Agtr1a (angiotensin II receptor, type 1a) - Rat Genome Database

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Gene: Agtr1a (angiotensin II receptor, type 1a) Rattus norvegicus
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Symbol: Agtr1a
Name: angiotensin II receptor, type 1a
RGD ID: 2070
Description: Enables D1 dopamine receptor binding activity; angiotensin type I receptor activity; and protein kinase binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; regulation of blood pressure; and response to glucocorticoid. Located in several cellular components, including basolateral plasma membrane; organelle outer membrane; and recycling endosome. Used to study several diseases, including asthma; chronic kidney disease; congestive heart failure; hypertension (multiple); and nephritis. Biomarker of several diseases, including anti-basement membrane glomerulonephritis; artery disease (multiple); glomerulosclerosis (multiple); hyperinsulinism; and placental insufficiency. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; artery disease (multiple); chronic kidney disease; neurodegenerative disease (multiple); and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1); PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; angiotensin III signaling pathway via AT1 receptor; G protein mediated signaling pathway via Galpha12/Galpha13 family; INTERACTS WITH (+)-pilocarpine; (R)-lipoic acid; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Agtr1; Angiotensin II receptor type 1 (AT1A); angiotensin II receptor, type 1; Angiotensin II receptor, type 1 (AT1A); angiotensin II type-1 receptor A; angiotensin II type-1A receptor; angiotensin receptor 1a; AT1; AT1 receptor A; AT1A; AT1R; type-1 angiotensin II receptor A; type-1A angiotensin II receptor; vascular type-1 angiotensin II receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Agtr1aem5Mcwi   Agtr1aem1Mcwi  
Genetic Models: SS-Agtr1aem1Mcwi SS-Agtr1aem5Mcwi
Is Marker For: QTLs:   Bp343  
Candidate Gene For: Bp343
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21734,173,446 - 34,226,892 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1734,174,429 - 34,226,946 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1734,003,015 - 34,054,637 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01735,606,893 - 35,658,508 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01733,998,820 - 34,050,440 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01735,907,102 - 35,958,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1735,907,108 - 35,958,077 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01737,217,810 - 37,270,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41740,629,318 - 40,684,982 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11740,632,160 - 40,687,823 (-)NCBI
Celera1733,705,975 - 33,757,157 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
AIDS-Associated Nephropathy  (ISO)
Alveolar Bone Loss  (IEP)
Alzheimer's disease  (ISO)
anti-basement membrane glomerulonephritis  (IEP)
asthma  (IMP,ISO)
atrial fibrillation  (ISO)
breast cancer  (ISO)
breast lobular carcinoma  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (IEP,IMP,ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (IEP)
cerebrovascular disease  (ISO)
Chronic Intermittent Hypoxia  (IEP)
chronic kidney disease  (IMP,ISO)
congestive heart failure  (IMP,ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
Diabetic Nephropathies  (IMP,ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
diffuse cystic renal dysplasia  (ISO)
dilated cardiomyopathy  (IEP,IMP)
Ductal Carcinoma  (ISO)
essential hypertension  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (IEP,ISO)
Experimental Radiation Injuries  (IMP)
Fetal Growth Retardation  (IEP)
Fibrosis  (IMP,ISO)
focal segmental glomerulosclerosis  (IEP)
Friedreich ataxia  (ISO)
genetic disease  (ISO)
glomerulosclerosis  (IEP)
glucose intolerance  (ISO)
glycogen storage disease XV  (ISO)
Huntington's disease  (ISO)
hyperinsulinism  (IEP)
hypertension  (IEP,IMP,ISO)
Hypertensive Nephropathy  (IMP)
IgA glomerulonephritis  (ISO)
Inflammation  (ISO)
intermediate coronary syndrome  (ISO)
kidney disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
limb ischemia  (ISO)
lung disease  (ISO)
Metabolic Syndrome  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Reperfusion Injury  (IEP)
Neoplasm Metastasis  (ISO)
nephritis  (IMP)
pancreatic ductal carcinoma  (ISO)
Parkinson's disease  (ISO)
patent ductus arteriosus  (ISO)
Pituitary Neoplasms  (ISO)
placental insufficiency  (IEP)
Postoperative Cognitive Dysfunction  (IEP)
Prenatal Exposure Delayed Effects  (IEP)
proteinuria  (IMP,ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
renal hypertension  (IEP)
Renal Tubular Dysgenesis  (ISO)
renovascular hypertension  (IEP,IMP)
sarcoidosis  (ISO)
Spontaneous Abortions  (ISO)
Vascular System Injuries  (ISO)
Ventricular Remodeling  (IEP)
