Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | age related macular degeneration 1 | | ISO | RGD:736378 | 8554872 | ClinVar more ... | ClinVar | PMID:25741868, PMID:28492532 | Alzheimer's disease | | ISO | RGD:736378 | 8554872 | ClinVar Annotator: match by term: Alzheimer disease, early onset | ClinVar | PMID:10213549 more ... | Alzheimer's disease 2 | | ISO | RGD:736378 | 8554872 | ClinVar more ... | ClinVar | PMID:10213549 more ... | Alzheimer's disease 3 | | ISO | RGD:736378 | 8554872 | ClinVar more ... | ClinVar | PMID:10432380 more ... | Alzheimer's disease 4 | | ISO | RGD:736378 | 8554872 | ClinVar more ... | ClinVar | PMID:10213152 more ... | Apolipoprotein E, Deficiency or Defect of | | ISO | RGD:736378 | 8554872 | ClinVar Annotator: match by term: Apolipoprotein e, deficiency or defect of | ClinVar | PMID:11500500 more ... | Broad-Betalipoproteinemia | | ISO | RGD:736378 | 8554872 | ClinVar more ... | ClinVar | PMID:11500500 more ... | Coumarin Sensitivity | | ISO | RGD:736378 | 8554872 | ClinVar Annotator: match by term: COUMARIN SENSITIVITY | ClinVar | PMID:10213549 more ... | Dysbetalipoproteinemia due to Defect in Apolipoprotein E-d | | ISO | RGD:736378 | 8554872 | ClinVar Annotator: match by term: Dysbetalipoproteinemia due to defect in apolipoprotein e-d | ClinVar | PMID:11500500 more ... | Dyslipidemias | | ISO | RGD:736378 | 8554872 | ClinVar Annotator: match by term: Dyslipidemia | ClinVar | | Familial Hyperbeta- and Prebetalipoproteinemia | | ISO | RGD:736378 | 8554872 | ClinVar Annotator: match by term: Familial hyperbeta- and prebetalipoproteinemia | ClinVar | PMID:11500500 more ... | familial hypercholesterolemia | | ISO | RGD:736378 | 8554872 | ClinVar Annotator: match by term: Familial hypercholesterolemia | ClinVar | | Floating-Betalipoproteinemia | | ISO | RGD:736378 | 8554872 | ClinVar Annotator: match by term: Floating-betalipoproteinemia | ClinVar | PMID:11500500 more ... | genetic disease | | ISO | RGD:736378 | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | Hypercholesterolemia | | ISO | RGD:736378 | 8554872 | ClinVar more ... | ClinVar | PMID:16103896 more ... | Hyperlipemia with Familial Hypercholesterolemic Xanthomatosis | | ISO | RGD:736378 | 8554872 | ClinVar Annotator: match by term: Hyperlipemia with familial hypercholesterolemic xanthomatosis | ClinVar | PMID:11500500 more ... | hyperlipoproteinemia type III | | ISO | RGD:736378 | 8554872 | ClinVar more ... | ClinVar | PMID:10587578 more ... | Lipoprotein Glomerulopathy | | ISO | RGD:736378 | 8554872 | ClinVar Annotator: match by term: Lipoprotein glomerulopathy | ClinVar | PMID:10213549 more ... | Presenile and Senile Dementia | | ISO | RGD:736378 | 8554872 | ClinVar Annotator: match by term: Presenile and senile dementia | ClinVar | PMID:10213549 more ... | sea-blue histiocytosis | | ISO | RGD:736378 | 8554872 | ClinVar more ... | ClinVar | PMID:25741868, PMID:28492532 | warfarin resistance | | ISO | RGD:736378 | 8554872 | ClinVar Annotator: match by term: Coumarin resistance | ClinVar | PMID:10213549 more ... | warfarin sensitivity | | ISO | RGD:736378 | 8554872 | ClinVar Annotator: match by term: Warfarin sensitivity | ClinVar | PMID:10213549 more ... | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice. | null |
| 2. | Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model. | Alikhani N, etal., Oncogene. 2013 Feb 21;32(8):961-7. doi: 10.1038/onc.2012.113. Epub 2012 Apr 2. |
| 3. | Polymorphisms of genes in the lipid metabolism pathway and risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China. | Andreotti G, etal., Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):525-34. Epub 2008 Feb 22. |
| 4. | Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex. | Arold S, etal., Acta Neuropathol. 2012 Jan;123(1):39-52. Epub 2011 Oct 22. |
| 5. | Deficiency of a transcriptional regulator, inhibitor of differentiation 3, induces glomerulonephritis in apolipoprotein E-deficient mice: a model linking hyperlipidemia and renal disease. | Bagavant H, etal., Am J Pathol. 2011 Aug;179(2):651-60. Epub 2011 Jun 14. |
| 6. | APOE and APOC1 genetic polymorphisms in age-associated memory impairment. | Bartres-Faz D, etal., Neurogenetics. 2001 Oct;3(4):215-9. |
