Alpl (alkaline phosphatase, biomineralization associated) - Rat Genome Database

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Gene: Alpl (alkaline phosphatase, biomineralization associated) Rattus norvegicus
Symbol: Alpl
Name: alkaline phosphatase, biomineralization associated
RGD ID: 2100
Description: Enables alkaline phosphatase activity. Involved in several processes, including cementum mineralization; response to insulin; and response to macrophage colony-stimulating factor. Located in extracellular space. Is active in extracellular membrane-bounded organelle. Biomarker of uremia. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; and infantile hypophosphatasia. Orthologous to human ALPL (alkaline phosphatase, biomineralization associated); PARTICIPATES IN hypophosphatasia pathway; vitamin B6 metabolic pathway; folate metabolic pathway; INTERACTS WITH (E)-thiamethoxam; (R,R)-tramadol; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Akp2; alkaline phosphatase 2 liver; alkaline phosphatase 2, liver; alkaline phosphatase liver/bone/kidney isozyme; alkaline phosphatase, liver/bone/kidney; alkaline phosphatase, tissue-nonspecific; alkaline phosphatase, tissue-nonspecific isozyme; AP-TNAP; MGC93545; PHOA; phosphoamidase; phosphocreatine phosphatase; tissue-nonspecific alkaline phosphatase; tissue-nonspecific ALP alkaline phosphatase; TNAP; TNSALP
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr85155,234,770 - 155,289,785 (-)NCBIGRCr8
mRatBN7.25149,951,397 - 150,006,424 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,951,409 - 150,006,446 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5152,647,183 - 152,702,235 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05154,421,476 - 154,476,524 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05154,403,485 - 154,458,535 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05156,086,496 - 156,141,513 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,086,497 - 156,141,537 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,841,916 - 159,897,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,501,739 - 156,558,727 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15156,511,778 - 156,568,766 (-)NCBI
Celera5148,347,371 - 148,402,292 (-)NCBICelera
RH 3.4 Map51009.6RGD
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(E)-thiamethoxam  (EXP)
(R,R)-tramadol  (EXP)
(S)-colchicine  (ISO)
(S)-mandelic acid  (ISO)
(S)-naringenin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,3-dinitrobenzene  (EXP)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
acephate  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
Actein  (ISO)
aflatoxin B1  (ISO)
alachlor  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (EXP)
alloxanthine  (EXP)
alpha-Zearalanol  (EXP)
aluminium atom  (ISO)
aluminium oxide  (ISO)
aluminium(0)  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
apocynin  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
atrazine  (ISO)
aucubin  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bezafibrate  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcidiol  (ISO)
calcitriol  (ISO)
calcium dichloride  (ISO)
calcium dihydroxide  (ISO)
calcium silicate  (ISO)
cannabidiol  (ISO)
captopril  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chitosan  (ISO)
chloramphenicol  (ISO)
chlorpyrifos  (ISO)
chromium atom  (EXP)
chromium(3+) trichloride  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cordycepin  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
cyanuric acid  (EXP)
cyclosporin A  (ISO)
cypermethrin  (EXP,ISO)
D-glucose  (EXP,ISO)
daidzein  (ISO)
decabromodiphenyl ether  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
difenoconazole  (EXP)
digoxin  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethoate  (ISO)
dioxygen  (ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP)
enalapril  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
eugenol  (ISO)
Falecalcitriol  (ISO)
fenofibrate  (ISO)
fenvalerate  (EXP,ISO)
ferric ammonium citrate  (ISO)
Fexaramine  (ISO)
fipronil  (ISO)
fisetin  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gallocatechin  (EXP)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP,ISO)
glucose  (EXP,ISO)
glycerol 2-phosphate  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
guggulsterone  (ISO)