vesicoureteral reflux  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (EXP,ISO)
(S)-nicotine  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-dihydroxybenzoic acid  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (EXP)
4-hydroxy-TEMPO  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-Br-cAMP  (ISO)
Ac-Ser-Asp-Lys-Pro-OH  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amlodipine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
aspartame  (ISO)
ATP  (EXP)
benazepril  (EXP,ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
butanal  (ISO)
caffeine  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
candesartan  (EXP,ISO)
Candesartan cilexetil  (EXP)
capsaicin  (EXP)
captopril  (EXP,ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
chromium(6+)  (ISO)
cilazapril monohydrate  (EXP)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
corticosterone  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
daunorubicin  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (EXP)
diuron  (EXP)
doxorubicin  (EXP)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP)
edaravone  (EXP)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (ISO)
endosulfan  (EXP)
esculetin  (EXP)
estriol  (ISO)
ethanol  (EXP)
flavonoids  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycochenodeoxycholic acid  (EXP)
glyoxylic acid  (EXP)
goralatide  (ISO)
Heptachlor epoxide  (ISO)
hexachlorobenzene  (EXP)
hydrochlorothiazide  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
inulin  (ISO)
irbesartan  (ISO)
isoprenaline  (ISO)
isotretinoin  (EXP)
L-ethionine  (EXP)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (EXP)
losartan  (EXP,ISO)
Magnolol  (EXP)
mangiferin  (EXP)
mechlorethamine  (EXP)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metformin  (ISO)
methamphetamine  (EXP)
mevinphos  (EXP)
mifepristone  (EXP)
monocrotaline  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
Nandrolone decanoate  (EXP)
nerolidol  (EXP)
nickel atom  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP)
nitrendipine  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
olmesartan  (ISO)
omeprazole  (EXP)
ouabain  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
perindopril  (EXP,ISO)
phenylarsine oxide  (EXP)
phosphane  (EXP)
picrotoxin  (EXP)
pioglitazone  (ISO)
pirfenidone  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregabalin  (EXP)
propanal  (ISO)
Ptaquiloside  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
spironolactone  (EXP)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sucrose  (EXP)
superoxide  (EXP)
telmisartan  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
triadimefon  (EXP)
tributylstannane  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triphenylstannane  (EXP)
troglitazone  (ISO)
tryptophan  (EXP)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vinclozolin  (EXP)
warfarin  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of Janus kinase activity  (IMP)
angiotensin-activated signaling pathway  (IMP,ISO)
blood vessel development  (ISO)
brain renin-angiotensin system  (ISO)
calcium-mediated signaling  (ISO)
cell chemotaxis  (ISO)
cellular response to dexamethasone stimulus  (IDA)
dopamine biosynthetic process  (IMP)
drinking behavior  (IMP,ISO)
G protein-coupled receptor signaling pathway  (IBA,IMP,ISO)
gene expression  (ISO)
heart development  (ISO)
inflammatory response  (IBA,ISO)
kidney development  (ISO)
maintenance of blood vessel diameter homeostasis by renin-angiotensin  (ISO,ISS)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of smooth muscle cell apoptotic process  (ISO)
neuron apoptotic process  (ISO)
phospholipase C-activating angiotensin-activated signaling pathway  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IDA,ISO)
positive regulation of angiogenesis  (IMP)
positive regulation of blood pressure  (IMP,ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (IMP)
positive regulation of calcium ion import across plasma membrane  (IMP)
positive regulation of cell population proliferation  (IMP)
positive regulation of cytokine production  (ISO)
positive regulation of cytosolic calcium ion concentration  (IBA,ISO)
positive regulation of macrophage derived foam cell differentiation  (ISO)
positive regulation of protein metabolic process  (ISO)
positive regulation of receptor recycling  (IDA)
positive regulation of superoxide anion generation  (IMP)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
regulation of blood pressure  (ISO)
regulation of pH  (IDA)
regulation of renal output by angiotensin  (ISO)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (ISO)
regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
regulation of vasoconstriction  (ISO)
renin secretion into blood stream  (ISO)
renin-angiotensin regulation of aldosterone production  (IMP,ISO)
response to activity  (IEP)
response to angiotensin  (IEP)
