Apoa4 (apolipoprotein A4) - Rat Genome Database

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Gene: Apoa4 (apolipoprotein A4) Rattus norvegicus
Analyze
Symbol: Apoa4
Name: apolipoprotein A4
RGD ID: 2132
Description: Predicted to enable several functions, including cation binding activity; cholesterol transfer activity; and phosphatidylcholine-sterol O-acyltransferase activator activity. Involved in peripheral nervous system axon regeneration and response to triglyceride. Part of chylomicron. Is active in synapse. Biomarker of major depressive disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant tubulointerstitial kidney disease 6; colitis; myocardial infarction; and ulcerative colitis. Orthologous to human APOA4 (apolipoprotein A4); PARTICIPATES IN altered lipoprotein metabolic pathway; lipoprotein metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 1-nitropropane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Acl; Apo-AIV; ApoA-IV; apoAIV; Apoc4; apolipoprotein A-IV; apolipoprotein C-IV; apolipoprotein CIV
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Apoa4em1Bcgen
Genetic Models: SD-Apoa4em1Bcgen
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8855,435,779 - 55,438,160 (+)NCBIGRCr8
GRCr8 Ensembl855,434,168 - 55,438,164 (+)EnsemblGRCr8 Ensembl
mRatBN7.2846,539,083 - 46,541,464 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl846,539,082 - 46,541,469 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx852,040,348 - 52,042,728 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0850,319,122 - 50,321,502 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0848,183,398 - 48,185,778 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0850,536,983 - 50,539,371 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,537,009 - 50,539,376 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0849,163,055 - 49,165,333 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4849,233,142 - 49,233,431 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera846,121,074 - 46,123,455 (+)NCBICelera
RGSC_v3.1849,245,005 - 49,245,297 (+)NCBI
RH 3.4 Map8473.3RGD
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Alzheimer's disease  (ISO)
anemia  (ISO)
atherosclerosis  (ISO)
autosomal dominant tubulointerstitial kidney disease 6  (ISO)
cardiovascular system disease  (ISO)
CD3epsilon deficiency  (ISO)
Chemically-Induced Disorders  (ISO)
chromosome 11 partial duplication syndrome  (ISO)
chronic kidney disease  (ISO)
Chronic Pancreatitis  (ISO)
colitis  (ISO)
Coronary Disease  (ISO)
Crohn's disease  (ISO)
diabetic retinopathy  (ISO)
Dwarfism  (ISO)
Experimental Arthritis  (IEP)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Familial Pancreatic Carcinoma  (ISO)
glaucoma  (ISO)
graft-versus-host disease  (ISO)
Guillain-Barre syndrome  (ISO)
hepatocellular carcinoma  (ISO)
Huntington's disease  (ISO)
Hyperlipoproteinemia Type II  (ISO)
Hyperlipoproteinemias  (ISO)
Hypertriglyceridemia  (ISO)
immunodeficiency 17  (ISO)
immunodeficiency 18  (ISO)
immunodeficiency 19  (ISO)
Inflammation  (IEP)
inflammatory bowel disease 28  (ISO)
intellectual disability  (ISO)
intermediate coronary syndrome  (ISO)
Intervertebral Disc Displacement  (ISO)
isolated microphthalmia 5  (ISO)
Leber hereditary optic neuropathy  (ISO)
major depressive disorder  (IEP)
myocardial infarction  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
nephronophthisis 15  (ISO)
obesity  (ISO)
Peripheral Nerve Injuries  (IEP)
peripheral nervous system disease  (ISO)
polyneuropathy  (ISO)
primary hypoalphalipoproteinemia 2  (ISO)
RASopathy  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
retinal detachment  (ISO)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
Seasonal Allergic Rhinitis  (ISO)
ulcerative colitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
1-nitropropane  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-hexanedione  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-diaminotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitropropane  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-acetylaminofluorene  (EXP)
4-nitro-1,2-phenylenediamine  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
cefaloridine  (EXP)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clofibrate  (EXP,ISO)
clomipramine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diquat  (ISO)
doramapimod  (ISO)
erianin  (ISO)
fenofibrate  (ISO)
flavonoids  (EXP)
fluconazole  (EXP)
folic acid  (ISO)
fructose  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (EXP)
hexadecanoic acid  (ISO)
high-density lipoprotein cholesterol  (ISO)
hydrazine  (EXP,ISO)
hydrogen peroxide  (ISO)
imipramine  (EXP)
inulin  (ISO)
isoniazide  (ISO)
ketoconazole  (EXP)
L-ethionine  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
metacetamol  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
octadecanoic acid  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
oleic acid  (ISO)
omeprazole  (EXP)
p-toluidine  (EXP)
paracetamol  (ISO)
perfluorobutanesulfonic acid  (EXP)
perfluorobutyric acid  (EXP)
perfluorododecanoic acid  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorohexanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP)
permethrin  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenytoin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rifaximin  (ISO)
rotenone  (EXP)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
sulfasalazine  (ISO)
tamoxifen  (ISO)
taurocholic acid  (EXP)
tebuconazole  (ISO)
tetrachloromethane  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
Torularhodin  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP,ISO)
triolein  (EXP)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Polymorphism of the apolipoprotein A-IV gene and its significance in lipid metabolism and coronary heart disease in a Japanese population. Bai H, etal., Eur J Clin Invest. 1996 Dec;26(12):1115-24.
2. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Evolution of the apolipoproteins. Structure of the rat apo-A-IV gene and its relationship to the human genes for apo-A-I, C-III, and E. Boguski MS, etal., J Biol Chem 1986 May 15;261(14):6398-407.
4. Rat apolipoprotein A-IV contains 13 tandem repetitions of a 22-amino acid segment with amphipathic helical potential. Boguski MS, etal., Proc Natl Acad Sci U S A 1984 Aug;81(16):5021-5.
5. Identification of differentially expressed proteins in the aqueous humor of primary congenital glaucoma. Bouhenni RA, etal., Exp Eye Res. 2011 Jan;92(1):67-75. Epub 2010 Nov 13.
6. Accumulation of apolipoproteins in the regenerating and remyelinating mammalian peripheral nerve. Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and apolipoprotein A-I. Boyles JK, etal., J Biol Chem. 1990 Oct 15;265(29):17805-15.
7. Apolipoprotein A-IV is an independent predictor of disease activity in patients with inflammatory bowel disease. Broedl UC, etal., Inflamm Bowel Dis. 2007 Apr;13(4):391-7.
8. Early-life stress and antidepressants modulate peripheral biomarkers in a gene-environment rat model of depression. Carboni L, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1037-48. Epub 2010 May 23.
9. SINGLE NUCLEOTIDE POLYMORPHISMS THAT INFLUENCE LIPID METABOLISM: Interaction with Dietary Factors. Corella D and Ordovas JM, Annu Rev Nutr. 2005;25:341-90.
10. Association of the apolipoprotein A-IV codon 360 mutation in patients with Alzheimer's disease. Csaszar A, etal., Neurosci Lett. 1997 Jul 25;230(3):151-4.
11. Genetic ablation of apolipoprotein A-IV accelerates Alzheimer's disease pathogenesis in a mouse model. Cui Y, etal., Am J Pathol. 2011 Mar;178(3):1298-308.
12. Differential cerebro spinal fluid proteome investigation of Leber hereditary optic neuropathy (LHON) and multiple sclerosis. D'Aguanno S, etal., J Neuroimmunol. 2008 Jan;193(1-2):156-60. Epub 2007 Dec 3.
13. The use of multiplexed MRM for the discovery of biomarkers to differentiate iron-deficiency anemia from anemia of inflammation. Domanski D, etal., J Proteomics. 2011 Nov 26.
14. Proteins of rat serum V: adjuvant arthritis and its modulation by nonsteroidal anti-inflammatory drugs. Ebrini I, etal., Electrophoresis. 2000 Jun;21(11):2170-9.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Linkage, evolution, and expression of the rat apolipoprotein A-I, C-III, and A-IV genes. Haddad IA, etal., J Biol Chem 1986 Oct 5;261(28):13268-77.
18. Increased prothrombin, apolipoprotein A-IV, and haptoglobin in the cerebrospinal fluid of patients with Huntington's disease. Huang YC, etal., PLoS One. 2011 Jan 31;6(1):e15809.
19. Hypertriglyceridemia as a result of human apo CIII gene expression in transgenic mice. Ito Y, etal., Science. 1990 Aug 17;249(4970):790-3.
20. No association between apolipoprotein A-IV codon 360 mutation and late-onset Alzheimer's disease in the Japanese population. Ji Y, etal., Dement Geriatr Cogn Disord. 1999 Nov-Dec;10(6):473-5.
21. Proteomic analysis of the cerebrospinal fluid of patients with schizophrenia. Jiang L, etal., Amino Acids. 2003 Jul;25(1):49-57.
22. Identification and verification of novel rodent postsynaptic density proteins. Jordan BA, etal., Mol Cell Proteomics. 2004 Sep;3(9):857-71. doi: 10.1074/mcp.M400045-MCP200. Epub 2004 May 28.
