Adm (adrenomedullin) - Rat Genome Database

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Gene: Adm (adrenomedullin) Rattus norvegicus
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Symbol: Adm
Name: adrenomedullin
RGD ID: 2047
Description: Enables adrenomedullin receptor binding activity. Involved in several processes, including androgen metabolic process; cAMP-mediated signaling; and regulation of heart contraction. Located in extracellular space. Used to study congestive heart failure and toxic shock syndrome. Biomarker of glomerulonephritis; hypertension; hypertrophic cardiomyopathy; obstructive jaundice; and ureteral obstruction. Human ortholog(s) of this gene implicated in brain infarction; breast cancer; pancreatic cancer; and pulmonary hypertension. Orthologous to human ADM (adrenomedullin); PARTICIPATES IN p38 MAPK signaling pathway; hypoxia inducible factor pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-hydroxy-5alpha-androstan-3-one.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adrenomedullin precursor; Ap; H39316; pro-adrenomedullin; RATAP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81174,164,178 - 174,182,372 (+)NCBIGRCr8
mRatBN7.21164,745,484 - 164,747,655 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,745,466 - 164,747,654 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1173,083,288 - 173,085,466 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01180,269,319 - 180,271,497 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01172,954,068 - 172,956,245 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01175,443,189 - 175,447,260 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1175,445,088 - 175,447,259 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01182,433,109 - 182,435,280 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41168,380,255 - 168,382,426 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11168,490,917 - 168,493,089 (+)NCBI
Celera1162,637,077 - 162,639,248 (+)NCBICelera
Cytogenetic Map1q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-butoxyethanol  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
alpha-Sanshool  (EXP)
ammonium chloride  (EXP)
antimony(0)  (ISO)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bucladesine  (ISO)
buta-1,3-diene  (ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon monoxide  (EXP)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDE  (EXP,ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
diethyl maleate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
diphenylcyclopropenone  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ferric oxide  (ISO)
fingolimod hydrochloride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
ionomycin  (EXP,ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
kenpaullone  (EXP)
leflunomide  (ISO)
letrozole  (EXP)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
malathion  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
mercaptopurine  (EXP)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
metacetamol  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
mycophenolic acid  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nitrates  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
nitroprusside  (EXP)
ochratoxin A  (EXP)
Octicizer  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pifithrin-?  (ISO)
pioglitazone  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
propranolol  (EXP)
prostaglandin E2  (ISO)
purine-6-thiol  (EXP)
quercetin  (ISO)
quinapril hydrochloride  (EXP)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
riddelliine  (EXP)
rotenone  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
SCH772984  (EXP)
serpentine asbestos  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
staurosporine  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
topotecan  (EXP)
tributyl phosphate  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vandetanib  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA,ISO)
adrenomedullin receptor signaling pathway  (IBA,ISO)
androgen metabolic process  (IDA)
animal organ regeneration  (IEP)
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
branching involved in labyrinthine layer morphogenesis  (ISO)
cAMP-mediated signaling  (IEP)
cell population proliferation  (ISO)
developmental growth  (ISO)
female pregnancy  (IEP)
G protein-coupled receptor internalization  (ISO)
heart development  (ISO)
negative regulation of cell population proliferation  (IMP)
negative regulation of vascular permeability  (ISO)
negative regulation of vasoconstriction  (ISO)
neural tube closure  (ISO)
neuron projection regeneration  (IMP)
odontogenesis of dentin-containing tooth  (IEP)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of heart rate  (IBA,IDA,ISO)
positive regulation of vasculogenesis  (ISO)
receptor internalization  (ISO)
regulation of systemic arterial blood pressure  (IBA,ISO)
regulation of the force of heart contraction  (IDA)
regulation of urine volume  (ISO)
response to ether  (IEP)
response to glucocorticoid  (IEP)
response to hypoxia  (IEP)
response to insulin  (IEP)
response to lipopolysaccharide  (IMP)
response to starvation  (IEP)
spongiotrophoblast layer development  (ISO)
vascular associated smooth muscle cell development  (ISO)
vasculogenesis  (ISO)

Cellular Component
cytoplasm  (ISO)
extracellular space  (IBA,IDA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The effect of vitamin E, L-arginine, N-nitro L-arginine methyl ester and forskolin on endocrine and metabolic changes of rats exposed to acute cold stress. Al-Ayadhi LY, etal., Saudi Med J. 2006 Jan;27(1):17-22.