response to corticosterone  (IEP)
response to estrogen  (IDA,IEP)
response to salt stress  (IEP)
Rho protein signal transduction  (ISO)
vascular associated smooth muscle cell proliferation  (ISO)
vasoconstriction  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
angiotensin II signaling pathway  (TAS)
angiotensin II signaling pathway via AT1 receptor  (IDA,IMP,TAS)
angiotensin III signaling pathway  (TAS)
angiotensin III signaling pathway via AT1 receptor  (IMP)
atenolol pharmacodynamics pathway  (ISO)
benazepril pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
calcium/calcium-mediated signaling pathway  (IEA)
candesartan pharmacodynamics pathway  (ISO)
captopril pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
cilazapril pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
enalapril pharmacodynamics pathway  (ISO)
eprosartan pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
forasartsn pharmacodynamics pathway  (ISO)
fosinopril pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
G protein mediated signaling pathway via Galpha12/Galpha13 family  (IMP)
G protein mediated signaling pathway via Galphaq family  (IMP)
ibutilide pharmacodynamics pathway  (ISO)
irbesartan pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lisinopril pharmacodynamics pathway  (ISO)
losartan pharmacodynamics pathway  (ISO,TAS)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
moexipril pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
olmesartan pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
perindopril pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinapril pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
ramipril pharmacodynamics pathway  (ISO)
renin-angiotensin cascade pathway  (IEA,TAS)
sotalol pharmacodynamics pathway  (ISO)
spirapril pharmacodynamics pathway  (ISO)
telmisartan pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
trandolapril pharmacodynamics pathway  (ISO)
valsartan pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits. Abdollahi MR, etal., Hum Mutat. 2007 Jan 8;28(4):365-373.
2. Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor. Ali MS, etal., J Biol Chem. 1997 Sep 12;272(37):23382-8.
3. Genotypic interactions of renin-angiotensin system genes in myocardial infarction. Araujo MA, etal., Int J Cardiol. 2005 Aug 3;103(1):27-32. Epub 2004 Dec 15.
4. Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: involvement of ACE2-Ang (1-7)-mas axis. Arumugam S, etal., Toxicology. 2012 Jan 27;291(1-3):139-45. doi: 10.1016/j.tox.2011.11.008. Epub 2011 Nov 23.
5. Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat. Baiardi G, etal., Regul Pept. 2005 Jan 15;124(1-3):7-17.
6. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
7. Differential responses to salt supplementation in adult male and female rat adrenal glands following intrauterine growth restriction. Bibeau K, etal., J Endocrinol. 2011 Apr;209(1):85-94. Epub 2011 Feb 8.
8. Gene polymorphisms of ACE and the angiotensin receptor AT2R1 influence serum ACE levels in sarcoidosis. Biller H, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2009 Jul;26(2):139-46.
9. Renal expression of angiotensin receptors in long-term diabetes and the effects of angiotensin type 1 receptor blockade. Bonnet F, etal., J Hypertens. 2002 Aug;20(8):1615-24.
10. Delineation of the intimate details of the backbone conformation of pyridine nucleotide coenzymes in aqueous solution. Bose KS and Sarma RH, Biochem Biophys Res Commun 1975 Oct 27;66(4):1173-9.
11. Effect of celecoxib on the antihypertensive effect of losartan in a rat model of renovascular hypertension. Boshra V, etal., Can J Physiol Pharmacol. 2011 Feb;89(2):103-7.
12. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
13. [Association of the renin-angiotensin system gene polymorphism with nephropathy in type II diabetes]. Buraczynska M, etal., Pol Arch Med Wewn. 2002 Aug;108(2):725-30.
14. Angiotensin type 2 receptor antagonism confers renal protection in a rat model of progressive renal injury. Cao Z, etal., J Am Soc Nephrol. 2002 Jul;13(7):1773-87.
15. Mutant animal models of stroke and gene expression: the stroke-prone spontaneously hypertensive rat. Carswell HV, etal., Methods Mol Med 2005;104:49-74.
16. MiR-133a regulates collagen 1A1: potential role of miR-133a in myocardial fibrosis in angiotensin II-dependent hypertension. Castoldi G, etal., J Cell Physiol. 2012 Feb;227(2):850-6. doi: 10.1002/jcp.22939.
17. Tubular expression of angiotensin II receptors and their regulation in IgA nephropathy. Chan LY, etal., J Am Soc Nephrol. 2005 Aug;16(8):2306-17. Epub 2005 Jun 1.
18. Upregulation of angiotensin II receptors in reflux nephropathy. Chertin B, etal., J Pediatr Surg. 2002 Feb;37(2):251-5.
19. Polymorphism in the angiotensin II type 1 receptor (AGTR1) is associated with age at diagnosis in pulmonary arterial hypertension. Chung WK, etal., J Heart Lung Transplant. 2009 Apr;28(4):373-9.
