Ampd3 (adenosine monophosphate deaminase 3) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Community Projects (beta) QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Ampd3 (adenosine monophosphate deaminase 3) Rattus norvegicus
Analyze
Symbol: Ampd3
Name: adenosine monophosphate deaminase 3
RGD ID: 2111
Description: Enables AMP deaminase activity. Predicted to be involved in erythrocyte homeostasis and purine ribonucleotide metabolic process. Predicted to act upstream of or within energy homeostasis and purine ribonucleotide metabolic process. Orthologous to human AMPD3 (adenosine monophosphate deaminase 3); PARTICIPATES IN purine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 3,7-dihydropurine-6-thione; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AMP deaminase 3; Ampd; Ampd isoform C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21164,884,823 - 164,929,899 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,885,320 - 164,929,887 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1173,223,024 - 173,267,566 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01180,409,049 - 180,453,593 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01173,093,501 - 173,137,978 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01175,585,301 - 175,630,479 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1175,586,097 - 175,630,467 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01182,573,239 - 182,618,415 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41168,519,462 - 168,568,291 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11168,644,154 - 168,678,954 (+)NCBI
Celera1162,776,701 - 162,820,660 (+)NCBICelera
RH 3.4 Map11330.8RGD
Cytogenetic Map1q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7beta-aminocephalosporanic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
atazanavir sulfate  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benomyl  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chenodeoxycholic acid  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
DDE  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
epichlorohydrin  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
graphite  (EXP)
hexamethylene diisocyanate  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
mechlorethamine  (ISO)
mercaptopurine  (EXP)
methamphetamine  (EXP)
methapyrilene  (EXP)
methoxychlor  (EXP)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
progesterone  (ISO)
propanal  (ISO)
purine-6-thiol  (EXP)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium nitrite  (ISO)
Soman  (EXP)
sotorasib  (ISO)
succimer  (ISO)
Sunset Yellow FCF  (ISO)
tartrazine  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
testosterone undecanoate  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Molecular biology of AMP deaminase deficiency. Gross M Pharm World Sci 1994 Apr 15;16(2):55-61.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
6. Regulation of rat AMP deaminase 3 (isoform C) by development and skeletal muscle fibre type. Mahnke-Zizelman DK, etal., Biochem J 1997 Sep 1;326 ( Pt 2):521-9.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1429593   PMID:7287721   PMID:9133604   PMID:9857047   PMID:16751776   PMID:23078545   PMID:23439682   PMID:23542464   PMID:23911318   PMID:24066180   PMID:24940686   PMID:29733818  
PMID:30053369   PMID:36815317  


Genomics

Comparative Map Data
Ampd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21164,884,823 - 164,929,899 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,885,320 - 164,929,887 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1173,223,024 - 173,267,566 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01180,409,049 - 180,453,593 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01173,093,501 - 173,137,978 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01175,585,301 - 175,630,479 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1175,586,097 - 175,630,467 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01182,573,239 - 182,618,415 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41168,519,462 - 168,568,291 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11168,644,154 - 168,678,954 (+)NCBI
Celera1162,776,701 - 162,820,660 (+)NCBICelera
RH 3.4 Map11330.8RGD
Cytogenetic Map1q33NCBI
AMPD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381110,450,388 - 10,507,579 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1110,308,313 - 10,507,579 (+)EnsemblGRCh38hg38GRCh38
GRCh371110,471,935 - 10,529,126 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,428,800 - 10,485,702 (+)NCBINCBI36Build 36hg18NCBI36
Build 341110,428,799 - 10,485,247NCBI
Celera1110,593,627 - 10,650,868 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef1110,144,687 - 10,201,742 (+)NCBIHuRef
CHM1_11110,469,929 - 10,527,173 (+)NCBICHM1_1
T2T-CHM13v2.01110,534,888 - 10,592,054 (+)NCBIT2T-CHM13v2.0
Ampd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397110,367,291 - 110,411,612 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7110,367,413 - 110,411,612 (+)EnsemblGRCm39 Ensembl
GRCm387110,767,790 - 110,812,409 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7110,768,206 - 110,812,405 (+)EnsemblGRCm38mm10GRCm38
MGSCv377117,916,118 - 117,955,909 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367110,563,781 - 110,603,572 (+)NCBIMGSCv36mm8
Celera7110,746,081 - 110,786,296 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map757.85NCBI
