Aqp5 (aquaporin 5) - Rat Genome Database

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Gene: Aqp5 (aquaporin 5) Rattus norvegicus
Analyze
Symbol: Aqp5
Name: aquaporin 5
RGD ID: 2144
Description: Predicted to enable identical protein binding activity and water channel activity. Involved in carbon dioxide transport. Located in apical plasma membrane. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in Bothnian type palmoplantar keratoderma. Orthologous to human AQP5 (aquaporin 5); PARTICIPATES IN E-cadherin signaling pathway; water transport pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AQP-5; aquaporin-5; MGC124967
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SD-Tg(Aqp5-GFP)ZboroRrrc  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87132,601,528 - 132,605,060 (+)NCBIGRCr8
mRatBN7.27130,722,675 - 130,726,207 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7130,721,748 - 130,726,209 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7132,526,264 - 132,529,796 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07134,751,843 - 134,755,375 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07134,664,370 - 134,667,902 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07141,249,044 - 141,252,576 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7141,249,044 - 141,252,578 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X115,753,747 - 115,757,279 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47138,337,725 - 138,341,257 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17138,414,167 - 138,417,694 (+)NCBI
Celera7127,204,033 - 127,207,565 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(S)-naringenin  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (EXP)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (ISO)
3-methylcholanthrene  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amoxicillin  (EXP)
amphotericin B  (ISO)
atropine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
calcitriol  (ISO)
carbachol  (ISO)
chloroquine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cordycepin  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (EXP)
folic acid  (ISO)
fosfomycin  (EXP)
fructose  (ISO)
furan  (EXP)
genistein  (ISO)
glucose  (ISO)
glycyrrhizinic acid  (ISO)
herbicide  (ISO)
histamine  (ISO)
hydrogen peroxide  (ISO)
L-methionine  (ISO)
methimazole  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
naringin  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
paraquat  (EXP)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
protein kinase inhibitor  (EXP)
quercetin  (EXP)
rac-lactic acid  (ISO)
roflumilast  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
terbutaline  (ISO)
tetrachloromethane  (EXP)
thalidomide  (ISO)
thiourea  (EXP)
titanium dioxide  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Aquaporins in the kidney. Kwon TH, etal., Handb Exp Pharmacol. 2009;(190):95-132. doi: 10.1007/978-3-540-79885-9_5.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Divergent expression and localization of aquaporin 5, an exocrine-type water channel, in the submandibular gland of Sprague-Dawley rats. Murdiastuti K, etal., Pflugers Arch 2002 Dec;445(3):405-12. Epub 2002 Oct 11.
6. Relative CO2/NH3 selectivities of AQP1, AQP4, AQP5, AmtB, and RhAG. Musa-Aziz R, etal., Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5406-11. doi: 10.1073/pnas.0813231106. Epub 2009 Mar 9.
7. Co-localization of rab4 with endocytosis-related proteins in the rat parotid glands. Nashida T, etal., Arch Histol Cytol. 2003 Mar;66(1):45-52.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Functional requirement of aquaporin-5 in plasma membranes of sweat glands. Nejsum LN, etal., Proc Natl Acad Sci U S A 2002 Jan 8;99(1):511-516.
10. Functional requirement of aquaporin-5 in plasma membranes of sweat glands. Nejsum LN, etal., Proc Natl Acad Sci U S A 2002 Jan 8;99(1):511-6.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. Molecular cloning and characterization of an aquaporin cDNA from salivary, lacrimal, and respiratory tissues. Raina S, etal., J Biol Chem 1995 Jan 27;270(4):1908-12.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Temporal changes in expression of aquaporin-3, -4, -5 and -8 in rat brains after permanent focal cerebral ischemia. Yang M, etal., Brain Res. 2009 Sep 22;1290:121-32. Epub 2009 Jul 16.
20. miR-96 and miR-330 overexpressed and targeted AQP5 in lipopolysaccharide-induced rat lung damage of disseminated intravascular coagulation. Zhang Y, etal., Blood Coagul Fibrinolysis. 2014 Oct;25(7):731-7. doi: 10.1097/MBC.0000000000000133.
Additional References at PubMed
PMID:1373524   PMID:1510932   PMID:9369468   PMID:9405233   PMID:9806845   PMID:9829975   PMID:10318966   PMID:10400615   PMID:10510269   PMID:10564231   PMID:10795927   PMID:11001937  
PMID:11034202   PMID:11076974   PMID:11573934   PMID:11707570   PMID:11891232   PMID:12042359   PMID:12084581   PMID:12522663   PMID:12631124   PMID:12801959   PMID:14701836   PMID:14988067  
PMID:15548853   PMID:15557451   PMID:15647389   PMID:15948717   PMID:15952563   PMID:16008975   PMID:16107722   PMID:16596446   PMID:16712780   PMID:16887054   PMID:16901987   PMID:17021794  
PMID:17108010   PMID:17178220   PMID:17380350   PMID:18202181   PMID:18448628   PMID:18450949   PMID:18501347   PMID:18511455   PMID:18696337   PMID:18762715   PMID:18768791   PMID:18768929  
PMID:19013448   PMID:19199708   PMID:19673936   PMID:20128285   PMID:21038658   PMID:21092464   PMID:21138418   PMID:21244858   PMID:21251984   PMID:21295117   PMID:21745799   PMID:21851171  
PMID:21991573   PMID:22424887   PMID:22903161   PMID:22921298   PMID:23199524   PMID:23313152   PMID:23538169   PMID:23922257   PMID:23942196   PMID:24192214   PMID:24570172   PMID:24644013  
PMID:25184686   PMID:25489856   PMID:25603543   PMID:25649359   PMID:26317897   PMID:26569106   PMID:27229103   PMID:27424549   PMID:27983600   PMID:29109472   PMID:29118028   PMID:30060820  
PMID:32439217   PMID:33840298   PMID:35324416   PMID:36210422   PMID:37005283   PMID:38453769  


