Apc (APC regulator of WNT signaling pathway) - Rat Genome Database

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Gene: Apc (APC regulator of WNT signaling pathway) Rattus norvegicus
Symbol: Apc
Name: APC regulator of WNT signaling pathway
RGD ID: 2123
Description: Enables microtubule binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; negative regulation of cardiac muscle cell proliferation; and regulation of glutamate metabolic process. Located in several cellular components, including cell body fiber; lateral plasma membrane; and synaptic vesicle membrane. Part of protein-containing complex. Used to study anemia; colon adenocarcinoma; colon cancer; and familial adenomatous polyposis. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial adenomatous polyposis 1; gastrointestinal system cancer (multiple); hereditary desmoid disease; and reproductive organ cancer (multiple). Orthologous to human APC (APC regulator of WNT signaling pathway); PARTICIPATES IN altered Wnt signaling, canonical pathway; colorectal cancer pathway; endometrial cancer pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
Previously known as: adenomatosis polyposis coli; adenomatous polyposis coli protein; APC, WNT signaling pathway regulator; RATAPC; WNT signaling pathway regulator
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: ApcPirc   Apcm1Kyo  
Genetic Models: F344-ApcPirc/Uwm ACI.F344-ApcPircUwm BN.F344-ApcPirc F344-Apcm1Kyo
Is Marker For: Strains:   F344-Apcm1Kyo  
Candidate Gene For: Colcr3
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81826,138,382 - 26,196,021 (+)NCBIGRCr8
mRatBN7.21825,828,558 - 25,925,511 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1825,864,222 - 25,922,696 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1825,991,644 - 26,049,283 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01826,754,554 - 26,812,186 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,089,458 - 26,147,091 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,011,710 - 27,106,323 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,047,382 - 27,105,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01826,725,560 - 26,820,837 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41826,732,147 - 26,790,383 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11826,758,792 - 26,817,029 (+)NCBI
Celera1825,606,119 - 25,663,749 (+)NCBICelera
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Abdominal Fibromatosis  (ISO)
Aberrant Crypt Foci  (ISO)
acinar cell carcinoma  (ISO)
adenocarcinoma  (ISO)
adenoma  (ISO)
Adenomatous Polyps  (ISO)
adult respiratory distress syndrome  (ISO)
Aggressive Fibromatosis  (ISO)
Alzheimer's disease  (ISO)
amenorrhea  (ISO)
anemia  (IMP)
Animal Mammary Neoplasms  (ISO)
ascending colon cancer  (ISO)
Attenuated Adenomatous Polyposis Coli  (ISO)
Attenuated Familial Adenomatous Polyposis  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
breast cancer  (ISO,ISS)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
cholangiocarcinoma  (ISO)
colon adenocarcinoma  (IMP,ISO)
colon cancer  (IAGP,ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (IMP,ISO)
Colonic Polyps  (IMP)
colorectal adenoma  (ISO)
colorectal cancer  (ISO,ISS)
Colorectal Neoplasms  (ISO)
craniopharyngioma  (ISO)
desmoid tumor  (ISO)
Digestive System Neoplasms  (ISO)
disease of cellular proliferation  (ISO)
duodenum adenocarcinoma  (ISO)
endometrial cancer  (ISO)
endometrial carcinoma  (ISO)
Endometrial Intraepithelial Neoplasia  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
Eye Abnormalities  (ISO)
familial adenomatous polyposis  (IMP,ISO,ISS)
familial adenomatous polyposis 1  (ISO)
familial hyperlipidemia  (ISO)
gallbladder cancer  (ISO)
Gallbladder Neoplasms  (ISO)
Gardner Syndrome  (ISO)
Gastric Adenocarcinoma and Proximal Polyposis of the Stomach  (ISO)
Gastric Polyposis  (ISO)
Gastrointestinal Hemorrhage  (ISO)
Gastrointestinal Neoplasms  (ISO)
gastrointestinal stromal tumor  (ISO)
glioblastoma  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO,ISS)
hereditary desmoid disease  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Hyperplasia  (ISO)
inflammatory bowel disease  (ISO)
intellectual disability  (ISO)
Intestinal Neoplasms  (IMP,ISO)
Intestinal Polyps  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
Jaw Neoplasms  (IMP)
Klatskin's tumor  (ISO)
Leukocytosis  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lynch syndrome  (ISO)
macrocytic anemia  (ISO)
medulloblastoma  (ISO)
Mesothelioma  (ISO)
mismatch repair cancer syndrome  (ISO)
Monoclonal B-Cell Lymphocytosis  (ISO)
Neoplastic Cell Transformation  (ISO)
Neurodevelopmental Disorders  (ISO)
ovarian cancer  (ISO,ISS)
pancreatic cancer  (ISO)
periampullary adenoma  (ISO)
prostate cancer  (ISO,ISS)
Prostatic Neoplasms  (ISO)
rectal benign neoplasm  (ISO)
rectum adenocarcinoma  (ISO)
renal cell carcinoma  (ISO)
sigmoid colon cancer  (ISO)
sigmoid neoplasm  (ISO)
Splenomegaly  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,8-cineole  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
