Akr1b1 Rat (1->4)-beta-D-glucan multiple interactions ISO Akr1b1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of AKR1B1 mRNA CTD PMID:36331819 Akr1b1 Rat (4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid decreases activity ISO AKR1B1 (Homo sapiens) 6480464 zopolrestat results in decreased activity of AKR1B1 protein CTD PMID:21334316 Akr1b1 Rat (4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens more ... CTD PMID:21334316 Akr1b1 Rat (E)-cinnamyl alcohol increases expression ISO AKR1B1 (Homo sapiens) 6480464 cinnamyl alcohol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 Akr1b1 Rat (E,E)-2,4-hexadienal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of 2 more ... CTD PMID:21329684 and PMID:9890881 Akr1b1 Rat (R)-acetoin increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of Acetoin CTD PMID:23295224 Akr1b1 Rat (R)-acetoin multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [AKR1B1 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2 more ... CTD PMID:23295224 Akr1b1 Rat (R,R,R)-alpha-tocopherol increases expression EXP 6480464 alpha-Tocopherol results in increased expression of AKR1B1 mRNA CTD PMID:16908007 Akr1b1 Rat 1,2-dimethylhydrazine multiple interactions ISO Akr1b1 (Mus musculus) 6480464 Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of AKR1B1 mRNA] CTD PMID:22206623 Akr1b1 Rat 1,2-naphthoquinone increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of 1 and 2-naphthoquinone CTD PMID:10510318 Akr1b1 Rat 1-chloro-2,4-dinitrobenzene increases expression ISO AKR1B1 (Homo sapiens) 6480464 Dinitrochlorobenzene results in increased expression of AKR1B1 mRNA CTD PMID:20566472 Akr1b1 Rat 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of AKR1B1 mRNA CTD PMID:25380136 Akr1b1 Rat 16-Ketoestrone increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of 16-ketoestrone CTD PMID:10510318 Akr1b1 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO AKR1B1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin affects the expression of AKR1B1 mRNA CTD PMID:20106945 and PMID:22298810 Akr1b1 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Akr1b1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of AKR1B1 mRNA CTD PMID:21570461 Akr1b1 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in decreased expression of AKR1B1 mRNA CTD PMID:19684285 and PMID:21632981 Akr1b1 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of AKR1B1 mRNA CTD PMID:22298810 and PMID:34747641 Akr1b1 Rat 2,3-dimethoxynaphthalene-1,4-dione decreases expression ISO AKR1B1 (Homo sapiens) 6480464 2 more ... CTD PMID:17547211 Akr1b1 Rat 2,4-Nonadienal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of 2 and 4-nonadienal CTD PMID:9890881 Akr1b1 Rat 2-acetamidofluorene increases expression ISO Akr1b1 (Mus musculus) 6480464 2-Acetylaminofluorene results in increased expression of AKR1B1 mRNA CTD PMID:17317680 Akr1b1 Rat 2-hexenal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of 2-hexenal and AKR1B1 protein results in increased reduction of 2-hexenal metabolite CTD PMID:21329684 and PMID:9890881 Akr1b1 Rat 2-hexenal affects reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein affects the reduction of 2-hexenal CTD PMID:11306073 Akr1b1 Rat 2-hydroxypropanoic acid increases expression ISO AKR1B1 (Homo sapiens) 6480464 Lactic Acid results in increased expression of AKR1B1 mRNA CTD PMID:20566472 Akr1b1 Rat 2-palmitoylglycerol increases expression ISO AKR1B1 (Homo sapiens) 6480464 2-palmitoylglycerol results in increased expression of AKR1B1 mRNA CTD PMID:37199045 Akr1b1 Rat 2-pentenal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of 2-pentenal CTD PMID:9890881 Akr1b1 Rat 2-pentenal affects reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein affects the reduction of 2-pentenal CTD PMID:11306073 Akr1b1 Rat 3,4-dihydroxybenzoic acid multiple interactions ISO Akr1b1 (Mus musculus) 6480464 protocatechuic acid inhibits the reaction [Galactose results in increased expression of AKR1B1 mRNA] CTD PMID:22687555 Akr1b1 Rat 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin results in decreased expression of AKR1B1 mRNA CTD PMID:28522335 Akr1b1 Rat 3-chloropropane-1,2-diol increases expression EXP 6480464 alpha-Chlorohydrin results in increased expression of AKR1B1 protein CTD PMID:34915118 Akr1b1 Rat 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of AKR1B1 mRNA CTD PMID:28628672 Akr1b1 Rat 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO Akr1b1 (Mus musculus) 6480464 [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of AKR1B1 mRNA CTD PMID:24848799 Akr1b1 Rat 3-nitrobenzaldehyde increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of 3-nitrobenzaldehyde CTD PMID:10510318 Akr1b1 Rat 4,4'-diaminodiphenylmethane increases expression EXP 6480464 4 and 4'-diaminodiphenylmethane results in increased expression of AKR1B1 mRNA CTD PMID:25380136 Akr1b1 Rat 4,4'-diaminodiphenylmethane increases expression ISO Akr1b1 (Mus musculus) 6480464 4 and 4'-diaminodiphenylmethane results in increased expression of AKR1B1 mRNA CTD PMID:18648102 Akr1b1 Rat 4,4'-sulfonyldiphenol multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of AKR1B1 mRNA CTD PMID:28628672 Akr1b1 Rat 4,4'-sulfonyldiphenol increases expression ISO AKR1B1 (Homo sapiens) 6480464 bisphenol S results in increased expression of AKR1B1 protein CTD PMID:34186270 Akr1b1 Rat 4-hydroxy-2-octenal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of 4-hydroxy-2-octenal CTD PMID:9890881 Akr1b1 Rat 4-hydroxy-2-octenal affects reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein affects the reduction of 4-hydroxy-2-octenal CTD PMID:11306073 Akr1b1 Rat 4-hydroxyhexenal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of 4-hydroxy-2-hexenal CTD PMID:9890881 Akr1b1 Rat 4-hydroxyhexenal affects reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein affects the reduction of 4-hydroxy-2-hexenal CTD PMID:11306073 Akr1b1 Rat 4-hydroxynon-2-enal affects reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein affects the reduction of 4-hydroxy-2-nonenal CTD PMID:11306073 Akr1b1 Rat 4-hydroxynon-2-enal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of 4-hydroxy-2-nonenal and AKR1B1 protein results in increased reduction of 4-hydroxy-2-nonenal metabolite CTD PMID:10510318 more ... Akr1b1 Rat 4-hydroxyphenyl retinamide decreases expression ISO Akr1b1 (Mus musculus) 6480464 Fenretinide results in decreased expression of