| 7. | The genetic association database. | Becker KG, etal., Nat Genet. 2004 May;36(5):431-2. |
| 8. | Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice. | Bellosta S, etal., J Clin Invest. 1995 Nov;96(5):2170-9. |
| 9. | Effective treatment of ocular HSK with a human apolipoprotein E mimetic peptide in a mouse eye model. | Bhattacharjee PS, etal., Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4263-8. doi: 10.1167/iovs.08-2077. Epub 2008 May 30. |
| 10. | Fetal adrenal gland alterations in a rat model of adverse intrauterine environment. | Bibeau K, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Apr;298(4):R899-911. Epub 2009 Nov 18. |
| 11. | Effects of apolipoproteins A-IV and A-I on the uptake of phospholipid liposomes by hepatocytes. | Bisgaier CL, etal., J Biol Chem. 1989 Jan 15;264(2):862-6. |
| 12. | Intestinal lipoproteins in the rat with D-(+)-galactosamine hepatitis. | Black DD, etal., J Lipid Res. 1983 Aug;24(8):977-92. |
| 13. | Apolipoprotein E epsilon4 allele is associated with left ventricular systolic dysfunction. | Bleumink GS, etal., Am Heart J. 2004 Apr;147(4):685-9. |
| 14. | Accumulation of apolipoproteins in the regenerating and remyelinating mammalian peripheral nerve. Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and apolipoprotein A-I. | Boyles JK, etal., J Biol Chem. 1990 Oct 15;265(29):17805-15. |
| 15. | A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve. | Boyles JK, etal., J Clin Invest. 1989 Mar;83(3):1015-31. |
| 16. | Protective peptides that are orally active and mechanistically nonchiral. | Brenneman DE, etal., J Pharmacol Exp Ther. 2004 Jun;309(3):1190-7. Epub 2004 Mar 8. |
| 17. | Studies of familial type III hyperlipoproteinemia using as a genetic marker the apoE phenotype E2/2. | Breslow JL, etal., J Lipid Res. 1982 Nov;23(8):1224-35. |
| 18. | Chronic renal failure alters endothelial function in cerebral circulation in mice. | Bugnicourt JM, etal., Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H1143-52. Epub 2011 Jun 24. |
| 19. | Apolipoprotein E gene polymorphisms are associated with psoriasis but do not determine disease response to acitretin. | Campalani E, etal., Br J Dermatol. 2006 Feb;154(2):345-52. |
| 20. | The apolipoprotein E genotype predicts postprandial hypertriglyceridemia in patients with the metabolic syndrome. | Cardona F, etal., J Clin Endocrinol Metab. 2005 May;90(5):2972-5. Epub 2005 Feb 15. |
| 21. | Alterations in lipoprotein composition associated with galactosamine-induced rat liver injury. | Cartwright CK, etal., J Lipid Res. 1982 Jul;23(5):667-79. |
| 22. | Microarray analysis of cultured rat hippocampal neurons treated with brain derived neurotrophic factor. | Cazzin C, etal., Mol Biol Rep. 2011 Feb;38(2):983-90. Epub 2010 Jun 10. |
| 23. | Characterizations and proteome analysis of platelet-free plasma-derived microparticles in beta-thalassemia/hemoglobin E patients. | Chaichompoo P, etal., J Proteomics. 2012 Dec 5;76 Spec No.:239-50. doi: 10.1016/j.jprot.2012.06.004. Epub 2012 Jun 15. |
| 24. | Influences of apolipoprotein E polymorphism on the risk for breast cancer and HER2/neu status in Taiwan. | Chang NW, etal., Breast Cancer Res Treat. 2005 Apr;90(3):257-61. |
| 25. | Association between the apolipoprotein E genotypes and breast cancer patients in Taiwanese. | Chang SJ, etal., Breast Cancer Res Treat. 2006 Jul;98(1):109-13. Epub 2006 Jun 5. |
| 26. | The effects of berberine on hyperhomocysteinemia and hyperlipidemia in rats fed with a long-term high-fat diet. | Chang XX, etal., Lipids Health Dis. 2012 Jul 4;11(1):86. |
| 27. | APOE polymorphism and angiographic coronary artery disease severity in the Women's Ischemia Syndrome Evaluation (WISE) study. | Chen Q, etal., Atherosclerosis. 2003 Jul;169(1):159-67. |
| 28. | Low cholesterol in dialysis patients--causal factor for mortality or an effect of confounding? | Chmielewski M, etal., Nephrol Dial Transplant. 2011 Oct;26(10):3325-31. Epub 2011 Feb 28. |
| 29. | SINGLE NUCLEOTIDE POLYMORPHISMS THAT INFLUENCE LIPID METABOLISM: Interaction with Dietary Factors. | Corella D and Ordovas JM, Annu Rev Nutr. 2005;25:341-90. |