2. Mid-regional pro-adrenomedullin is associated with pulse pressure, left ventricular mass, and albuminuria in African Americans with hypertension. Al-Omari MA, etal., Am J Hypertens. 2009 Aug;22(8):860-6. Epub 2009 May 7.
3. Adrenomedullin and vascular endothelium growth factor genes are overexpressed in the regenerating rat adrenal cortex, and AM and VEGF reciprocally enhance their mRNA expression in cultured rat adrenocortical cells. Albertin G, etal., Int J Mol Med. 2005 Sep;16(3):431-5.
4. ZD6474 inhibits tumor growth and intraperitoneal dissemination in a highly metastatic orthotopic gastric cancer model. Arao T, etal., Int J Cancer. 2006 Jan 15;118(2):483-9. doi: 10.1002/ijc.21340.
5. Vasodilator mRNA levels are increased in the livers of portal hypertensive NO-synthase 3-deficient mice. Biecker E, etal., Eur J Clin Invest. 2004 Apr;34(4):283-9.
6. Plasma adrenomedullin concentrations in patients with renovascular or malignant hypertension. Caliumi C, etal., Minerva Cardioangiol. 2004 Aug;52(4):313-22.
7. Plasma levels of adrenomedullin, a vasoactive peptide, in type 2 diabetic patients with and without retinopathy. Caliumi C, etal., Minerva Endocrinol. 2007 Jun;32(2):73-8.
8. Adrenomedullin and adrenomedullin-binding protein-1 downregulate inflammatory cytokines and attenuate tissue injury after gut ischemia-reperfusion. Carrizo GJ, etal., Surgery. 2007 Feb;141(2):245-53. Epub 2006 Sep 14.
9. Adrenomedullin in the rat testis. I: Its production, actions on testosterone secretion, regulation by human chorionic gonadotropin, and its interaction with endothelin 1 in the leydig cell. Chan YF, etal., Biol Reprod. 2008 Apr;78(4):773-9. Epub 2007 Dec 19.
10. Peripheral administration of human adrenomedullin and its binding protein attenuates stroke-induced apoptosis and brain injury in rats. Chaung WW, etal., Mol Med. 2011;17(9-10):1075-83. doi: 10.2119/molmed.2010.00104. Epub 2011 Jun 17.
11. Increased myocardial expression of RAMP1 and RAMP3 in rats with chronic heart failure. Cueille C, etal., Biochem Biophys Res Commun 2002 Jun 7;294(2):340-6.
12. Hypoxic induction of receptor activity-modifying protein 2 alters regulation of pulmonary endothelin-1 by adrenomedullin: induction under normoxia versus inhibition under hypoxia. Dschietzig T, etal., J Pharmacol Exp Ther. 2007 Apr;321(1):409-19. Epub 2007 Jan 24.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Effects of Adrenomedullin on the Glomerular Adrenomedullin System in a Rat Model of Anti-Thy1 Glomerulonephritis. Geissler B, etal., Nephron Exp Nephrol. 2010 Apr 30;115(3):e80-e88.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Adrenomedullin inhibits adipogenesis under transcriptional control of insulin. Harmancey R, etal., Diabetes. 2007 Mar;56(3):553-63.
17. Changes in expression of adrenomedullin in the myocardium of streptozotocin-induced diabetic rats. He RX, etal., Chin Med J (Engl). 2007 Feb 5;120(3):187-91.
18. Adrenomedullin production is increased in colorectal adenocarcinomas; its relation to matrix metalloproteinase-9. Hikosaka T, etal., Peptides. 2011 Sep;32(9):1825-31. doi: 10.1016/j.peptides.2011.07.012. Epub 2011 Aug 3.
19. Adrenomedullin facilitates reinnervation of phenol-injured perivascular nerves in the rat mesenteric resistance artery. Hobara N, etal., Neuroscience. 2007 Jan 19;144(2):721-30. Epub 2006 Nov 13.
