Agtr1b (angiotensin II receptor, type 1b) - Rat Genome Database

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Gene: Agtr1b (angiotensin II receptor, type 1b) Rattus norvegicus
Analyze
Symbol: Agtr1b
Name: angiotensin II receptor, type 1b
RGD ID: 2071
Description: Predicted to enable angiotensin type I receptor activity. Involved in several processes, including cellular response to hormone stimulus; positive regulation of branching involved in ureteric bud morphogenesis; and response to estrogen. Biomarker of hypertension and renovascular hypertension. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; artery disease (multiple); chronic kidney disease; neurodegenerative disease (multiple); and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1); PARTICIPATES IN angiotensin III signaling pathway via AT1 receptor; angiotensin II signaling pathway via AT1 receptor; angiotensin III signaling pathway; INTERACTS WITH (S)-nicotine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Agtr1; Angiotensin II receptor, type 1 (AT1B); angiotensin II receptor, type-1; angiotensin II type-1 receptor; angiotensin II type-1 receptor B; angiotensin II type-1B receptor; angiotensin receptor 1; angiotensin receptor 1b; AT1; AT1 receptor B; At1b; AT3; AT1R; type-1 angiotensin II receptor B; type-1B angiotensin II receptor
RGD Orthologs
Mouse
Alliance Genes
More Info more info ...
Allele / Splice: Agtr1bm1Mcwi  
Genetic Models: FHH-Agtr1bm1Mcwi
Is Marker For: Strains:   SD-Tg(Ren2)27   SS.MNS-(D2Mit6-Adh1)/Ayd   SHR  
QTLs:   Bp36   Bp99  
Candidate Gene For: Bp132 Smcn1 Stresp14 Stresp15 Kiddil5 Kiddil6
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22102,844,969 - 102,920,232 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2102,844,969 - 102,920,232 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2109,389,316 - 109,463,548 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02107,510,501 - 107,584,761 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02102,444,366 - 102,513,153 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02105,149,020 - 105,224,335 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2105,149,020 - 105,224,295 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02124,879,262 - 124,954,378 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42105,503,269 - 105,602,591 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12105,448,230 - 105,547,520 (-)NCBI
Celera298,214,526 - 98,286,355 (-)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. A gene expression analysis in rat kidney following high and low salt intake. Barta P, etal., J Hypertens. 2002 Jun;20(6):1115-20.
2. MiR-133a regulates collagen 1A1: potential role of miR-133a in myocardial fibrosis in angiotensin II-dependent hypertension. Castoldi G, etal., J Cell Physiol. 2012 Feb;227(2):850-6. doi: 10.1002/jcp.22939.
3. Angiotensin II attenuates renal cortical cyclooxygenase-2 expression. Cheng HF, etal., J Clin Invest 1999 Apr;103(7):953-61.
4. Transcription factor NF-kappa B is necessary for up-regulation of type 1 angiotensin II receptor mRNA in rat cardiac fibroblasts treated with tumor necrosis factor-alpha or interleukin-1 beta. Cowling RT, etal., J Biol Chem 2002 Feb 22;277(8):5719-24.
5. International union of pharmacology. XXIII. The angiotensin II receptors. de Gasparo M, etal., Pharmacol Rev. 2000 Sep;52(3):415-72.
6. Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. Deng AY, etal., J Clin Invest 1994 Jul;94(1):431-6
7. Effect of AT(1) receptor blockade on cardiac apoptosis in angiotensin II-induced hypertension. Diep QN, etal., Am J Physiol Heart Circ Physiol 2002 May;282(5):H1635-41.
8. A quantitative trait locus for aortic smooth muscle cell number acting independently of blood pressure: implicating the angiotensin receptor AT1B gene as a candidate. Dutil J, etal., Physiol Genomics 2005 Mar 1;.
