Aldoc (aldolase, fructose-bisphosphate C) - Rat Genome Database

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Gene: Aldoc (aldolase, fructose-bisphosphate C) Rattus norvegicus
Analyze
Symbol: Aldoc
Name: aldolase, fructose-bisphosphate C
RGD ID: 2091
Description: Enables fructose-bisphosphate aldolase activity and identical protein binding activity. Involved in several processes, including aging; animal organ regeneration; and response to hypoxia. Located in axon and cytoplasm. Is active in postsynaptic cytosol. Biomarker of borna disease and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system. Orthologous to human ALDOC (aldolase, fructose-bisphosphate C); PARTICIPATES IN fructose and mannose metabolic pathway; gluconeogenesis pathway; glycolysis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ALDCAA; aldolase C; aldolase C, fructose-biphosphate; aldolase C, fructose-bisphosphate; brain-type aldolase; F16dip7; fructose-bisphosphate aldolase C; RATALDCAA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Stl1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21063,217,477 - 63,221,066 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,217,451 - 63,221,066 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1067,849,778 - 67,853,367 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01067,355,127 - 67,358,716 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01062,826,255 - 62,829,844 (+)NCBIRnor_WKY
Rnor_6.01065,586,504 - 65,590,093 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,586,504 - 65,590,126 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01066,049,065 - 66,052,654 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41064,308,826 - 64,312,415 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11064,322,448 - 64,326,038 (-)NCBI
Celera1062,195,147 - 62,198,736 (+)NCBICelera
Cytogenetic Map10q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
aconitine  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
ammonium chloride  (EXP)
Archazolid B  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
cisplatin  (ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diclofenac  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethylarsinic acid  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dizocilpine maleate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenthion  (ISO)
flavonoids  (EXP)
flutamide  (EXP,ISO)
folpet  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
haloperidol  (EXP)
hydroxyurea  (ISO)
indometacin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
lead diacetate  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
methamphetamine  (EXP)
methidathion  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
mifepristone  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
obeticholic acid  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
perfluorobutyric acid  (ISO)
perfluorononanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phenylpropanolamine  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
sarin  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
SKF 38393  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sotorasib  (ISO)
sulindac sulfide  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tapentadol  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
trametinib  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
Yessotoxin  (ISO)
yohimbine  (ISO)
zearalenone  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IDA)
cytoplasm  (IDA)
cytosol  (IBA)
postsynaptic cytosol  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Reappearance of aldolase C in rat liver during compensatory regeneration after partial hepatectomy. Berges J, etal., FEBS Lett. 1974 Nov 1;48(1):76-8.
2. Neuronal surface glycolytic enzymes are autoantigen targets in post-streptococcal autoimmune CNS disease. Dale RC, etal., J Neuroimmunol. 2006 Mar;172(1-2):187-97. Epub 2005 Dec 13.
3. The glutamate transporter EAAT4 in rat cerebellar Purkinje cells: a glutamate-gated chloride channel concentrated near the synapse in parts of the dendritic membrane facing astroglia. Dehnes Y, etal., J Neurosci. 1998 May 15;18(10):3606-19.
4. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. Deng AY and Rapp JP, J Clin Invest 1995 May;95(5):2170-7
5. Studies on the fate of aldolase molecules in the aging rat lens. Dovrat A and Gershon D, Biochim Biophys Acta. 1983 May 25;757(2):164-7.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Reversal of the expression pattern of Aldolase C mRNA in Purkinje cells and Ube 1x mRNA in Golgi cells by a dopamine D1 receptor agonist injections in the methamphetamine sensitized-rat cerebellum. Hamamura M, etal., J Neural Transm. 2008 Jul;115(7):959-71. Epub 2008 Feb 26.
9. Location of adult and fetal aldolases A, B, and C by immunoperoxidase technique in LF fast-growing rat hepatomas. Hatzfeld A, etal., Cancer Res. 1978 Jan;38(1):16-22.