8-Br-cAMP  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
bromobenzene  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
camptothecin  (ISO)
carmustine  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clorgyline  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
curcumin  (ISO)
cypermethrin  (EXP,ISO)
D-glucose  (EXP)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
ethosuximide  (EXP)
etodolac  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
glucose  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
lutein  (ISO)
malonaldehyde  (ISO)
manganese(II) chloride  (ISO)
metacetamol  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
miconazole  (ISO)
molibresib  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel dichloride  (EXP)
oxybenzone  (ISO)
ozone  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sulindac  (EXP)
tamibarotene  (ISO)
temozolomide  (ISO)
theaflavin  (ISO)
thimerosal  (ISO)
thiram  (ISO)
tipifarnib  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acinar cell proliferation  (ISO)
anterior/posterior pattern specification  (ISO)
apoptotic process  (ISO)
axis specification  (ISO)
axonogenesis  (ISO)
canonical Wnt signaling pathway  (ISO)
canonical Wnt signaling pathway involved in negative regulation of apoptotic process  (ISO)
canonical Wnt signaling pathway involved in positive regulation of apoptotic process  (ISO)
cell adhesion  (ISO)
cell division  (ISO)
cell fate specification  (IBA)
cell migration  (IBA,IEA,ISO,ISS)
cell population proliferation  (ISO)
cellular response to nerve growth factor stimulus  (IEP)
chromosome organization  (ISO)
cytoplasmic microtubule organization  (ISO)
DNA damage response  (IEA,ISO,ISS)
dorsal/ventral pattern formation  (ISO)
endothelial cell proliferation  (ISO)
epithelial cell apoptotic process  (ISO)
epithelial cell proliferation  (ISO)
epithelial cell proliferation involved in prostate gland development  (ISO)
establishment or maintenance of cell polarity  (IDA)
fibroblast apoptotic process  (ISO)
fibroblast migration  (ISO)
hair follicle development  (ISO)
insulin receptor signaling pathway  (IEA,ISO)
kidney development  (ISO)
MAPK cascade  (ISO)
metaphase/anaphase transition of mitotic cell cycle  (ISO)
microtubule depolymerization  (ISO)
microtubule polymerization  (ISO)
mitotic cytokinesis  (IEA,ISO)
mitotic spindle assembly checkpoint signaling  (IEA,ISO)
muscle cell cellular homeostasis  (ISO)
negative regulation of acinar cell proliferation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of canonical Wnt signaling pathway  (IBA,IEA,ISO)
negative regulation of cardiac muscle cell proliferation  (IMP)
negative regulation of cell cycle G1/S phase transition  (ISO,ISS)
negative regulation of cell population proliferation  (IEA,ISO,ISS)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of epithelial cell apoptotic process  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of epithelial cell proliferation involved in prostate gland development  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (IEA,ISO)
negative regulation of MAPK cascade  (ISO)
negative regulation of microtubule depolymerization  (IBA,IEA,ISO,ISS)
negative regulation of odontogenesis  (ISO)
negative regulation of Wnt signaling pathway  (IEA,ISO)
nervous system development  (IBA)
neuron projection development  (IMP)
odontogenesis  (ISO)
pancreas development  (IEP)
pattern specification process  (IBA,ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of cell division  (ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of fibroblast apoptotic process  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of microtubule polymerization  (ISO)
positive regulation of protein catabolic process  (IEA,ISO)
positive regulation of protein localization to centrosome  (IEA,ISO)
positive regulation of pseudopodium assembly  (IEA,ISO)
protein catabolic process  (ISO)
protein-containing complex assembly  (IEA,ISO,ISS)
proximal/distal pattern formation  (ISO)
regulation of attachment of spindle microtubules to kinetochore  (IEA,ISO)
regulation of cell cycle  (ISO)
regulation of cell differentiation  (ISO)
regulation of cell migration  (ISO)
regulation of epithelial cell differentiation  (ISO)
regulation of epithelial cell migration  (ISO)
regulation of glutamate metabolic process  (IDA)
regulation of metabolic process  (ISO)
regulation of microtubule-based movement  (IEA,ISO)
regulation of microtubule-based process  (ISO,ISS)
regulation of osteoblast differentiation  (ISO)
regulation of osteoclast differentiation  (ISO)
response to alcohol  (IEP)
response to xenobiotic stimulus  (IEP)
retina development in camera-type eye  (ISO)
skin development  (ISO)
somatic stem cell population maintenance  (ISO)
stem cell population maintenance  (ISO)
T cell differentiation in thymus  (ISO)
thymus development  (ISO)
Wnt signaling pathway  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway. Abraham SC, etal., Am J Pathol. 2002 Mar;160(3):953-62.