9. Species variability in angiotensin receptor expression by cultured cardiac fibroblasts and the infarcted heart. Gallagher AM, etal., Am J Physiol 1998 Mar;274(3 Pt 2):H801-9.
10. Angiotensin II type 1 receptor A1166C gene polymorphism. Absence of an association with the risk of coronary artery disease and myocardial infarction and of a synergistic effect with angiotensin-converting enzyme gene polymorphism on the risk of these diseases. Gardemann A, etal., Eur Heart J. 1998 Nov;19(11):1657-65.
11. Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Garrett MR, etal., Genome Res 1998 Jul;8(7):711-23
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. Gribouval O, etal., Nat Genet. 2005 Sep;37(9):964-8. Epub 2005 Aug 14.
14. Angiotensin receptor subtypes in thin and muscular juxtamedullary efferent arterioles of rat kidney. Helou CM, etal., Am J Physiol Renal Physiol 2003 Sep;285(3):F507-14. Epub 2003 May 6.
15. Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload. Herzig TC, etal., Proc Natl Acad Sci U S A 1997 Jul 8;94(14):7543-8.
16. Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II. Hunyady L and Catt KJ, Mol Endocrinol. 2006 May;20(5):953-70. Epub 2005 Sep 1.
17. Differential PI 3-kinase dependence of early and late phases of recycling of the internalized AT1 angiotensin receptor. Hunyady L, etal., J Cell Biol 2002 Jun 24;157(7):1211-22.
18. Ventrolateral medulla AT1 receptors support blood pressure in hypertensive rats. Ito S, etal., Hypertension 2002 Oct;40(4):552-9.
19. Role of ANG II in coronary capillary angiogenesis at the insulin-resistant stage of a NIDDM rat model. Jesmin S, etal., Am J Physiol Heart Circ Physiol 2002 Oct;283(4):H1387-97.
20. Angiotensin II AT(1) and AT(2) receptors contribute to maintain basal adrenomedullary norepinephrine synthesis and tyrosine hydroxylase transcription. Jezova M, etal., Endocrinology 2003 May;144(5):2092-101.
21. Restraint stress modulates brain, pituitary and adrenal expression of angiotensin II AT(1A), AT(1B) and AT(2) receptors. Leong DS, etal., Neuroendocrinology. 2002 Apr;75(4):227-40.
22. Chronic hypoxia upregulates the expression and function of AT(1) receptor in rat carotid body. Leung PS, etal., J Endocrinol. 2000 Dec;167(3):517-24.
23. [Dynamic changes of angiotensin II type-1 receptor mRNA expression in volume-overloaded ventricular hypertrophy]. Li YQ, etal., Sheng Li Xue Bao. 1998 Jun;50(3):303-8.
24. Prophylactic angiotensin type 1 receptor antagonism confers neuroprotection in an aged rat model of postoperative cognitive dysfunction. Li Z, etal., Biochem Biophys Res Commun. 2014 Jun 20;449(1):74-80. doi: 10.1016/j.bbrc.2014.04.153. Epub 2014 May 9.
25. Retrovirus-mediated transfer of an angiotensin type I receptor (AT1-R) antisense sequence decreases AT1-Rs and angiotensin II action in astroglial and neuronal cells in primary cultures from the brain. Lu D, etal., Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):1162-6.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. Constitutive activation of angiotensin II type 1 receptor alters the orientation of transmembrane Helix-2. Miura S and Karnik SS, J Biol Chem 2002 Jul 5;277(27):24299-305.
28. TM2-TM7 interaction in coupling movement of transmembrane helices to activation of the angiotensin II type-1 receptor. Miura S, etal., J Biol Chem 2003 Feb 7;278(6):3720-5.
29. Distribution of angiotensin AT1 and AT2 receptor subtypes in the rat kidney. Miyata N, etal., Am J Physiol 1999 Sep;277(3 Pt 2):F437-46.
30. Angiotensin II blockade reduces radiation-induced proliferation in experimental radiation nephropathy. Moulder JE, etal., Radiat Res 2002 Apr;157(4):393-401.
31. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. Increased gene expression of components of the renin-angiotensin system in glomeruli of genetically hypertensive rats. Obata J, etal., J Hypertens. 2000 Sep;18(9):1247-55.
33. Renocortical mRNA expression of vasoactive factors during spironolactone protective effect in chronic cyclosporine nephrotoxicity. Perez-Rojas JM, etal., Am J Physiol Renal Physiol. 2005 Nov;289(5):F1020-30. Epub 2005 Jul 5.
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. The luminal membrane of rat thick limb expresses AT1 receptor and aminopeptidase activities. Poumarat JS, etal., Kidney Int. 2002 Aug;62(2):434-45.
36. Angiotensin III: a central regulator of vasopressin release and blood pressure. Reaux A, etal., Trends Endocrinol Metab. 2001 May-Jun;12(4):157-62.
37. GOA pipeline RGD automated data pipeline
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. AT-1 receptor and phospholipase C are involved in angiotensin III modulation of hypothalamic noradrenergic transmission. Rodriguez-Campos M, etal., Cell Mol Neurobiol. 2000 Dec;20(6):747-62.
40. Regulation of angiotensin II receptor AT1 subtypes in renal afferent arterioles during chronic changes in sodium diet. Ruan X, etal., J Clin Invest. 1997 Mar 1;99(5):1072-81.
41. Independence of angiotensin II-induced MAP kinase activation from angiotensin type 1 receptor internalization in clone 9 hepatocytes. Shah BH, etal., Mol Endocrinol 2002 Mar;16(3):610-20.
42. Effects of dexamethasone exposure on rat metanephric development: in vitro and in vivo studies. Singh RR, etal., Am J Physiol Renal Physiol. 2007 Aug;293(2):F548-54. Epub 2007 May 30.
43. Role of the proline-rich domain of dynamin-2 and its interactions with Src homology 3 domains during endocytosis of the AT1 angiotensin receptor. Szaszak M, etal., J Biol Chem 2002 Jun 14;277(24):21650-6.
44. Dilatation of cerebral parenchymal vessels mediated by angiotensin type 1 receptor in cats. Takao M, etal., Neurosci Lett 2002 Jan 25;318(2):108-12.
45. Exaggerated natriuresis after selective AT1 receptor blockade in Dahl salt-sensitive rats. Tallam LS and Jandhyala BS, Clin Exp Hypertens 2001 Nov;23(8):623-31.
46. Localization of the genes encoding the three rat angiotensin II receptors, Agtr1a, Agtr1b, Agtr2, and the human AGTR2 receptor respectively to rat chromosomes 17q12, 2q24 and Xq34, and the human Xq22. Tissir F, etal., Cytogenet Cell Genet 1995;71(1):77-80.
47. Effect of prenatal exposure to nicotine on kidney glomerular mass and AT1R expression in genetically diverse strains of rats. Toledo-Rodriguez M, etal., Toxicol Lett. 2012 Sep 3;213(2):228-34. doi: 10.1016/j.toxlet.2012.06.009. Epub 2012 Jun 20.
48. Positive feedback regulation of angiotensin II-AT1B receptor gene expression in rat adrenal glands. Wagner C and Kurtz A, Pflugers Arch. 1998 Aug;436(3):323-8.
49. Regulation of type 1 angiotensin II receptor and its subtype gene expression in kidney by sodium loading and angiotensin II infusion. Wang DH, etal., J Hypertens. 1996 Dec;14(12):1409-15.
50. Estrogen regulates adrenal angiotensin AT1 receptors by modulating AT1 receptor translation. Wu Z, etal., Endocrinology. 2003 Jul;144(7):3251-61.
51. Epistatic interaction between variations in the angiotensin I converting enzyme and angiotensin II type 1 receptor genes in relation to extent of coronary atherosclerosis. Ye S, etal., Heart. 2003 Oct;89(10):1195-9.