10. Purification of aldolase C from rat brain and hepatoma. Hatzfeld A, etal., Eur J Biochem. 1977 Jul 1;77(1):37-43.
11. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
12. Phospholipase D2 directly interacts with aldolase via Its PH domain. Kim JH, etal., Biochemistry. 2002 Mar 12;41(10):3414-21.
13. Aldolase C/zebrin II is released to the extracellular space after stroke and inhibits the network activity of cortical neurons. Linke S, etal., Neurochem Res. 2006 Nov;31(11):1297-303. Epub 2006 Oct 20.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. The structure of the brain-specific rat aldolase C gene and its regional expression. Mukai T, etal., Biochem Biophys Res Commun 1991 Jan 31;174(2):1035-42.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. The complete amino acid sequence of the human aldolase C isozyme derived from genomic clones. Rottmann WH, etal., Biochimie 1987 Feb;69(2):137-45.
22. Molecular cloning and expression of rat aldolase C messenger RNA during development and hepatocarcinogenesis. Skala H, etal., Eur J Biochem. 1987 Mar 16;163(3):513-8.
23. Novel target sequences for Pax-6 in the brain-specific activating regions of the rat aldolase C gene. Skala-Rubinson H, etal., J Biol Chem 2002 Dec 6;277(49):47190-6.
24. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
25. Projection of reconstructed single Purkinje cell axons in relation to the cortical and nuclear aldolase C compartments of the rat cerebellum. Sugihara I, etal., J Comp Neurol. 2009 Jan 10;512(2):282-304.
26. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
27. Construction of rat aldolase C expression plasmid and the hybrid formation between rat aldolase C and human aldolase A or B co-expressed in Escherichia coli. Takasaki Y and Hori K, Protein Eng. 1990 Mar;3(4):273-7.
28. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
29. Spatiotemporal analysis of purkinje cell degeneration relative to parasagittal expression domains in a model of neonatal viral infection. Williams BL, etal., J Virol. 2007 Mar;81(6):2675-87. Epub 2006 Dec 20.
Additional References at PubMed
PMID:2831050   PMID:6696436   PMID:8168514   PMID:9244396   PMID:9443807   PMID:14651853   PMID:14697656   PMID:15489334   PMID:15537755   PMID:16854843   PMID:17183552   PMID:19056867  
PMID:19182904   PMID:20458337   PMID:21280042   PMID:21492153   PMID:22420779   PMID:22871113   PMID:23376485   PMID:23533145   PMID:31505169   PMID:32357304  


Genomics

Comparative Map Data
Aldoc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21063,217,477 - 63,221,066 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,217,451 - 63,221,066 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1067,849,778 - 67,853,367 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01067,355,127 - 67,358,716 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01062,826,255 - 62,829,844 (+)NCBIRnor_WKY
Rnor_6.01065,586,504 - 65,590,093 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,586,504 - 65,590,126 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01066,049,065 - 66,052,654 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41064,308,826 - 64,312,415 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11064,322,448 - 64,326,038 (-)NCBI
Celera1062,195,147 - 62,198,736 (+)NCBICelera
Cytogenetic Map10q25NCBI
ALDOC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381728,573,120 - 28,576,895 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1728,573,115 - 28,576,948 (-)EnsemblGRCh38hg38GRCh38
GRCh371726,900,138 - 26,903,913 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361723,924,260 - 23,928,078 (-)NCBINCBI36Build 36hg18NCBI36
Build 341723,924,265 - 23,927,989NCBI
Celera1723,759,160 - 23,762,978 (-)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1723,108,999 - 23,112,817 (-)NCBIHuRef
CHM1_11726,961,834 - 26,965,652 (-)NCBICHM1_1
T2T-CHM13v2.01729,515,745 - 29,519,520 (-)NCBIT2T-CHM13v2.0
Aldoc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,213,899 - 78,218,607 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1178,213,794 - 78,218,607 (+)EnsemblGRCm39 Ensembl
GRCm381178,323,073 - 78,327,781 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,322,968 - 78,327,781 (+)EnsemblGRCm38mm10GRCm38