2. A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer. Amos-Landgraf JM, etal., Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4036-41. Epub 2007 Feb 27.
3. MicroRNA-210-mediated proliferation, survival, and angiogenesis promote cardiac repair post myocardial infarction in rodents. Arif M, etal., J Mol Med (Berl). 2017 Dec;95(12):1369-1385. doi: 10.1007/s00109-017-1591-8. Epub 2017 Sep 25.
4. Brain tumors in individuals with familial adenomatous polyposis: a cancer registry experience and pooled case report analysis. Attard TM, etal., Cancer. 2007 Feb 15;109(4):761-6.
5. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
6. Periampullary adenomas and adenocarcinomas in familial adenomatous polyposis: cumulative risks and APC gene mutations. Bjork J, etal., Gastroenterology. 2001 Nov;121(5):1127-35.
7. Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun. Blum CA, etal., Mol Carcinog 2003 Apr;36(4):195-203.
8. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. Brenman JE, etal., J Neurosci. 1998 Nov 1;18(21):8805-13.
9. Mitogen-activated protein kinase (MAPK/ERK) regulates adenomatous polyposis coli during growth-factor-induced cell extension. Caro-Gonzalez HY, etal., J Cell Sci. 2012 Mar 1;125(Pt 5):1247-58. doi: 10.1242/jcs.095166. Epub 2012 Mar 7.
10. Distinct DNA methylation epigenotypes in bladder cancer from different Chinese sub-populations and its implication in cancer detection using voided urine. Chen PC, etal., BMC Med Genomics. 2011 May 20;4:45. doi: 10.1186/1755-8794-4-45.
11. Interaction between murine germline mutations in p53 and APC predisposes to pancreatic neoplasia but not to increased intestinal malignancy. Clarke AR, etal., Oncogene. 1995 Nov 2;11(9):1913-20.
12. APC nuclear membrane association and microtubule polarity. Collin L, etal., Biol Cell. 2008 Apr;100(4):243-52.
13. Association between Hepatitis C Virus Infection, p53 Phenotypes, and Gene Variants of Adenomatous Polyposis Coli in Hepatocellular Carcinomas. Council LN, etal., J Dig Dis Hepatol. 2016;2016(5). Epub 2016 Dec 23.
14. Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. Etienne-Manneville S and Hall A, Nature 2003 Feb 13;421(6924):753-6.
15. Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons. Farias GG, etal., J Neurosci. 2007 May 16;27(20):5313-25.
16. A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Fodde R, etal., Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8969-73.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Proteomic analysis demonstrates adolescent vulnerability to lasting hippocampal changes following chronic alcohol consumption. Hargreaves GA, etal., Alcohol Clin Exp Res. 2009 Jan;33(1):86-94. Epub 2008 Oct 18.
20. Frequent somatic mutations of the APC gene in human pancreatic cancer. Horii A, etal., Cancer Res. 1992 Dec 1;52(23):6696-8.
21. APC promoter hypermethylation is an early event in endometrial tumorigenesis. Ignatov A, etal., Cancer Sci. 2010 Feb;101(2):321-7. doi: 10.1111/j.1349-7006.2009.01397.x. Epub 2009 Oct 12.
