Apoa2 (apolipoprotein A2) - Rat Genome Database

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Gene: Apoa2 (apolipoprotein A2) Rattus norvegicus
Analyze
Symbol: Apoa2
Name: apolipoprotein A2
RGD ID: 2131
Description: Enables cholesterol transfer activity. Involved in several processes, including animal organ regeneration; response to estrogen; and response to glucocorticoid. Predicted to be part of chylomicron; spherical high-density lipoprotein particle; and very-low-density lipoprotein particle. Predicted to be active in extracellular space. Biomarker of hyperthyroidism. Orthologous to human APOA2 (apolipoprotein A2); PARTICIPATES IN lipoprotein metabolic pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH (+)-schisandrin B; 1-nitropropane; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Apo-AII; ApoA-II; APOAII; apolipoprotein A-II
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   F344.ACI-Lmx1aqc/Kyo  
QTLs:   GLUCO223_H  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,176,767 - 86,178,819 (+)NCBIGRCr8
GRCr8 Ensembl1386,174,741 - 86,179,410 (+)EnsemblGRCr8 Ensembl
mRatBN7.21383,644,460 - 83,646,358 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,644,470 - 83,646,355 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,150,563 - 86,152,200 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,548,803 - 87,550,440 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,780,423 - 84,782,059 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,596,872 - 89,598,805 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,597,138 - 89,598,802 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,223,741 - 94,225,670 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,114,734 - 87,116,372 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1383,275,901 - 83,277,538 (+)NCBICelera
RGSC_v3.11387,303,617 - 87,305,256 (+)NCBI
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-ephedrine  (ISO)
1,1-dichloroethene  (ISO)
1-nitropropane  (EXP)
17beta-estradiol  (EXP,ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-diaminotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitropropane  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-acetylaminofluorene  (EXP)
4-nitro-1,2-phenylenediamine  (EXP)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
atenolol  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP,ISO)
bezafibrate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
calcium silicate  (ISO)
carbon nanotube  (ISO)
chlorohydrocarbon  (EXP)
clofibric acid  (EXP)
Clofop  (EXP)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyproterone acetate  (ISO)
dextran sulfate  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
fenofibrate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
graphene oxide  (ISO)
graphite  (EXP)
hexadecanoic acid  (ISO)
hydrazine  (EXP)
indometacin  (EXP)
isoprenaline  (ISO)
lead(0)  (ISO)
manganese(II) chloride  (EXP)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methylmercury chloride  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nifedipine  (ISO)
nitrofen  (EXP)
obeticholic acid  (ISO)
okadaic acid  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
pentetic acid  (ISO)
perflubutane  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
Torularhodin  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IDA)
cellular response to amyloid-beta  (ISO)
cellular response to lipoprotein particle stimulus  (ISO)
cholesterol efflux  (ISO)
cholesterol homeostasis  (IBA,ISO)
cholesterol metabolic process  (ISO)
cholesterol transport  (IBA,IDA)
diacylglycerol catabolic process  (ISO)
high-density lipoprotein particle assembly  (ISO)
high-density lipoprotein particle clearance  (ISO)
high-density lipoprotein particle remodeling  (ISO)
lipid transport  (IEA,ISO)
lipoprotein metabolic process  (IEA,ISO)
low-density lipoprotein particle remodeling  (ISO)
negative regulation of cholesterol import  (ISO)
negative regulation of cholesterol transport  (ISO)
negative regulation of cytokine production involved in immune response  (ISO)
negative regulation of lipase activity  (ISO)
negative regulation of lipid catabolic process  (ISO)
negative regulation of very-low-density lipoprotein particle remodeling  (ISO)
peptidyl-methionine modification  (ISO)
phosphatidylcholine biosynthetic process  (ISO)
phospholipid catabolic process  (ISO)
phospholipid efflux  (ISO)
positive regulation of interleukin-8 production  (ISO,ISS)
positive regulation of lipid catabolic process  (ISO)
positive regulation of phagocytosis  (ISO,ISS)
protein oxidation  (ISO)
protein stabilization  (ISO,ISS)
regulation of intestinal cholesterol absorption  (ISO)
regulation of protein stability  (ISO)
response to estrogen  (IEP)
response to glucocorticoid  (IEP)
response to glucose  (ISO)
response to xenobiotic stimulus  (IEP)
reverse cholesterol transport  (ISO)
signal transduction  (IEA)
triglyceride-rich lipoprotein particle remodeling  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Biochemical and genetic association of plasma apolipoprotein A-II levels with familial combined hyperlipidemia. Allayee H, etal., Circ Res 2003 Jun 13;92(11):1262-7. Epub 2003 May 8.
