 123,067,226 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7123,061,514 - 123,067,227 (+)EnsemblGRCm39 Ensembl
GRCm387123,462,294 - 123,468,003 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7123,462,291 - 123,468,004 (+)EnsemblGRCm38mm10GRCm38
MGSCv377130,605,808 - 130,611,517 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367123,253,460 - 123,259,134 (+)NCBIMGSCv36mm8
Celera7123,345,814 - 123,351,523 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map767.42NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554933,550,120 - 3,559,206 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554933,550,697 - 3,558,875 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21826,625,618 - 26,639,032 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11631,146,930 - 31,160,329 (+)NCBINHGRI_mPanPan1
PanPan1.11625,456,998 - 25,469,713 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1625,458,165 - 25,469,713 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1620,984,868 - 20,992,647 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl620,984,908 - 20,992,524 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha622,560,101 - 22,567,873 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0621,124,913 - 21,132,686 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl621,124,953 - 21,132,569 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1620,928,723 - 20,936,525 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0620,830,570 - 20,838,344 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0621,225,638 - 21,233,418 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024409344121,332,842 - 121,340,934 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365019,430,775 - 9,436,813 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365019,430,872 - 9,438,182 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl321,491,719 - 21,503,863 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1321,493,564 - 21,503,778 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2322,088,868 - 22,099,108 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1522,928,230 - 22,940,814 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl522,928,350 - 22,940,856 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660686,785,501 - 6,798,873 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462478210,075,062 - 10,082,076 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478210,074,875 - 10,082,628 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Aqp8
40 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:114
Count of miRNA genes:86
Interacting mature miRNAs:102
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1172949660181830018Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1164747558181133855Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,998,862 - 177,999,027 (+)MAPPERmRatBN7.2
Rnor_6.01193,430,372 - 193,430,536NCBIRnor6.0
Rnor_5.01200,489,136 - 200,489,300UniSTSRnor5.0
RGSC_v3.41182,336,998 - 182,337,162UniSTSRGSC3.4
Celera1175,687,167 - 175,687,331UniSTS
Cytogenetic Map1q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,998,874 - 177,999,091 (+)MAPPERmRatBN7.2
Rnor_6.01193,430,384 - 193,430,600NCBIRnor6.0
Rnor_5.01200,489,148 - 200,489,364UniSTSRnor5.0
RGSC_v3.41182,337,010 - 182,337,226UniSTSRGSC3.4
Celera1175,687,179 - 175,687,395UniSTS
RH 3.4 Map11377.6UniSTS
Cytogenetic Map1q36UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1 37 37 37 10
Low 1 18 7 4 8 4 3 3 5 15 20 3 3
Below cutoff 1 16 13 9 3 4 40 18 11 7 3


RefSeq Acc Id: ENSRNOT00000019939   ⟹   ENSRNOP00000019939
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,993,305 - 177,999,158 (+)Ensembl
Rnor_6.0 Ensembl1193,424,812 - 193,430,676 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118056   ⟹   ENSRNOP00000092342
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,993,543 - 177,999,158 (+)Ensembl
RefSeq Acc Id: NM_019158   ⟹   NP_062031
Rat AssemblyChrPosition (strand)Source
GRCr81187,424,443 - 187,430,240 (+)NCBI
mRatBN7.21177,993,359 - 177,999,156 (+)NCBI
Rnor_6.01193,424,868 - 193,430,665 (+)NCBI
Rnor_5.01200,483,584 - 200,489,432 (+)NCBI
RGSC_v3.41182,331,494 - 182,337,291 (+)RGD
Celera1175,681,663 - 175,687,460 (+)RGD
RefSeq Acc Id: XM_006230187   ⟹   XP_006230249
Rat AssemblyChrPosition (strand)Source
GRCr81187,424,314 - 187,430,243 (+)NCBI
mRatBN7.21177,993,313 - 177,999,158 (+)NCBI
Rnor_6.01193,424,818 - 193,430,395 (+)NCBI
Rnor_5.01200,483,584 - 200,489,432 (+)NCBI
RefSeq Acc Id: NP_062031   ⟸   NM_019158
- UniProtKB: P56405 (UniProtKB/Swiss-Prot),   A0A8I6GK50 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230249   ⟸   XM_006230187
- Peptide Label: isoform X1
- UniProtKB: A0A0H2UHM1 (UniProtKB/TrEMBL),   A6I904 (UniProtKB/TrEMBL),   A0A8I6GK50 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019939   ⟸   ENSRNOT00000019939
RefSeq Acc Id: ENSRNOP00000092342   ⟸   ENSRNOT00000118056

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56405-F1-model_v2 AlphaFold P56405 1-263 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690382
Promoter ID:EPDNEW_R907
Type:initiation region
Description:aquaporin 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01193,424,911 - 193,424,971EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2146 AgrOrtholog
BioCyc Gene G2FUF-57520 BioCyc
Ensembl Genes ENSRNOG00000014652 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019939.7 UniProtKB/TrEMBL
  ENSRNOT00000118056.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aquaporin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aquaporin_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aquaporin_transptr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29172 UniProtKB/Swiss-Prot
  PTHR45665 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aqp8 PhenoGen
  MINTRINSICP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014652 RatGTEx
Superfamily-SCOP SSF81338 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC219837

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Aqp8  aquaporin 8      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process increases cell membrane water permeability facilitating rapid movement of water in response to osmotic gradients 67930
gene_process contributes to water transport in cAMP-stimulated hepatocytes 67930