22. Frequent somatic mutations of the APC and p53 genes in sporadic ampullary carcinomas. Imai Y, etal., Jpn J Cancer Res. 1997 Sep;88(9):846-54.
23. Branched-chain amino acid metabolon: interaction of glutamate dehydrogenase with the mitochondrial branched-chain aminotransferase (BCATm). Islam MM, etal., J Biol Chem. 2010 Jan 1;285(1):265-76. Epub 2009 Oct 26.
24. Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Kakiuchi H, etal., Proc Natl Acad Sci U S A 1995 Jan 31;92(3):910-4.
25. Mutation of p53 and K-ras, and loss of heterozygosity of APC in intrahepatic cholangiocarcinoma. Kang YK, etal., Lab Invest. 1999 Apr;79(4):477-83.
26. APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers. Kariola R, etal., Fam Cancer. 2005;4(2):187-90. doi: 10.1007/s10689-004-6130-4.
27. Wnt signalling and its impact on development and cancer. Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98.
28. Adenomatous polyposis coli localization is both cell type and cell context dependent. Langford KJ, etal., Cell Motil Cytoskeleton. 2006 Aug;63(8):483-92.
29. Increase of adenomatous polyposis coli immunoreactivity is a marker of reactive astrocytes in Alzheimer's disease and in other pathological conditions. Leroy K, etal., Acta Neuropathol. 2001 Jul;102(1):1-10.
30. Extensive metabolic disorders are present in APC(min) tumorigenesis mice. Liu Z, etal., Mol Cell Endocrinol. 2016 May 15;427:57-64. doi: 10.1016/j.mce.2016.03.004. Epub 2016 Mar 4.
31. Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. Matsumine A, etal., Science. 1996 May 17;272(5264):1020-3. doi: 10.1126/science.272.5264.1020.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. Abnormalities of the APC/beta-catenin pathway in endometrial cancer. Moreno-Bueno G, etal., Oncogene. 2002 Nov 14;21(52):7981-90.
34. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
35. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
36. Colocalization of APC and PSD-95 in the nerve fiber as well as in the post-synapse of matured neurons. Onouchi T, etal., Med Mol Morphol. 2012 Jun;45(3):152-60. Epub 2012 Sep 22.
37. Loss of heterozygosity and protein expression of APC gene in renal cell carcinomas. Pecina-Slaus N, etal., J Mol Med (Berl). 1999 May;77(5):446-53.
38. Genetic changes of the E-cadherin and APC tumour suppressor genes in clear cell renal cell carcinoma. Pecina-SLaus N, etal., Pathology. 2004 Apr;36(2):145-51.
39. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
40. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
41. [Expression and methylation of adenomatous polyposis coli gene in endometrioid adenocarcinoma]. Qian B, etal., Ai Zheng. 2008 Jun;27(6):585-9.
42. GOA pipeline RGD automated data pipeline
43. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Promoter hypermethylation as an independent prognostic factor for relapse in patients with prostate cancer following radical prostatectomy. Rosenbaum E, etal., Clin Cancer Res. 2005 Dec 1;11(23):8321-5. doi: 10.1158/1078-0432.CCR-05-1183.
46. Apc deficiency predisposes to renal carcinoma in the mouse. Sansom OJ, etal., Oncogene. 2005 Dec 8;24(55):8205-10.
47. Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Sansom OJ, etal., Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14122-7. Epub 2006 Sep 7.
48. Subcellular localization of the tumor suppressor protein APC in developing cultured neurons. Shimomura A, etal., Neurosci Lett. 2005 Feb 28;375(2):81-6. Epub 2004 Dec 10.
49. Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas. Strom A, etal., Development. 2007 Aug;134(15):2719-25. Epub 2007 Jun 27.
50. Aberrant promoter hypermethylation of multiple genes in gallbladder carcinoma and chronic cholecystitis. Takahashi T, etal., Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6126-33.
51. Stromal deletion of the APC tumor suppressor in mice triggers development of endometrial cancer. Tanwar PS, etal., Cancer Res. 2011 Mar 1;71(5):1584-96. doi: 10.1158/0008-5472.CAN-10-3166.
52. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
53. Computational development of a molecular-based approach to improve risk stratification of endometrial cancer patients. Torricelli F, etal., Oncotarget. 2018 May 22;9(39):25517-25528. doi: 10.18632/oncotarget.25354. eCollection 2018 May 22.
54. A mouse model for endometrioid ovarian cancer arising from the distal oviduct. van der Horst PH, etal., Int J Cancer. 2014 Sep 1;135(5):1028-37. doi: 10.1002/ijc.28746. Epub 2014 Mar 20.
55. Alterations in Wnt-ß-catenin and Pten signalling play distinct roles in endometrial cancer initiation and progression. van der Zee M, etal., J Pathol. 2013 May;230(1):48-58. doi: 10.1002/path.4160. Epub 2013 Mar 14.
56. Neurite outgrowth involves adenomatous polyposis coli protein and beta-catenin. Votin V, etal., J Cell Sci. 2005 Dec 15;118(Pt 24):5699-708. Epub 2005 Nov 22.
57. Wnt/beta-catenin signaling pathway is active in pancreatic development of rat embryo. Wang QM, etal., World J Gastroenterol. 2006 Apr 28;12(16):2615-9.
58. Association of Wnt signaling pathway genetic variants in gallbladder cancer susceptibility and survival. Yadav A, etal., Tumour Biol. 2016 Jun;37(6):8083-95. doi: 10.1007/s13277-015-4728-9. Epub 2015 Dec 29.
59. Promoter methylation profiles of tumor suppressor genes in intrahepatic and extrahepatic cholangiocarcinoma. Yang B, etal., Mod Pathol. 2005 Mar;18(3):412-20.
60. A novel miR-193a-5p-YY1-APC regulatory axis in human endometrioid endometrial adenocarcinoma. Yang Y, etal., Oncogene. 2013 Jul 18;32(29):3432-42. doi: 10.1038/onc.2012.360. Epub 2012 Aug 20.
61. Enhanced colitis-associated colon carcinogenesis in a novel Apc mutant rat. Yoshimi K, etal., Cancer Sci. 2009 Nov;100(11):2022-7. doi: 10.1111/j.1349-7006.2009.01287.x. Epub 2009 Jul 17.
62. Cell density and phosphorylation control the subcellular localization of adenomatous polyposis coli protein. Zhang F, etal., Mol Cell Biol. 2001 Dec;21(23):8143-56.
Additional References at PubMed
PMID:1541640   PMID:7806582   PMID:7890674   PMID:7954428   PMID:8521819   PMID:8563176   PMID:8638126   PMID:8670282   PMID:8945508   PMID:8978062   PMID:8978063   PMID:8988060  
PMID:9037065   PMID:9060821   PMID:9135000   PMID:9159163   PMID:9288104   PMID:9371501   PMID:9453487   PMID:9506519   PMID:9515784   PMID:9601641   PMID:9707618   PMID:9771477  
PMID:9865728   PMID:9927046   PMID:10334197   PMID:10346819   PMID:10451698   PMID:10506110   PMID:10535960   PMID:10626800   PMID:10708962   PMID:10716720   PMID:10773885   PMID:10783317  
PMID:10919675   PMID:10951583   PMID:10969066   PMID:10982921   PMID:10987272   PMID:11035805   PMID:11166179   PMID:11197776   PMID:11245490   PMID:11274413   PMID:11283619   PMID:11309311  
PMID:11381263   PMID:11385109   PMID:11478486   PMID:11533658   PMID:11533709   PMID:11559569   PMID:11606502   PMID:11731407   PMID:11756652   PMID:11773073   PMID:11809702   PMID:11972058  
PMID:12072559   PMID:12370429   PMID:12645927   PMID:12874278   PMID:12952940   PMID:12955080   PMID:14728717   PMID:14758356   PMID:15198980   PMID:15207235   PMID:15314168   PMID:15380519  
PMID:15550389   PMID:15556865   PMID:15563600   PMID:15684064   PMID:15767571   PMID:15802266   PMID:15958588   PMID:16007074   PMID:16025118   PMID:16188939   PMID:16368433   PMID:16478791  
PMID:16525027   PMID:16611247   PMID:16621792   PMID:16638711   PMID:16641100   PMID:16709231   PMID:16740478   PMID:16753179   PMID:16815997   PMID:16887818   PMID:16950562   PMID:17002498  
PMID:17192415   PMID:17200209   PMID:17227893   PMID:17299058   PMID:17363566   PMID:17371273   PMID:17377531   PMID:17570218   PMID:17615359   PMID:17671182   PMID:17681179   PMID:17875695  
PMID:17893240   PMID:17893885   PMID:17956267   PMID:17989230   PMID:18056981   PMID:18076571   PMID:18258607   PMID:18281465   PMID:18464259   PMID:18485889   PMID:18502210   PMID:18644872  
PMID:18656477   PMID:18716223   PMID:18719115   PMID:18725524   PMID:19151759   PMID:19632184   PMID:20623542   PMID:20937854   PMID:21471006   PMID:22898821   PMID:23382461   PMID:23395091  
PMID:25036633   PMID:26658992   PMID:28057765   PMID:30934153   PMID:34003864  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81826,138,382 - 26,196,021 (+)NCBIGRCr8
mRatBN7.21825,828,558 - 25,925,511 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1825,864,222 - 25,922,696 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1825,991,644 - 26,049,283 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01826,754,554 - 26,812,186 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,089,458 - 26,147,091 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,011,710 - 27,106,323 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,047,382 - 27,105,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01826,725,560 - 26,820,837 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41826,732,147 - 26,790,383 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11826,758,792 - 26,817,029 (+)NCBI
