Grn (granulin precursor) - Rat Genome Database

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Gene: Grn (granulin precursor) Heterocephalus glaber
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Symbol: Grn
Name: granulin precursor
RGD ID: 18933770
Description: ENCODES a protein that exhibits protein-folding chaperone binding (ortholog); INVOLVED IN astrocyte activation involved in immune response (ortholog); blastocyst hatching (ortholog); chondrocyte proliferation (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); amyotrophic lateral sclerosis type 10 (ortholog); FOUND IN cerebellar climbing fiber to Purkinje cell synapse (ortholog); endoplasmic reticulum (ortholog); endosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: granulins
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624795704,252 - 707,165 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624795704,066 - 708,721 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
astrocyte activation involved in immune response  (ISO)
blastocyst hatching  (ISO)
chondrocyte proliferation  (ISO)
embryo implantation  (ISO)
epithelial cell proliferation  (ISO)
locomotory exploration behavior  (ISO)
lysosomal lumen acidification  (ISO)
lysosomal protein catabolic process  (ISO)
lysosomal transport  (ISO)
lysosome organization  (ISO)
maintenance of synapse structure  (ISO)
male mating behavior  (ISO)
microglial cell activation involved in immune response  (ISO)
negative regulation of hydrolase activity  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of innate immune response  (ISO)
negative regulation of microglial cell activation  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neutrophil activation  (ISO)
negative regulation of respiratory burst involved in inflammatory response  (ISO)
neural precursor cell proliferation  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of aspartic-type peptidase activity  (ISO)
positive regulation of axon regeneration  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of defense response to bacterium  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of inflammatory response to wounding  (ISO)
positive regulation of lysosome organization  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of protein folding  (ISO)
positive regulation of trophectodermal cell proliferation  (ISO)
protein stabilization  (ISO)
regulation of lysosome organization  (ISO)
response to estradiol  (ISO)
retina development in camera-type eye  (ISO)
synaptic vesicle endocytosis  (ISO)
trophectodermal cell proliferation  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Grn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624795704,252 - 707,165 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624795704,066 - 708,721 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
GRN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381744,345,302 - 44,353,106 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1744,345,246 - 44,353,106 (+)EnsemblGRCh38hg38GRCh38
GRCh371742,422,670 - 42,430,474 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,778,017 - 39,785,996 (+)NCBINCBI36Build 36hg18NCBI36
Build 341739,778,016 - 39,785,996NCBI
Celera1739,132,112 - 39,140,095 (+)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1738,186,768 - 38,194,753 (+)NCBIHuRef
CHM1_11742,658,166 - 42,666,146 (+)NCBICHM1_1
T2T-CHM13v2.01745,199,297 - 45,207,105 (+)NCBIT2T-CHM13v2.0
Grn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911102,321,333 - 102,327,635 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11102,321,141 - 102,327,874 (+)EnsemblGRCm39 Ensembl
GRCm3811102,430,507 - 102,436,809 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,430,315 - 102,437,048 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711102,291,636 - 102,298,123 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611102,246,597 - 102,252,895 (+)NCBIMGSCv36mm8
Celera11114,140,482 - 114,146,970 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1166.29NCBI
Grn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,887,834 - 87,893,938 (+)NCBIGRCr8
mRatBN7.21087,387,672 - 87,393,777 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,387,638 - 87,393,775 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1092,424,835 - 92,430,942 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01091,890,037 - 91,896,139 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01087,283,370 - 87,289,472 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01090,377,103 - 90,383,207 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,376,933 - 90,383,205 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01090,165,634 - 90,171,738 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,536,135 - 91,542,239 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11091,552,883 - 91,556,599 (+)NCBI
Celera1086,096,583 - 86,102,687 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
Grn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545117,368,428 - 17,372,377 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545117,368,600 - 17,371,981 (+)NCBIChiLan1.0ChiLan1.0
GRN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21920,557,091 - 20,565,084 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11722,521,447 - 22,529,431 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01713,046,329 - 13,054,236 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11713,211,784 - 13,219,793 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1713,211,784 - 13,219,609 (-)Ensemblpanpan1.1panPan2
GRN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,077,430 - 19,085,443 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,077,427 - 19,082,268 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha918,467,174 - 18,474,620 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0919,771,801 - 19,779,240 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl919,771,806 - 19,779,115 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1918,625,608 - 18,633,045 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0918,808,582 - 18,816,025 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0918,952,849 - 18,960,290 (-)NCBIUU_Cfam_GSD_1.0
Grn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560218,390,156 - 18,401,106 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936541793,523 - 800,217 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936541793,548 - 800,271 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1218,893,770 - 18,900,446 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11218,893,772 - 18,900,444 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,212,414 - 19,216,283 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11662,037,344 - 62,045,765 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1662,036,412 - 62,045,614 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607732,804,031 - 32,812,724 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021240276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01067267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000015138   ⟹   ENSHGLP00000014988
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624795704,252 - 707,165 (-)Ensembl
RefSeq Acc Id: XM_021240276   ⟹   XP_021095935
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624795704,066 - 708,721 (-)NCBI
Protein Sequences
Protein RefSeqs XP_021095935 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000014988
RefSeq Acc Id: XP_021095935   ⟸   XM_021240276
- UniProtKB: A0AAX6RKS3 (UniProtKB/TrEMBL),   G5BIZ8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000014988   ⟸   ENSHGLT00000015138


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000010728 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000015138 ENTREZGENE
Gene3D-CATH Granulin UniProtKB/TrEMBL
InterPro Granulin UniProtKB/TrEMBL
  Granulin_fam UniProtKB/TrEMBL
  Granulin_sf UniProtKB/TrEMBL
NCBI Gene Grn ENTREZGENE
PANTHER GRANULIN UniProtKB/TrEMBL
  PROGRANULIN UniProtKB/TrEMBL
Pfam Granulin UniProtKB/TrEMBL
PROSITE GRANULINS UniProtKB/TrEMBL
SMART GRAN UniProtKB/TrEMBL
Superfamily-SCOP Granulin repeat UniProtKB/TrEMBL
UniProt A0AAX6RKS3 ENTREZGENE, UniProtKB/TrEMBL
  G5BIZ8 ENTREZGENE, UniProtKB/TrEMBL