| 30. | [Comparative plasma proteomic analysis of patients with multiple myeloma treated with bortezomib-based regimens]. | Cumova J, etal., Klin Onkol. 2012;25(1):17-25. |
| 31. | Concentration of intracellular hepatic apolipoprotein E in Golgi apparatus saccular distensions and endosomes. | Dahan S, etal., J Cell Biol. 1994 Dec;127(6 Pt 2):1859-69. |
| 32. | Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. | Daugherty A, etal., J Clin Invest. 2000 Jun;105(11):1605-12. |
| 33. | Apolipoprotein E-deficient mice have an impaired immune response to Klebsiella pneumoniae. | de Bont N, etal., Eur J Clin Invest. 2000 Sep;30(9):818-22. |
| 34. | Impaired fibrinolytic system in ApoE gene-deleted mice with hyperlipidemia augments deep vein thrombosis. | Diaz JA, etal., J Vasc Surg. 2012 Mar;55(3):815-22. Epub 2011 Nov 25. |
| 35. | Magnesium sulfate reduces bacterial LPS-induced inflammation at the maternal-fetal interface. | Dowling O, etal., Placenta. 2012 May;33(5):392-8. doi: 10.1016/j.placenta.2012.01.013. Epub 2012 Feb 16. |
| 36. | Apolipoprotein E epsilon4 allele as a genetic risk factor for left ventricular failure in homozygous beta-thalassemia. | Economou-Petersen E, etal., Blood. 1998 Nov 1;92(9):3455-9. |
| 37. | Effect of polymorphisms of the MTHFR and APOE genes on susceptibility to diabetes and severity of diabetic retinopathy in Brazilian patients. | Errera FI, etal., Braz J Med Biol Res. 2006 Jul;39(7):883-8. |
| 38. | Severe type III hyperlipoproteinemia associated with unusual apolipoprotein E1 phenotype and epsilon 1/'null' genotype. | Feussner G, etal., Eur J Clin Invest. 1992 Sep;22(9):599-608. |
| 39. | Subsets of SNPs define rare genotype classes that predict ischemic heart disease. | Frikke-Schmidt R, etal., Hum Genet. 2007 Feb;120(6):865-877. Epub 2006 Sep 28. |
| 40. | Age-related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene. | Fritsche LG, etal., Hum Mutat. 2009 Jul;30(7):1048-53. doi: 10.1002/humu.20957. |
| 41. | Apolipoprotein E is present in primary localized cutaneous amyloidosis. | Furumoto H, etal., J Invest Dermatol. 1998 Sep;111(3):417-21. |
| 42. | Involvement of apolipoprotein E in excess fat accumulation and insulin resistance. | Gao J, etal., Diabetes. 2007 Jan;56(1):24-33. |
| 43. | Establishment of a rat model with diet-induced coronary atherosclerosis. | Gao M, etal., J Biomed Res. 2016 Oct 17;31(1):47-55. doi: 10.7555/JBR.31.20160020. |
| 44. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 45. | Apolipoprotein E genotype is associated with differential expansion rates of small abdominal aortic aneurysms. | Gerdes LU, etal., Br J Surg. 2000 Jun;87(6):760-5. |
| 46. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
| 47. | The association of Apoprotein E polymorphisms with recurrent pregnancy loss. | Goodman C, etal., Am J Reprod Immunol. 2009 Jan;61(1):34-8. doi: 10.1111/j.1600-0897.2008.00659.x. |
| 48. | Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach. | Gronborg M, etal., Mol Cell Proteomics. 2006 Jan;5(1):157-71. Epub 2005 Oct 8. |
| 49. | Ethanol induces cholesterol efflux and up-regulates ATP-binding cassette cholesterol transporters in fetal astrocytes. | Guizzetti M, etal., J Biol Chem. 2007 Jun 29;282(26):18740-9. Epub 2007 May 3. |
| 50. | Apolipoprotein E-containing lipoproteins protect neurons from apoptosis via a signaling pathway involving low-density lipoprotein receptor-related protein-1. | Hayashi H, etal., J Neurosci. 2007 Feb 21;27(8):1933-41. |
| 51. | Association of gene polymorphisms with coronary artery disease in low- or high-risk subjects defined by conventional risk factors. | Hirashiki A, etal., J Am Coll Cardiol. 2003 Oct 15;42(8):1429-37. |
| 52. | The apolipoprotein E epsilon4-allele and antihypertensive treatment are associated with increased risk of cerebral MRI white matter hyperintensities. | Hogh P, etal., Acta Neurol Scand. 2007 Apr;115(4):248-53. |
| 53. | Selective alterations in the cellular distribution of apolipoprotein E immunoreactivity following transient cerebral ischaemia in the rat. | Horsburgh K and Nicoll JA, Neuropathol Appl Neurobiol. 1996 Aug;22(4):342-9. |