2. The compositional abnormalities of lipoproteins in diabetic renal failure. Attman PO, etal., Nephrol Dial Transplant. 1998 Nov;13(11):2833-41.
3. Apolipoprotein A-II is inversely associated with risk of future coronary artery disease. Birjmohun RS, etal., Circulation. 2007 Oct 30;116(18):2029-35. Epub 2007 Oct 8.
4. Studies with apolipoprotein A-II transgenic mice indicate a role for HDLs in adiposity and insulin resistance. Castellani LW, etal., Diabetes. 2001 Mar;50(3):643-51.
5. Quantification of apolipoprotein AI-containing lipoprotein particles in non-insulin-dependent diabetes mellitus. Contiero E, etal., Diabetes Res Clin Pract. 1998 Mar;39(3):201-9.
6. SINGLE NUCLEOTIDE POLYMORPHISMS THAT INFLUENCE LIPID METABOLISM: Interaction with Dietary Factors. Corella D and Ordovas JM, Annu Rev Nutr. 2005;25:341-90.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Association between apolipoprotein A2 MspI polymorphism and hypertriglyceridemia in Koreans. Hong SH, etal., Hum Biol. 1998 Feb;70(1):41-6.
10. Structure and evolution of the apolipoprotein multigene family. Luo CC, etal., J Mol Biol 1986 Feb 5;187(3):325-40.
11. Cellular cholesterol efflux. Role of cell membrane kinetic pools and interaction with apolipoproteins AI, AII, and Cs. Mahlberg FH and Rothblat GH, J Biol Chem. 1992 Mar 5;267(7):4541-50.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Amino acid sequence of rat apolipoprotein A-II deduced from the nucleotide sequence of cloned cDNA. Nagashima M, etal., J Lipid Res 1986 Jul;27(7):706-12.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Predominance of large low density lipoprotein particles and lower fractional esterification rate of cholesterol in high density lipoprotein in children with insulin-dependent diabetes mellitus. Ohta T, etal., Eur J Pediatr. 1998 Apr;157(4):276-81.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Impaired anti-inflammatory function of apolipoprotein A-II concentrations predicts metabolic syndrome and diabetes at 4 years follow-up in elderly Turks. Onat A, etal., Clin Chem Lab Med. 2009 Oct 12.
18. Transcriptional and posttranscriptional regulation of apolipoprotein E, A-I, and A-II gene expression in normal rat liver and during several pathophysiologic states. Panduro A, etal., Biochemistry. 1990 Sep 11;29(36):8430-5.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Comprehensive gene review and curation RGD comprehensive gene curation
24. Increased high density lipoprotein (HDL), defective hepatic catabolism of ApoA-I and ApoA-II, and decreased ApoA-I mRNA in ob/ob mice. Possible role of leptin in stimulation of HDL turnover. Silver DL, etal., J Biol Chem. 1999 Feb 12;274(7):4140-6.
25. Differences in HDL-cholesterol:apoA-I + apoA-II ratio and apoE phenotype with albuminuric status in Type I diabetic patients. Soedamah-Muthu SS, etal., Diabetologia. 2000 Nov;43(11):1353-9.
26. Variable effects of different corticosteroids on plasma lipids, apolipoproteins, and hepatic apolipoprotein mRNA levels in rats. Staels B, etal., Arterioscler Thromb. 1991 May-Jun;11(3):760-9.
27. Fibrates influence the expression of genes involved in lipoprotein metabolism in a tissue-selective manner in the rat. Staels B, etal., Arterioscler Thromb. 1992 Mar;12(3):286-94.
28. Influence of development, estrogens, and food intake on apolipoprotein A-I, A-II, and E mRNA in rat liver and intestine. Staels B, etal., J Lipid Res. 1989 Aug;30(8):1137-45.
29. Differential regulation of hepatic apolipoprotein A-I and A-II gene expression by thyroid hormone in rat liver. Strobl W, etal., Atherosclerosis. 1992 Dec;97(2-3):161-70.