20. Possible involvement of adrenomedullin in lipopolysaccharide-induced small-intestinal motility changes in conscious rats. Hussain S, etal., J Gastroenterol. 2005 Dec;40(12):1123-9.
21. Age-related changes in adrenomedullin expression and hypoxia-inducible factor-1 activity in the rat lung and their responses to hypoxia. Hwang IS, etal., J Gerontol A Biol Sci Med Sci. 2007 Jan;62(1):41-9.
22. The gene expression of adrenomedullin, calcitonin-receptor-like receptor and receptor activity modifying proteins (RAMPs) in CCl4-induced rat liver cirrhosis. Hwang IS, etal., Regul Pept. 2006 Jul 15;135(1-2):69-77. Epub 2006 May 19.
23. Increased production of adrenomedullin in glomeruli from anti-glomerular basement membrane glomerulonephritis rats treated with methylprednisolone. Iwatsubo S, etal., Nephron Exp Nephrol. 2006;104(1):e41-7. Epub 2006 May 6.
24. Vasodilator effects of adrenomedullin on retinal arterioles in streptozotocin-induced diabetic rats. Kaneko Y, etal., J Ocul Pharmacol Ther. 2006 Oct;22(5):317-22.
25. Cloning and expression of cDNA encoding a rat adrenomedullin receptor. Kapas S, etal., J Biol Chem 1995 Oct 27;270(43):25344-7.
26. Plasma adrenomedullin level and development of hypertension. Kato J, etal., J Hum Hypertens. 2006 Aug;20(8):566-70. Epub 2006 Apr 20.
27. Effects of proadrenomedullin N-terminal 20 peptide and calcitonin on isolated perfused rat hearts. Kaygisiz Z, etal., Anadolu Kardiyol Derg. 2009 Jun;9(3):176-82.
28. Adrenomedullin, a new peptide, in patients with insulinoma. Letizia C, etal., Eur J Endocrinol. 2001 May;144(5):517-20.
29. Acute hyperinsulinemia is associated with increased plasma adrenomedullin concentrations in uncomplicated obesity. Letizia C, etal., Exp Clin Endocrinol Diabetes. 2005 Mar;113(3):171-5.
30. Adrenomedullin in the rostral ventrolateral medulla is involved in the regulation of cardiovascular component of defensive responses induced by electrical stimulation of dorsal periaquaductal gray of the midbrain. Li X, etal., Sheng Li Xue Bao. 2009 Aug 25;61(4):347-55.
31. Effect of aging on the expression of adrenomedullin and its receptor component proteins in the male reproductive system of the rat. Li YY, etal., J Gerontol A Biol Sci Med Sci. 2007 Dec;62(12):1346-51.
32. Study on the signalling pathway of inhibitory effect of adreno-medullin on the growth of cultured glomerular mesangial cells. Liu XG, etal., Chin Med J (Engl). 2005 Aug 20;118(16):1374-9.
33. Adrenomedullin acts via nitric oxide and peroxynitrite to protect against myocardial ischaemia-induced arrhythmias in anaesthetized rats. Looi YH, etal., Br J Pharmacol. 2006 Jul;148(5):599-609. Epub 2006 May 22.
34. A role for adrenomedullin as a pain-related peptide in the rat. Ma W, etal., Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):16027-32. Epub 2006 Oct 16.
35. Differential regulation of adrenomedullin gene expression in the fundic and pyloric regions of the rat stomach during acute and chronic starvation. Man SY, etal., Neuropeptides. 2007 Jun;41(3):177-87. Epub 2007 Mar 1.
36. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. McLatchie LM, etal., Nature. 1998 May 28;393(6683):333-9.
37. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
38. Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist. Miseki T, etal., Cancer Gene Ther. 2007 Jan;14(1):39-44. Epub 2006 Jul 14.
39. Adrenomedullin is expressed during rodent dental tissue development and promotes cell growth and mineralization. Musson DS, etal., Biol Cell. 2010 Jan 6;102(3):145-57.
40. Effects of adrenomedullin inhalation on hemodynamics and exercise capacity in patients with idiopathic pulmonary arterial hypertension. Nagaya N, etal., Circulation. 2004 Jan 27;109(3):351-6. Epub 2004 Jan 12.
41. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
42. Ventricular adrenomedullin system in the transition from LVH to heart failure in rats. Nishikimi T, etal., Hypertension 2003 Mar;41(3):512-8.
43. Increased renal adrenomedullin expression in rats with ureteral obstruction. Norregaard R, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Jan;296(1):R185-92. Epub 2008 Oct 22.
44. Potentiated response to adrenomedullin in myocardia and aortas in spontaneously hypertensive rat. Pan ChS, etal., Basic Res Cardiol. 2006 May;101(3):193-203. Epub 2006 Feb 6.
45. Expression of adrenomedullin in adipose tissue of lean and obese women. Paulmyer-Lacroix O, etal., Eur J Endocrinol. 2006 Jul;155(1):177-85.
46. Adrenomedullin antagonist treatment during early gestation in rats causes fetoplacental growth restriction through apoptosis. Penchalaneni J, etal., Biol Reprod. 2004 Nov;71(5):1475-83. Epub 2004 Jun 30.
47. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
48. Adrenomedullin is expressed in pancreatic cancer and stimulates cell proliferation and invasion in an autocrine manner via the adrenomedullin receptor, ADMR. Ramachandran V, etal., Cancer Res. 2007 Mar 15;67(6):2666-75.
49. Adrenomedullin and its receptors are expressed in the zona glomerulosa of immature and adult rat adrenals: evidences of upregulation of ADM system in immature glands. Rebuffat P, etal., Int J Mol Med 2002 Jul;10(1):85-8.
50. GOA pipeline RGD automated data pipeline
51. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
52. Attenuation of renal ischemia and reperfusion injury by human adrenomedullin and its binding protein. Shah KG, etal., J Surg Res. 2010 Sep;163(1):110-7. doi: 10.1016/j.jss.2010.03.064. Epub 2010 Apr 24.
53. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
54. Adrenomedullin as a sensitive marker for coronary and peripheral arterial complications in patients with atherosclerotic risks. Suzuki Y, etal., Peptides. 2004 Aug;25(8):1321-6.
55. Ether stress increases adrenomedullin gene expression and levels in the rat adrenal. Tang F, etal., Horm Metab Res. 2005 Oct;37(10):585-8.
56. Ribozyme compromise of adrenomedullin mRNA reveals a physiological role in the regulation of water intake. Taylor MM and Samson WK, Am J Physiol Regul Integr Comp Physiol 2002 Jun;282(6):R1739-45.
57. Adrenomedullin reduces vascular hyperpermeability and improves survival in rat septic shock. Temmesfeld-Wollbruck B, etal., Intensive Care Med. 2007 Apr;33(4):703-10. Epub 2007 Feb 22.
58. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
59. Adrenomedullin inhibits doxorubicin-induced cultured rat cardiac myocyte apoptosis via a cAMP-dependent mechanism. Tokudome T, etal., Endocrinology 2002 Sep;143(9):3515-21.
60. Adrenomedullin in mast cells of abdominal aortic aneurysm. Tsuruda T, etal., Cardiovasc Res. 2006 Apr 1;70(1):158-64. Epub 2006 Mar 9.
61. Vascular expression of adrenomedullin is increased in Wistar rats during early pregnancy. van der Heijden OW, etal., Eur J Obstet Gynecol Reprod Biol. 2005 Nov 1;123(1):35-40.
62. Discovery of adrenomedullin in rat ischemic cortex and evidence for its role in exacerbating focal brain ischemic damage. Wang X, etal., Proc Natl Acad Sci U S A 1995 Dec 5;92(25):11480-4.
63. Study on increasing expression of adrenomedullin in diabetic rats' retinal pigment epithelium cells. Weng Y, etal., Fen Zi Xi Bao Sheng Wu Xue Bao. 2006 Aug;39(4):373-7.
64. A possible relationship between brain-derived adrenomedullin and oxytocin in the regulation of sodium balance. White MM and Samson WK, J Endocrinol. 2009 Nov;203(2):253-62. Epub 2009 Sep 1.
65. Placental and fetal growth and development in late rat gestation is dependent on adrenomedullin. Witlin AG, etal., Biol Reprod 2002 Sep;67(3):1025-31.
66. Mechanisms responsible for vascular hyporesponsiveness to adrenomedullin after hemorrhage: the central role of adrenomedullin binding protein-1. Wu R, etal., Ann Surg. 2005 Jul;242(1):115-23.