| 54. | Proteomic identification of biomarkers of vascular injury. | Huang NF, etal., Am J Transl Res. 2011 Feb;3(2):139-48. Epub 2010 Nov 21. |
| 55. | Expression of apolipoprotein E during nerve degeneration and regeneration. | Ignatius MJ, etal., Proc Natl Acad Sci U S A. 1986 Feb;83(4):1125-9. |
| 56. | Synergistic effects of prothrombotic polymorphisms and atherogenic factors on the risk of myocardial infarction in young males. | Inbal A, etal., Blood. 1999 Apr 1;93(7):2186-90. |
| 57. | Virus-mediated transduction of apolipoprotein E (ApoE)-sendai develops lipoprotein glomerulopathy in ApoE-deficient mice. | Ishigaki Y, etal., J Biol Chem. 2000 Oct 6;275(40):31269-73. |
| 58. | Apolipoprotein E modifies neurological outcome by affecting cerebral edema but not hematoma size after intracerebral hemorrhage in humans. | James ML, etal., J Stroke Cerebrovasc Dis. 2009 Mar-Apr;18(2):144-9. |
| 59. | Apolipoprotein E epsilon4 allele and outcomes of traumatic spinal cord injury. | Jha A, etal., J Spinal Cord Med. 2008;31(2):171-6. |
| 60. | Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing. | Jordan BD, etal., JAMA. 1997 Jul 9;278(2):136-40. |
| 61. | Abnormalities of lipoprotein metabolism in patients with the nephrotic syndrome. | Joven J, etal., N Engl J Med. 1990 Aug 30;323(9):579-84. |
| 62. | Is the ApoE polymorphism associated with dilated cardiomyopathy? | Jurkovicova D, etal., Gen Physiol Biophys. 2006 Mar;25(1):3-10. |
| 63. | Spatiotemporal changes of apolipoprotein E immunoreactivity and apolipoprotein E mRNA expression after transient middle cerebral artery occlusion in rat brain. | Kamada H, etal., J Neurosci Res 2003 Aug 15;73(4):545-56. |
| 64. | Proteome analysis of rat serum proteins adsorbed onto synthetic octacalcium phosphate crystals. | Kaneko H, etal., Anal Biochem. 2011 Nov 15;418(2):276-85. Epub 2011 Jul 26. |
| 65. | Apolipoprotein E gene polymorphism in psoriasis. | Karpouzis A, etal., Arch Dermatol Res. 2009 Jul;301(6):405-10. doi: 10.1007/s00403-009-0968-0. Epub 2009 Jun 5. |
| 66. | KEGG: Kyoto Encyclopedia of Genes and Genomes | KEGG |
| 67. | Effect of fungal polysaccharides on the modulation of plasma proteins in streptozotocin-induced diabetic rats. | Kim SW, etal., Proteomics. 2006 Oct;6(19):5291-302. |
| 68. | Glycoproteomic analysis of plasma from patients with atopic dermatitis: CD5L and ApoE as potential biomarkers. | Kim WK, etal., Exp Mol Med. 2008 Dec 31;40(6):677-85. |
| 69. | Preferential interactions between ApoE-containing lipoproteins and Abeta revealed by a detection method that combines size exclusion chromatography with non-reducing gel-shift. | LaDu MJ, etal., Biochim Biophys Acta. 2012 Feb;1821(2):295-302. Epub 2011 Nov 23. |
| 70. | Association of human, rat, and rabbit apolipoprotein E with beta-amyloid. | LaDu MJ, etal., J Neurosci Res. 1997 Jul 1;49(1):9-18. |
| 71. | Association of apolipoprotein E polymorphisms with normal tension glaucoma in a Chinese population. | Lam CY, etal., J Glaucoma. 2006 Jun;15(3):218-22. |
| 72. | Expression profiles of cholesterol metabolism-related genes are altered during development of experimental autoimmune encephalomyelitis in the rat spinal cord. | Lavrnja I, etal., Sci Rep. 2017 Jun 2;7(1):2702. doi: 10.1038/s41598-017-02638-8. |
| 73. | Red mold rice promotes neuroprotective sAPPalpha secretion instead of Alzheimer's risk factors and amyloid beta expression in hyperlipidemic Abeta40-infused rats. | Lee CL, etal., J Agric Food Chem. 2010 Feb 24;58(4):2230-8. doi: 10.1021/jf904027y. |
| 74. | Knockout rat models mimicking human atherosclerosis created by Cpf1-mediated gene targeting. | Lee JG, etal., Sci Rep. 2019 Feb 22;9(1):2628. doi: 10.1038/s41598-019-38732-2. |
| 75. | Combined effects of EFA deficiency and tumor necrosis factor-alpha on circulating lipoproteins in rats. | Levy E, etal., Lipids. 2003 Jun;38(6):595-602. |
| 76. | An apolipoprotein E-mimetic stimulates axonal regeneration and remyelination after peripheral nerve injury. | Li FQ, etal., J Pharmacol Exp Ther. 2010 Jul;334(1):106-15. Epub 2010 Apr 20. |
| 77. | Glucose concentration in the dialysate does not contribute to lipid profiles in patients undergoing CAPD. | Li Z and Fengxian H, Ren Fail. 2011;33(2):124-30. |