GW 4064  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP)
hexane  (EXP)
hydrogen peroxide  (ISO)
hydroxychloroquine  (ISO)
icariside II  (EXP,ISO)
Icaritin  (EXP)
indinavir  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
inulin  (ISO)
isocyanuric acid  (EXP)
isoniazide  (ISO)
isoproturon  (EXP)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
levamisole  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
loliolide  (ISO)
LY294002  (ISO)
malathion  (EXP)
mandelic acid  (ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
menaquinone  (EXP)
menaquinone-4  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (EXP)
methoxychlor  (EXP,ISO)
methylparaben  (ISO)
microcystin-LR  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Morroniside  (EXP,ISO)
Moxestrol  (ISO)
Muraglitazar  (EXP)
myricitrin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-Acetyl-S- (3-hydroxypropyl)-cysteine  (ISO)
N-Acetyl-S-(2-carbamoylethyl)-cysteine  (ISO)
N-Acetyl-S-(2-cyanoethyl)-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP,ISO)
naphthalene  (ISO)
nebivolol  (EXP)
niclosamide  (ISO)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
orphenadrine  (EXP)
ozone  (ISO)
pamidronate  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
paricalcitol  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenethyl caffeate  (EXP,ISO)
phenobarbital  (ISO)
phenol  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
phytoestrogen  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
procaine  (ISO)
progesterone  (ISO)
pyridoxal 5'-phosphate  (ISO)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP)
raloxifene  (EXP)
ramipril  (EXP)
resveratrol  (EXP)
rifampicin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salidroside  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
sodium cholate  (ISO)
sodium fluoride  (EXP,ISO)
sodium hypochlorite  (ISO)
sophoraflavanone B  (ISO)
spironolactone  (ISO)
styrene  (ISO)
sucrose  (EXP)
sulindac  (ISO)
syringic acid  (EXP)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
telmisartan  (EXP)
terbutylazine  (ISO)
Tesaglitazar  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiamethoxam  (EXP)
thioacetamide  (EXP)
thymoquinone  (EXP)
titanium dioxide  (ISO)
tramadol  (EXP)
tributylstannane  (ISO)
triflumizole  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (EXP,ISO)
uranium atom  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vitamin E  (EXP)
warfarin  (ISO)
xanthohumol  (ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP,ISO)
zinc(0)  (EXP,ISO)
zineb  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Effects of pioglitazone in familial combined hyperlipidaemia. Abbink EJ, etal., J Intern Med. 2006 Jan;259(1):107-16.
2. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
3. Lipid composition modulates ATP hydrolysis and calcium phosphate mineral propagation by TNAP-harboring proteoliposomes. Favarin BZ, etal., Arch Biochem Biophys. 2020 Sep 30;691:108482. doi: 10.1016/ Epub 2020 Jul 22.
4. Association of high alpha(2)-Heremans-Schmid glycoprotein/fetuin concentration in serum and intima-media thickness in patients with atherosclerotic vascular disease and low bone mass. Fiore CE, etal., Atherosclerosis. 2006 Sep 28;.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. A homoallelic Gly317-->Asp mutation in ALPL causes the perinatal (lethal) form of hypophosphatasia in Canadian mennonites. Greenberg CR, etal., Genomics. 1993 Jul;17(1):215-7.
7. Liver markers and development of the metabolic syndrome: the insulin resistance atherosclerosis study. Hanley AJ, etal., Diabetes. 2005 Nov;54(11):3140-7.
8. Identification of pulmonary surfactant that bears intestinal-type and tissue-nonspecific-type alkaline phosphatase in endotoxin-induced rat bronchoalveolar fluid. Harada T, etal., Cell Tissue Res. 2002 Jan;307(1):69-77. Epub 2001 Oct 30.
9. Increased expression of the receptor for activation of NF-kappaB and decreased runt-related transcription factor 2 expression in bone of rats with streptozotocin-induced diabetes. Hie M and Tsukamoto I, Int J Mol Med. 2010 Oct;26(4):611-8. doi: 10.3892/ijmm_00000506.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. Phosphatase actions at the site of appositional mineralization in bisphosphonate-affected bones of the rat. Li Y, etal., J Med Dent Sci. 2008 Sep;55(3-4):255-65.