67. Adrenomedullin and adrenomedullin binding protein-1 prevent metabolic acidosis after uncontrolled hemorrhage in rats. Wu R, etal., Crit Care Med. 2007 Mar;35(3):912-8.
68. Reversing established sepsis in rats with human vasoactive hormone adrenomedullin and its binding protein. Wu R, etal., Mol Med. 2009 Jan-Feb;15(1-2):28-33. doi: 10.2119/molmed.2008.00092. Epub 2008 Oct 10.
69. Human vasoactive hormone adrenomedullin and its binding protein rescue experimental animals from shock. Wu R, etal., Peptides. 2008 Jul;29(7):1223-30. doi: 10.1016/j.peptides.2008.02.021. Epub 2008 Mar 8.
70. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA Xu CS, etal., Di Yi Jun Yi Da Xue Xue Bao. 2005 Sep;25(9):1149-51.
71. Adrenomedullin Stimulates Nitric Oxide Production from Primary Rat Hypothalamic Neurons: Roles of Calcium and Phosphatases. Xu Y and Krukoff TL, Mol Pharmacol. 2007 Apr 19;.
72. Human adrenomedullin and its binding protein attenuate organ injury and reduce mortality after hepatic ischemia-reperfusion. Yang J, etal., Ann Surg. 2009 Feb;249(2):310-7. doi: 10.1097/SLA.0b013e3181961d43.
73. Human adrenomedullin and its binding protein ameliorate sepsis-induced organ injury and mortality in jaundiced rats. Yang J, etal., Peptides. 2010 May;31(5):872-7. doi: 10.1016/j.peptides.2010.01.010. Epub 2010 Feb 2.
74. Correlation of electroretinography b-wave absolute latency, plasma levels of human basic fibroblast growth factor, vascular endothelial growth factor, soluble fatty acid synthase, and adrenomedullin in diabetic retinopathy. Zakareia FA, etal., J Diabetes Complications. 2009 Feb 11.
75. The effect of adrenomedullin on the L-type calcium current in myocytes from septic shock rats: Signaling pathway. Zhang XH, etal., Am J Physiol Heart Circ Physiol. 2007 Aug 31;.
Additional References at PubMed
PMID:7690563   PMID:10225288   PMID:10882736   PMID:11410113   PMID:11556887   PMID:11927154   PMID:11954957   PMID:11963825   PMID:12060855   PMID:12126744   PMID:12165411   PMID:12379507  
PMID:12419522   PMID:12491794   PMID:12573799   PMID:12574099   PMID:12606469   PMID:12630816   PMID:12732346   PMID:12906842   PMID:12913064   PMID:14715486   PMID:14715505   PMID:14717924  
PMID:14766677   PMID:15005274   PMID:15070851   PMID:15192039   PMID:15256273   PMID:15271873   PMID:15315911   PMID:15489334   PMID:15511634   PMID:15576460   PMID:15579624   PMID:15613468  
PMID:15619030   PMID:15623431   PMID:15680493   PMID:15752540   PMID:15913808   PMID:15949644   PMID:15962372   PMID:16040721   PMID:16337713   PMID:16389603   PMID:16537897   PMID:16596251  
PMID:16672720   PMID:16821090   PMID:16964401   PMID:16981008   PMID:17645630   PMID:17786287   PMID:17898545   PMID:17932560   PMID:18094364   PMID:18097473   PMID:18401014   PMID:18434369  
PMID:18685068   PMID:19636336   PMID:19681873   PMID:19738161   PMID:19823891   PMID:20074556   PMID:20802507   PMID:20844145   PMID:21034462   PMID:21173072   PMID:21595896   PMID:21664393  
PMID:21824440   PMID:21958875   PMID:22021555   PMID:22042486   PMID:22365702   PMID:22500019   PMID:22956308   PMID:23939287   PMID:24177018   PMID:24505304   PMID:25061099   PMID:25781901  
PMID:25990643   PMID:26259851   PMID:27184601   PMID:27737007   PMID:30366012   PMID:31489964   PMID:34978596  


Genomics

Comparative Map Data
Adm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81174,164,178 - 174,182,372 (+)NCBIGRCr8
mRatBN7.21164,745,484 - 164,747,655 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,745,466 - 164,747,654 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1173,083,288 - 173,085,466 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01180,269,319 - 180,271,497 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01172,954,068 - 172,956,245 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01175,443,189 - 175,447,260 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1175,445,088 - 175,447,259 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01182,433,109 - 182,435,280 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41168,380,255 - 168,382,426 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11168,490,917 - 168,493,089 (+)NCBI
Celera1162,637,077 - 162,639,248 (+)NCBICelera
Cytogenetic Map1q33NCBI