AKR1B1 mRNA CTD PMID:28973697 Akr1b1 Rat 4-nitrobenzaldehyde increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of 4-nitrobenzaldehyde CTD PMID:10510318 Akr1b1 Rat 7,9-dihydro-1H-purine-2,6,8(3H)-trione multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 acetovanillone inhibits the reaction [Uric Acid results in increased expression of AKR1B1 mRNA] CTD PMID:30651350 Akr1b1 Rat 7,9-dihydro-1H-purine-2,6,8(3H)-trione increases expression ISO AKR1B1 (Homo sapiens) 6480464 Uric Acid results in increased expression of AKR1B1 mRNA CTD PMID:30651350 Akr1b1 Rat 9,10-phenanthroquinone increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of 9 and 10-phenanthrenequinone CTD PMID:10510318 Akr1b1 Rat 9,10-phenanthroquinone multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of and affects the activity of 9 and 10-phenanthrenequinone CTD PMID:21910479 Akr1b1 Rat acetamide increases expression EXP 6480464 acetamide results in increased expression of AKR1B1 mRNA CTD PMID:31881176 Akr1b1 Rat acetoin increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of Acetoin CTD PMID:23295224 Akr1b1 Rat acetoin multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [AKR1B1 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2 more ... CTD PMID:23295224 Akr1b1 Rat acrolein affects reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein affects the reduction of Acrolein CTD PMID:11306073 Akr1b1 Rat acrolein increases expression ISO Akr1b1 (Mus musculus) 6480464 Acrolein results in increased expression of AKR1B1 protein CTD PMID:28482051 Akr1b1 Rat acrolein increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of Acrolein and AKR1B1 protein results in increased reduction of Acrolein metabolite CTD PMID:10510318 more ... Akr1b1 Rat aflatoxin B1 affects expression ISO AKR1B1 (Homo sapiens) 6480464 Aflatoxin B1 affects the expression of AKR1B1 protein CTD PMID:20106945 Akr1b1 Rat aflatoxin B1 increases expression ISO AKR1B1 (Homo sapiens) 6480464 Aflatoxin B1 results in increased expression of AKR1B1 mRNA CTD PMID:22100608 more ... Akr1b1 Rat aldehydo-D-glucose multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein promotes the reaction [Glucose results in increased abundance of Sorbitol] CTD PMID:25451566 Akr1b1 Rat aldehydo-D-glucose increases expression ISO Akr1b1 (Mus musculus) 6480464 Glucose results in increased expression of AKR1B1 mRNA and Glucose results in increased expression of AKR1B1 protein CTD PMID:16805838 Akr1b1 Rat all-trans-4-oxoretinal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of 4-oxoretinaldehyde CTD PMID:19014918 Akr1b1 Rat all-trans-dehydroretinal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of dehydroretinal CTD PMID:19014918 Akr1b1 Rat all-trans-retinal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of Retinaldehyde CTD PMID:19014918 Akr1b1 Rat all-trans-retinoic acid decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Tretinoin results in decreased expression of AKR1B1 mRNA CTD PMID:33167477 Akr1b1 Rat all-trans-retinol decreases response to substance ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in decreased susceptibility to Vitamin A and AKR1B1 protein results in decreased susceptibility to Vitamin A metabolite CTD PMID:19014918 Akr1b1 Rat alpha-D-galactose increases expression ISO Akr1b1 (Mus musculus) 6480464 Galactose results in increased expression of AKR1B1 mRNA CTD PMID:22687555 Akr1b1 Rat alpha-D-galactose multiple interactions ISO Akr1b1 (Mus musculus) 6480464 protocatechuic acid inhibits the reaction [Galactose results in increased expression of AKR1B1 mRNA] CTD PMID:22687555 Akr1b1 Rat alpha-hexylcinnamaldehyde increases expression ISO AKR1B1 (Homo sapiens) 6480464 hexyl cinnamic aldehyde results in increased expression of AKR1B1 mRNA CTD PMID:20566472 Akr1b1 Rat alpha-Zearalanol multiple interactions EXP 6480464 [Zeranol co-treated with perfluorooctanoic acid] results in increased expression of AKR1B1 mRNA CTD PMID:35163327 Akr1b1 Rat ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of AKR1B1 mRNA CTD PMID:16483693 Akr1b1 Rat anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA] CTD PMID:17640564 Akr1b1 Rat antimony(0) decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Antimony results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 Akr1b1 Rat antimycin A decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Antimycin A results in decreased expression of AKR1B1 mRNA CTD PMID:33512557 Akr1b1 Rat apocynin multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 acetovanillone inhibits the reaction [Uric Acid results in increased expression of AKR1B1 mRNA] CTD PMID:30651350 Akr1b1 Rat aristolochic acid A increases expression ISO AKR1B1 (Homo sapiens) 6480464 aristolochic acid I results in increased expression of AKR1B1 mRNA and aristolochic acid I results in increased expression of AKR1B1 protein CTD PMID:33212167 Akr1b1 Rat arsenous acid increases expression ISO AKR1B1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of AKR1B1 mRNA CTD PMID:36801614 Akr1b1 Rat arsenous acid decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 Akr1b1 Rat Azoxymethane multiple interactions ISO Akr1b1 (Mus musculus) 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of AKR1B1 mRNA more ... CTD PMID:21355597 and PMID:29950665 Akr1b1 Rat Azoxymethane increases expression ISO Akr1b1 (Mus musculus) 6480464 Azoxymethane results in increased expression of AKR1B1 mRNA and Azoxymethane results in increased expression of AKR1B1 protein CTD PMID:21355597 Akr1b1 Rat azoxystrobin decreases expression ISO AKR1B1 (Homo sapiens) 6480464 azoxystrobin results in decreased expression of AKR1B1 mRNA CTD PMID:33512557 Akr1b1 Rat Bandrowski's base increases expression ISO AKR1B1 (Homo sapiens) 6480464 Bandrowski's base results in increased expression of AKR1B1 mRNA CTD PMID:20566472 Akr1b1 Rat benzo[a]pyrene multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [Benzo(a)pyrene co-treated with 1 more ... CTD PMID:17690111 Akr1b1 Rat benzo[a]pyrene increases expression ISO Akr1b1 (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of AKR1B1 mRNA CTD PMID:20127859 and PMID:22228805 Akr1b1 Rat benzo[a]pyrene decreases methylation ISO AKR1B1 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased methylation of AKR1B1 promoter CTD PMID:27901495 Akr1b1 Rat benzo[a]pyrene increases expression ISO AKR1B1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of AKR1B1 mRNA