Adrb3 (adrenoceptor beta 3) - Rat Genome Database

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Gene: Adrb3 (adrenoceptor beta 3) Rattus norvegicus
Symbol: Adrb3
Name: adrenoceptor beta 3
RGD ID: 2061
Description: Enables epinephrine binding activity and norepinephrine binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and eating behavior. Predicted to be located in membrane. Predicted to be part of receptor complex. Biomarker of colitis; congestive heart failure; and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); dilated cardiomyopathy 1H; metabolic dysfunction-associated steatotic liver disease; and type 2 diabetes mellitus. Orthologous to human ADRB3 (adrenoceptor beta 3); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; calcium/calcium-mediated signaling pathway; endocytosis pathway; INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; (R)-octopamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ADRB; adrenergic receptor, beta 3; adrenergic, beta-3-, receptor; beta-3 adrenergic receptor; beta-3 adrenoceptor; beta-3 adrenoreceptor
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Arunc1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81671,544,603 - 71,547,410 (+)NCBIGRCr8
mRatBN7.21664,839,820 - 64,844,552 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1664,841,788 - 64,844,552 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1670,125,571 - 70,128,335 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01673,531,913 - 73,534,677 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01668,777,172 - 68,779,936 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01669,003,541 - 69,006,632 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1669,003,868 - 69,006,632 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01668,673,983 - 68,676,747 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41669,163,620 - 69,166,384 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11669,163,825 - 69,166,590 (+)NCBI
Celera1662,763,279 - 62,766,043 (+)NCBICelera
RH 3.4 Map16573.12RGD
Cytogenetic Map16q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
(R)-octopamine  (EXP,ISO)
1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (ISO)
alprenolol  (ISO)
Amibegron  (EXP,ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
atenolol  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP,ISO)
CGP 12177  (EXP,ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
clenbuterol  (EXP)
clofibrate  (ISO)
colforsin daropate hydrochloride  (ISO)
Cuprizon  (EXP)
D-glucose  (ISO)
dehydroepiandrosterone  (EXP)
dexamethasone  (ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
diiodine  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
dobutamine  (EXP)
ethanol  (ISO)
fenoterol  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formoterol fumarate  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (ISO)
glucose  (ISO)
griseofulvin  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
ICI 118551  (EXP,ISO)
isoprenaline  (EXP,ISO)
kojic acid  (ISO)
L-methionine  (ISO)
Licarin A  (ISO)
mangiferin  (ISO)
methimazole  (EXP)
metoprolol  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
octopamine  (EXP,ISO)
ozone  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenytoin  (EXP)
pindolol  (EXP,ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propranolol  (ISO)
pyruvic acid  (ISO)
rac-lactic acid  (ISO)
Salmeterol xinafoate  (ISO)
sodium arsenite  (ISO)
solabegron  (ISO)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
terbutaline  (EXP,ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
valproic acid  (EXP)
zinc oxide  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. An association between the Trp64Arg polymorphism in the beta3-adrenergic receptor gene and endometrial cancer and obesity. Babol K, etal., J Exp Clin Cancer Res. 2004 Dec;23(4):669-74.
2. betaAR signaling required for diet-induced thermogenesis and obesity resistance. Bachman ES, etal., Science 2002 Aug 2;297(5582):843-5.
3. Mepartricin long-term administration regulates steroid hormone and adrenergic receptor concentrations in the prostate of aged rats. Barbero R, etal., J Vet Pharmacol Ther. 2006 Aug;29(4):289-97.
4. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
5. The rat beta 3-adrenergic receptor gene contains an intron. Bensaid M, etal., FEBS Lett 1993 Mar 8;318(3):223-6.
6. Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytes. Boivin B, etal., Cardiovasc Res. 2006 Jul 1;71(1):69-78. Epub 2006 Mar 24.
7. beta1, beta2, and beta3 adrenoceptors and Na+/H+ exchanger regulatory factor 1 expression in human bronchi and their modifications in cystic fibrosis. Bossard F, etal., Am J Respir Cell Mol Biol. 2011 Jan;44(1):91-8. Epub 2010 Mar 4.