Celera1825,606,119 - 25,663,749 (+)NCBICelera
Cytogenetic Map18p12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh385112,707,498 - 112,846,239 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5112,707,518 - 112,846,239 (+)EnsemblGRCh38hg38GRCh38
GRCh375112,043,195 - 112,181,936 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365112,101,483 - 112,209,835 (+)NCBINCBI36Build 36hg18NCBI36
Build 345112,101,482 - 112,209,834NCBI
Celera5107,988,802 - 108,127,503 (+)NCBICelera
Cytogenetic Map5q22.2NCBI
HuRef5107,222,330 - 107,361,030 (+)NCBIHuRef
CHM1_15111,476,576 - 111,615,241 (+)NCBICHM1_1
T2T-CHM13v2.05113,218,062 - 113,356,772 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391834,353,350 - 34,455,243 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1834,353,977 - 34,455,605 (+)EnsemblGRCm39 Ensembl
GRCm381834,220,297 - 34,322,190 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,220,924 - 34,322,552 (+)EnsemblGRCm38mm10GRCm38
MGSCv371834,380,638 - 34,481,844 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361834,385,824 - 34,443,409 (+)NCBIMGSCv36mm8
Celera1834,670,234 - 34,773,431 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.53NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554182,566,975 - 2,674,832 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554182,567,804 - 2,675,062 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v24107,966,719 - 108,104,333 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15106,120,377 - 106,257,991 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05108,070,697 - 108,208,273 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15113,873,993 - 114,009,709 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5113,904,352 - 114,009,709 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13252,052 - 380,506 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3253,081 - 322,993 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha31,652,296 - 1,781,970 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0393,843 - 224,101 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl394,206 - 190,576 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1386,997 - 217,003 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0386,045 - 214,151 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03249,524 - 377,618 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213154,592,489 - 154,711,938 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365316,899,788 - 7,019,453 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365316,899,580 - 7,019,016 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl2116,812,582 - 117,034,887 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12116,913,354 - 116,985,303 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22121,515,522 - 121,573,844 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12315,992,437 - 16,135,117 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2316,042,287 - 16,137,067 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603462,320,613 - 62,469,122 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462474330,546,323 - 30,635,737 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474330,517,034 - 30,635,740 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Apc
388 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:143
Count of miRNA genes:112
Interacting mature miRNAs:119
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181194427326548295Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181194427326548295Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181194427326548295Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181194427326548295Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181194427326548295Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181194427326548295Rat
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194427326548295Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181823456431359530Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181823456431359530Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21825,918,112 - 25,918,430 (+)MAPPERmRatBN7.2
Rnor_6.01827,101,582 - 27,101,899NCBIRnor6.0
Rnor_5.01826,815,121 - 26,815,438UniSTSRnor5.0
RGSC_v3.41826,786,632 - 26,786,949UniSTSRGSC3.4
Celera1825,659,998 - 25,660,315UniSTS
Cytogenetic Map18p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21825,871,434 - 25,872,299 (+)MAPPERmRatBN7.2
Rnor_6.01827,054,594 - 27,055,458NCBIRnor6.0