CTD PMID:20106945 more ... Akr1b1 Rat benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of AKR1B1 protein CTD PMID:16456883 Akr1b1 Rat benzo[a]pyrene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with 1 more ... CTD PMID:16456883 and PMID:18711122 Akr1b1 Rat Benzo[a]pyrene-7,8-diol multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [AKR1B1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7 and 8-dihydrodiol CTD PMID:21910479 Akr1b1 Rat benzo[a]pyrene-7,8-dione multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [AKR1B1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7 and 8-dione CTD PMID:21910479 Akr1b1 Rat benzo[b]fluoranthene multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of AKR1B1 mRNA CTD PMID:17690111 Akr1b1 Rat Benzo[k]fluoranthene increases expression ISO Akr1b1 (Mus musculus) 6480464 benzo(k)fluoranthene results in increased expression of AKR1B1 mRNA CTD PMID:26377693 Akr1b1 Rat benzoic acid increases expression ISO AKR1B1 (Homo sapiens) 6480464 Benzoic Acid results in increased expression of AKR1B1 mRNA CTD PMID:20566472 Akr1b1 Rat benzyl alcohol increases oxidation ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased oxidation of Benzyl Alcohol CTD PMID:17194029 Akr1b1 Rat bisphenol A multiple interactions EXP 6480464 [Fructose co-treated with bisphenol A] results in increased expression of AKR1B1 protein CTD PMID:26930160 Akr1b1 Rat bisphenol A decreases expression ISO Akr1b1 (Mus musculus) 6480464 bisphenol A results in decreased expression of AKR1B1 protein CTD PMID:35999755 Akr1b1 Rat bisphenol A decreases expression ISO AKR1B1 (Homo sapiens) 6480464 bisphenol A results in decreased expression of AKR1B1 protein CTD PMID:34186270 Akr1b1 Rat bisphenol A affects expression ISO AKR1B1 (Homo sapiens) 6480464 bisphenol A affects the expression of AKR1B1 mRNA CTD PMID:30903817 Akr1b1 Rat bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of AKR1B1 gene CTD PMID:28505145 Akr1b1 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of AKR1B1 mRNA and bisphenol A results in decreased expression of AKR1B1 protein CTD PMID:20219716 and PMID:34947998 Akr1b1 Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of AKR1B1 mRNA CTD PMID:25181051 Akr1b1 Rat bisphenol AF increases expression ISO AKR1B1 (Homo sapiens) 6480464 bisphenol AF results in increased expression of AKR1B1 protein CTD PMID:34186270 Akr1b1 Rat Bisphenol B increases expression ISO AKR1B1 (Homo sapiens) 6480464 bisphenol B results in increased expression of AKR1B1 protein CTD PMID:34186270 Akr1b1 Rat bisphenol F increases expression ISO AKR1B1 (Homo sapiens) 6480464 bisphenol F results in increased expression of AKR1B1 protein CTD PMID:34186270 Akr1b1 Rat bortezomib increases expression ISO AKR1B1 (Homo sapiens) 6480464 Bortezomib results in increased expression of AKR1B1 mRNA and Bortezomib results in increased expression of AKR1B1 protein CTD PMID:21215737 Akr1b1 Rat butanal affects reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein affects the reduction of butyraldehyde CTD PMID:11306073 Akr1b1 Rat butanal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of butyraldehyde CTD PMID:9890881 Akr1b1 Rat butane-2,3-diol multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [AKR1B1 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2 and 3-butylene glycol CTD PMID:23295224 Akr1b1 Rat butane-2,3-dione increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of Diacetyl CTD PMID:23295224 Akr1b1 Rat butane-2,3-dione multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [AKR1B1 protein results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin CTD PMID:23295224 Akr1b1 Rat cadmium atom decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Cadmium results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 Akr1b1 Rat cadmium dichloride decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Cadmium Chloride results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 Akr1b1 Rat cadmium dichloride increases expression ISO AKR1B1 (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of AKR1B1 protein CTD PMID:24527689 Akr1b1 Rat candesartan decreases expression EXP 6480464 candesartan results in decreased expression of AKR1B1 mRNA CTD PMID:14871019 Akr1b1 Rat capecitabine decreases response to substance ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 Akr1b1 Rat carbon nanotube affects expression ISO AKR1B1 (Homo sapiens) 6480464 Nanotubes and Carbon affects the expression of AKR1B1 protein CTD PMID:22001959 Akr1b1 Rat carbon nanotube increases expression ISO Akr1b1 (Mus musculus) 6480464 Nanotubes and Carbon analog results in increased expression of AKR1B1 mRNA CTD PMID:25554681 Akr1b1 Rat carboplatin increases expression EXP 6480464 Carboplatin results in increased expression of AKR1B1 mRNA CTD PMID:18172885 Akr1b1 Rat carmustine affects response to substance ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 mRNA affects the susceptibility to Carmustine CTD PMID:16365179 Akr1b1 Rat cefaloridine increases expression EXP 6480464 Cephaloridine results in increased expression of AKR1B1 mRNA CTD PMID:18172885 Akr1b1 Rat ceruletide increases expression EXP 6480464 Ceruletide results in increased expression of AKR1B1 protein CTD PMID:18024178 Akr1b1 Rat CGP 52608 multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to AKR1B1 gene] CTD PMID:28238834 Akr1b1 Rat chlordecone decreases expression ISO Akr1b1 (Mus musculus) 6480464 Chlordecone results in decreased expression of AKR1B1 mRNA CTD PMID:33711761 Akr1b1 Rat choline multiple interactions ISO Akr1b1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AKR1B1 mRNA CTD PMID:20938992 Akr1b1 Rat chromium atom decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Chromium results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 Akr1b1 Rat chromium(6+) affects expression ISO Akr1b1 (Mus musculus) 6480464 chromium hexavalent ion affects the expression of AKR1B1 mRNA CTD PMID:28472532 Akr1b1 Rat cinnamyl alcohol increases expression ISO AKR1B1 (Homo sapiens) 6480464 cinnamyl alcohol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 Akr1b1 Rat cisplatin decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Cisplatin results in decreased expression of AKR1B1 protein CTD PMID:16803524 Akr1b1 Rat cisplatin increases phosphorylation ISO Akr1b1 (Mus musculus) 6480464 Cisplatin results in increased phosphorylation of AKR1B1 protein CTD PMID:22006019 