8. Metabolic syndrome and ADRB3 gene polymorphism in severely obese patients from South Italy. Bracale R, etal., Eur J Clin Nutr. 2007 Oct;61(10):1213-9. Epub 2007 Feb 14.
9. Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. Clement K, etal., N Engl J Med 1995 Aug 10;333(6):352-4.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Molecular cloning and expression of the rat beta 3-adrenergic receptor. Granneman JG, etal., Mol Pharmacol 1991 Dec;40(6):895-9.
13. Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci. Hamilton G, etal., Am J Med Genet B Neuropsychiatr Genet. 2007 Jun 5;144B(4):508-16.
14. Association of a genetic variation in the beta 3-adrenergic receptor gene with coronary heart disease among Japanese. Higashi K, etal., Biochem Biophys Res Commun. 1997 Mar 27;232(3):728-30.
15. Polymorphism of the human beta3-adrenoceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor function. Hoffstedt J, etal., Diabetes. 1999 Jan;48(1):203-5.
16. Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting. Jimenez M, etal., FEBS Lett. 2002 Oct 23;530(1-3):37-40.
17. Association of beta3-adrenergic receptor gene polymorphism with insulin resistance in Japanese-American men. Kawamura T, etal., Metabolism. 1999 Nov;48(11):1367-70.
18. Studies on the expression and function of beta-3-adrenoceptors in the colon of rats with acetic acid-induced colitis. Khan I, etal., Pharmacology. 2002 Feb;64(2):98-105.
19. Beta3-adrenergic regulation of leptin, food intake, and adiposity is impaired with age. Kumar MV, etal., Pflugers Arch. 1999 Oct;438(5):681-8.
20. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
21. Intense exercise training induces adaptation in expression and responsiveness of cardiac beta-adrenoceptors in diabetic rats. Lahaye Sle D, etal., Cardiovasc Diabetol. 2010 Nov 5;9:72.
22. A novel missense mutation in ADRB3 increases risk for type 2 diabetes in a Mexican American family. Lehman DM, etal., Diabetes Metab Res Rev. 2006 Jul-Aug;22(4):331-6.
23. [Dynamic changes of alpha-AR, beta1-AR and beta2-AR expression during hepatic fibrogenesis]. Liu N, etal., Zhonghua Gan Zang Bing Za Zhi. 2009 Sep;17(9):653-6.
24. Gender effects on adrenergic receptor expression and lipolysis in white adipose tissue of rats. Llado I, etal., Obes Res 2002 Apr;10(4):296-305.
25. The complex of human Gs protein with the beta 3 adrenergic receptor: a computer-aided molecular modeling study. Mahmoudian M J Mol Graph. 1994 Mar;12(1):22-8, 34.
26. Acupuncture and exercise restore adipose tissue expression of sympathetic markers and improve ovarian morphology in rats with dihydrotestosterone-induced PCOS. Manneras L, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Apr;296(4):R1124-31. Epub 2009 Jan 21.
27. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
28. Upregulation of beta(3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium. Moniotte S, etal., Circulation. 2001 Mar 27;103(12):1649-55.
29. Sepsis is associated with an upregulation of functional beta3 adrenoceptors in the myocardium. Moniotte S, etal., Eur J Heart Fail. 2007 Dec;9(12):1163-71. Epub 2007 Nov 19.
30. Effect of the combination of the variants -75G/A APOA1 and Trp64Arg ADRB3 on the risk of type 2 diabetes (DM2). Morcillo S, etal., Clin Endocrinol (Oxf). 2008 Jan;68(1):102-7. Epub 2007 Aug 28.
31. Polymorphism of the beta3-adrenergic receptor and lipid profile in patients with rheumatoid arthritis and systemic lupus erythematosus treated with chloroquine. Munoz-Valle JF, etal., Rheumatol Int. 2003 May;23(3):99-103. Epub 2003 Mar 12.
32. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. Polymorphisms of interleukin-1 beta and beta 3-adrenergic receptor in Japanese patients with nonalcoholic steatohepatitis. Nozaki Y, etal., Alcohol Clin Exp Res. 2004 Aug;28(8 Suppl Proceedings):106S-110S.
34. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. The codon 64 polymorphism of the beta3-adrenergic receptor gene is not associated with coronary heart disease or insulin resistance in nondiabetic subjects and non-insulin-dependent diabetic patients. Pulkkinen A, etal., Metabolism. 1999 Jul;48(7):853-6.
37. GOA pipeline RGD automated data pipeline
38. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
39. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
40. Comprehensive gene review and curation RGD comprehensive gene curation
41. The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is associated with hypertension in men with type 2 diabetes mellitus. Ringel J, etal., Am J Hypertens. 2000 Sep;13(9):1027-31.
42. Role of the adrenergic system in a mouse model of oxygen-induced retinopathy: antiangiogenic effects of beta-adrenoreceptor blockade. Ristori C, etal., Invest Ophthalmol Vis Sci. 2011 Jan 5;52(1):155-70. Print 2011 Jan.
43. Beta 3-adrenoreceptor gene polymorphism: a newly identified risk factor for proliferative retinopathy in NIDDM patients. Sakane N, etal., Diabetes. 1997 Oct;46(10):1633-6.
44. Trp64Arg mutation of beta3-adrenoceptor gene is associated with diabetic nephropathy in Type II diabetes mellitus. Sakane N, etal., Diabetologia. 1998 Dec;41(12):1533-4.
45. No evidence for an association between genetic polymorphisms of beta(2)- and beta(3)-adrenergic receptor genes with body mass index in Aymara natives from Chile. Santos JL, etal., Nutrition. 2002 Mar;18(3):255-8.
46. Differential down-regulation of beta3-adrenergic receptor mRNA and signal transduction by cold exposure in brown adipose tissue of young and senescent rats. Scarpace PJ, etal., Pflugers Arch. 1999 Feb;437(3):479-83.
47. Diet-induced obese mice are leptin insufficient after weight reduction. Shi H, etal., Obesity (Silver Spring). 2009 Sep;17(9):1702-9. Epub 2009 Apr 16.
48. The beta3-adrenergic receptor Trp64Arg mutation is not associated with coronary artery disease. Stangl K, etal., Metabolism. 2001 Feb;50(2):184-8.
49. Testosterone modulation of cardiac beta-adrenergic signals in a rat model of heart failure. Sun J, etal., Gen Comp Endocrinol. 2011 Jul 1;172(3):518-25. Epub 2011 Apr 28.
50. Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetes. Surwit RS, etal., Endocrinology. 2000 Oct;141(10):3630-7.
51. Targeted disruption of the beta 3-adrenergic receptor gene. Susulic VS, etal., J Biol Chem. 1995 Dec 8;270(49):29483-92.
52. The beta3-adrenoceptor agonist SR58611A ameliorates experimental colitis in rats. Vasina V, etal., Neurogastroenterol Motil. 2008 Sep;20(9):1030-41. Epub 2008 May 15.
53. Beta3-adrenergic receptor polymorphism and the antiretroviral therapy-related lipodystrophy syndrome. Vonkeman HE, etal., AIDS. 2000 Jul 7;14(10):1463-4.
54. Positive correlation between Beta-3-Adrenergic Receptor (ADRB3) gene and gout in a Chinese male population. Wang B, etal., J Rheumatol. 2011 Apr;38(4):738-40. Epub 2011 Feb 1.
55. Polymorphisms of beta-adrenoceptor and natriuretic peptide receptor genes influence the susceptibility to and the severity of idiopathic dilated cardiomyopathy in a Chinese cohort. Wang L, etal., J Card Fail. 2010 Jan;16(1):36-44. Epub 2009 Sep 25.
56. Independent predictive roles of eotaxin Ala23Thr, paraoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on cardiac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients. Wang Y, etal., Diabet Med. 2010 Apr;27(4):376-83.
57. Deletion of Nhlh2 results in a defective torpor response and reduced Beta adrenergic receptor expression in adipose tissue. Wankhade UD, etal., PLoS One. 2010 Aug 23;5(8):e12324.