Additional References at PubMed
PMID:1374402   PMID:1544458   PMID:1567388   PMID:1575725   PMID:1599457   PMID:8193170   PMID:9310306   PMID:9466969   PMID:10880053   PMID:11702851   PMID:11853871   PMID:11991202  
PMID:12047908   PMID:12056549   PMID:12203396   PMID:12221292   PMID:12433659   PMID:12433968   PMID:12452333   PMID:12472784   PMID:12482596   PMID:12522132   PMID:12527732   PMID:12573806  
PMID:12597523   PMID:12609817   PMID:12621312   PMID:12623981   PMID:12650989   PMID:12660888   PMID:12675280   PMID:12686508   PMID:12746278   PMID:12746279   PMID:12810755   PMID:12824079  
PMID:12828922   PMID:12837289   PMID:14508196   PMID:14567501   PMID:14618237   PMID:14693687   PMID:14722318   PMID:14754891   PMID:15037565   PMID:15148062   PMID:15153558   PMID:15226636  
PMID:15342638   PMID:15448113   PMID:15523401   PMID:15526249   PMID:15544836   PMID:15554451   PMID:15572519   PMID:15585668   PMID:15638358   PMID:15699451   PMID:15722410   PMID:15809068  
PMID:15833808   PMID:15870381   PMID:15879490   PMID:16014039   PMID:16043661   PMID:16098473   PMID:16099820   PMID:16123226   PMID:16144989   PMID:16172423   PMID:16210417   PMID:16286564  
PMID:16330679   PMID:16391174   PMID:16569213   PMID:16690611   PMID:16897002   PMID:17256744   PMID:17766473   PMID:17891894   PMID:18413143   PMID:18976642   PMID:19126659   PMID:19204403  
PMID:19298848   PMID:19353416   PMID:19404405   PMID:19955853   PMID:21123758   PMID:22038231   PMID:22411927   PMID:23089979   PMID:23132538   PMID:24529758   PMID:24587998   PMID:28161727  
PMID:37132556   PMID:37322348  


Genomics

Comparative Map Data
Agtr1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22102,844,969 - 102,920,232 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2102,844,969 - 102,920,232 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2109,389,316 - 109,463,548 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02107,510,501 - 107,584,761 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02102,444,366 - 102,513,153 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02105,149,020 - 105,224,335 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2105,149,020 - 105,224,295 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02124,879,262 - 124,954,378 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42105,503,269 - 105,602,591 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12105,448,230 - 105,547,520 (-)NCBI
Celera298,214,526 - 98,286,355 (-)NCBICelera
Cytogenetic Map2q24NCBI
Agtr1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39320,368,637 - 20,421,341 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl320,368,637 - 20,421,341 (-)EnsemblGRCm39 Ensembl
GRCm38320,314,473 - 20,367,177 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl320,314,473 - 20,367,177 (-)EnsemblGRCm38mm10GRCm38
MGSCv37320,213,395 - 20,266,099 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36320,505,546 - 20,558,250 (-)NCBIMGSCv36mm8
Celera320,303,573 - 20,356,081 (-)NCBICelera
Cytogenetic Map3A2NCBI
cM Map36.37NCBI

Variants

.