Akr1b1 Rat cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of AKR1B1 mRNA CTD PMID:18172885 Akr1b1 Rat clobetasol increases expression ISO Akr1b1 (Mus musculus) 6480464 Clobetasol results in increased expression of AKR1B1 mRNA CTD PMID:27462272 Akr1b1 Rat Clofop increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of fenofibric acid CTD PMID:27599626 Akr1b1 Rat copper atom multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of AKR1B1 mRNA and [NSC 689534 binds to Copper] which results in increased expression of AKR1B1 mRNA CTD PMID:20971185 and PMID:30911355 Akr1b1 Rat copper atom decreases expression EXP 6480464 Copper deficiency results in decreased expression of AKR1B1 protein and Copper results in decreased expression of AKR1B1 mRNA CTD PMID:18993053 and PMID:30556269 Akr1b1 Rat copper atom increases expression EXP 6480464 Copper results in increased expression of AKR1B1 mRNA CTD PMID:22465980 Akr1b1 Rat copper(0) multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of AKR1B1 mRNA and [NSC 689534 binds to Copper] which results in increased expression of AKR1B1 mRNA CTD PMID:20971185 and PMID:30911355 Akr1b1 Rat copper(0) decreases expression EXP 6480464 Copper deficiency results in decreased expression of AKR1B1 protein and Copper results in decreased expression of AKR1B1 mRNA CTD PMID:18993053 and PMID:30556269 Akr1b1 Rat copper(0) increases expression EXP 6480464 Copper results in increased expression of AKR1B1 mRNA CTD PMID:22465980 Akr1b1 Rat copper(II) chloride increases expression ISO AKR1B1 (Homo sapiens) 6480464 cupric chloride results in increased expression of AKR1B1 mRNA CTD PMID:38568856 Akr1b1 Rat crocidolite asbestos increases expression ISO AKR1B1 (Homo sapiens) 6480464 Asbestos and Crocidolite results in increased expression of AKR1B1 mRNA CTD PMID:29523930 Akr1b1 Rat crotonaldehyde increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of 2-butenal and AKR1B1 protein results in increased reduction of 2-butenal metabolite CTD PMID:21329684 and PMID:9890881 Akr1b1 Rat curcumin increases expression ISO Akr1b1 (Mus musculus) 6480464 Curcumin results in increased expression of AKR1B1 mRNA CTD PMID:18200517 Akr1b1 Rat curcumin multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA] more ... CTD PMID:17640564 and PMID:18588981 Akr1b1 Rat curcumin increases expression EXP 6480464 Curcumin results in increased expression of AKR1B1 mRNA and Curcumin results in increased expression of AKR1B1 protein CTD PMID:17640564 more ... Akr1b1 Rat curcumin increases activity EXP 6480464 Curcumin results in increased activity of AKR1B1 protein CTD PMID:17640564 Akr1b1 Rat cyclosporin A increases expression ISO AKR1B1 (Homo sapiens) 6480464 Cyclosporine results in increased expression of AKR1B1 mRNA CTD PMID:20106945 Akr1b1 Rat cyclosporin A decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Cyclosporine results in decreased expression of AKR1B1 mRNA CTD PMID:25562108 and PMID:27989131 Akr1b1 Rat D-glucitol multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein promotes the reaction [Glucose results in increased abundance of Sorbitol] CTD PMID:25451566 Akr1b1 Rat D-glucitol increases abundance ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased abundance of Sorbitol CTD PMID:25541468 Akr1b1 Rat D-glucose multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein promotes the reaction [Glucose results in increased abundance of Sorbitol] CTD PMID:25451566 Akr1b1 Rat D-glucose increases expression ISO Akr1b1 (Mus musculus) 6480464 Glucose results in increased expression of AKR1B1 mRNA and Glucose results in increased expression of AKR1B1 protein CTD PMID:16805838 Akr1b1 Rat D-glyceraldehyde increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of Glyceraldehyde CTD PMID:19014918 Akr1b1 Rat D-glyceraldehyde decreases activity ISO AKR1B1 (Homo sapiens) 6480464 Glyceraldehyde results in decreased activity of AKR1B1 protein CTD PMID:30469331 Akr1b1 Rat daunorubicin increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of Daunorubicin CTD PMID:10510318 Akr1b1 Rat DDE decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Dichlorodiphenyl Dichloroethylene results in decreased expression of AKR1B1 mRNA CTD PMID:38568856 Akr1b1 Rat decanal affects reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein affects the reduction of decanaldehyde CTD PMID:11306073 Akr1b1 Rat decanal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of decanaldehyde CTD PMID:9890881 Akr1b1 Rat deguelin decreases expression ISO AKR1B1 (Homo sapiens) 6480464 deguelin results in decreased expression of AKR1B1 mRNA CTD PMID:33512557 Akr1b1 Rat dexamethasone decreases expression ISO Akr1b1 (Mus musculus) 6480464 Dexamethasone results in decreased expression of AKR1B1 protein CTD PMID:33567340 Akr1b1 Rat dexamethasone multiple interactions ISO Akr1b1 (Mus musculus) 6480464 [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of AKR1B1 mRNA CTD PMID:24848799 Akr1b1 Rat dexamethasone multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of AKR1B1 mRNA CTD PMID:28628672 Akr1b1 Rat dextran sulfate multiple interactions ISO Akr1b1 (Mus musculus) 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of AKR1B1 mRNA CTD PMID:29950665 Akr1b1 Rat dextran sulfate decreases expression ISO Akr1b1 (Mus musculus) 6480464 Dextran Sulfate results in decreased expression of AKR1B1 protein CTD PMID:35999755 Akr1b1 Rat dextran sulfate increases expression ISO Akr1b1 (Mus musculus) 6480464 Dextran Sulfate results in increased expression of AKR1B1 mRNA CTD PMID:35093514 Akr1b1 Rat diarsenic trioxide increases expression ISO AKR1B1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of AKR1B1 mRNA CTD PMID:36801614 Akr1b1 Rat diarsenic trioxide decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 Akr1b1 Rat dibenz[a,h]anthracene multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [Benzo(a)pyrene co-treated with 1 more ... CTD PMID:17690111 Akr1b1 Rat dibenz[a,h]anthracene multiple interactions EXP 6480464 [1 more ... CTD PMID:18711122 Akr1b1 Rat dibenzo[a,l]pyrene multiple interactions EXP 6480464 [1 more ... CTD PMID:18711122 Akr1b1 Rat dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of AKR1B1 mRNA CTD PMID:21266533 Akr1b1 Rat dioxygen multiple interactions EXP 6480464 AKR1B1 protein inhibits the reaction [Oxygen deficiency results in increased phosphorylation of EIF2A protein] and AKR1B1 protein inhibits the reaction [Oxygen deficiency results in increased phosphorylation of EIF2AK3 protein] CTD PMID:19041636 Akr1b1 Rat dioxygen multiple interactions ISO Akr1b1 (Mus musculus) 6480464 AKR1B1 protein promotes the reaction [Oxygen deficiency results in increased expression of TNF protein] and AKR1B1 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA protein] CTD PMID:30682331 Akr1b1 Rat dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate increases expression ISO AKR1B1 (Homo sapiens) 6480464 Antimony Potassium Tartrate results in increased expression of AKR1B1 mRNA CTD PMID:28713220 Akr1b1 Rat dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Antimony Potassium Tartrate results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 Akr1b1 Rat diquat decreases expression ISO Akr1b1 (Mus musculus) 6480464 Diquat results in decreased expression of AKR1B1 mRNA CTD PMID:36851058 Akr1b1 Rat disulfiram increases expression ISO AKR1B1 (Homo sapiens) 6480464 Disulfiram results in increased expression of AKR1B1 mRNA CTD PMID:20566472 Akr1b1 Rat diuron increases expression EXP 6480464 Diuron results in increased expression of AKR1B1 mRNA CTD PMID:21551480 and PMID:25152437 Akr1b1 Rat diuron decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Diuron results in decreased expression of AKR1B1 mRNA CTD PMID:35967413 Akr1b1 Rat dorsomorphin multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1B1 mRNA CTD PMID:27188386 Akr1b1 Rat doxifluridine decreases response to substance ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 Akr1b1 Rat doxorubicin increases expression ISO AKR1B1 (Homo sapiens) 6480464 Doxorubicin results in increased expression of AKR1B1 mRNA CTD PMID:29803840 Akr1b1 Rat doxorubicin multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased abundance of and results in increased susceptibility to Doxorubicin CTD PMID:37257577 Akr1b1 Rat doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of AKR1B1 protein CTD PMID:37257577 Akr1b1 Rat endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of AKR1B1 mRNA CTD PMID:29391264 Akr1b1 Rat enzyme inhibitor multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of AKR1B1 protein CTD PMID:23301498 Akr1b1 Rat ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of AKR1B1 mRNA CTD PMID:15353170 Akr1b1 Rat ethanol affects splicing ISO Akr1b1 (Mus musculus) 6480464 Ethanol affects the splicing of AKR1B1 mRNA CTD PMID:30319688 Akr1b1 Rat eugenol increases expression ISO AKR1B1 (Homo sapiens) 6480464 Eugenol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 Akr1b1 Rat fenpyroximate decreases expression ISO AKR1B1 (Homo sapiens) 6480464 fenpyroximate results in decreased expression of AKR1B1 mRNA CTD PMID:33512557 Akr1b1 Rat Fidarestat multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 fidarestat binds to and results in decreased activity of AKR1B1 protein CTD PMID:23295227 Akr1b1 Rat Fidarestat affects binding ISO AKR1B1 (Homo sapiens) 6480464 NADP binds to AKR1B1 protein binds to fidarestat CTD PMID:23295227 Akr1b1 Rat fipronil increases expression EXP 6480464 fipronil results in increased expression of AKR1B1 mRNA CTD PMID:23962444 Akr1b1 Rat fluoranthene multiple interactions EXP 6480464 [1 more ... CTD PMID:18711122 Akr1b1 Rat fluoranthene multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of AKR1B1 mRNA CTD PMID:17690111 Akr1b1 Rat flutamide increases expression EXP 6480464 Flutamide results in increased expression of AKR1B1 protein CTD PMID:17311803 Akr1b1 Rat folic acid multiple interactions ISO Akr1b1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AKR1B1 mRNA more ... CTD PMID:20938992 and PMID:22206623 Akr1b1 Rat fonofos increases methylation ISO AKR1B1 (Homo sapiens) 6480464 Fonofos results in increased methylation of AKR1B1 promoter CTD PMID:22847954 Akr1b1 Rat fructosamine multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein promotes the reaction [[ALB protein binds to Fructosamine] which results in increased secretion of TNF protein] CTD PMID:30682331 Akr1b1 Rat fructose multiple interactions EXP 6480464 [Fructose co-treated with bisphenol A] results in increased expression of AKR1B1 protein CTD PMID:26930160 Akr1b1 Rat galactose increases expression ISO Akr1b1 (Mus musculus) 6480464 Galactose results in increased expression of AKR1B1 mRNA CTD PMID:22687555 Akr1b1 Rat galactose multiple interactions ISO Akr1b1 (Mus musculus) 6480464 protocatechuic acid inhibits the reaction [Galactose results in increased expression of AKR1B1 mRNA] CTD PMID:22687555 Akr1b1 Rat gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of AKR1B1 mRNA CTD PMID:22061828 and PMID:33387578 Akr1b1 Rat glucose multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein promotes the reaction [Glucose results in increased abundance of Sorbitol] CTD PMID:25451566 Akr1b1 Rat glucose increases expression ISO Akr1b1 (Mus musculus) 6480464 Glucose results in increased expression of AKR1B1 mRNA and Glucose results in increased expression of AKR1B1 protein CTD PMID:16805838 Akr1b1 Rat glutathione increases glutathionylation ISO AKR1B1 (Homo sapiens) 6480464 Glutathione results in increased glutathionylation of AKR1B1 protein modified form CTD PMID:19061876 Akr1b1 Rat glutathione increases reduction ISO AKR1B1 (Homo sapiens) 6480464 Glutathione results in increased reduction of AKR1B1 protein modified form CTD PMID:19061876 Akr1b1 Rat glutathione affects binding ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein binds to Glutathione CTD PMID:11306073 Akr1b1 Rat glyceraldehyde increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of Glyceraldehyde CTD PMID:19014918 Akr1b1 Rat glyceraldehyde decreases activity ISO AKR1B1 (Homo sapiens) 6480464 Glyceraldehyde results in decreased activity of AKR1B1 protein CTD PMID:30469331 Akr1b1 Rat glycine betaine decreases expression EXP 6480464 Betaine results in decreased expression of AKR1B1 mRNA CTD PMID:26391144 Akr1b1 Rat glyoxal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of Glyoxal CTD PMID:10510318 Akr1b1 Rat glyphosate decreases expression EXP 6480464 Glyphosate results in decreased expression of AKR1B1 mRNA CTD PMID:26302742 Akr1b1 Rat hept-2-enal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of 2-heptenal CTD PMID:9890881 Akr1b1 Rat heptanal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of heptanal CTD PMID:9890881 Akr1b1 Rat heptanal affects reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein affects