58. Effects of UCP2 -866 G/A and ADRB3 Trp64Arg on rosiglitazone response in Chinese patients with Type 2 diabetes. Yang M, etal., Br J Clin Pharmacol. 2009 Jul;68(1):14-22.
Additional References at PubMed
PMID:1721063   PMID:7738011   PMID:8889548   PMID:9305915   PMID:10358009   PMID:15123695   PMID:15750837   PMID:17092981   PMID:17131040   PMID:17440824   PMID:17600560   PMID:17631141  
PMID:18031735   PMID:18154937   PMID:18583384   PMID:18703049   PMID:18799656   PMID:19120133   PMID:19577538   PMID:19726315   PMID:20097768   PMID:20432431   PMID:20443655   PMID:20654104  
PMID:20661603   PMID:21046653   PMID:21661032   PMID:21901314   PMID:22248722   PMID:23008154   PMID:23373597   PMID:24055266   PMID:24161401   PMID:24220331   PMID:24378642   PMID:24727346  
PMID:25139049   PMID:25144690   PMID:25322941   PMID:25804391   PMID:25920933   PMID:28276515   PMID:28446460   PMID:29208473   PMID:29363058   PMID:29566368   PMID:29859189   PMID:30613975  
PMID:31295748   PMID:36884028   PMID:38278068  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81671,544,603 - 71,547,410 (+)NCBIGRCr8
mRatBN7.21664,839,820 - 64,844,552 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1664,841,788 - 64,844,552 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1670,125,571 - 70,128,335 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01673,531,913 - 73,534,677 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01668,777,172 - 68,779,936 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01669,003,541 - 69,006,632 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1669,003,868 - 69,006,632 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01668,673,983 - 68,676,747 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41669,163,620 - 69,166,384 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11669,163,825 - 69,166,590 (+)NCBI
Celera1662,763,279 - 62,766,043 (+)NCBICelera
RH 3.4 Map16573.12RGD
Cytogenetic Map16q12.3NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38837,962,990 - 37,966,599 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl837,962,990 - 37,966,599 (-)EnsemblGRCh38hg38GRCh38
GRCh37837,820,508 - 37,824,117 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36837,939,673 - 37,943,341 (-)NCBINCBI36Build 36hg18NCBI36
Build 34837,939,672 - 37,943,341NCBI
Celera836,772,222 - 36,775,893 (-)NCBICelera
Cytogenetic Map8p11.23NCBI
HuRef836,354,913 - 36,358,584 (-)NCBIHuRef
CHM1_1838,021,981 - 38,025,652 (-)NCBICHM1_1
T2T-CHM13v2.0838,239,389 - 38,242,998 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39827,715,804 - 27,720,833 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl827,715,804 - 27,740,644 (-)EnsemblGRCm39 Ensembl
GRCm38827,225,776 - 27,230,845 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl827,225,776 - 27,250,616 (-)EnsemblGRCm38mm10GRCm38
MGSCv37828,336,248 - 28,340,060 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36828,691,712 - 28,695,524 (-)NCBIMGSCv36mm8
Celera828,716,093 - 28,719,905 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map815.94NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_00495546313,663,064 - 13,665,553 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2756,524,236 - 56,529,230 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1832,241,318 - 32,246,461 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0837,263,730 - 37,267,475 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1834,440,099 - 34,444,043 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl834,441,311 - 34,443,949 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11627,445,601 - 27,446,796 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1627,445,601 - 27,447,521 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1627,962,835 - 27,964,030 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01629,344,866 - 29,346,061 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1629,344,866 - 29,346,786 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11627,566,781 - 27,567,975 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01628,144,259 - 28,145,454 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01628,183,588 - 28,184,783 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494350,047,746 - 50,068,949 