30. The usefulness of measuring body fat deposition for detecting obesity and atherogenesity in Japanese school children. Takahashi H, etal., Acta Paediatr Jpn. 1996 Dec;38(6):634-9.
31. Effect of acute inflammation on rat apolipoprotein mRNA levels. Tu GF, etal., Inflammation. 1987 Jun;11(2):241-51.
32. Diagnostic and prognostic significance of mRNA expressions of apolipoprotein A and C family genes in hepatitis B virus-related hepatocellular carcinoma. Wang X, etal., J Cell Biochem. 2019 Oct;120(10):18246-18265. doi: 10.1002/jcb.29131. Epub 2019 Jun 18.
Additional References at PubMed
PMID:210174   PMID:218942   PMID:1596514   PMID:1606170   PMID:3104518   PMID:6403543   PMID:7837794   PMID:7918467   PMID:8106353   PMID:8245722   PMID:8422330   PMID:8636092  
PMID:8640403   PMID:8647961   PMID:8962133   PMID:9150245   PMID:9186920   PMID:9651324   PMID:10357838   PMID:10764676   PMID:11027668   PMID:11162594   PMID:11591715   PMID:12458630  
PMID:12576517   PMID:14729860   PMID:14967812   PMID:14988251   PMID:16682745   PMID:17264082   PMID:17652309   PMID:19056867   PMID:19199708   PMID:20495215   PMID:22516433   PMID:23376485  
PMID:23533145   PMID:27477018  


Genomics

Comparative Map Data
Apoa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,176,767 - 86,178,819 (+)NCBIGRCr8
GRCr8 Ensembl1386,174,741 - 86,179,410 (+)EnsemblGRCr8 Ensembl
mRatBN7.21383,644,460 - 83,646,358 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,644,470 - 83,646,355 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,150,563 - 86,152,200 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,548,803 - 87,550,440 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,780,423 - 84,782,059 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,596,872 - 89,598,805 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,597,138 - 89,598,802 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,223,741 - 94,225,670 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,114,734 - 87,116,372 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1383,275,901 - 83,277,538 (+)NCBICelera
RGSC_v3.11387,303,617 - 87,305,256 (+)NCBI
Cytogenetic Map13q24NCBI
APOA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,222,292 - 161,223,628 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,222,290 - 161,223,631 (-)EnsemblGRCh38hg38GRCh38
GRCh371161,192,082 - 161,193,418 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,458,707 - 159,460,042 (-)NCBINCBI36Build 36hg18NCBI36
Build 341158,005,155 - 158,006,491NCBI
Celera1134,259,238 - 134,260,561 (-)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,549,030 - 132,550,353 (-)NCBIHuRef
CHM1_11162,588,335 - 162,589,660 (-)NCBICHM1_1
T2T-CHM13v2.01160,359,748 - 160,361,078 (-)NCBIT2T-CHM13v2.0
Apoa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,049,133 - 171,053,948 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1171,052,623 - 171,053,948 (+)EnsemblGRCm39 Ensembl
GRCm381171,221,564 - 171,226,379 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,225,054 - 171,226,379 (+)EnsemblGRCm38mm10GRCm38
MGSCv371173,155,185 - 173,156,510 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361173,061,764 - 173,063,045 (+)NCBIMGSCv36mm8
Celera1173,673,195 - 173,674,520 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.22NCBI
Apoa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546812,977,956 - 12,979,753 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546812,977,956 - 12,979,282 (-)NCBIChiLan1.0ChiLan1.0
APOA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,627,887 - 88,629,720 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1188,318,208 - 88,320,039 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,634,754 - 136,636,122 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,546,591 - 140,547,959 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,546,591 - 140,547,959 (-)Ensemblpanpan1.1panPan2
APOA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,263,641 - 21,265,887 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,262,789 - 21,265,887 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,338,500 - 21,340,743 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,381,461 - 21,383,727 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,380,609 - 21,383,727 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,278,560 - 21,279,234 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,683,795 - 21,686,027 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,092,910 - 22,095,161 (+)NCBIUU_Cfam_GSD_1.0