20. First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia. Coelho NR, etal., Pharmacol Res. 2020 Sep;159:104869. doi: 10.1016/j.phrs.2020.104869. Epub 2020 May 19.
21. Association between the A1166C polymorphism of the angiotensin II receptor type 1 and progression of chronic renal insufficiency. Coll E, etal., J Nephrol. 2003 May-Jun;16(3):357-64.
22. Angiotensin II receptor type 1 is upregulated in atrial tissue of patients with rheumatic valvular disease with atrial fibrillation. Cong H, etal., J Thorac Cardiovasc Surg. 2010 Aug;140(2):298-304. Epub 2010 Jan 18.
23. Chronic infusion of angiotensin receptor antagonists in the hypothalamic paraventricular nucleus prevents hypertension in a rat model of sleep apnea. da Silva AQ, etal., Brain Res. 2011 Jan 12;1368:231-8. Epub 2010 Oct 30.
24. Involvement of the AT1 receptor in the venoconstriction induced by angiotensin II in both the inferior vena cava and femoral vein. da Silva OG, etal., Peptides. 2011 Jan;32(1):112-7. Epub 2010 Oct 16.
25. International union of pharmacology. XXIII. The angiotensin II receptors. de Gasparo M, etal., Pharmacol Rev. 2000 Sep;52(3):415-72.
26. Expression of cardiac angiotensin II AT1 receptor genes in rat hearts is regulated by steroids but not by angiotensin II. Della Bruna R, etal., J Hypertens. 1995 Jul;13(7):763-9.
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35. Angiotensin II AT-1A receptor immunolabeling in rat medial nucleus tractus solitarius neurons: subcellular targeting and relationships with catecholamines. Glass MJ, etal., Neuroscience. 2005;130(3):713-23.
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38. Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane. Guo DF, etal., Biochem Biophys Res Commun. 2003 Oct 31;310(4):1254-65.
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41. Angiotensin receptor subtypes in thin and muscular juxtamedullary efferent arterioles of rat kidney. Helou CM, etal., Am J Physiol Renal Physiol 2003 Sep;285(3):F507-14. Epub 2003 May 6.
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43. Androgen increases AT1a receptor expression in abdominal aortas to promote angiotensin II-induced AAAs in apolipoprotein E-deficient mice. Henriques T, etal., Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1251-6. Epub 2008 May 1.
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45. Radionuclide imaging of angiotensin II type 1 receptor upregulation after myocardial ischemia-reperfusion injury. Higuchi T, etal., J Nucl Med. 2010 Dec;51(12):1956-61. Epub 2010 Nov 15.
46. Maternal Resveratrol Therapy Protects Male Rat Offspring against Programmed Hypertension Induced by TCDD and Dexamethasone Exposures: Is It Relevant to Aryl Hydrocarbon Receptor? Hsu CN, etal., Int J Mol Sci. 2018 Aug 20;19(8):2459. doi: 10.3390/ijms19082459.
47. Maternal Tryptophan Supplementation Protects Adult Rat Offspring against Hypertension Programmed by Maternal Chronic Kidney Disease: Implication of Tryptophan-Metabolizing Microbiome and Aryl Hydrocarbon Receptor. Hsu CN, etal., Int J Mol Sci. 2020 Jun 26;21(12):4552. doi: 10.3390/ijms21124552.
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49. Reactive oxygen species-mediated homologous downregulation of angiotensin II type 1 receptor mRNA by angiotensin II. Ichiki T, etal., Hypertension 2001 Feb;37(2 Part 2):535-40.
50. Attenuation of hypertension-mediated glomerulosclerosis in conjunction with increased angiotensin (1-7). Igase M, etal., Ther Adv Cardiovasc Dis. 2011 Dec;5(6):297-304. doi: 10.1177/1753944711429343. Epub 2011 Nov 16.
51. Alterations in sarcoplasmic reticulum and angiotensin II type 1 receptor gene expression after myocardial infarction in rats. Iijima K, etal., Jpn Circ J. 1998 Jun;62(6):449-54.
52. Gene Expression Profiling Distinguishes Between Spontaneous and Radiation-induced Rat Mammary Carcinomas. Imaoka T, etal., J Radiat Res (Tokyo). 2008 Apr 16;.
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72. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
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79. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
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84. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
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86. Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling. Paradis P, etal., Proc Natl Acad Sci U S A 2000 Jan 18;97(2):931-6.