Variants in Agtr1b
620 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:462
Count of miRNA genes:255
Interacting mature miRNAs:301
Transcripts:ENSRNOT00000014178
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)259324377103795077Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)259324377103795077Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)259846005104846005Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)264366971109366971Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat

Markers in Region
D2Mco34  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22102,854,285 - 102,854,485 (+)MAPPERmRatBN7.2
Rnor_6.02105,158,337 - 105,158,532NCBIRnor6.0
Rnor_5.02124,888,579 - 124,888,774UniSTSRnor5.0
RGSC_v3.42105,512,585 - 105,512,781RGDRGSC3.4
RGSC_v3.42105,512,586 - 105,512,781UniSTSRGSC3.4
RGSC_v3.12105,457,547 - 105,457,743RGD
Celera298,223,850 - 98,224,041UniSTS
Cytogenetic Map2q24UniSTS
D2Mco35  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22102,853,080 - 102,853,371 (+)MAPPERmRatBN7.2
Rnor_6.02105,157,132 - 105,157,422NCBIRnor6.0
Rnor_5.02124,887,374 - 124,887,664UniSTSRnor5.0
RGSC_v3.42105,511,380 - 105,511,671RGDRGSC3.4
RGSC_v3.42105,511,381 - 105,511,671UniSTSRGSC3.4
RGSC_v3.12105,456,342 - 105,456,633RGD
Celera298,222,645 - 98,222,935UniSTS
Cytogenetic Map2q24UniSTS
Agtr1a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22102,846,542 - 102,846,612 (+)MAPPERmRatBN7.2
Rnor_6.02105,150,594 - 105,150,663NCBIRnor6.0
Rnor_5.02124,880,836 - 124,880,905UniSTSRnor5.0
RGSC_v3.42105,504,843 - 105,504,912UniSTSRGSC3.4
Celera298,216,100 - 98,216,169UniSTS
Cytogenetic Map2q24UniSTS
Cytogenetic Map17q12UniSTS
UniSTS:256387  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22102,846,187 - 102,846,878 (+)MAPPERmRatBN7.2
Rnor_6.02105,150,239 - 105,150,929NCBIRnor6.0
Rnor_5.02124,880,481 - 124,881,171UniSTSRnor5.0
RGSC_v3.42105,504,488 - 105,505,178UniSTSRGSC3.4
Celera298,215,745 - 98,216,435UniSTS
Cytogenetic Map2q24UniSTS
UniSTS:256385  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,175,936 - 34,176,577 (+)MAPPERmRatBN7.2
mRatBN7.22102,846,237 - 102,846,878 (+)MAPPERmRatBN7.2
Rnor_6.02105,150,289 - 105,150,929NCBIRnor6.0
Rnor_6.01735,908,280 - 35,908,920NCBIRnor6.0
Rnor_5.01737,220,006 - 37,220,646UniSTSRnor5.0
Rnor_5.02124,880,531 - 124,881,171UniSTSRnor5.0
RGSC_v3.41740,630,492 - 40,631,132UniSTSRGSC3.4
RGSC_v3.42105,504,538 - 105,505,178UniSTSRGSC3.4
Celera298,215,795 - 98,216,435UniSTS
Celera1733,707,149 - 33,707,789UniSTS
Cytogenetic Map2q24UniSTS
Cytogenetic Map17q12UniSTS


Related Rat Strains
The following Strains have been annotated to Agtr1b
SD-Tg(Ren2)27     SHR     SS.MNS-(D2Mit6-Adh1)/Ayd     SS.MNS-(D2Mit6-Adh)/Ayd    


Genetic Models
This gene Agtr1b is modified in the following models/strains:
FHH-Agtr1bm1Mcwi    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 7 3
Low 1 1 28 22 2
Below cutoff 2 13 19 11 15 11 6 6 24 15 7 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014178   ⟹   ENSRNOP00000014175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2102,844,969 - 102,920,232 (-)Ensembl
Rnor_6.0 Ensembl2105,149,020 - 105,224,295 (-)Ensembl
RefSeq Acc Id: NM_031009   ⟹   NP_112271
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22102,844,969 - 102,920,232 (-)NCBI
Rnor_6.02105,149,020 - 105,224,295 (-)NCBI
Rnor_5.02124,879,262 - 124,954,378 (-)NCBI
RGSC_v3.42105,503,269 - 105,602,591 (-)RGD
Celera298,214,526 - 98,286,355 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_112271 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40704 (Get FASTA)   NCBI Sequence Viewer  
  AAA40739 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014175
GenBank Protein P29089 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_112271   ⟸   NM_031009
- UniProtKB: P29089 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014175   ⟸   ENSRNOT00000014178

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AT1b I-TASSER model P29089 1-359 view protein structure