the reduction of heptanal CTD PMID:11306073 Akr1b1 Rat hexanal affects reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein affects the reduction of n-hexanal and AKR1B1 protein affects the reduction of n-hexanal analog CTD PMID:11306073 Akr1b1 Rat hexanal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of n-hexanal CTD PMID:9890881 Akr1b1 Rat hexane increases expression ISO AKR1B1 (Homo sapiens) 6480464 n-hexane results in increased expression of AKR1B1 mRNA CTD PMID:20566472 Akr1b1 Rat hexane-2,3-dione multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [AKR1B1 protein results in increased reduction of 2 and 3-hexanedione] which results in increased chemical synthesis of Hexanones CTD PMID:23295224 Akr1b1 Rat hexane-2,3-dione increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of 2 and 3-hexanedione CTD PMID:10510318 and PMID:23295224 Akr1b1 Rat hypochlorous acid increases expression ISO Akr1b1 (Mus musculus) 6480464 Hypochlorous Acid results in increased expression of AKR1B1 mRNA CTD PMID:19376150 Akr1b1 Rat indometacin multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of AKR1B1 mRNA CTD PMID:28628672 Akr1b1 Rat inulin multiple interactions ISO Akr1b1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of AKR1B1 mRNA CTD PMID:36331819 Akr1b1 Rat isatin increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of Isatin CTD PMID:10510318 Akr1b1 Rat isoeugenol increases expression ISO AKR1B1 (Homo sapiens) 6480464 isoeugenol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 Akr1b1 Rat ivermectin decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Ivermectin results in decreased expression of AKR1B1 protein CTD PMID:32959892 Akr1b1 Rat L-ascorbic acid increases reduction ISO AKR1B1 (Homo sapiens) 6480464 Ascorbic Acid results in increased reduction of AKR1B1 protein modified form CTD PMID:19061876 Akr1b1 Rat L-methionine multiple interactions ISO Akr1b1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AKR1B1 mRNA CTD PMID:20938992 Akr1b1 Rat lead diacetate increases expression ISO AKR1B1 (Homo sapiens) 6480464 lead acetate results in increased expression of AKR1B1 mRNA CTD PMID:38568856 Akr1b1 Rat lipopolysaccharide multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] more ... CTD PMID:21334316 Akr1b1 Rat lipopolysaccharide multiple interactions ISO Akr1b1 (Mus musculus) 6480464 Lipopolysaccharides inhibits the reaction [Sodium Chloride results in increased expression of AKR1B1 mRNA] CTD PMID:23867654 Akr1b1 Rat LY294002 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA] CTD PMID:17640564 Akr1b1 Rat maneb multiple interactions ISO Akr1b1 (Mus musculus) 6480464 [Paraquat co-treated with Maneb] results in decreased expression of AKR1B1 mRNA CTD PMID:18386188 Akr1b1 Rat manganese(II) chloride increases expression EXP 6480464 manganese chloride results in increased expression of AKR1B1 mRNA CTD PMID:22281203 Akr1b1 Rat mercury atom decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Mercury results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 Akr1b1 Rat mercury(0) decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Mercury results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 Akr1b1 Rat methapyrilene increases expression EXP 6480464 Methapyrilene results in increased expression of AKR1B1 mRNA CTD PMID:30467583 Akr1b1 Rat methyl salicylate increases expression ISO AKR1B1 (Homo sapiens) 6480464 methyl salicylate results in increased expression of AKR1B1 mRNA CTD PMID:20566472 Akr1b1 Rat methylglyoxal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of Pyruvaldehyde CTD PMID:10510318 Akr1b1 Rat methylphenidate decreases expression ISO Akr1b1 (Mus musculus) 6480464 Methylphenidate results in decreased expression of AKR1B1 mRNA CTD PMID:22470460 Akr1b1 Rat methylseleninic acid increases expression ISO AKR1B1 (Homo sapiens) 6480464 methylselenic acid results in increased expression of AKR1B1 mRNA CTD PMID:18548127 Akr1b1 Rat microcystin-LR increases expression ISO Akr1b1 (Mus musculus) 6480464 cyanoginosin LR results in increased expression of AKR1B1 mRNA CTD PMID:17654400 Akr1b1 Rat morphine decreases expression EXP 6480464 Morphine results in decreased expression of AKR1B1 protein CTD PMID:23056601 Akr1b1 Rat N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases expression ISO AKR1B1 (Homo sapiens) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of AKR1B1 mRNA CTD PMID:21215737 Akr1b1 Rat N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of AKR1B1 mRNA CTD PMID:19638242 Akr1b1 Rat N-nitrosodiethylamine increases expression ISO Akr1b1 (Mus musculus) 6480464 Diethylnitrosamine results in increased expression of AKR1B1 mRNA CTD PMID:24535843 Akr1b1 Rat N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of AKR1B1 mRNA CTD PMID:25380136 Akr1b1 Rat N-nitrosodimethylamine decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Dimethylnitrosamine results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 Akr1b1 Rat N-Nitrosopyrrolidine increases expression ISO AKR1B1 (Homo sapiens) 6480464 N-Nitrosopyrrolidine results in increased expression of AKR1B1 mRNA CTD PMID:32234424 Akr1b1 Rat NADP zwitterion multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [AKR1B1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7 more ... CTD PMID:21910479 Akr1b1 Rat NADP zwitterion affects binding ISO AKR1B1 (Homo sapiens) 6480464 NADP binds to AKR1B1 protein binds to fidarestat CTD PMID:23295227 Akr1b1 Rat NADP zwitterion increases activity ISO AKR1B1 (Homo sapiens) 6480464 NADP results in increased activity of AKR1B1 protein CTD PMID:23295224 Akr1b1 Rat NADP(+) multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [AKR1B1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7 more ... CTD PMID:21910479 Akr1b1 Rat NADP(+) increases activity ISO AKR1B1 (Homo sapiens) 6480464 NADP results in increased activity of AKR1B1 protein CTD PMID:23295224 Akr1b1 Rat NADP(+) affects binding ISO AKR1B1 (Homo sapiens) 6480464 NADP binds to AKR1B1 protein binds to fidarestat CTD PMID:23295227 Akr1b1 Rat naphthalenes multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of and affects the activity of Naphthalenes CTD PMID:21910479 Akr1b1 Rat nickel dichloride decreases expression ISO AKR1B1 (Homo sapiens) 6480464 nickel chloride results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 Akr1b1 Rat nickel sulfate increases expression ISO AKR1B1 (Homo sapiens) 6480464 nickel