23. Lack of association between genetic variations of apo A-I-C-III-A-IV gene cluster and myocardial infarction in a sample of European male: ECTIM study. Kee F, etal., Atherosclerosis. 1999 Jul;145(1):187-95.
24. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
25. Characterization of the peripheral neuropathy in neonatal and adult mice that are homozygous for the fatty liver dystrophy (fld) mutation. Langner CA, etal., J Biol Chem. 1991 Jun 25;266(18):11955-64.
26. Screening disease-associated proteins from sera of patients with rheumatoid arthritis: a comparative proteomic study. Li TW, etal., Chin Med J (Engl). 2010 Mar 5;123(5):537-43.
27. Diurnal rhythm of apolipoprotein A-IV in rat hypothalamus and its relation to food intake and corticosterone. Liu M, etal., Endocrinology. 2004 Jul;145(7):3232-8. Epub 2004 Apr 1.
28. Proteomic analysis of the cerebrospinal fluid of patients with lumbar disk herniation. Liu XD, etal., Proteomics. 2006 Feb;6(3):1019-28.
29. Chronic kidney disease-related atherosclerosis - proteomic studies of blood plasma. Luczak M, etal., Proteome Sci. 2011 May 13;9:25.
30. Apolipoprotein A-IV is a candidate target molecule for the treatment of seasonal allergic rhinitis. Makino Y, etal., J Allergy Clin Immunol. 2010 Dec;126(6):1163-9.e5.
31. Serum proteomic profiling and haptoglobin polymorphisms in patients with GVHD after allogeneic hematopoietic cell transplantation. McGuirk J, etal., J Hematol Oncol. 2009 Apr 20;2:17.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease. Papassotiropoulos A, etal., J Clin Psychiatry. 2005 Jul;66(7):940-7.
35. Effect of the inflammation, chronic hyperglycemia, or malabsorption on the apolipoprotein A-IV concentration in type 1 diabetes mellitus and in diabetes secondary to chronic pancreatitis. Quilliot D, etal., Metabolism. 2001 Sep;50(9):1019-24.
36. ApoA-IV polymorphism associated with myocardial infarction in obese NIDDM patients. The San Luis Valley Diabetes Study. Rewers M, etal., Diabetes. 1994 Dec;43(12):1485-9.
37. GOA pipeline RGD automated data pipeline
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. Dietary oil modifies the plasma proteome during aging in the rat. Santos-Gonzalez M, etal., Age (Dordr). 2011 Apr 7.
40. Apolipoprotein C-II and C-III levels in hyperlipoproteinemia. Schonfeld G, etal., Metabolism. 1979 Oct;28(10):1001-10.
41. Proteome Profiling of Vitreoretinal Diseases by Cluster Analysis. Shitama T, etal., Proteomics Clin Appl. 2008 Sep;2(9):1265-1280.
42. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
43. Candidate biomarkers of chronic inflammatory demyelinating polyneuropathy (CIDP): proteome analysis of cerebrospinal fluid. Tumani H, etal., J Neuroimmunol. 2009 Sep 29;214(1-2):109-12. Epub 2009 Jul 9.
44. CSF proteome analysis in clinically isolated syndrome (CIS): candidate markers for conversion to definite multiple sclerosis. Tumani H, etal., Neurosci Lett. 2009 Mar 13;452(2):214-7. Epub 2009 Jan 29.
45. Apolipoprotein A-IV inhibits experimental colitis. Vowinkel T, etal., J Clin Invest. 2004 Jul;114(2):260-9.
46. Diagnostic and prognostic significance of mRNA expressions of apolipoprotein A and C family genes in hepatitis B virus-related hepatocellular carcinoma. Wang X, etal., J Cell Biochem. 2019 Oct;120(10):18246-18265. doi: 10.1002/jcb.29131. Epub 2019 Jun 18.
47. Apolipoprotein A-IV involves in glucose and lipid metabolism of rat. Wang Z, etal., Nutr Metab (Lond). 2019 Jul 2;16:41. doi: 10.1186/s12986-019-0367-2. eCollection 2019.
48. Apolipoprotein AIV gene variant S347 is associated with increased risk of coronary heart disease and lower plasma apolipoprotein AIV levels. Wong WM, etal., Circ Res. 2003 May 16;92(9):969-75. Epub 2003 Apr 3.
49. Comparative proteomics analysis of cerebrospinal fluid of patients with Guillain-Barre syndrome. Yang YR, etal., Cell Mol Neurobiol. 2008 Aug;28(5):737-44. Epub 2008 Mar 15.