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88. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
89. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
90. The luminal membrane of rat thick limb expresses AT1 receptor and aminopeptidase activities. Poumarat JS, etal., Kidney Int. 2002 Aug;62(2):434-45.
91. Renin-angiotensin polymorphisms and QTc interval prolongation in end-stage renal disease. Raizada V, etal., Kidney Int. 2005 Sep;68(3):1186-9.
92. Angiotensin III: a central regulator of vasopressin release and blood pressure. Reaux A, etal., Trends Endocrinol Metab. 2001 May-Jun;12(4):157-62.
93. GOA pipeline RGD automated data pipeline
94. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
95. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
96. AT-1 receptor and phospholipase C are involved in angiotensin III modulation of hypothalamic noradrenergic transmission. Rodriguez-Campos M, etal., Cell Mol Neurobiol. 2000 Dec;20(6):747-62.
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98. Evidence for the importance of angiotensin II type 1 receptor in ischemia-induced angiogenesis. Sasaki K, etal., J Clin Invest 2002 Mar;109(5):603-11.
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101. Angiotensin-II type 1 receptor and NOX2 mediate TCF/LEF and CREB dependent WISP1 induction and cardiomyocyte hypertrophy. Shanmugam P, etal., J Mol Cell Cardiol. 2011 Mar 2.
102. Effects of dexamethasone exposure on rat metanephric development: in vitro and in vivo studies. Singh RR, etal., Am J Physiol Renal Physiol. 2007 Aug;293(2):F548-54. Epub 2007 May 30.
103. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
104. Transcriptional suppression of type 1 angiotensin II receptor gene expression by peroxisome proliferator-activated receptor-gamma in vascular smooth muscle cells. Sugawara A, etal., Endocrinology 2001 Jul;142(7):3125-34.
105. Salt-induced renal injury in SHRs is mediated by AT1 receptor activation. Susic D, etal., J Hypertens. 2011 Apr;29(4):716-23.
106. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
107. Angiotensin II type 1 receptor blockade prevents up-regulation of angiotensin II type 1A receptors in rat injured artery. Tazawa S, etal., J Pharmacol Exp Ther. 1999 Feb;288(2):898-904.
108. G Protein-Coupled Receptors Directly Bind Filamin A with High Affinity and Promote Filamin Phosphorylation. Tirupula KC, etal., Biochemistry. 2015 Nov 10;54(44):6673-83. doi: 10.1021/acs.biochem.5b00975. Epub 2015 Nov 2.
109. Renoprotective mechanisms of angiotensin II antagonism in experimental chronic renal failure. Uhlenius N, etal., Kidney Blood Press Res. 2002;25(2):71-9.
110. Addition of angiotensin II type 1 receptor blocker to CCR2 antagonist markedly attenuates crescentic glomerulonephritis. Urushihara M, etal., Hypertension. 2011 Mar;57(3):586-93. Epub 2011 Jan 31.
111. Inhibition of corneal neovascularization by blocking the angiotensin II type 1 receptor. Usui T, etal., Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4370-6. doi: 10.1167/iovs.07-0964.
112. Selective silencing of angiotensin receptor subtype 1a (AT1aR) by RNA interference. Vazquez J, etal., Hypertension. 2005 Jan;45(1):115-9. Epub 2004 Nov 29.
113. Positive feedback regulation of angiotensin II-AT1B receptor gene expression in rat adrenal glands. Wagner C and Kurtz A, Pflugers Arch. 1998 Aug;436(3):323-8.
114. Regulation of type 1 angiotensin II receptor and its subtype gene expression in kidney by sodium loading and angiotensin II infusion. Wang DH, etal., J Hypertens. 1996 Dec;14(12):1409-15.
115. [Role of angiotensin II type 1 receptor in activation of nuclear factor-kappaB and activator protein-1 in lung of mice with acute lung injury]. Wang F, etal., Zhonghua Shao Shang Za Zhi. 2010 Apr;26(2):113-6.
116. Effect of valsartan on the expression of angiotensin II receptors in the lung of chronic antigen exposure rats. Wang T, etal., Chin Med J (Engl). 2008 Nov 20;121(22):2312-9.
117. Angiotensin II type 2 receptor antagonist reduces bleomycin-induced pulmonary fibrosis in mice. Waseda Y, etal., Respir Res. 2008 May 23;9:43.
118. Estrogen regulates adrenal angiotensin AT1 receptors by modulating AT1 receptor translation. Wu Z, etal., Endocrinology. 2003 Jul;144(7):3251-61.