sulfate results in increased expression of AKR1B1 mRNA CTD PMID:20566472 Akr1b1 Rat non-2-enal affects reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein affects the reduction of 2-nonenal CTD PMID:11306073 Akr1b1 Rat non-2-enal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of 2-nonenal CTD PMID:9890881 Akr1b1 Rat nonanal affects reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein affects the reduction of nonanal and AKR1B1 protein affects the reduction of nonanal analog CTD PMID:11306073 Akr1b1 Rat nonanal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of nonanal CTD PMID:9890881 Akr1b1 Rat O-methyleugenol increases expression ISO AKR1B1 (Homo sapiens) 6480464 methyleugenol results in increased expression of AKR1B1 mRNA CTD PMID:32234424 Akr1b1 Rat ochratoxin A increases expression ISO AKR1B1 (Homo sapiens) 6480464 ochratoxin A results in increased expression of AKR1B1 mRNA CTD PMID:32905824 Akr1b1 Rat oct-2-enal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of 2-octenal CTD PMID:9890881 Akr1b1 Rat oct-2-enal affects reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein affects the reduction of 2-octenal CTD PMID:11306073 Akr1b1 Rat octanal affects reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein affects the reduction of caprylic aldehyde CTD PMID:11306073 Akr1b1 Rat oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of AKR1B1 mRNA CTD PMID:25729387 Akr1b1 Rat ozone increases phosphorylation EXP 6480464 Ozone results in increased phosphorylation of AKR1B1 protein CTD PMID:33146391 Akr1b1 Rat ozone increases expression EXP 6480464 Ozone results in increased expression of AKR1B1 protein CTD PMID:33146391 Akr1b1 Rat paclitaxel increases response to substance ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased susceptibility to Paclitaxel CTD PMID:16734730 Akr1b1 Rat paracetamol increases expression ISO AKR1B1 (Homo sapiens) 6480464 Acetaminophen results in increased expression of AKR1B1 mRNA CTD PMID:22230336 Akr1b1 Rat paraquat increases expression ISO AKR1B1 (Homo sapiens) 6480464 Paraquat results in increased expression of AKR1B1 protein CTD PMID:34064677 Akr1b1 Rat paraquat multiple interactions ISO Akr1b1 (Mus musculus) 6480464 [Paraquat co-treated with Maneb] results in decreased expression of AKR1B1 mRNA CTD PMID:18386188 Akr1b1 Rat parathion increases methylation ISO AKR1B1 (Homo sapiens) 6480464 Parathion results in increased methylation of AKR1B1 promoter CTD PMID:22847954 Akr1b1 Rat pentanal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of pentanal CTD PMID:9890881 Akr1b1 Rat pentanal affects reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein affects the reduction of pentanal CTD PMID:11306073 Akr1b1 Rat pentane-2,3-dione increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of 2 and 3-pentanedione CTD PMID:23295224 Akr1b1 Rat pentane-2,3-dione multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [AKR1B1 protein results in increased reduction of 2 and 3-pentanedione] which results in increased chemical synthesis of Pentanones CTD PMID:23295224 Akr1b1 Rat perfluorooctane-1-sulfonic acid multiple interactions ISO Akr1b1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of AKR1B1 mRNA and [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of AKR1B1 mRNA CTD PMID:36331819 Akr1b1 Rat perfluorooctanoic acid multiple interactions EXP 6480464 [Zeranol co-treated with perfluorooctanoic acid] results in increased expression of AKR1B1 mRNA CTD PMID:35163327 Akr1b1 Rat phenethyl caffeate decreases activity ISO AKR1B1 (Homo sapiens) 6480464 caffeic acid phenethyl ester results in decreased activity of AKR1B1 protein CTD PMID:27163852 Akr1b1 Rat phenobarbital affects expression ISO AKR1B1 (Homo sapiens) 6480464 Phenobarbital affects the expression of AKR1B1 mRNA CTD PMID:19084549 Akr1b1 Rat phenobarbital affects expression ISO Akr1b1 (Mus musculus) 6480464 Phenobarbital affects the expression of AKR1B1 mRNA CTD PMID:23091169 Akr1b1 Rat Phenylglyoxal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of Phenylglyoxal CTD PMID:10510318 Akr1b1 Rat picoxystrobin decreases expression ISO AKR1B1 (Homo sapiens) 6480464 picoxystrobin results in decreased expression of AKR1B1 mRNA CTD PMID:33512557 Akr1b1 Rat pirinixic acid decreases activity ISO AKR1B1 (Homo sapiens) 6480464 pirinixic acid results in decreased activity of AKR1B1 protein CTD PMID:17194029 Akr1b1 Rat potassium dichromate decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Potassium Dichromate results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 Akr1b1 Rat propan-2-ol increases expression ISO AKR1B1 (Homo sapiens) 6480464 2-Propanol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 Akr1b1 Rat propanal affects reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein affects the reduction of propionaldehyde analog CTD PMID:11306073 Akr1b1 Rat propanal increases reduction ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 protein results in increased reduction of propionaldehyde CTD PMID:9890881 Akr1b1 Rat prostaglandin E2 multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone] more ... CTD PMID:21334316 Akr1b1 Rat pterostilbene multiple interactions ISO Akr1b1 (Mus musculus) 6480464 pterostilbene inhibits the reaction [Azoxymethane results in increased expression of AKR1B1 mRNA] and pterostilbene inhibits the reaction [Azoxymethane results in increased expression of AKR1B1 protein] CTD PMID:21355597 Akr1b1 Rat pyrimidifen decreases expression ISO AKR1B1 (Homo sapiens) 6480464 pyrimidifen results in decreased expression of AKR1B1 mRNA CTD PMID:33512557 Akr1b1 Rat quercetin increases expression ISO AKR1B1 (Homo sapiens) 6480464 Quercetin results in increased expression of AKR1B1 mRNA CTD PMID:21632981 Akr1b1 Rat rac-lactic acid increases expression ISO AKR1B1 (Homo sapiens) 6480464 Lactic Acid results in increased expression of AKR1B1 mRNA CTD PMID:20566472 Akr1b1 Rat reactive oxygen species multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] more ... CTD PMID:21334316 Akr1b1 Rat resveratrol increases expression EXP 6480464 resveratrol results in increased expression of AKR1B1 mRNA CTD PMID:25905778 Akr1b1 Rat resveratrol multiple interactions ISO Akr1b1 (Mus musculus) 6480464 Resveratrol inhibits the reaction [Azoxymethane results in increased expression of AKR1B1 mRNA] and Resveratrol inhibits the reaction [Azoxymethane results in increased expression of AKR1B1 protein] CTD