Rnor_5.01826,768,424 - 26,769,288UniSTSRnor5.0
RGSC_v3.41826,739,361 - 26,740,225UniSTSRGSC3.4
Celera1825,613,340 - 25,614,204UniSTS
RH 3.4 Map18364.1UniSTS
Cytogenetic Map18p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21825,915,866 - 25,916,194 (+)MAPPERmRatBN7.2
Rnor_6.01827,099,336 - 27,099,663NCBIRnor6.0
Rnor_5.01826,812,875 - 26,813,202UniSTSRnor5.0
RGSC_v3.41826,784,386 - 26,784,713UniSTSRGSC3.4
Celera1825,657,752 - 25,658,079UniSTS
Cytogenetic Map18p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21825,920,013 - 25,920,121 (+)MAPPERmRatBN7.2
Rnor_6.01827,103,483 - 27,103,590NCBIRnor6.0
Rnor_5.01826,817,022 - 26,817,129UniSTSRnor5.0
RGSC_v3.41826,788,533 - 26,788,640UniSTSRGSC3.4
Celera1825,661,899 - 25,662,006UniSTS
Cytogenetic Map18p12UniSTS

Related Rat Strains
The following Strains have been annotated to Apc

Genetic Models
This gene Apc is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 34 30 14 19 14 7 7 74 35 36 11 7
Low 1 9 27 27 27 1 4 5 1
Below cutoff


RefSeq Acc Id: ENSRNOT00000027691   ⟹   ENSRNOP00000027691
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1825,864,222 - 25,922,696 (+)Ensembl
Rnor_6.0 Ensembl1827,047,382 - 27,105,333 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090264   ⟹   ENSRNOP00000074593
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1825,864,222 - 25,922,696 (+)Ensembl
Rnor_6.0 Ensembl1827,047,418 - 27,105,531 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102176   ⟹   ENSRNOP00000080591
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1825,864,222 - 25,922,696 (+)Ensembl
RefSeq Acc Id: NM_012499   ⟹   NP_036631
Rat AssemblyChrPosition (strand)Source
GRCr81826,138,382 - 26,196,021 (+)NCBI
mRatBN7.21825,864,222 - 25,921,864 (+)NCBI
Rnor_6.01827,047,382 - 27,105,333 (+)NCBI
Rnor_5.01826,725,560 - 26,820,837 (+)NCBI
RGSC_v3.41826,732,147 - 26,790,383 (+)RGD
Celera1825,606,119 - 25,663,749 (+)RGD
RefSeq Acc Id: NP_036631   ⟸   NM_012499
- UniProtKB: P70478 (UniProtKB/Swiss-Prot),   A6J2T3 (UniProtKB/TrEMBL),   G3V8Q9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074593   ⟸   ENSRNOT00000090264
RefSeq Acc Id: ENSRNOP00000027691   ⟸   ENSRNOT00000027691
RefSeq Acc Id: ENSRNOP00000080591   ⟸   ENSRNOT00000102176

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2123 AgrOrtholog
BioCyc Gene G2FUF-7966 BioCyc
Ensembl Genes ENSRNOG00000020423 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027691 ENTREZGENE
  ENSRNOT00000027691.4 UniProtKB/TrEMBL
  ENSRNOT00000090264.2 UniProtKB/TrEMBL
  ENSRNOT00000102176.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helix hairpin bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro APC_15aa_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_basic_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Apc_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_rep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Armadillo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EB1-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24205 UniProtKB/Swiss-Prot
PANTHER PTHR12607 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12607:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam APC_15aa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_basic UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_N_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_r UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_rep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_u13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_u14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_u15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_u5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APC_u9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arm UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arm_APC_u3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EB1_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Suppressor_APC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Apc PhenoGen
RatGTEx ENSRNOG00000020423 RatGTEx
SMART ARM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF58050 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82931 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228425
UniProt A0A0G2K8G0_RAT UniProtKB/TrEMBL
  APC_RAT UniProtKB/Swiss-Prot
  Q920M0_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Apc  Adenomatosis polyposis coli      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutations are associated with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced colon tumors 634649
gene_disease human homolog is involved in colon tumorigenesis 634649
gene_function interacts with microtubles 632398
gene_process may play a role in the regulation of cell polarity 632398