| 78. | Apolipoprotein E gene polymorphisms and retinal vascular signs: the atherosclerosis risk in communities (ARIC) study. | Liew G, etal., Arch Ophthalmol. 2007 Jun;125(6):813-8. |
| 79. | Herpes simplex encephalitis: involvement of apolipoprotein E genotype. | Lin WR, etal., J Neurol Neurosurg Psychiatry. 2001 Jan;70(1):117-9. |
| 80. | Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors. | Liu L, etal., J Neuroinflammation. 2011 Dec 15;8:175. |
| 81. | Insulin increases central apolipoprotein E levels as revealed by an improved technique for collection of cerebrospinal fluid from rats. | Liu M, etal., J Neurosci Methods. 2012 Jul 30;209(1):106-12. Epub 2012 Jun 9. |
| 82. | Fcgamma receptor deficiency attenuates diabetic nephropathy. | Lopez-Parra V, etal., J Am Soc Nephrol. 2012 Sep;23(9):1518-27. Epub 2012 Aug 2. |
| 83. | A role for LRP4 in neuronal cell viability is related to apoE-binding. | Lu Y, etal., Brain Res. 2007 Oct 26;1177:19-28. Epub 2007 Aug 25. |
| 84. | Apolipoprotein E promoter polymorphisms (-491A/T and -427T/C) and Alzheimer's disease: no evidence of association in the Irish population. | Lynch CA, etal., Ir J Med Sci. 2008 Mar;177(1):29-33. Epub 2007 Dec 5. |
| 85. | The apolipoprotein E gene polymorphism is associated with open angle glaucoma in the Japanese population. | Mabuchi F, etal., Mol Vis. 2005 Aug 12;11:609-12. |
| 86. | Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. | Malek G, etal., Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11900-5. Epub 2005 Aug 3. |
| 87. | Chronic ethanol exposure in rats affects rabs-dependent hepatic trafficking of apolipoprotein E and transferrin. | Marmillot P, etal., Alcohol. 2001 Nov;25(3):195-200. |
| 88. | Meta-analysis of genome-wide gene expression differences in onset and maintenance phases of genetic hypertension. | Marques FZ, etal., Hypertension. 2010 Aug;56(2):319-24. Epub 2010 Jun 28. |
| 89. | Involvement of low-density lipoprotein receptor-related protein and ABCG1 in stimulation of axonal extension by apoE-containing lipoproteins. | Matsuo M, etal., Biochim Biophys Acta. 2011 Jan;1811(1):31-8. Epub 2010 Oct 30. |
| 90. | High density lipoprotein subpopulations from galactosamine-treated rats and their transformation by lecithin:cholesterol acyltransferase. | Matsuura JE and Swaney JB, J Lipid Res. 1991 Apr;32(4):581-94. |
| 91. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
| 92. | Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes. | Miklossy J, etal., Neurobiol Aging. 2008 Oct 23. |
| 93. | Isoform-specific effects of ApoE on HSV immediate early gene expression and establishment of latency. | Miller RM and Federoff HJ, Neurobiol Aging. 2008 Jan;29(1):71-7. Epub 2006 Nov 13. |
| 94. | Genetic associations in diabetic nephropathy: a meta-analysis. | Mooyaart AL, etal., Diabetologia. 2011 Mar;54(3):544-53. Epub 2010 Dec 3. |
| 95. | Apolipoprotein E genotyping in sporadic amyotrophic lateral sclerosis: evidence for a major influence on the clinical presentation and prognosis. | Moulard B, etal., J Neurol Sci. 1996 Aug;139 Suppl:34-7. |
| 96. | Apolipoprotein E and lipoprotein lipase increase triglyceride-rich particle binding but decrease particle penetration in arterial wall. | Mullick AE, etal., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):2080-5. |
| 97. | Impact of artificial sunlight therapy on the progress of non-alcoholic fatty liver disease in rats. | Nakano T, etal., J Hepatol. 2011 Aug;55(2):415-25. Epub 2010 Dec 22. |
| 98. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 99. | Liver X receptors regulate cholesterol homeostasis in oligodendrocytes. | Nelissen K, etal., J Neurosci Res. 2012 Jan;90(1):60-71. doi: 10.1002/jnr.22743. Epub 2011 Oct 3. |
| 100. | FGF-1-induced reactions for biogenesis of apoE-HDL are mediated by src in rat astrocytes. | Nishida T, etal., J Biochem. 2009 Dec;146(6):881-6. Epub 2009 Aug 27. |
| 101. | Apolipoprotein E alleles and sensorineural hearing loss. | O'Grady G, etal., Int J Audiol. 2007 Apr;46(4):183-6. |