PMID:21355597 Akr1b1 Rat rotenone decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Rotenone results in decreased expression of AKR1B1 mRNA CTD PMID:33512557 Akr1b1 Rat SB 203580 multiple interactions EXP 6480464 SB 203580 inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA] CTD PMID:17640564 Akr1b1 Rat SB 431542 multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1B1 mRNA CTD PMID:27188386 Akr1b1 Rat silicon dioxide increases secretion ISO AKR1B1 (Homo sapiens) 6480464 Silicon Dioxide analog results in increased secretion of AKR1B1 protein CTD PMID:25895662 Akr1b1 Rat sodium arsenate increases expression ISO AKR1B1 (Homo sapiens) 6480464 sodium arsenate results in increased expression of AKR1B1 mRNA CTD PMID:12727804 Akr1b1 Rat sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of AKR1B1 protein CTD PMID:16456883 Akr1b1 Rat sodium arsenite affects expression ISO AKR1B1 (Homo sapiens) 6480464 sodium arsenite affects the expression of AKR1B1 mRNA CTD PMID:34032870 Akr1b1 Rat sodium arsenite multiple interactions EXP 6480464 Benzo(a)pyrene promotes the reaction [sodium arsenite results in increased expression of AKR1B1 protein] and sodium arsenite promotes the reaction [Benzo(a)pyrene results in increased expression of AKR1B1 protein] CTD PMID:16456883 Akr1b1 Rat sodium arsenite increases expression ISO AKR1B1 (Homo sapiens) 6480464 sodium arsenite results in increased expression of AKR1B1 mRNA CTD PMID:20886546 more ... Akr1b1 Rat sodium chloride multiple interactions ISO Akr1b1 (Mus musculus) 6480464 Lipopolysaccharides inhibits the reaction [Sodium Chloride results in increased expression of AKR1B1 mRNA] CTD PMID:23867654 Akr1b1 Rat sodium chloride increases expression ISO Akr1b1 (Mus musculus) 6480464 Sodium Chloride results in increased expression of AKR1B1 mRNA CTD PMID:23867654 Akr1b1 Rat sodium dodecyl sulfate increases expression ISO AKR1B1 (Homo sapiens) 6480464 Sodium Dodecyl Sulfate results in increased expression of AKR1B1 mRNA CTD PMID:20566472 Akr1b1 Rat sorbinil decreases activity ISO AKR1B1 (Homo sapiens) 6480464 sorbinil results in decreased activity of AKR1B1 protein CTD PMID:21334316 Akr1b1 Rat sorbinil multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] more ... CTD PMID:21334316 and PMID:28137510 Akr1b1 Rat streptozocin multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 Streptozocin inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK1 protein] more ... CTD PMID:25541468 Akr1b1 Rat sulindac multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 Sulindac analog binds to and results in decreased activity of AKR1B1 protein and Sulindac binds to and results in decreased activity of AKR1B1 protein CTD PMID:25532697 Akr1b1 Rat sulindac sulfone multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 sulindac sulfone binds to and results in decreased activity of AKR1B1 protein CTD PMID:25532697 Akr1b1 Rat sunitinib decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Sunitinib results in decreased expression of AKR1B1 mRNA CTD PMID:31533062 Akr1b1 Rat tebufenpyrad decreases expression ISO AKR1B1 (Homo sapiens) 6480464 4-chloro-N-((4-(1 and 1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in decreased expression of AKR1B1 mRNA CTD PMID:33512557 Akr1b1 Rat temozolomide affects response to substance ISO AKR1B1 (Homo sapiens) 6480464 AKR1B1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 Akr1b1 Rat temozolomide decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Temozolomide results in decreased expression of AKR1B1 mRNA CTD PMID:31758290 Akr1b1 Rat terbufos increases methylation ISO AKR1B1 (Homo sapiens) 6480464 terbufos results in increased methylation of AKR1B1 promoter CTD PMID:22847954 Akr1b1 Rat thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of AKR1B1 mRNA CTD PMID:34492290 Akr1b1 Rat titanium dioxide decreases phosphorylation ISO AKR1B1 (Homo sapiens) 6480464 titanium dioxide results in decreased phosphorylation of AKR1B1 protein CTD PMID:21439344 Akr1b1 Rat titanium dioxide multiple interactions ISO Akr1b1 (Mus musculus) 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of AKR1B1 mRNA CTD PMID:29950665 Akr1b1 Rat titanium dioxide decreases methylation ISO Akr1b1 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of AKR1B1 promoter CTD PMID:35295148 Akr1b1 Rat topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of AKR1B1 mRNA CTD PMID:25729387 Akr1b1 Rat trans-isoeugenol increases expression ISO AKR1B1 (Homo sapiens) 6480464 isoeugenol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 Akr1b1 Rat tributylstannane increases expression ISO Akr1b1 (Mus musculus) 6480464 tributyltin results in increased expression of AKR1B1 mRNA CTD PMID:24848799 Akr1b1 Rat Triptolide increases expression EXP 6480464 triptolide results in increased expression of AKR1B1 protein CTD PMID:32519852 Akr1b1 Rat triptonide increases expression ISO Akr1b1 (Mus musculus) 6480464 triptonide results in increased expression of AKR1B1 mRNA CTD PMID:33045310 Akr1b1 Rat valproic acid decreases methylation ISO AKR1B1 (Homo sapiens) 6480464 Valproic Acid results in decreased methylation of AKR1B1 gene CTD PMID:29154799 Akr1b1 Rat valproic acid affects expression ISO Akr1b1 (Mus musculus) 6480464 Valproic Acid affects the expression of AKR1B1 mRNA CTD PMID:17963808 Akr1b1 Rat valproic acid decreases expression ISO AKR1B1 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of AKR1B1 mRNA CTD PMID:29501571 Akr1b1 Rat valproic acid affects expression ISO AKR1B1 (Homo sapiens) 6480464 Valproic Acid affects the expression of AKR1B1 mRNA CTD PMID:25979313 Akr1b1 Rat valproic acid increases expression ISO AKR1B1 (Homo sapiens) 6480464 Valproic Acid results in increased expression of AKR1B1 mRNA and Valproic Acid results in increased expression of AKR1B1 protein CTD PMID:23179753 more ... Akr1b1 Rat valproic acid multiple interactions ISO AKR1B1 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1B1 mRNA CTD PMID:27188386 Akr1b1 Rat vitamin E increases expression ISO AKR1B1 (Homo sapiens) 6480464 Vitamin E results in increased expression of AKR1B1 mRNA CTD PMID:19244175 Akr1b1 Rat zearalenone decreases expression ISO Akr1b1 (Mus musculus) 6480464 Zearalenone results in decreased expression of AKR1B1 protein CTD PMID:36252740 Akr1b1 Rat zoledronic acid increases expression ISO AKR1B1 (Homo sapiens) 6480464 zoledronic acid results in increased expression of AKR1B1 mRNA CTD PMID:24714768