MGSCv371178,137,700 - 78,140,262 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361178,140,393 - 78,142,955 (+)NCBIMGSCv36mm8
Celera1187,956,279 - 87,958,841 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
Aldoc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554814,576,913 - 4,580,999 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554814,576,913 - 4,580,999 (+)NCBIChiLan1.0ChiLan1.0
ALDOC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11728,702,447 - 28,706,507 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1728,700,976 - 28,706,507 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01728,198,895 - 28,202,950 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ALDOC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1942,778,637 - 42,782,950 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl942,778,637 - 42,782,479 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha941,935,297 - 41,939,139 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0943,597,372 - 43,601,698 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl943,597,399 - 43,601,698 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1942,380,447 - 42,384,288 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0942,673,144 - 42,676,986 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0942,750,567 - 42,754,409 (-)NCBIUU_Cfam_GSD_1.0
Aldoc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560241,921,047 - 41,924,788 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365384,798,989 - 4,802,994 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365384,798,991 - 4,802,700 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDOC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1244,822,780 - 44,827,597 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11244,823,376 - 44,827,273 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21246,807,780 - 46,811,676 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALDOC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11622,342,750 - 22,346,811 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1622,341,318 - 22,346,620 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660757,779,923 - 7,784,075 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldoc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247861,158,248 - 1,162,916 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247861,158,270 - 1,162,801 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aldoc
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:114
Count of miRNA genes:48
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000015535, ENSRNOT00000046388
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
1331839Eae18bExperimental allergic encephalomyelitis QTL 18b5.80.03nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)106124830367785171Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631526Bp76Blood pressure QTL 760.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106134541366743655Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat

Markers in Region
D10Wox15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21063,221,037 - 63,221,291 (+)MAPPERmRatBN7.2
Rnor_6.01065,590,065 - 65,590,318NCBIRnor6.0
Rnor_5.01066,048,840 - 66,049,093UniSTSRnor5.0
RGSC_v3.41064,308,600 - 64,308,854RGDRGSC3.4
RGSC_v3.41064,308,601 - 64,308,854UniSTSRGSC3.4
RGSC_v3.11064,322,223 - 64,322,477RGD
Celera1062,198,708 - 62,198,964UniSTS
RH 2.0 Map10606.0RGD
Cytogenetic Map10q25UniSTS
Cytogenetic Map10q31-q32.1UniSTS
D10Arb9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21063,221,094 - 63,221,223 (+)MAPPERmRatBN7.2
Rnor_6.01065,590,122 - 65,590,250NCBIRnor6.0
Rnor_5.01066,048,908 - 66,049,036UniSTSRnor5.0
RGSC_v3.41064,308,668 - 64,308,797RGDRGSC3.4
RGSC_v3.41064,308,669 - 64,308,797UniSTSRGSC3.4
RGSC_v3.11064,322,291 - 64,322,420RGD
Celera1062,198,765 - 62,198,896UniSTS
FHH x ACI Map1052.73RGD
FHH x ACI Map1052.73UniSTS
Cytogenetic Map10q25UniSTS
Cytogenetic Map10q31-q32.1UniSTS
BE096286  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21063,219,275 - 63,219,514 (+)MAPPERmRatBN7.2
Rnor_6.01065,588,303 - 65,588,541NCBIRnor6.0
Rnor_5.01066,050,617 - 66,050,855UniSTSRnor5.0
RGSC_v3.41064,310,378 - 64,310,616UniSTSRGSC3.4
Celera1062,196,946 - 62,197,184UniSTS