| 102. | Apolipoprotein E Sendai (arginine 145-->proline): a new variant associated with lipoprotein glomerulopathy. | Oikawa S, etal., J Am Soc Nephrol. 1997 May;8(5):820-3. |
| 103. | OMIM Disease Annotation Pipeline | OMIM Disease Annotation Pipeline |
| 104. | Combined germline variations of thrombophilic genes promote genesis of lung cancer. | Ozen F, etal., Asian Pac J Cancer Prev. 2013;14(9):5449-54. |
| 105. | Regulation of apolipoprotein A-1 and E gene expression in liver and intestine of nephrotic and pair-fed rats. | Panduro A, etal., Nephron. 1993;65(1):100-7. |
| 106. | The apolipoprotein E epsilon4 allele is unlikely to be a major risk factor of age-related macular degeneration in Chinese. | Pang CP, etal., Ophthalmologica. 2000;214(4):289-91. |
| 107. | Apolipoprotein E polymorphism influences lipid phenotypes in Chinese families with familial combined hyperlipidemia. | Pei WD, etal., Circ J. 2006 Dec;70(12):1606-10. |
| 108. | Presence of apolipoprotein E epsilon4 allele predisposes to early onset of primary Sjogren's syndrome. | Pertovaara M, etal., Rheumatology (Oxford). 2004 Dec;43(12):1484-7. Epub 2004 Aug 24. |
| 109. | Angiotensin II Infusion Does Not Cause Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Rats. | Phillips EH, etal., J Vasc Res. 2018;55(1):1-12. doi: 10.1159/000484086. Epub 2017 Nov 23. |
| 110. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 111. | Early hypercholesterolemia contributes to vasomotor dysfunction and injury associated atherogenesis that can be inhibited by nitric oxide. | Raman KG, etal., J Vasc Surg. 2011 Mar;53(3):754-63. Epub 2010 Dec 15. |
| 112. | Postprandial triglyceride levels in familial combined hyperlipidemia. The role of apolipoprotein E and lipoprotein lipase polymorphisms. | Reiber I, etal., J Nutr Biochem. 2003 Jul;14(7):394-400. |
| 113. | Human recombinant apolipoprotein E redirects lipopolysaccharide from Kupffer cells to liver parenchymal cells in rats In vivo. | Rensen PC, etal., J Clin Invest. 1997 May 15;99(10):2438-45. |
| 114. | Apolipoprotein E promoter polymorphisms do not have a major influence on the risk of developing primary open angle glaucoma. | Ressiniotis T, etal., Mol Vis. 2004 Oct 28;10:805-7. |
| 115. | GOA pipeline | RGD automated data pipeline |
| 116. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 117. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 118. | Combined serum and tissue proteomic study applied to a c-Myc transgenic mouse model of hepatocellular carcinoma identified novel disease regulated proteins suitable for diagnosis and therapeutic intervention strategies. | Ritorto MS and Borlak J, J Proteome Res. 2011 Jul 1;10(7):3012-30. Epub 2011 Jun 6. |
| 119. | Epistatic Interactions between apolipoprotein E and hemoglobin S Genes in regulation of malaria parasitemia. | Rougeron V, etal., PLoS One. 2013 Oct 8;8(10):e76924. doi: 10.1371/journal.pone.0076924. eCollection 2013. |
| 120. | Enriched environment reduces apolipoprotein E (ApoE) in reactive astrocytes and attenuates inflammation of the peri-infarct tissue after experimental stroke. | Ruscher K, etal., J Cereb Blood Flow Metab. 2009 Nov;29(11):1796-805. Epub 2009 Jul 22. |
| 121. | The effect of old age on apolipoprotein E and its receptors in rat liver. | Sabaretnam T, etal., Age (Dordr). 2009 Oct 7. |
| 122. | Plasma levels of apolipoprotein E and genetic markers in elderly patients with Alzheimer's disease. | Scacchi R, etal., Neurosci Lett. 1999 Jan 4;259(1):33-6. |
| 123. | A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy. | Schmidt S, etal., Ophthalmic Genet. 2002 Dec;23(4):209-23. |
| 124. | Robust association of the APOE epsilon4 allele with premature myocardial infarction especially in patients without hypercholesterolaemia: the Aachen study. | Schmitz F, etal., Eur J Clin Invest. 2007 Feb;37(2):106-8. |
| 125. | Apolipoprotein E gene polymorphism is not a strong risk factor for diabetic nephropathy and retinopathy in Type I diabetes: case-control study. | Shcherbak NS BMC Med Genet. 2001;2:8. Epub 2001 Jul 24. |
| 126. | Hepatic and renal expression of rat apolipoprotein E under control of the metallothionein promoter in transgenic mice. | Shimano H, etal., Biochim Biophys Acta. 1991 Aug 27;1090(1):91-4. |