Genomics

Comparative Map Data
Aqp5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87132,601,528 - 132,605,060 (+)NCBIGRCr8
mRatBN7.27130,722,675 - 130,726,207 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7130,721,748 - 130,726,209 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7132,526,264 - 132,529,796 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07134,751,843 - 134,755,375 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07134,664,370 - 134,667,902 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07141,249,044 - 141,252,576 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7141,249,044 - 141,252,578 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X115,753,747 - 115,757,279 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47138,337,725 - 138,341,257 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17138,414,167 - 138,417,694 (+)NCBI
Celera7127,204,033 - 127,207,565 (+)NCBICelera
Cytogenetic Map7q36NCBI
AQP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381249,961,872 - 49,965,682 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1249,961,872 - 49,965,682 (+)EnsemblGRCh38hg38GRCh38
GRCh371250,355,655 - 50,359,465 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361248,641,546 - 48,645,227 (+)NCBINCBI36Build 36hg18NCBI36
Build 341248,641,545 - 48,645,227NCBI
Celera1249,151,383 - 49,155,562 (+)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1247,386,849 - 47,390,948 (+)NCBIHuRef
CHM1_11250,321,440 - 50,325,624 (+)NCBICHM1_1
T2T-CHM13v2.01249,924,863 - 49,928,671 (+)NCBIT2T-CHM13v2.0
Aqp5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391599,488,909 - 99,492,710 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1599,488,663 - 99,492,710 (+)EnsemblGRCm39 Ensembl
GRCm381599,591,028 - 99,594,829 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1599,590,782 - 99,594,829 (+)EnsemblGRCm38mm10GRCm38
MGSCv371599,421,459 - 99,425,260 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361599,418,814 - 99,422,856 (+)NCBIMGSCv36mm8
Celera15101,746,743 - 101,750,221 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.13NCBI
Aqp5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955547558,927 - 564,376 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955547558,296 - 562,455 (+)NCBIChiLan1.0ChiLan1.0
AQP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21044,223,016 - 44,226,823 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11244,219,778 - 44,223,584 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01238,789,505 - 38,793,305 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11239,683,503 - 39,687,772 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1239,684,008 - 39,687,127 (-)Ensemblpanpan1.1panPan2
AQP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1274,735,313 - 4,742,975 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl274,735,538 - 4,737,650 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2741,517,676 - 41,521,418 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0274,785,875 - 4,789,618 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1274,750,857 - 4,754,598 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,740,684 - 4,744,421 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02741,912,308 - 41,916,050 (+)NCBIUU_Cfam_GSD_1.0
Aqp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494565,521,588 - 65,525,295 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365127,639,668 - 7,642,756 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365127,639,518 - 7,643,242 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AQP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl515,876,407 - 15,880,067 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1515,876,527 - 15,879,608 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2516,079,774 - 16,082,855 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AQP5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11146,190,504 - 46,195,461 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037199,926,134 - 199,930,017 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aqp5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248162,326,010 - 2,329,544 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248162,326,059 - 2,329,525 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aqp5
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:137
Count of miRNA genes:100
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000024102
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
RH94612  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27130,726,029 - 130,726,202 (+)MAPPERmRatBN7.2
Rnor_6.07141,252,399 - 141,252,571NCBIRnor6.0
Rnor_5.0X115,757,102 - 115,757,274UniSTSRnor5.0
RGSC_v3.47138,341,080 - 138,341,252UniSTSRGSC3.4
Celera7127,207,388 - 127,207,560UniSTS
Cytogenetic Map7q36UniSTS
RH134628  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27130,725,823 - 130,726,015 (+)MAPPERmRatBN7.2
Rnor_6.07141,252,193 - 141,252,384NCBIRnor6.0
Rnor_5.0X115,756,896 - 115,757,087UniSTSRnor5.0
RGSC_v3.47138,340,874 - 138,341,065UniSTSRGSC3.4
Celera7127,207,182 - 127,207,373UniSTS
RH 3.4 Map71076.2UniSTS
Cytogenetic Map7q36UniSTS
Aqp5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27130,724,763 - 130,725,681 (+)MAPPERmRatBN7.2
Rnor_6.07141,251,133 - 141,252,050NCBIRnor6.0
Rnor_5.0X115,755,836 - 115,756,753UniSTSRnor5.0
RGSC_v3.47138,339,814 - 138,340,731UniSTSRGSC3.4
Celera7127,206,122 - 127,207,039UniSTS
Cytogenetic Map7q36UniSTS
Aqp5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27130,724,244 - 130,725,657 (+)MAPPERmRatBN7.2
Rnor_6.07141,250,614 - 141,252,026NCBIRnor6.0
Rnor_5.0X115,755,317 - 115,756,729UniSTSRnor5.0
Celera7127,205,603 - 127,207,015UniSTS
Cytogenetic Map7q36UniSTS