Cytogenetic Map10q31-q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 9
Medium 14 63 34 2
Low 3 29 55 39 19 39 8 11 2 35 7 9 8
Below cutoff 2 2 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB017483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M63656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X06984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000015535   ⟹   ENSRNOP00000015535
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1063,217,451 - 63,221,064 (+)Ensembl
Rnor_6.0 Ensembl1065,586,504 - 65,590,093 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000046388   ⟹   ENSRNOP00000048591
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1063,217,451 - 63,221,064 (+)Ensembl
Rnor_6.0 Ensembl1065,586,535 - 65,590,086 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086036   ⟹   ENSRNOP00000072735
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1063,218,018 - 63,221,066 (+)Ensembl
Rnor_6.0 Ensembl1065,586,993 - 65,590,126 (+)Ensembl
RefSeq Acc Id: NM_012497   ⟹   NP_036629
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21063,217,477 - 63,221,066 (+)NCBI
Rnor_6.01065,586,504 - 65,590,093 (+)NCBI
Rnor_5.01066,049,065 - 66,052,654 (-)NCBI
RGSC_v3.41064,308,826 - 64,312,415 (-)RGD
Celera1062,195,147 - 62,198,736 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036629   ⟸   NM_012497
- UniProtKB: Q63037 (UniProtKB/Swiss-Prot),   P09117 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000048591   ⟸   ENSRNOT00000046388
RefSeq Acc Id: ENSRNOP00000072735   ⟸   ENSRNOT00000086036
RefSeq Acc Id: ENSRNOP00000015535   ⟸   ENSRNOT00000015535

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09117-F1-model_v2 AlphaFold P09117 1-363 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697476
Promoter ID:EPDNEW_R8001
Type:initiation region
Name:Aldoc_1
Description:aldolase, fructose-bisphosphate C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01065,586,508 - 65,586,568EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2091 AgrOrtholog
BioCyc Gene G2FUF-24069 BioCyc
BioCyc Pathway ANAGLYCOLYSIS-PWY [glycolysis III (from glucose)] BioCyc
  PWY66-373 [sucrose degradation V (sucrose alpha-glucosidase)] BioCyc
  PWY66-399 [gluconeogenesis III] BioCyc
Ensembl Genes ENSRNOG00000011452 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000015535 ENTREZGENE
  ENSRNOP00000015535.4 UniProtKB/Swiss-Prot
  ENSRNOP00000048591.6 UniProtKB/TrEMBL
  ENSRNOP00000072735.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015535 ENTREZGENE
  ENSRNOT00000015535.9 UniProtKB/Swiss-Prot
  ENSRNOT00000046388.6 UniProtKB/TrEMBL
  ENSRNOT00000086036.2 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599032 IMAGE-MGC_LOAD
InterPro Aldolase_I_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FBA_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24191 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124642 IMAGE-MGC_LOAD
NCBI Gene 24191 ENTREZGENE
PANTHER FRUCTOSE-BISPHOSPHATE ALDOLASE C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11627 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glycolytic UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aldoc PhenoGen
PROSITE ALDOLASE_CLASS_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Aldolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217615
UniProt A0A0G2K3Q6_RAT UniProtKB/TrEMBL
  A0A0G2QC57_RAT UniProtKB/TrEMBL
  ALDOC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63037 ENTREZGENE
  Q6PCU3_RAT UniProtKB/TrEMBL
UniProt Secondary E9PTN8 UniProtKB/TrEMBL
  Q54AI4 UniProtKB/Swiss-Prot
  Q63037 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Aldoc  aldolase, fructose-bisphosphate C  Aldoc  aldolase C, fructose-bisphosphate  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Aldoc  aldolase C, fructose-bisphosphate  Aldoc  aldolase C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Aldoc  aldolase C    aldolase C, fructose-biphosphate  Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed specifically in brain 632189
gene_expression expressed in cerebellar cortex Purkinje cells 632190
gene_process may be involved in neurogenesis 632189
gene_product member of the aldolase enzyme family 632189
gene_regulation expression may be regulated by Pax6 632189
gene_transcript has two transcription initiation sites 632190