| 127. | Intermediate phenotypes identify divergent pathways to Alzheimer's disease. | Shulman JM, etal., PLoS One. 2010 Jun 21;5(6):e11244. doi: 10.1371/journal.pone.0011244. |
| 128. | A discovery-phase urine proteomics investigation in type 1 diabetes. | Soggiu A, etal., Acta Diabetol. 2012 Jun 8. |
| 129. | The epsilon4 allele of the apolipoprotein E gene as a potential protective factor for exudative age-related macular degeneration. | Souied EH, etal., Am J Ophthalmol. 1998 Mar;125(3):353-9. |
| 130. | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
| 131. | The usefulness of measuring body fat deposition for detecting obesity and atherogenesity in Japanese school children. | Takahashi H, etal., Acta Paediatr Jpn. 1996 Dec;38(6):634-9. |
| 132. | Tentative Sequence Identification Numbers | Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 133. | Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man. | Utermann G, etal., Nature. 1977 Oct 13;269(5629):604-7. |
| 134. | Apolipoprotein E gene promoter (-219G/T) polymorphism is associated with premature coronary heart disease. | Viitanen L, etal., J Mol Med. 2001 Dec;79(12):732-7. Epub 2001 Jul 25. |
| 135. | Chronic Cerebral Hypoperfusion Induced Synaptic Proteome Changes in the rat Cerebral Cortex. | Völgyi K, etal., Mol Neurobiol. 2018 May;55(5):4253-4266. doi: 10.1007/s12035-017-0641-0. Epub 2017 Jun 15. |
| 136. | Proteinuria decreases tissue lipoprotein receptor levels resulting in altered lipoprotein structure and increasing lipid levels. | Wang L, etal., Kidney Int. 2012 Jul 11. doi: 10.1038/ki.2012.244. |
| 137. | Olfactory identification and apolipoprotein E epsilon 4 allele in mild cognitive impairment. | Wang QS, etal., Brain Res. 2002 Sep 27;951(1):77-81. |
| 138. | Apolipoprotein E genotype as a determinant of survival in chronic lymphocytic leukemia. | Weinberg JB, etal., Leukemia. 2008 Dec;22(12):2184-92. doi: 10.1038/leu.2008.241. Epub 2008 Sep 11. |
| 139. | Effects of triiodothyronine and propylthiouracil on plasma lipoproteins in male rats. | Wilcox HG, etal., J Lipid Res. 1982 Nov;23(8):1159-66. |
| 140. | Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis. | Wilhelmus MM, etal., Am J Pathol. 2011 Nov;179(5):2152-6. doi: 10.1016/j.ajpath.2011.07.021. Epub 2011 Sep 9. |
| 141. | Cell surface "blanket" of apolipoprotein E on rat adrenocortical cells. | Williams DL, etal., J Lipid Res. 1995 Apr;36(4):745-58. |
| 142. | Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virus. | Wozniak MA, etal., Hepatology. 2002 Aug;36(2):456-63. |
| 143. | Role of apolipoprotein E in lipoprotein metabolism and in the process of atherosclerosis. | Yamada N, etal., J Atheroscler Thromb. 1995;2 Suppl 1:S29-33. |
| 144. | Genetic risk for coronary artery disease in individuals with or without type 2 diabetes. | Yamada Y, etal., Mol Genet Metab. 2004 Apr;81(4):282-90. |
| 145. | Genetic risk for atherothrombotic cerebral infarction in individuals stratified by sex or conventional risk factors for atherosclerosis. | Yamaguchi S, etal., Int J Mol Med. 2006 Nov;18(5):871-83. |
| 146. | Confounding effect of obstructive jaundice in the interpretation of proteomic plasma profiling data for pancreatic cancer. | Yan L, etal., J Proteome Res. 2009 Jan;8(1):142-8. |
| 147. | Effects of apolipoprotein E genotypes on the development of exfoliation syndrome. | Yilmaz A, etal., Exp Eye Res. 2005 Jun;80(6):871-5. |
| 148. | Investigation of the relationship between apolipoprotein E gene polymorphisms and hepatitis B virus infection in northern China. | Yin Z, etal., Clin Chem Lab Med. 2010 Dec;48(12):1803-7. doi: 10.1515/CCLM.2010.354. Epub 2010 Oct 20. |
| 149. | [A study on the association of apolipoprotein E genotypes with primary open-angle glaucoma and primary angle-closure glaucoma in northeast of China]. | Yuan HP, etal., Zhonghua Yan Ke Za Zhi. 2007 May;43(5):416-20. |
| 150. | Endogenous adipocyte apolipoprotein E is colocalized with caveolin at the adipocyte plasma membrane. | Yue L and Mazzone T, J Lipid Res. 2011 Mar;52(3):489-98. Epub 2010 Dec 16. |
| 151. | Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. | Zhang SH, etal., Science 1992 Oct 16;258(5081):468-71. |