Apoa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,311,984 - 7,313,278 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936903520,650 - 521,910 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936903520,420 - 521,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,237,511 - 89,240,319 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,237,514 - 89,239,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,094,196 - 97,095,808 (+)NCBISscrofa10.2Sscrofa10.2susScr3
APOA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,757,939 - 2,760,356 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl202,759,237 - 2,760,686 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660381,806,549 - 1,808,724 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apoa2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624794164,370 - 166,248 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624794164,351 - 165,676 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Apoa2
6 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:33
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000004662
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat


Related Rat Strains
The following Strains have been annotated to Apoa2
F344.ACI-Lmx1aqc/Kyo    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 9 24 74 91 90 59 25 59 6 185 70 54 39 53 31 8 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001429558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC099236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M28615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X03468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000004662   ⟹   ENSRNOP00000004662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1386,176,960 - 86,179,410 (+)Ensembl
mRatBN7.2 Ensembl1383,644,470 - 83,646,355 (+)Ensembl
Rnor_6.0 Ensembl1389,597,138 - 89,598,802 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000150823   ⟹   ENSRNOP00000111793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1386,174,741 - 86,179,410 (+)Ensembl
RefSeq Acc Id: NM_013112   ⟹   NP_037244
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,177,179 - 86,178,816 (+)NCBI
mRatBN7.21383,644,718 - 83,646,355 (+)NCBI
Rnor_6.01389,597,165 - 89,598,802 (+)NCBI
Rnor_5.01394,223,741 - 94,225,670 (+)NCBI
RGSC_v3.41387,114,734 - 87,116,372 (+)RGD
Celera1383,275,901 - 83,277,538 (+)RGD
Sequence:
RefSeq Acc Id: XM_006250238   ⟹   XP_006250300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,176,767 - 86,178,819 (+)NCBI
mRatBN7.21383,644,460 - 83,646,358 (+)NCBI
Rnor_6.01389,596,875 - 89,598,805 (+)NCBI
Rnor_5.01394,223,741 - 94,225,670 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250239   ⟹   XP_006250301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,176,922 - 86,178,819 (+)NCBI
mRatBN7.21383,644,464 - 83,646,358 (+)NCBI
Rnor_6.01389,596,872 - 89,598,805 (+)NCBI
Rnor_5.01394,223,741 - 94,225,670 (+)NCBI
Sequence:
RefSeq Acc Id: NP_037244   ⟸   NM_013112
- Peptide Label: preproprotein
- UniProtKB: P04638 (UniProtKB/Swiss-Prot),   A6JFV5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250301   ⟸   XM_006250239
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006250300   ⟸   XM_006250238
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000004662   ⟸   ENSRNOT00000004662
Ensembl Acc Id: ENSRNOP00000111793   ⟸   ENSRNOT00000150823

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04638-F1-model_v2 AlphaFold P04638 1-102 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2131 AgrOrtholog
BioCyc Gene G2FUF-17383 BioCyc
Ensembl Genes ENSRNOG00000003500 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004662 ENTREZGENE
  ENSRNOT00000004662.5 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.250.100 UniProtKB/Swiss-Prot
InterPro ApoA-II UniProtKB/Swiss-Prot
  ApoA-II_sf UniProtKB/Swiss-Prot
KEGG Report rno:25649 UniProtKB/Swiss-Prot
NCBI Gene 25649 ENTREZGENE
PANTHER APOLIPOPROTEIN A-II UniProtKB/Swiss-Prot
  PTHR11027 UniProtKB/Swiss-Prot
Pfam ApoA-II UniProtKB/Swiss-Prot
PhenoGen Apoa2 PhenoGen
RatGTEx ENSRNOG00000003500 RatGTEx
Superfamily-SCOP SSF82936 UniProtKB/Swiss-Prot
UniProt A6JFV5 ENTREZGENE, UniProtKB/TrEMBL
  A6JFV6_RAT UniProtKB/TrEMBL
  APOA2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Apoa2  apolipoprotein A2  Apoa2  apolipoprotein A-II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Apoa2  apolipoprotein A-II    Apolipoprotein A-II  Name updated 629478 APPROVED
2002-06-10 Apoa2  Apolipoprotein A-II      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a lipid binding domain 634654
gene_function may bind lipids 634654
gene_homology has high homology with human Apoa2 over the lipid binding domain although the overall homology is only about 50% 634654
gene_product member of the apolipoprotein gene family 634655