ADM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381110,305,073 - 10,307,397 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1110,305,073 - 10,307,397 (+)EnsemblGRCh38hg38GRCh38
GRCh371110,326,620 - 10,328,944 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,283,218 - 10,285,499 (+)NCBINCBI36Build 36hg18NCBI36
Build 341110,283,217 - 10,285,499NCBI
Celera1110,448,490 - 10,450,771 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef119,999,508 - 10,001,789 (+)NCBIHuRef
CHM1_11110,324,758 - 10,327,040 (+)NCBICHM1_1
T2T-CHM13v2.01110,389,576 - 10,391,900 (+)NCBIT2T-CHM13v2.0
Adm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397110,226,864 - 110,229,027 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7110,226,868 - 110,229,027 (+)EnsemblGRCm39 Ensembl
GRCm387110,627,657 - 110,629,820 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7110,627,661 - 110,629,820 (+)EnsemblGRCm38mm10GRCm38
MGSCv377117,771,183 - 117,773,333 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367110,418,846 - 110,420,996 (+)NCBIMGSCv36mm8
Celera7110,600,687 - 110,602,837 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map757.7NCBI
Adm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541425,951,349 - 25,953,645 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541425,951,473 - 25,953,593 (+)NCBIChiLan1.0ChiLan1.0
ADM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2912,745,404 - 12,748,234 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11112,705,550 - 12,710,554 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01110,437,712 - 10,440,053 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11110,165,423 - 10,167,842 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1110,165,418 - 10,167,842 (+)Ensemblpanpan1.1panPan2
ADM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12133,472,197 - 33,474,472 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2133,471,623 - 33,474,495 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2133,038,463 - 33,040,738 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02134,350,243 - 34,352,518 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2134,350,217 - 34,352,540 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12133,612,009 - 33,614,284 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02133,781,446 - 33,783,719 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02134,074,331 - 34,076,606 (+)NCBIUU_Cfam_GSD_1.0
Adm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494751,971,243 - 51,973,608 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365288,005,189 - 8,007,643 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365288,005,223 - 8,007,586 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl249,229,223 - 49,231,866 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1249,229,223 - 49,231,521 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2252,576,219 - 52,578,518 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1154,518,359 - 54,520,683 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl154,518,358 - 54,520,686 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038152,185,898 - 152,188,305 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247662,401,769 - 2,404,446 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247662,402,152 - 2,404,343 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adm
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:165
Count of miRNA genes:118
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000036718
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1164747558181133855Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1155422851172949803Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1156677124176484451Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat

Markers in Region
D1Wox34  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21164,747,424 - 164,747,558 (+)MAPPERmRatBN7.2
Rnor_6.01175,447,029 - 175,447,162NCBIRnor6.0
Rnor_5.01182,435,050 - 182,435,183UniSTSRnor5.0
RGSC_v3.41168,382,195 - 168,382,329RGDRGSC3.4
RGSC_v3.41168,382,196 - 168,382,329UniSTSRGSC3.4
RGSC_v3.11168,492,858 - 168,492,992RGD
Celera1162,639,018 - 162,639,151UniSTS
RH 3.4 Map11338.3UniSTS
RH 3.4 Map11338.3RGD
RH 2.0 Map1910.1RGD
Cytogenetic Map1q33UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 3 5 6