AF-P29089-F1-model_v2 AlphaFold P29089 1-359 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2071 AgrOrtholog
BioCyc Gene G2FUF-53601 BioCyc
Ensembl Genes ENSRNOG00000010640 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014178 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro ATII_AT1_rcpt UniProtKB/Swiss-Prot
  ATII_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:81638 UniProtKB/Swiss-Prot
NCBI Gene 81638 ENTREZGENE
PANTHER C-C CHEMOKINE RECEPTOR TYPE 4 UniProtKB/Swiss-Prot
  CELL ADHESION MOLECULE UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Agtr1b PhenoGen
PRINTS ANGIOTENSINR UniProtKB/Swiss-Prot
  ANGIOTENSN1R UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010640 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt AGTRB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-18 Agtr1b  angiotensin II receptor, type 1b  Agtr1b  angiotensin receptor 1b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-22 Agtr1b  angiotensin receptor 1b  Agtr1  angiotensin II receptor, type-1  Data merged from RGD:67391 737654 APPROVED
2005-09-30 Agtr1        Symbol and Name status set to provisional 70820 PROVISIONAL
2005-09-02   angiotensin II receptor, type-1  Agtr1  angiotensin II type-1 receptor  Name updated 1299863 APPROVED
2002-06-10 Agtr1b  angiotensin receptor 1b      Name updated 70585 PROVISIONAL
2001-10-19 Agtr1  angiotensin II type-1 receptor      Name updated 68916 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease receptor affinity may play a role in salt-dependent hypertension in Dahl salt-sensitive rats 1299144
gene_disease abnormality of receptor function can cause hypertension, water-electrolyte imbalance, hyperaldosteronism, cardiac hypertrophy, and heart failure 625708
gene_disease involved in the pathogenesis of coronary capillary remodeling observed in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of human non-insulin-dependent diabetes mellitus (NIDDM) 625708
gene_domains constitutive activation induces movement of the transmembrane (TM)2 helix and is a critical mechanism for the conformational change of the receptor 625708
gene_drugs dose related decrease in mean arterial pressure observed when rostral ventrolateral medulla of choralose-anesthetized adult was injected with nonpeptide AT1 receptor antagonist valsartan 625708
gene_expression expressed in the cardiac muscle of the heart 625708
gene_expression expressed in rostral ventrolateral medulla of vasomotor neurons 625708
gene_expression expressed in the proximal tubules of hte outer medulla and in the vasculature of the renal cortex 1357917
gene_function may inhibit cyclooxygenase-2 expression 632167
gene_physical_interaction coupled to the G-protein, Gq11 625708
gene_process has a role in induction of extracellular matrix remodeling and increasing mortality in animal models of myocardial infarction 70782
gene_process has a role in induction of extracellular matrix remodeling and increasing mortality in animal models of myocardial infarction 628328
gene_process mediates angiotensin II induced apoptosis in cardiomyocytes in vitro 628328
gene_regulation maximal up-regulation occurs when IKK activity increases or IkappaB is degraded in the continued presence of TNF-alpha 70782
gene_regulation increased expression caused by TNF-alpha and IL-1beta requires NF-kappaB activation in cardiac fibroblasts 70782
gene_regulation stimulated by angiotensin II 70782
gene_regulation regulated by signals from hypothalamus 625708
gene_regulation gene expression is induced by pressure overload (PO) in cardiac muscle and mediated by a functional interaction between AP-1 and GATA-4 transcription factors 625708
gene_regulation expression is increased in infarcted area following coronary artery ligation 1358972
gene_transcript mutation T to C at position 6 and A to G at position 118 associated with aortic smooth cell number and Smcn1 QTL 1357419