Spp1 (secreted phosphoprotein 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Spp1 (secreted phosphoprotein 1) Heterocephalus glaber
Analyze
Symbol: Spp1
Name: secreted phosphoprotein 1
RGD ID: 18933474
Description: ENCODES a protein that exhibits small molecule binding (ortholog); INVOLVED IN bone mineralization (ortholog); calcium ion homeostasis (ortholog); cell adhesion (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; diabetic nephropathy pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); Albuminuria (ortholog); FOUND IN apical part of cell (ortholog); cell projection (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Osteopontin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248724,505,522 - 4,513,742 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248724,505,796 - 4,513,247 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
adenocarcinoma  (ISO)
Albuminuria  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
Aneurysm  (ISO)
Angina Pectoris  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
aortic aneurysm  (ISO)
aortic dissection  (ISO)
asbestosis  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
biliary atresia  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
calcinosis  (ISO)
Cardiomegaly  (ISO)
carotid stenosis  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis C  (ISO)
coronary artery disease  (ISO)
coronary restenosis  (ISO)
Cystic, Mucinous, and Serous Neoplasms  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
encephalomyelitis  (ISO)
Endometrioid Carcinomas  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Experimental Seizures  (ISO)
Fibrosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
Foreign-Body Reaction  (ISO)
glomerulonephritis  (ISO)
glomerulosclerosis  (ISO)
heart disease  (ISO)
heart valve disease  (ISO)
hepatitis  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Inflammation  (ISO)
Kidney Calculi  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Laryngeal Neoplasms  (ISO)
Leukoencephalopathies  (ISO)
liver cirrhosis  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
malaria  (ISO)
melanoma  (ISO)
Mesothelioma  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Neoplasm Metastasis  (ISO)
Neovascularization, Pathologic  (ISO)
Nervous System Trauma  (ISO)
Osteolysis  (ISO)
Ovarian Neoplasms  (ISO)
pancreas disease  (ISO)
pancreatic cancer  (ISO)
Pleural Neoplasms  (ISO)
pneumonia  (ISO)
progressive osseous heteroplasia  (ISO)
prostate carcinoma  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
pulmonary fibrosis  (ISO)
radiculopathy  (ISO)
renovascular hypertension  (ISO)
Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
scrapie  (ISO)
Spinal Cord Injuries  (ISO)
Stomach Neoplasms  (ISO)
Thyroid Neoplasms  (ISO)
tuberculosis  (ISO)
uremia  (ISO)
urinary bladder cancer  (ISO)
Urinary Calculi  (ISO)
Vascular System Injuries  (ISO)
Wounds and Injuries  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Spp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248724,505,522 - 4,513,742 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248724,505,796 - 4,513,247 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SPP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38487,975,714 - 87,983,411 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl487,975,667 - 87,983,532 (+)EnsemblGRCh38hg38GRCh38
GRCh37488,896,866 - 88,904,563 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36489,115,826 - 89,123,587 (+)NCBINCBI36Build 36hg18NCBI36
Build 34489,253,980 - 89,261,741NCBI
Celera486,188,727 - 86,196,490 (+)NCBICelera
Cytogenetic Map4q22.1NCBI
HuRef484,643,231 - 84,650,994 (+)NCBIHuRef
CHM1_1488,873,591 - 88,881,352 (+)NCBICHM1_1
T2T-CHM13v2.0491,302,203 - 91,309,899 (+)NCBIT2T-CHM13v2.0
Spp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395104,582,977 - 104,588,919 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5104,582,984 - 104,588,916 (+)EnsemblGRCm39 Ensembl
GRCm385104,435,111 - 104,441,053 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5104,435,118 - 104,441,050 (+)EnsemblGRCm38mm10GRCm38
MGSCv375104,864,137 - 104,870,069 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365104,657,300 - 104,681,345 (+)NCBIMGSCv36mm8
Celera5101,744,286 - 101,750,760 (+)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.68NCBI
Spp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8145,613,569 - 5,620,695 (-)NCBIGRCr8
mRatBN7.2145,308,885 - 5,315,120 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl145,308,885 - 5,315,162 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx145,269,750 - 5,275,787 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0146,569,945 - 6,575,982 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0145,261,625 - 5,267,707 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0146,673,686 - 6,679,965 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl146,673,686 - 6,679,901 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0146,653,086 - 6,658,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1146,422,741 - 6,426,400 (-)NCBI
Celera145,447,814 - 5,453,553 (-)NCBICelera
RH 3.4 Map1484.5RGD
Cytogenetic Map14p22NCBI
Spp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554741,913,829 - 1,922,016 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554741,914,477 - 1,922,025 (-)NCBIChiLan1.0ChiLan1.0
SPP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2385,977,678 - 85,985,354 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1486,240,086 - 86,247,760 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0480,263,711 - 80,271,466 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1490,988,200 - 90,995,935 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl490,988,200 - 90,995,935 (+)Ensemblpanpan1.1panPan2
SPP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13211,354,070 - 11,362,325 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3211,353,953 - 11,362,069 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3230,592,131 - 30,600,371 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03211,406,381 - 11,414,630 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3211,406,395 - 11,414,631 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13211,490,535 - 11,498,773 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03211,316,506 - 11,324,744 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03228,630,350 - 28,638,599 (-)NCBIUU_Cfam_GSD_1.0
Spp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052851,729,610 - 1,736,282 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936905148,945 - 156,079 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936905148,956 - 156,023 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8131,077,786 - 131,085,340 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18131,077,786 - 131,085,334 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28140,307,933 - 140,315,453 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap8qNCBI
SPP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1736,337,165 - 36,344,927 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl736,338,386 - 36,344,407 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603715,089,529 - 15,097,556 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000017739   ⟹   ENSHGLP00000017564
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248724,505,522 - 4,513,742 (+)Ensembl
RefSeq Acc Id: XM_004870558   ⟹   XP_004870615
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248724,505,796 - 4,513,247 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004870615 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB12353 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000017564
GenBank Protein JAN96771 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004870615   ⟸   XM_004870558
- UniProtKB: G5BSU2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000017564   ⟸   ENSHGLT00000017739


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000012567 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000017739 ENTREZGENE, UniProtKB/TrEMBL
InterPro Osteopontin UniProtKB/TrEMBL
KEGG Report hgl:101726269 UniProtKB/TrEMBL
NCBI Gene Spp1 ENTREZGENE
PANTHER OSTEOPONTIN UniProtKB/TrEMBL
  PTHR10607 UniProtKB/TrEMBL
Pfam Osteopontin UniProtKB/TrEMBL
PRINTS OSTEOPONTIN UniProtKB/TrEMBL
SMART OSTEO UniProtKB/TrEMBL
UniProt G5BSU2 ENTREZGENE, UniProtKB/TrEMBL