13. Upregulation of alkaline phosphatase and pyrophosphate hydrolysis: potential mechanism for uremic vascular calcification. Lomashvili KA, etal., Kidney Int. 2008 May;73(9):1024-30. Epub 2008 Feb 20.
14. Apocynin alleviated hepatic oxidative burden and reduced liver injury in hypercholesterolaemia. Lu LS, etal., Liver Int. 2007 May;27(4):529-37.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Rat alkaline phosphatase. I. Purification and characterization of the enzyme from osteosarcoma: generation of monoclonal and polyclonal antibodies. Nair BC, etal., Arch Biochem Biophys. 1987 Apr;254(1):18-27.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Comprehensive gene review and curation RGD comprehensive gene curation
25. Heterogeneity in alkaline phosphatase isozyme expression in human testicular germ cell tumours: An enzyme-/immunohistochemical and molecular analysis. Roelofs H, etal., J Pathol. 1999 Oct;189(2):236-44.
26. Changes in liver histology accompanying massive weight loss after gastroplasty for morbid obesity. Stratopoulos C, etal., Obes Surg. 2005 Sep;15(8):1154-60.
27. Structure and expression of rat osteosarcoma (ROS 17/2.8) alkaline phosphatase: product of a single copy gene. Thiede MA, etal., Proc Natl Acad Sci U S A 1988 Jan;85(2):319-23.
28. Administration of colony stimulating factor-1 to toothless osteopetrotic rats normalizes osteoblast, but not osteoclast, gene expression. Wisner-Lynch LA, etal., Bone. 1995 Jun;16(6):611-8. doi: 10.1016/8756-3282(95)00114-s.
29. Mineralization process during acellular cementogenesis in rat molars: a histochemical and immunohistochemical study using fresh-frozen sections. Yamamoto T, etal., Histochem Cell Biol. 2007 Mar;127(3):303-11. Epub 2006 Oct 17.
30. Tissue-specific and dexamethasone-inducible expression of alkaline phosphatase from alternative promoters of the rat bone/liver/kidney/placenta gene. Zernik J, etal., Biochem Biophys Res Commun. 1991 May 15;176(3):1149-56.
Additional References at PubMed
PMID:2133555   PMID:2544423   PMID:2834351   PMID:2895632   PMID:3484182   PMID:7533563   PMID:10787428   PMID:12477932   PMID:15489334   PMID:15728361   PMID:16210410   PMID:17023519  
PMID:17540358   PMID:18031938   PMID:19056867   PMID:19084045   PMID:19451200   PMID:19874193   PMID:19931660   PMID:20684022   PMID:21191615   PMID:21418901   PMID:21636885   PMID:22206666  
PMID:23376485   PMID:23533145   PMID:24888842   PMID:24894822   PMID:25411053   PMID:27590577   PMID:27885436   PMID:31969558  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr85155,234,770 - 155,289,785 (-)NCBIGRCr8
mRatBN7.25149,951,397 - 150,006,424 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,951,409 - 150,006,446 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5152,647,183 - 152,702,235 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05154,421,476 - 154,476,524 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05154,403,485 - 154,458,535 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05156,086,496 - 156,141,513 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,086,497 - 156,141,537 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,841,916 - 159,897,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,501,739 - 156,558,727 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15156,511,778 - 156,568,766 (-)NCBI
Celera5148,347,371 - 148,402,292 (-)NCBICelera
RH 3.4 Map51009.6RGD
Cytogenetic Map5q36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38121,508,984 - 21,578,410 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl121,509,397 - 21,578,410 (+)EnsemblGRCh38hg38GRCh38
GRCh37121,835,477 - 21,904,903 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36121,708,445 - 21,777,492 (+)NCBINCBI36Build 36hg18NCBI36
Build 34121,581,174 - 21,650,208NCBI
Celera120,158,568 - 20,227,624 (+)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef120,079,620 - 20,148,672 (+)NCBIHuRef
CHM1_1121,947,891 - 22,016,920 (+)NCBICHM1_1