Related Rat Strains
The following Strains have been annotated to Aqp5


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 9 2 94 61 68 37 23 37 6 119 32 82 39 49 31

Sequence


Ensembl Acc Id: ENSRNOT00000084911   ⟹   ENSRNOP00000073596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7130,721,748 - 130,726,209 (+)Ensembl
Rnor_6.0 Ensembl7141,249,044 - 141,252,578 (+)Ensembl
RefSeq Acc Id: NM_012779   ⟹   NP_036911
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87132,601,528 - 132,605,060 (+)NCBI
mRatBN7.27130,722,675 - 130,726,207 (+)NCBI
Rnor_6.07141,249,044 - 141,252,576 (+)NCBI
Rnor_5.0X115,753,747 - 115,757,279 (+)NCBI
RGSC_v3.47138,337,725 - 138,341,257 (+)RGD
Celera7127,204,033 - 127,207,565 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036911 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA66221 (Get FASTA)   NCBI Sequence Viewer  
  AAH78904 (Get FASTA)   NCBI Sequence Viewer  
  AAH92572 (Get FASTA)   NCBI Sequence Viewer  
  AAI10046 (Get FASTA)   NCBI Sequence Viewer  
  AAK96897 (Get FASTA)   NCBI Sequence Viewer  
  EDL86980 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073596.2
GenBank Protein P47864 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036911   ⟸   NM_012779
- UniProtKB: Q2YDV0 (UniProtKB/Swiss-Prot),   Q569C5 (UniProtKB/Swiss-Prot),   P47864 (UniProtKB/Swiss-Prot),   A6KCG2 (UniProtKB/TrEMBL),   Q6AYU6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073596   ⟸   ENSRNOT00000084911

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47864-F1-model_v2 AlphaFold P47864 1-265 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695645
Promoter ID:EPDNEW_R6170
Type:single initiation site
Name:Aqp5_1
Description:aquaporin 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07141,249,024 - 141,249,084EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2144 AgrOrtholog
BioCyc Gene G2FUF-32066 BioCyc
Ensembl Genes ENSRNOG00000051970 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000084911.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7100092 IMAGE-MGC_LOAD
  IMAGE:7122974 IMAGE-MGC_LOAD
  IMAGE:7124184 IMAGE-MGC_LOAD
InterPro Aquaporin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aquaporin_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aquaporin_transptr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25241 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108763 IMAGE-MGC_LOAD
  MGC:124967 IMAGE-MGC_LOAD
  MGC:93652 IMAGE-MGC_LOAD
NCBI Gene 25241 ENTREZGENE
PANTHER PTHR19139 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19139:SF38 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aqp5 PhenoGen
PRINTS AQUAPORIN5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MINTRINSICP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000051970 RatGTEx
Superfamily-SCOP SSF81338 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC209610
UniProt A0A8L2R7H8_RAT UniProtKB/TrEMBL
  A6KCG2 ENTREZGENE, UniProtKB/TrEMBL
  AQP5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q2YDV0 ENTREZGENE
  Q569C5 ENTREZGENE
  Q6AYU6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q2YDV0 UniProtKB/Swiss-Prot
  Q569C5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Aqp5  aquaporin 5      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in paw sweat gland secretory cells and lung 70240
gene_function water channel protein 70240
gene_process functions in sweat production 70240