50. Differential gene expression in patients genetically predisposed to pancreatic cancer. Zervos EE, etal., J Surg Res. 2006 Oct;135(2):317-22. Epub 2006 Jun 30.
Additional References at PubMed
PMID:1935934   PMID:2307668   PMID:3095477   PMID:7798939   PMID:9186920   PMID:9300780   PMID:9323588   PMID:11162594   PMID:11940599   PMID:12477932   PMID:15082422   PMID:15117731  
PMID:16159879   PMID:16166201   PMID:16945374   PMID:17086191   PMID:17154273   PMID:18577393   PMID:19020287   PMID:20551380   PMID:22516433   PMID:22579246   PMID:22715380   PMID:23027805  
PMID:23376485   PMID:23533145   PMID:23911221   PMID:24564397   PMID:25051443   PMID:25585692   PMID:27068509   PMID:27559042   PMID:29037812   PMID:33322656  


Genomics

Comparative Map Data
Apoa4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8855,435,779 - 55,438,160 (+)NCBIGRCr8
GRCr8 Ensembl855,434,168 - 55,438,164 (+)EnsemblGRCr8 Ensembl
mRatBN7.2846,539,083 - 46,541,464 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl846,539,082 - 46,541,469 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx852,040,348 - 52,042,728 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0850,319,122 - 50,321,502 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0848,183,398 - 48,185,778 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0850,536,983 - 50,539,371 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,537,009 - 50,539,376 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0849,163,055 - 49,165,333 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4849,233,142 - 49,233,431 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera846,121,074 - 46,123,455 (+)NCBICelera
RGSC_v3.1849,245,005 - 49,245,297 (+)NCBI
RH 3.4 Map8473.3RGD
Cytogenetic Map8q22NCBI
APOA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811116,820,700 - 116,823,304 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11116,820,700 - 116,823,304 (-)EnsemblGRCh38hg38GRCh38
GRCh3711116,691,416 - 116,694,020 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,196,628 - 116,199,221 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411116,196,628 - 116,199,162NCBI
Celera11113,849,234 - 113,851,827 (-)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11112,623,690 - 112,626,283 (-)NCBIHuRef
CHM1_111116,576,178 - 116,578,767 (-)NCBICHM1_1
T2T-CHM13v2.011116,835,812 - 116,838,412 (-)NCBIT2T-CHM13v2.0
Apoa4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39946,152,142 - 46,154,756 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl946,151,994 - 46,154,757 (+)EnsemblGRCm39 Ensembl
GRCm38946,240,844 - 46,243,458 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl946,240,696 - 46,243,459 (+)EnsemblGRCm38mm10GRCm38
MGSCv37946,048,927 - 46,051,541 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36945,992,149 - 45,994,285 (+)NCBIMGSCv36mm8
Celera943,529,774 - 43,532,388 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.36NCBI
Apoa4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541218,155,801 - 18,160,701 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541218,158,095 - 18,160,636 (-)NCBIChiLan1.0ChiLan1.0
APOA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29117,524,912 - 117,527,516 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111118,630,121 - 118,632,725 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011111,659,186 - 111,661,790 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111115,591,788 - 115,594,382 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11115,591,788 - 115,594,382 (-)Ensemblpanpan1.1panPan2
APOA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1516,751,588 - 16,754,215 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl516,751,799 - 16,754,837 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha516,803,839 - 16,806,395 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0516,698,167 - 16,700,719 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl516,698,240 - 16,701,326 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1516,835,250 - 16,837,800 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0516,737,834 - 16,740,384 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0516,780,743 - 16,783,293 (+)NCBIUU_Cfam_GSD_1.0
Apoa4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494799,177,114 - 99,179,837 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365422,098,683 - 2,101,127 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365422,098,683 - 2,101,127 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl944,201,508 - 44,204,206 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1944,201,587 - 44,204,072 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2949,273,837 - 49,276,322 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APOA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11108,186,627 - 108,190,508 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1108,186,921 - 108,189,698 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604317,861,078 - 17,863,578 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apoa4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478412,233,593 - 12,239,763 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478412,237,329 - 12,240,013 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Apoa4