T2T-CHM13v2.0121,332,916 - 21,402,323 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm394137,469,042 - 137,523,695 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4137,469,044 - 137,523,695 (-)EnsemblGRCm39 Ensembl
GRCm384137,741,731 - 137,796,384 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,741,733 - 137,796,384 (-)EnsemblGRCm38mm10GRCm38
MGSCv374137,297,647 - 137,352,292 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364137,013,815 - 137,068,399 (-)NCBIMGSCv36mm8
Celera4135,949,159 - 136,007,413 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.02NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554521,820,174 - 1,874,226 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554521,820,212 - 1,873,877 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21205,360,590 - 205,430,382 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11204,472,488 - 204,542,348 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0120,702,509 - 20,772,301 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1121,667,732 - 21,736,688 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl121,667,732 - 21,736,688 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1277,559,791 - 77,614,102 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,559,791 - 77,614,820 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha274,073,609 - 74,088,831 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0278,128,381 - 78,182,495 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl278,128,381 - 78,182,455 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1274,947,430 - 74,962,684 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,958,433 - 75,973,647 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0276,961,389 - 76,976,632 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440505841,362,174 - 41,405,120 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364747,209,093 - 7,229,989 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364747,209,196 - 7,229,899 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl679,589,045 - 79,649,644 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1679,589,695 - 79,649,646 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.120111,055,583 - 111,124,143 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20111,055,558 - 111,081,850 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660335,163,162 - 5,231,388 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247646,393,765 - 6,447,829 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247646,393,741 - 6,447,739 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Alpl
262 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:253
Count of miRNA genes:160
Interacting mature miRNAs:169
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25149,938,708 - 149,938,927 (+)MAPPERmRatBN7.2
Rnor_6.05156,073,805 - 156,074,023NCBIRnor6.0
Rnor_5.05159,829,320 - 159,829,538UniSTSRnor5.0
RGSC_v3.45156,538,159 - 156,538,377UniSTSRGSC3.4
RGSC_v3.45156,489,046 - 156,489,264UniSTSRGSC3.4
Celera5148,334,678 - 148,334,896UniSTS
RH 3.4 Map51014.5UniSTS
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25149,951,529 - 149,951,731 (+)MAPPERmRatBN7.2
Rnor_6.05156,086,624 - 156,086,825NCBIRnor6.0
Rnor_5.05159,842,044 - 159,842,245UniSTSRnor5.0
RGSC_v3.45156,501,865 - 156,502,066UniSTSRGSC3.4
Celera5148,347,497 - 148,347,698UniSTS
RH 3.4 Map51010.6UniSTS
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25149,951,504 - 149,951,683 (+)MAPPERmRatBN7.2
Rnor_6.05156,086,599 - 156,086,777NCBIRnor6.0
Rnor_5.05159,842,019 - 159,842,197UniSTSRnor5.0
RGSC_v3.45156,501,840 - 156,502,018UniSTSRGSC3.4
Celera5148,347,472 - 148,347,650UniSTS
RH 3.4 Map51009.6UniSTS
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25149,951,635 - 149,952,195 (+)MAPPERmRatBN7.2
Rnor_6.05156,086,730 - 156,087,289NCBIRnor6.0
Rnor_5.05159,842,150 - 159,842,709UniSTSRnor5.0
RGSC_v3.45156,501,971 - 156,502,530UniSTSRGSC3.4
Celera5148,347,603 - 148,348,162UniSTS
Cytogenetic Map5q36UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 8 10 6 6 22 29 28 11