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120. Exercise training combined with angiotensin II receptor blockade limits post-infarct ventricular remodelling in rats. Xu X, etal., Cardiovasc Res. 2008 Jun 1;78(3):523-32. doi: 10.1093/cvr/cvn028. Epub 2008 Feb 5.
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Genomics

Comparative Map Data
Agtr1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21734,173,446 - 34,226,892 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1734,174,429 - 34,226,946 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1734,003,015 - 34,054,637 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01735,606,893 - 35,658,508 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01733,998,820 - 34,050,440 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01735,907,102 - 35,958,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1735,907,108 - 35,958,077 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01737,217,810 - 37,270,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41740,629,318 - 40,684,982 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11740,632,160 - 40,687,823 (-)NCBI
Celera1733,705,975 - 33,757,157 (-)NCBICelera
Cytogenetic Map17p12NCBI
AGTR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383148,697,903 - 148,743,003 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3148,697,784 - 148,743,008 (+)EnsemblGRCh38hg38GRCh38
GRCh373148,415,690 - 148,460,790 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363149,898,348 - 149,943,480 (+)NCBINCBI36Build 36hg18NCBI36
Build 343149,940,284 - 149,943,486NCBI
Celera3146,826,000 - 146,871,131 (+)NCBICelera
Cytogenetic Map3q24NCBI
HuRef3145,788,031 - 145,833,163 (+)NCBIHuRef
CHM1_13148,378,782 - 148,423,918 (+)NCBICHM1_1
T2T-CHM13v2.03151,448,936 - 151,494,033 (+)NCBIT2T-CHM13v2.0
Agtr1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391330,520,339 - 30,566,850 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1330,520,424 - 30,566,850 (+)EnsemblGRCm39 Ensembl
GRCm381330,336,356 - 30,382,867 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1330,336,441 - 30,382,867 (+)EnsemblGRCm38mm10GRCm38
MGSCv371330,428,225 - 30,474,736 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361330,343,922 - 30,390,332 (+)NCBIMGSCv36mm8
Celera1330,550,710 - 30,597,281 (+)NCBICelera
Cytogenetic Map13A3.2NCBI
cM Map1313.19NCBI
Agtr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554748,733,942 - 8,781,255 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554748,733,942 - 8,781,305 (-)NCBIChiLan1.0ChiLan1.0
AGTR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan13146,599,078 - 146,643,902 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03145,722,475 - 145,767,550 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13153,301,331 - 153,346,268 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3153,341,947 - 153,345,380 (+)Ensemblpanpan1.1panPan2
AGTR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12343,569,658 - 43,617,113 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2343,614,035 - 43,616,238 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2343,434,074 - 43,481,582 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02344,190,631 - 44,238,133 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12343,779,664 - 43,827,179 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02343,832,799 - 43,880,312 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02344,086,806 - 44,134,323 (+)NCBIUU_Cfam_GSD_1.0
Agtr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560282,859,961 - 82,902,941 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365196,831,096 - 6,873,985 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365196,831,096 - 6,873,977 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGTR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1388,934,868 - 88,983,105 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11388,934,873 - 88,980,317 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21396,933,114 - 96,978,419 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AGTR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11541,957,826 - 42,002,776 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604114,800,710 - 14,845,597 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Agtr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473025,964,811 - 26,006,463 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473025,964,848 - 26,006,468 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Agtr1a
243 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:89
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000038532