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367101,411,446 - 1,413,098 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367101,410,589 - 1,413,279 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1548,475,144 - 48,479,562 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11548,468,803 - 48,478,370 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21555,481,787 - 55,489,921 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1835,993,553 - 35,998,200 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl835,994,775 - 35,997,060 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660526,000,510 - 6,004,793 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046247805,653,499 - 5,656,138 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Adrb3
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:307
Count of miRNA genes:171
Interacting mature miRNAs:197
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21664,843,935 - 64,844,184 (+)MAPPERmRatBN7.2
Rnor_6.01669,006,016 - 69,006,264NCBIRnor6.0
Rnor_5.01668,676,131 - 68,676,379UniSTSRnor5.0
RGSC_v3.41669,165,768 - 69,166,016UniSTSRGSC3.4
Celera1662,765,427 - 62,765,675UniSTS
RH 3.4 Map16573.12UniSTS
Cytogenetic Map16q12.3UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21664,842,153 - 64,842,231 (+)MAPPERmRatBN7.2
Rnor_6.01669,004,234 - 69,004,311NCBIRnor6.0
Rnor_5.01668,674,349 - 68,674,426UniSTSRnor5.0
RGSC_v3.41669,163,986 - 69,164,063UniSTSRGSC3.4
Celera1662,763,645 - 62,763,722UniSTS
Cytogenetic Map16q12.3UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21664,843,067 - 64,843,579 (+)MAPPERmRatBN7.2
Rnor_6.01669,005,148 - 69,005,659NCBIRnor6.0
Rnor_5.01668,675,263 - 68,675,774UniSTSRnor5.0
RGSC_v3.41669,164,900 - 69,165,411UniSTSRGSC3.4
Celera1662,764,559 - 62,765,070UniSTS
Cytogenetic Map16q12.3UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 4 2 1
Low 3 1 12 6 4 9 10 8
Below cutoff 19 2 2 4 2 6 6 37 11 19 1 6


RefSeq Acc Id: ENSRNOT00000016907   ⟹   ENSRNOP00000016907
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1664,841,788 - 64,844,552 (+)Ensembl
Rnor_6.0 Ensembl1669,003,868 - 69,006,632 (+)Ensembl
RefSeq Acc Id: NM_013108   ⟹   NP_037240
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81671,544,646 - 71,547,410 (+)NCBI
mRatBN7.21664,841,788 - 64,844,552 (+)NCBI
Rnor_6.01669,003,868 - 69,006,632 (+)NCBI
Rnor_5.01668,673,983 - 68,676,747 (+)NCBI
RGSC_v3.41669,163,620 - 69,166,384 (+)RGD
Celera1662,763,279 - 62,766,043 (+)RGD
RefSeq Acc Id: XM_008771315   ⟹   XP_008769537
Rat AssemblyChrPosition (strand)Source
GRCr81671,544,603 - 71,547,410 (+)NCBI
mRatBN7.21664,839,820 - 64,844,552 (+)NCBI
Rnor_6.01669,003,541 - 69,006,632 (+)NCBI
RefSeq Acc Id: NP_037240   ⟸   NM_013108
- UniProtKB: P26255 (UniProtKB/Swiss-Prot),   A6IVX3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769537   ⟸   XM_008771315
- Peptide Label: isoform X1
- UniProtKB: A6IVX2 (UniProtKB/TrEMBL),   A6IVX3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016907   ⟸   ENSRNOT00000016907
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26255-F1-model_v2 AlphaFold P26255 1-400 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2061 AgrOrtholog
BioCyc Gene G2FUF-11036 BioCyc
Ensembl Genes ENSRNOG00000012674 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016907 ENTREZGENE
  ENSRNOT00000016907.3 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADRB3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25645 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adrb3 PhenoGen
  ADRENRGCB3AR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012674 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-13 Adrb3  adrenoceptor beta 3  Adrb3  adrenergic, beta-3-, receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Adrb3  adrenergic, beta-3-, receptor  Adrb3  adrenergic receptor, beta 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Adrb3  adrenergic receptor, beta 3    Adrenergic receptor, beta 3  Name updated 625702 APPROVED
2002-06-10 Adrb3  Adrenergic receptor, beta 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in colon 632161
gene_expression expressed in adipose tissue 632162
gene_function binds to BRL 37344 with high affinity and to norepinephrine with lower affinity 632162
gene_process may be involved in an adrenergic signaling pathway 632162