Ampd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541426,072,855 - 26,116,448 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541426,073,192 - 26,116,448 (+)NCBIChiLan1.0ChiLan1.0
AMPD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11112,852,321 - 12,911,287 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01110,581,730 - 10,638,777 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11110,309,436 - 10,365,369 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1110,309,436 - 10,365,369 (+)Ensemblpanpan1.1panPan2
AMPD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.02134,487,335 - 34,534,074 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2134,487,920 - 34,534,063 (+)EnsemblROS_Cfam_1.0 Ensembl
Ampd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494751,814,360 - 51,857,818 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365287,848,096 - 7,890,627 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365287,847,156 - 7,891,585 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMPD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl249,028,923 - 49,083,590 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1249,026,695 - 49,084,982 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2252,377,794 - 52,432,705 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AMPD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1154,318,746 - 54,374,361 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl154,316,334 - 54,373,619 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038151,984,708 - 152,040,518 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ampd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247662,545,932 - 2,587,025 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247662,542,021 - 2,586,912 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ampd3
235 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:188
Count of miRNA genes:137
Interacting mature miRNAs:160
Transcripts:ENSRNOT00000024933
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1155422851172949803Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1156677124176484451Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1164747558181133855Rat

Markers in Region
RH142177  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21164,928,760 - 164,928,957 (+)MAPPERmRatBN7.2
Rnor_6.01175,629,341 - 175,629,537NCBIRnor6.0
Rnor_5.01182,617,277 - 182,617,473UniSTSRnor5.0
RGSC_v3.41168,567,165 - 168,567,361UniSTSRGSC3.4
Celera1162,819,534 - 162,819,730UniSTS
RH 3.4 Map11330.8UniSTS
Cytogenetic Map1q35-q36UniSTS
D1Bda34  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21164,929,146 - 164,929,673 (+)MAPPERmRatBN7.2
Rnor_6.01175,629,727 - 175,630,253NCBIRnor6.0
Rnor_5.01182,617,663 - 182,618,189UniSTSRnor5.0
RGSC_v3.41168,567,551 - 168,568,077UniSTSRGSC3.4
Celera1162,819,920 - 162,820,446UniSTS
Cytogenetic Map1q35-q36UniSTS
RH139645  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21164,929,564 - 164,929,766 (+)MAPPERmRatBN7.2
Rnor_6.01175,630,145 - 175,630,346NCBIRnor6.0
Rnor_5.01182,618,081 - 182,618,282UniSTSRnor5.0
RGSC_v3.41168,567,969 - 168,568,170UniSTSRGSC3.4
Celera1162,820,338 - 162,820,539UniSTS
RH 3.4 Map11330.8UniSTS
Cytogenetic Map1q35-q36UniSTS
MARC_44785-45781:1101739916:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21164,922,360 - 164,923,531 (+)MAPPERmRatBN7.2
Rnor_6.01175,622,943 - 175,624,113NCBIRnor6.0
Rnor_5.01182,610,879 - 182,612,049UniSTSRnor5.0
RGSC_v3.41168,560,767 - 168,561,937UniSTSRGSC3.4
Celera1162,813,170 - 162,814,340UniSTS
Cytogenetic Map1q35-q36UniSTS
MARC_45777-45778:1101741591:5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21164,920,109 - 164,920,658 (+)MAPPERmRatBN7.2
Rnor_6.01175,620,692 - 175,621,240NCBIRnor6.0
Rnor_5.01182,608,628 - 182,609,176UniSTSRnor5.0
RGSC_v3.41168,558,516 - 168,559,064UniSTSRGSC3.4
Celera1162,810,919 - 162,811,467UniSTS
Cytogenetic Map1q35-q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 20 12 12 11 12 38 25 7 9
Low 1 23 43 27 8 27 8 11 26 10 30 2 8
Below cutoff 2 2 2 10 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005499585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ604380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U90888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000024933   ⟹   ENSRNOP00000024933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1164,885,320 - 164,929,887 (+)Ensembl
Rnor_6.0 Ensembl1175,586,097 - 175,630,467 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106719   ⟹   ENSRNOP00000088165
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1164,890,847 - 164,929,887 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112866   ⟹   ENSRNOP00000084681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1164,885,765 - 164,929,887 (+)Ensembl
RefSeq Acc Id: NM_031544   ⟹   NP_113732
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21164,885,320 - 164,929,887 (+)NCBI
Rnor_6.01175,586,097 - 175,630,467 (+)NCBI
Rnor_5.01182,573,239 - 182,618,415 (+)NCBI
RGSC_v3.41168,519,462 - 168,568,291 (+)RGD
Celera1162,776,701 - 162,820,660 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230010   ⟹   XP_006230072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21164,890,819 - 164,929,899 (+)NCBI
Rnor_6.01175,591,107 - 175,630,479 (+)NCBI
Rnor_5.01182,573,239 - 182,618,415 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230011   ⟹   XP_006230073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21164,885,599 - 164,929,899 (+)NCBI