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172702794936146731Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173199078450909196Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat

Markers in Region
D17Arb4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,225,566 - 34,225,727 (+)MAPPERmRatBN7.2
mRatBN7.21734,225,481 - 34,225,727 (+)MAPPERmRatBN7.2
mRatBN7.21734,225,481 - 34,225,872 (+)MAPPERmRatBN7.2
Rnor_6.01735,956,457 - 35,957,000NCBIRnor6.0
Rnor_6.01735,956,457 - 35,956,698NCBIRnor6.0
Rnor_5.01737,268,920 - 37,269,463UniSTSRnor5.0
Rnor_5.01737,268,920 - 37,269,161UniSTSRnor5.0
RGSC_v3.41740,683,664 - 40,683,905UniSTSRGSC3.4
RGSC_v3.41740,683,663 - 40,683,905RGDRGSC3.4
RGSC_v3.11740,686,504 - 40,686,746RGD
SHRSP x BN Map1726.9699RGD
SHRSP x BN Map1726.9699UniSTS
Cytogenetic Map17q12UniSTS
D17Mco9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,227,036 - 34,227,298 (+)MAPPERmRatBN7.2
Rnor_6.01735,958,310 - 35,958,571NCBIRnor6.0
Rnor_5.01737,270,773 - 37,271,034UniSTSRnor5.0
RGSC_v3.41740,685,215 - 40,685,476UniSTSRGSC3.4
Celera1733,757,390 - 33,757,651UniSTS
Cytogenetic Map17q12UniSTS
D17Mco8  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01737,271,013 - 37,271,345UniSTSRnor5.0
Celera1733,757,630 - 33,757,962UniSTS
Cytogenetic Map17q12UniSTS
D17Wox34  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,227,276 - 34,227,609 (+)MAPPERmRatBN7.2
Rnor_6.01735,958,550 - 35,958,882NCBIRnor6.0
Rnor_5.01737,271,013 - 37,271,345UniSTSRnor5.0
RGSC_v3.41740,685,455 - 40,685,787UniSTSRGSC3.4
Celera1733,757,630 - 33,757,962UniSTS
Cytogenetic Map17q12UniSTS
RH94717  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,174,927 - 34,175,204 (+)MAPPERmRatBN7.2
Rnor_6.01735,907,271 - 35,907,547NCBIRnor6.0
Rnor_5.01737,218,997 - 37,219,273UniSTSRnor5.0
RGSC_v3.41740,629,483 - 40,629,759UniSTSRGSC3.4
Celera1733,706,140 - 33,706,416UniSTS
Cytogenetic Map17q12UniSTS
Agtr1a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22102,846,542 - 102,846,612 (+)MAPPERmRatBN7.2
Rnor_6.02105,150,594 - 105,150,663NCBIRnor6.0
Rnor_5.02124,880,836 - 124,880,905UniSTSRnor5.0
RGSC_v3.42105,504,843 - 105,504,912UniSTSRGSC3.4
Celera298,216,100 - 98,216,169UniSTS
Cytogenetic Map2q24UniSTS
Cytogenetic Map17q12UniSTS
RH130649  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,174,980 - 34,175,163 (+)MAPPERmRatBN7.2
Rnor_6.01735,907,324 - 35,907,506NCBIRnor6.0
Rnor_5.01737,219,050 - 37,219,232UniSTSRnor5.0
RGSC_v3.41740,629,536 - 40,629,718UniSTSRGSC3.4
Celera1733,706,193 - 33,706,375UniSTS
Cytogenetic Map17q12UniSTS
UniSTS:256385  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,175,936 - 34,176,577 (+)MAPPERmRatBN7.2
mRatBN7.22102,846,237 - 102,846,878 (+)MAPPERmRatBN7.2
Rnor_6.02105,150,289 - 105,150,929NCBIRnor6.0
Rnor_6.01735,908,280 - 35,908,920NCBIRnor6.0
Rnor_5.01737,220,006 - 37,220,646UniSTSRnor5.0
Rnor_5.02124,880,531 - 124,881,171UniSTSRnor5.0
RGSC_v3.41740,630,492 - 40,631,132UniSTSRGSC3.4
RGSC_v3.42105,504,538 - 105,505,178UniSTSRGSC3.4
Celera298,215,795 - 98,216,435UniSTS
Celera1733,707,149 - 33,707,789UniSTS
Cytogenetic Map2q24UniSTS
Cytogenetic Map17q12UniSTS
Agtr1a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21734,175,886 - 34,176,577 (+)MAPPERmRatBN7.2
Rnor_6.01735,908,230 - 35,908,920NCBIRnor6.0
Rnor_5.01737,219,956 - 37,220,646UniSTSRnor5.0
RGSC_v3.41740,630,442 - 40,631,132UniSTSRGSC3.4
Celera1733,707,099 - 33,707,789UniSTS
Cytogenetic Map17q12UniSTS


Genetic Models
This gene Agtr1a is modified in the following models/strains:
SS-Agtr1aem1Mcwi     SS-Agtr1aem5Mcwi    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 47 39 5 39 1 1 35 18 11 1
Low 2 37 10 2 14 2 7 10 70 20 7
Below cutoff 6 4 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000038532   ⟹   ENSRNOP00000034687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1734,174,429 - 34,226,946 (-)Ensembl
Rnor_6.0 Ensembl1735,907,108 - 35,958,077 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102465   ⟹   ENSRNOP00000091615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1734,174,444 - 34,226,675 (-)Ensembl
RefSeq Acc Id: NM_030985   ⟹   NP_112247
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21734,174,763 - 34,226,804 (-)NCBI
Rnor_6.01735,907,106 - 35,958,077 (-)NCBI
Rnor_5.01737,217,810 - 37,270,540 (-)NCBI
RGSC_v3.41740,629,318 - 40,684,982 (-)RGD
Celera1733,705,975 - 33,757,157 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253882   ⟹   XP_006253944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21734,173,446 - 34,226,647 (-)NCBI
Rnor_6.01735,907,102 - 35,957,940 (-)NCBI