| 152. | Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats. | Zhao Y, etal., Atherosclerosis. 2018 Apr;271:26-35. doi: 10.1016/j.atherosclerosis.2018.02.015. Epub 2018 Feb 12. |
| 153. | Identification of differentially expressed proteins in rats with spinal cord injury during the transitional phase using an iTRAQ-based quantitative analysis. | Zhou H, etal., Gene. 2018 Jul 20. pii: S0378-1119(18)30820-5. doi: 10.1016/j.gene.2018.07.050. |
| 154. | Less gelatinases is associated with apolipoprotein E accumulation in glomerulosclerosis rats. | Zhou TB, etal., Histol Histopathol. 2012 Feb;27(2):249-56. |
| 155. | All-trans retinoic acid can regulate the expressions of gelatinases and apolipoprotein E in glomerulosclerosis rats. | Zhou TB, etal., Vascul Pharmacol. 2011 Nov-Dec;55(5-6):169-77. Epub 2011 Sep 2. |
Additional References at PubMed
| PMID:210174 | PMID:210175 | PMID:1384047 | PMID:1423598 | PMID:1530612 | PMID:1911868 | PMID:1917954 | PMID:2280190 | PMID:2745454 | PMID:2762297 | PMID:3020048 | PMID:3771793 |
| PMID:3797247 | PMID:4066713 | PMID:6190813 | PMID:7566652 | PMID:7592957 | PMID:7635945 | PMID:7683668 | PMID:7766086 | PMID:7798939 | PMID:8071364 | PMID:8089103 | PMID:8127890 |
| PMID:8185566 | PMID:8245722 | PMID:8300609 | PMID:8340399 | PMID:8647961 | PMID:8773783 | PMID:8939961 | PMID:8995232 | PMID:9003062 | PMID:9186920 | PMID:9240444 | PMID:9300780 |
| PMID:9325076 | PMID:9488694 | PMID:9649566 | PMID:9685360 | PMID:9788969 | PMID:9826706 | PMID:11120757 | PMID:11162594 | PMID:11305869 | PMID:11551841 | PMID:11553788 | PMID:12042316 |
| PMID:12401887 | PMID:12870266 | PMID:12950167 | PMID:13130124 | PMID:14595002 | PMID:14741101 | PMID:14754908 | PMID:15269218 | PMID:15489334 | PMID:15654758 | PMID:15866734 | PMID:15950758 |
| PMID:16230502 | PMID:16273551 | PMID:16376010 | PMID:16443932 | PMID:16497717 | PMID:16502470 | PMID:16524875 | PMID:16802110 | PMID:16805831 | PMID:16935699 | PMID:17012232 | PMID:17126342 |
| PMID:17154273 | PMID:17305370 | PMID:17326667 | PMID:17336988 | PMID:17720994 | PMID:18288929 | PMID:18360691 | PMID:18377911 | PMID:18559657 | PMID:19056867 | PMID:19362542 | PMID:19382209 |
| PMID:19414061 | PMID:19717566 | PMID:19816508 | PMID:19946888 | PMID:20005821 | PMID:20456011 | PMID:20458337 | PMID:20551380 | PMID:21593558 | PMID:21630459 | PMID:21700703 | PMID:21784977 |
| PMID:22206666 | PMID:22516433 | PMID:22637583 | PMID:22674573 | PMID:22871113 | PMID:23103361 | PMID:23142051 | PMID:23376485 | PMID:23533145 | PMID:23620513 | PMID:23640054 | PMID:23658023 |
| PMID:23676495 | PMID:23741427 | PMID:23845000 | PMID:24154541 | PMID:24259049 | PMID:24328732 | PMID:24345162 | PMID:24412220 | PMID:24446231 | PMID:24769233 | PMID:24814386 | PMID:25015123 |
| PMID:25122793 | PMID:25207746 | PMID:25778834 | PMID:26397958 | PMID:26545012 | PMID:26782580 | PMID:27044754 | PMID:27068509 | PMID:27277003 | PMID:27477018 | PMID:27559042 | PMID:27683909 |
| PMID:28111074 | PMID:28164773 | PMID:28356228 | PMID:29336888 | PMID:30303984 | PMID:30958617 | PMID:31432127 | PMID:33564035 | PMID:33575839 | PMID:33932558 | PMID:34575848 | PMID:36104381 |
Genomics
Comparative Map Data
| Apoe (Rattus norvegicus - Norway rat) |
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| APOE (Homo sapiens - human) |
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| Apoe (Mus musculus - house mouse) |
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| Apoe (Chinchilla lanigera - long-tailed chinchilla) |
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| APOE (Pan paniscus - bonobo/pygmy chimpanzee) |
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| APOE (Canis lupus familiaris - dog) |
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| Apoe (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| APOE (Sus scrofa - pig) |
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| APOE (Chlorocebus sabaeus - green monkey) |
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| Apoe (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Apoe
31 total Variants 
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