Low 3 35 47 35 19 35 8 11 52 6 13 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000019004   ⟹   ENSRNOP00000019004
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5149,951,409 - 150,006,446 (-)Ensembl
Rnor_6.0 Ensembl5156,086,497 - 156,141,537 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078851   ⟹   ENSRNOP00000071620
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5156,086,598 - 156,105,867 (-)Ensembl
RefSeq Acc Id: NM_013059   ⟹   NP_037191
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr85155,234,770 - 155,289,785 (-)NCBI
mRatBN7.25149,951,404 - 150,006,424 (-)NCBI
Rnor_6.05156,086,498 - 156,141,513 (-)NCBI
Rnor_5.05159,841,916 - 159,897,391 (-)NCBI
RGSC_v3.45156,501,739 - 156,558,727 (-)RGD
Celera5148,347,371 - 148,402,292 (-)RGD
RefSeq Acc Id: XM_006239136   ⟹   XP_006239198
Rat AssemblyChrPosition (strand)Source
GRCr85155,234,770 - 155,264,318 (-)NCBI
mRatBN7.25149,951,397 - 149,980,897 (-)NCBI
Rnor_6.05156,086,496 - 156,115,986 (-)NCBI
Rnor_5.05159,841,916 - 159,897,391 (-)NCBI
RefSeq Acc Id: XM_063287200   ⟹   XP_063143270
Rat AssemblyChrPosition (strand)Source
GRCr85155,234,770 - 155,267,386 (-)NCBI
RefSeq Acc Id: NP_037191   ⟸   NM_013059
- Peptide Label: precursor
- UniProtKB: P14055 (UniProtKB/Swiss-Prot),   P08289 (UniProtKB/Swiss-Prot),   P70707 (UniProtKB/Swiss-Prot),   A6ITE7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239198   ⟸   XM_006239136
- Peptide Label: isoform X1
- UniProtKB: P14055 (UniProtKB/Swiss-Prot),   P70707 (UniProtKB/Swiss-Prot),   P08289 (UniProtKB/Swiss-Prot),   A6ITE7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019004   ⟸   ENSRNOT00000019004
RefSeq Acc Id: ENSRNOP00000071620   ⟸   ENSRNOT00000078851
RefSeq Acc Id: XP_063143270   ⟸   XM_063287200
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08289-F1-model_v2 AlphaFold P08289 1-524 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694182
Promoter ID:EPDNEW_R4707
Type:single initiation site
Description:alkaline phosphatase, liver/bone/kidney
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.05156,141,528 - 156,141,588EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2100 AgrOrtholog
BioCyc Gene G2FUF-39471 BioCyc
Ensembl Genes ENSRNOG00000013954 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055024897 UniProtKB/Swiss-Prot
  ENSRNOG00060029423 UniProtKB/Swiss-Prot
  ENSRNOG00065024638 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019004.6 UniProtKB/Swiss-Prot
  ENSRNOT00055042918 UniProtKB/Swiss-Prot
  ENSRNOT00060051094 UniProtKB/Swiss-Prot
  ENSRNOT00065042311 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.720.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Alkaline_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alkaline_phosphatase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alkaline_phosphatase_core_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25586 UniProtKB/Swiss-Prot
  PTHR11596 UniProtKB/Swiss-Prot
Pfam Alk_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Alpl PhenoGen
RatGTEx ENSRNOG00000013954 RatGTEx
  ENSRNOG00055024897 RatGTEx
  ENSRNOG00060029423 RatGTEx
  ENSRNOG00065024638 RatGTEx
SMART alkPPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Alkaline phosphatase-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  PPBT_RAT UniProtKB/Swiss-Prot
UniProt Secondary P14055 UniProtKB/Swiss-Prot
  P70707 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-27 Alpl  alkaline phosphatase, biomineralization associated  Alpl  alkaline phosphatase, liver/bone/kidney  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Alpl  alkaline phosphatase, liver/bone/kidney  Alpl  alkaline phosphatase, tissue-nonspecific  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-06-29 Alpl  Tissue-nonspecific ALP alkaline phosphatase      Name withdrawn 67952 WITHDRAWN
2001-06-29 Alpl  alkaline phosphatase, tissue-nonspecific      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver, bone, and kidney 632198
gene_function catalyzes the conversion of an orthophosphoric monoester to an alcohol phosphate 632198