Rnor_5.01737,217,810 - 37,270,540 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771594   ⟹   XP_008769816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21734,173,446 - 34,226,892 (-)NCBI
Rnor_6.01735,907,102 - 35,958,136 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095335   ⟹   XP_038951263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21734,173,446 - 34,226,892 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_112247   ⟸   NM_030985
- UniProtKB: Q9QVS5 (UniProtKB/Swiss-Prot),   P25095 (UniProtKB/Swiss-Prot),   A6J7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253944   ⟸   XM_006253882
- Peptide Label: isoform X1
- UniProtKB: Q9QVS5 (UniProtKB/Swiss-Prot),   P25095 (UniProtKB/Swiss-Prot),   A6J7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769816   ⟸   XM_008771594
- Peptide Label: isoform X1
- UniProtKB: Q9QVS5 (UniProtKB/Swiss-Prot),   P25095 (UniProtKB/Swiss-Prot),   A6J7M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000034687   ⟸   ENSRNOT00000038532
RefSeq Acc Id: XP_038951263   ⟸   XM_039095335
- Peptide Label: isoform X1
- UniProtKB: P25095 (UniProtKB/Swiss-Prot),   Q9QVS5 (UniProtKB/Swiss-Prot),   A6J7M4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000091615   ⟸   ENSRNOT00000102465
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AT1a I-TASSER model P25095 1-359 view protein structure
AF-P25095-F1-model_v2 AlphaFold P25095 1-359 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700428
Promoter ID:EPDNEW_R10952
Type:multiple initiation site
Name:Agtr1a_1
Description:angiotensin II receptor, type 1a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01735,958,089 - 35,958,149EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2070 AgrOrtholog
BioCyc Gene G2FUF-9530 BioCyc
Ensembl Genes ENSRNOG00000018346 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000038532 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000102465 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7126918 IMAGE-MGC_LOAD
InterPro ATII_AT1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATII_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24180 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93396 IMAGE-MGC_LOAD
NCBI Gene 24180 ENTREZGENE
PANTHER C-C CHEMOKINE RECEPTOR TYPE 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CELL ADHESION MOLECULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB AGTR1 RGD
PhenoGen Agtr1a PhenoGen
PRINTS ANGIOTENSINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANGIOTENSN1R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018346 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6J7M4 ENTREZGENE, UniProtKB/TrEMBL
  AGTRA_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9QVS5 ENTREZGENE
UniProt Secondary Q9QVS5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-04-03 Agtr1a  angiotensin II receptor, type 1a  Agtr1  angiotensin II receptor, type 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Agtr1  angiotensin II receptor, type 1  Agtr1a  angiotensin II receptor, type 1a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Agtr1a  angiotensin II receptor, type 1a  Agtr1a  angiotensin II receptor, type 1 (AT1A)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Agtr1a  angiotensin receptor 1a      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in adrenal gland, liver and kidney 1298647
gene_expression expression is increased in brain microvessels in SHRSP strain compared with WKY rat strain 1553895
gene_function receptor for angiotensin II 68888
gene_function receptor for angiotensin II 69670
gene_process activation induces cell contraction, proliferation and migration in vascular smooth muscle cells (VSMCs) 68888
gene_process activation induces cell contraction, proliferation and migration in vascular smooth muscle cells (VSMCs) 69670
gene_process functions to regulate aldosterone secretion and to control blood pressure and cardiac volume 68888
gene_process functions to regulate aldosterone secretion and to control blood pressure and cardiac volume 69670
gene_process may be involved in regulating myocardial efficiency and ischemic contracture 1298607
gene_process couples to intracellular Ca2+ signaling with vasoconstricting effects on glomerular arterioles 1298648
gene_regulation repressed by peroxisome proliferator activated receptor gamma (Pparg) through inhibition of Sp1 via a protein-protein interaction 69670
gene_regulation activation in vascular smooth muscle cells (VSMCs) is mainly through several signaling transduction pathways, including tyrosine kinases and mitogen activated protein kinase 69670
gene_regulation transcription may be regulated by sodium in adrenal tissue 1298647
gene_regulation expression may be developmentally regulated 1298647