Low 3 37 54 41 19 41 8 11 74 35 35 5 8
Below cutoff 1

Sequence


RefSeq Acc Id: ENSRNOT00000036718   ⟹   ENSRNOP00000035811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1164,745,466 - 164,747,654 (+)Ensembl
Rnor_6.0 Ensembl1175,445,088 - 175,447,259 (+)Ensembl
RefSeq Acc Id: NM_012715   ⟹   NP_036847
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81174,180,200 - 174,182,371 (+)NCBI
mRatBN7.21164,745,484 - 164,747,655 (+)NCBI
Rnor_6.01175,445,088 - 175,447,259 (+)NCBI
Rnor_5.01182,433,109 - 182,435,280 (+)NCBI
RGSC_v3.41168,380,255 - 168,382,426 (+)RGD
Celera1162,637,077 - 162,639,248 (+)RGD
Sequence:
RefSeq Acc Id: XM_063281152   ⟹   XP_063137222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81174,164,178 - 174,182,372 (+)NCBI
RefSeq Acc Id: XM_063281156   ⟹   XP_063137226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81174,178,258 - 174,182,372 (+)NCBI
RefSeq Acc Id: NP_036847   ⟸   NM_012715
- Peptide Label: precursor
- UniProtKB: P43145 (UniProtKB/Swiss-Prot),   A6I816 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000035811   ⟸   ENSRNOT00000036718
RefSeq Acc Id: XP_063137222   ⟸   XM_063281152
- Peptide Label: isoform X1
- UniProtKB: P43145 (UniProtKB/Swiss-Prot),   A6I816 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137226   ⟸   XM_063281156
- Peptide Label: isoform X1
- UniProtKB: P43145 (UniProtKB/Swiss-Prot),   A6I816 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43145-F1-model_v2 AlphaFold P43145 1-185 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690314
Promoter ID:EPDNEW_R839
Type:single initiation site
Name:Adm_1
Description:adrenomedullin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01175,445,070 - 175,445,130EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2047 AgrOrtholog
BioCyc Gene G2FUF-57834 BioCyc
Ensembl Genes ENSRNOG00000027030 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055025720 UniProtKB/Swiss-Prot
  ENSRNOG00060020499 UniProtKB/Swiss-Prot
  ENSRNOG00065029586 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000036718 ENTREZGENE
  ENSRNOT00000036718.2 UniProtKB/Swiss-Prot
  ENSRNOT00055044376 UniProtKB/Swiss-Prot
  ENSRNOT00060035522 UniProtKB/Swiss-Prot
  ENSRNOT00065051097 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5621783 IMAGE-MGC_LOAD
InterPro Adrenomedullin UniProtKB/Swiss-Prot
  Calcitonin/adrenomedullin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pro-ADM UniProtKB/TrEMBL
KEGG Report rno:25026 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72547 IMAGE-MGC_LOAD
NCBI Gene 25026 ENTREZGENE
PANTHER ADRENOMEDULLIN, ADM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRO-ADRENOMEDULLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Calc_CGRP_IAPP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ADM RGD
PhenoGen Adm PhenoGen
PRINTS ADRENOMEDULN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027030 RatGTEx
  ENSRNOG00055025720 RatGTEx
  ENSRNOG00060020499 RatGTEx
  ENSRNOG00065029586 RatGTEx
TIGR TC234620
UniProt A6I816 ENTREZGENE, UniProtKB/TrEMBL
  A6I817_RAT UniProtKB/TrEMBL
  ADML_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Adm  adrenomedullin      Symbol and Name status set to approved 70586 APPROVED
2001-04-19 Ap  Adrenomedullin precursor      Symbol withdrawn, duplicate entry of Adm (RGD:2047) 61478 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_disease may be involved in the progression of ischemic brain damage in a model for stroke 69742
gene_expression expressed in atria and ventricles of the heart 625420
gene_expression expressed in brain cortex 69742
gene_expression expressed in the adrenal zona glomerulosa 631805
gene_function has vasodilator activity 632209
gene_process required for embryonic growth and development 632209
gene_process involved in regulation of adrenal development 631805
gene_process inhibits the apoptotic effects of doxorubicin on cardiomyocytes and suppresses the doxorubicin-induced effects of DNA fragmentation and caspase-3 activation in cardiomyocytes 628358
gene_process capable of acting as a hormone 628358
gene_process has a protective role against cardiomyocyte injury through a cAMP-dependent mechanism 628358
gene_product member of the calcitonin gene-related peptide family 69742
gene_protein 52 amino acids 628358