Rnor_6.01175,586,576 - 175,630,479 (+)NCBI
Rnor_5.01182,573,239 - 182,618,415 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230012   ⟹   XP_006230074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21164,889,741 - 164,929,899 (+)NCBI
Rnor_6.01175,590,172 - 175,630,479 (+)NCBI
Rnor_5.01182,573,239 - 182,618,415 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230013   ⟹   XP_006230075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21164,889,741 - 164,929,899 (+)NCBI
Rnor_6.01175,590,172 - 175,630,479 (+)NCBI
Rnor_5.01182,573,239 - 182,618,415 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230014   ⟹   XP_006230076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21164,884,823 - 164,929,899 (+)NCBI
Rnor_6.01175,585,301 - 175,630,479 (+)NCBI
Rnor_5.01182,573,239 - 182,618,415 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230015   ⟹   XP_006230077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21164,886,741 - 164,929,896 (+)NCBI
Rnor_6.01175,587,167 - 175,630,479 (+)NCBI
Rnor_5.01182,573,239 - 182,618,415 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101357   ⟹   XP_038957285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21164,890,819 - 164,929,899 (+)NCBI
RefSeq Acc Id: XM_039101362   ⟹   XP_038957290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21164,885,194 - 164,927,237 (+)NCBI
RefSeq Acc Id: XM_039101364   ⟹   XP_038957292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21164,885,194 - 164,927,216 (+)NCBI
RefSeq Acc Id: XM_039101372   ⟹   XP_038957300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21164,911,522 - 164,929,899 (+)NCBI
RefSeq Acc Id: XR_005499585
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21164,885,194 - 164,928,401 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_113732   ⟸   NM_031544
- UniProtKB: O09178 (UniProtKB/Swiss-Prot),   F1M7Q5 (UniProtKB/TrEMBL),   A6I819 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230076   ⟸   XM_006230014
- Peptide Label: isoform X3
- UniProtKB: O09178 (UniProtKB/Swiss-Prot),   A6I821 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230073   ⟸   XM_006230011
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A0N2 (UniProtKB/TrEMBL),   A6I820 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230077   ⟸   XM_006230015
- Peptide Label: isoform X3
- UniProtKB: O09178 (UniProtKB/Swiss-Prot),   A6I821 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230074   ⟸   XM_006230012
- Peptide Label: isoform X3
- UniProtKB: O09178 (UniProtKB/Swiss-Prot),   A6I821 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230075   ⟸   XM_006230013
- Peptide Label: isoform X3
- UniProtKB: O09178 (UniProtKB/Swiss-Prot),   A6I821 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230072   ⟸   XM_006230010
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A9F8 (UniProtKB/TrEMBL),   A6I820 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024933   ⟸   ENSRNOT00000024933
RefSeq Acc Id: XP_038957290   ⟸   XM_039101362
- Peptide Label: isoform X4
- UniProtKB: A6I820 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957292   ⟸   XM_039101364
- Peptide Label: isoform X5
- UniProtKB: O09178 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038957285   ⟸   XM_039101357
- Peptide Label: isoform X3
- UniProtKB: O09178 (UniProtKB/Swiss-Prot),   A6I821 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957300   ⟸   XM_039101372
- Peptide Label: isoform X6
RefSeq Acc Id: ENSRNOP00000088165   ⟸   ENSRNOT00000106719
RefSeq Acc Id: ENSRNOP00000084681   ⟸   ENSRNOT00000112866

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O09178-F1-model_v2 AlphaFold O09178 1-765 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2111 AgrOrtholog
BioCyc Gene G2FUF-57826 BioCyc
Ensembl Genes ENSRNOG00000018262 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024933 ENTREZGENE
  ENSRNOT00000024933.6 UniProtKB/TrEMBL
  ENSRNOT00000106719 ENTREZGENE
  ENSRNOT00000106719.1 UniProtKB/TrEMBL
  ENSRNOT00000112866 ENTREZGENE
  ENSRNOT00000112866.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.800.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metal-dependent hydrolases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A/AMP_deam_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMPD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metal_Hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25095 UniProtKB/Swiss-Prot
NCBI Gene 25095 ENTREZGENE
PANTHER PTHR11359 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11359:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AMP_deaminase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ampd3 PhenoGen
PIRSF AMP_deaminase_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE A_DEAMINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018262 RatGTEx
Superfamily-SCOP SSF51556 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A0N2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A9F8 ENTREZGENE, UniProtKB/TrEMBL
  A6I819 ENTREZGENE, UniProtKB/TrEMBL
  A6I820 ENTREZGENE, UniProtKB/TrEMBL
  A6I821 ENTREZGENE, UniProtKB/TrEMBL
  AMPD3_RAT UniProtKB/Swiss-Prot
  F1M7Q5 ENTREZGENE, UniProtKB/TrEMBL
  O09178 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ampd3  Adenosine monophosphate deaminase 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function catalyzes the conversion of AMP to IMP 632203
gene_transcript contains several transcripts with heterogeneity in the 5 sequence 632203