21 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:43
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000073593
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)85158969958991895Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)83412590255607752Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat

Markers in Region
RH128325  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,541,254 - 46,541,442 (+)MAPPERmRatBN7.2
Rnor_6.0850,539,162 - 50,539,349NCBIRnor6.0
Rnor_5.0849,165,124 - 49,165,311UniSTSRnor5.0
RGSC_v3.4849,233,222 - 49,233,409UniSTSRGSC3.4
Celera846,123,246 - 46,123,433UniSTS
RH 3.4 Map8491.69UniSTS
Cytogenetic Map8q22UniSTS
RH94460  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,541,008 - 46,541,185 (+)MAPPERmRatBN7.2
Rnor_6.0850,538,916 - 50,539,092NCBIRnor6.0
Rnor_5.0849,164,878 - 49,165,054UniSTSRnor5.0
Celera846,123,000 - 46,123,176UniSTS
RH 3.4 Map8473.3UniSTS
Cytogenetic Map8q22UniSTS


Genetic Models
This gene Apoa4 is modified in the following models/strains:
SD-Apoa4em1Bcgen    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
8 9 12 41 85 84 59 21 59 4 151 48 4 27 28 48 25

Sequence


Ensembl Acc Id: ENSRNOT00000080658   ⟹   ENSRNOP00000069659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl855,434,168 - 55,438,164 (+)Ensembl
mRatBN7.2 Ensembl846,539,082 - 46,541,469 (+)Ensembl
Rnor_6.0 Ensembl850,537,009 - 50,539,376 (+)Ensembl
RefSeq Acc Id: NM_012737   ⟹   NP_036869
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8855,435,779 - 55,438,160 (+)NCBI
mRatBN7.2846,539,083 - 46,541,464 (+)NCBI
Rnor_6.0850,536,983 - 50,539,371 (+)NCBI
Rnor_5.0849,163,055 - 49,165,333 (+)NCBI
RGSC_v3.4849,233,142 - 49,233,431 (+)RGD
Celera846,121,074 - 46,123,455 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036869 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40747 (Get FASTA)   NCBI Sequence Viewer  
  AAA40748 (Get FASTA)   NCBI Sequence Viewer  
  AAA85909 (Get FASTA)   NCBI Sequence Viewer  
  AAH91159 (Get FASTA)   NCBI Sequence Viewer  
  EDL95397 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069659
  ENSRNOP00000069659.2
GenBank Protein P02651 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036869   ⟸   NM_012737
- Peptide Label: precursor
- UniProtKB: P02651 (UniProtKB/Swiss-Prot),   Q5BK92 (UniProtKB/Swiss-Prot),   A6J474 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069659   ⟸   ENSRNOT00000080658

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02651-F1-model_v2 AlphaFold P02651 1-391 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695928
Promoter ID:EPDNEW_R6453
Type:multiple initiation site
Name:Apoa4_1
Description:apolipoprotein A4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0850,536,983 - 50,537,043EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2132 AgrOrtholog
BioCyc Gene G2FUF-30650 BioCyc
Ensembl Genes ENSRNOG00000055909 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000080658 ENTREZGENE
  ENSRNOT00000080658.2 UniProtKB/Swiss-Prot
Gene3D-CATH Apolipoprotein UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7373033 IMAGE-MGC_LOAD
InterPro ApoA_E UniProtKB/Swiss-Prot
  Apolipoprotein_A1/A4/E UniProtKB/Swiss-Prot
KEGG Report rno:25080 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108730 IMAGE-MGC_LOAD
NCBI Gene 25080 ENTREZGENE
PANTHER APOLIPOPROTEIN UniProtKB/Swiss-Prot
  APOLIPOPROTEIN A-IV UniProtKB/Swiss-Prot
Pfam Apolipoprotein UniProtKB/Swiss-Prot
PharmGKB APOA4 RGD
PhenoGen Apoa4 PhenoGen
RatGTEx ENSRNOG00000055909 RatGTEx
Superfamily-SCOP Apolipoprotein A-I UniProtKB/Swiss-Prot
TIGR TC208020
UniProt A0A0G2JVX7_RAT UniProtKB/TrEMBL
  A6J474 ENTREZGENE, UniProtKB/TrEMBL
  APOA4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5BK92 ENTREZGENE
UniProt Secondary Q5BK92 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Apoa4  apolipoprotein A4  Apoa4  apolipoprotein A-IV  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Apoa4  apolipoprotein A-IV    Apolipoprotein A-IV  Name updated 629478 APPROVED
2001-05-08 Apoa4  Apolipoprotein A-IV      Name changed to reflect Human and Mouse nomenclature 62408 APPROVED
2001-05-08 Apoa4  Apolipoprotein C-IV      Name withdrawn, does not match Human and Mouse nomenclature 62408 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver and intestine 634656
gene_function may bind lipids 634657
gene_process may play a role in lipid transport 634656
gene_product member of the apolipoprotein gene family 634656
gene_product is a component of chylomicrons and of high density lipoproteins 634658