Th (tyrosine hydroxylase) - Rat Genome Database

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Gene: Th (tyrosine hydroxylase) Heterocephalus glaber
Analyze
Symbol: Th
Name: tyrosine hydroxylase
RGD ID: 18929693
Description: ENCODES a protein that exhibits amino acid binding (ortholog); dopamine binding (ortholog); enzyme binding (ortholog); INVOLVED IN aminergic neurotransmitter loading into synaptic vesicle (ortholog); animal organ morphogenesis (ortholog); catecholamine biosynthetic process (ortholog); PARTICIPATES IN aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; dopamine biosynthetic pathway; ASSOCIATED WITH Beckwith-Wiedemann syndrome (ortholog); brain disease (ortholog); Brain Injuries (ortholog); FOUND IN axon (ortholog); cytoplasmic side of plasma membrane (ortholog); cytoplasmic vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tyrosine 3-monooxygenase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476715,003,092 - 15,010,154 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476715,003,073 - 15,010,207 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Beckwith-Wiedemann syndrome  (ISO)
brain disease  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Catalepsy  (ISO)
congestive heart failure  (ISO)
Contusions  (ISO)
delta beta-thalassemia  (ISO)
depressive disorder  (ISO)
developmental and epileptic encephalopathy  (ISO)
DOPA-responsive dystonia  (ISO)
Drug-Induced Dyskinesia  (ISO)
dystonia  (ISO)
early infantile epileptic encephalopathy  (ISO)
epilepsy  (ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
generalized dystonia  (ISO)
genetic disease  (ISO)
heart disease  (ISO)
hepatocellular carcinoma  (ISO)
heroin dependence  (ISO)
Hyperkinesis  (ISO)
Hyperproinsulinemia  (ISO)
hyperprolactinemia  (ISO)
hypertension  (ISO)
hypoglycemia  (ISO)
Hypoinsulinemia  (ISO)
immunodeficiency 39  (ISO)
intellectual disability  (ISO)
learning disability  (ISO)
Lewy body dementia  (ISO)
Machado-Joseph disease  (ISO)
maturity-onset diabetes of the young  (ISO)
maturity-onset diabetes of the young type 1  (ISO)
maturity-onset diabetes of the young type 10  (ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
neonatal diabetes mellitus  (ISO)
Nerve Degeneration  (ISO)
neuroblastoma  (ISO)
neuronal ceroid lipofuscinosis  (ISO)
obesity  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
Permanent Neonatal Diabetes Mellitus 4  (ISO)
pheochromocytoma  (ISO)
polycystic ovary syndrome  (ISO)
portal hypertension  (ISO)
Reperfusion Injury  (ISO)
schizophrenia  (ISO)
Segawa Syndrome, Autosomal Recessive  (ISO)
transient neonatal diabetes mellitus  (ISO)
traumatic brain injury  (ISO)
type 1 diabetes mellitus  (ISO)
type 1 diabetes mellitus 2  (ISO)
type 2 diabetes mellitus  (ISO)
Type 2 Diabetes Mellitus 1  (ISO)
uremia  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aminergic neurotransmitter loading into synaptic vesicle  (ISO)
animal organ morphogenesis  (ISO)
aromatic amino acid metabolic process  (IEA)
catecholamine biosynthetic process  (IEA,ISO)
cellular response to alkaloid  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to manganese ion  (ISO)
cellular response to nicotine  (ISO)
cellular response to xenobiotic stimulus  (ISO)
cerebral cortex development  (ISO)
circadian sleep/wake cycle  (ISO)
cognition  (ISO)
dopamine biosynthetic process  (IEA)
dopamine biosynthetic process from tyrosine  (IEA,ISO)
eating behavior  (ISO)
embryonic camera-type eye morphogenesis  (ISO)
epinephrine biosynthetic process  (ISO)
eye photoreceptor cell development  (ISO)
fatty acid metabolic process  (ISO)
glycoside metabolic process  (ISO)
heart development  (IEA,ISO)
hyaloid vascular plexus regression  (ISO)
isoquinoline alkaloid metabolic process  (ISO)
learning  (ISO)
locomotory behavior  (ISO)
mating behavior  (ISO)
memory  (ISO)
norepinephrine biosynthetic process  (ISO)
phthalate metabolic process  (ISO)
phytoalexin metabolic process  (ISO)
regulation of heart contraction  (ISO)
response to activity  (ISO)
response to amphetamine  (ISO)
response to corticosterone  (ISO)
response to curcumin  (ISO)
response to electrical stimulus  (ISO)
response to estradiol  (ISO)
response to ethanol  (IEA,ISO)
response to ether  (ISO)
response to growth factor  (ISO)
response to herbicide  (ISO)
response to hypoxia  (IEA,ISO)
response to immobilization stress  (ISO)
response to insecticide  (ISO)
response to isolation stress  (ISO)
response to light stimulus  (ISO)
response to lipopolysaccharide  (ISO)
response to metal ion  (ISO)
response to nicotine  (ISO)
response to nutrient levels  (ISO)
response to peptide hormone  (ISO)
response to pyrethroid  (ISO)
response to salt stress  (ISO)
response to steroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
response to zinc ion  (ISO)
social behavior  (ISO)
sphingolipid metabolic process  (ISO)
synaptic transmission, dopaminergic  (ISO)
terpene metabolic process  (ISO)
visual perception  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Th
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476715,003,092 - 15,010,154 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476715,003,073 - 15,010,207 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,163,929 - 2,171,815 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl112,163,929 - 2,171,815 (-)EnsemblGRCh38hg38GRCh38
GRCh37112,185,159 - 2,193,045 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,141,735 - 2,149,611 (-)NCBINCBI36Build 36hg18NCBI36
Build 34112,141,735 - 2,149,605NCBI
Celera112,221,752 - 2,229,624 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,975,424 - 1,983,299 (-)NCBIHuRef
CHM1_1112,183,941 - 2,191,817 (-)NCBICHM1_1
T2T-CHM13v2.0112,253,295 - 2,261,192 (-)NCBIT2T-CHM13v2.0
Th
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,446,516 - 142,453,732 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,446,489 - 142,484,865 (-)EnsemblGRCm39 Ensembl
GRCm387142,892,779 - 142,899,995 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,892,752 - 142,931,128 (-)EnsemblGRCm38mm10GRCm38
MGSCv377150,078,681 - 150,085,871 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367142,702,166 - 142,709,356 (-)NCBIMGSCv36mm8
Celera7142,648,392 - 142,655,582 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.06NCBI
Th
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81207,500,959 - 207,508,276 (-)NCBIGRCr8
mRatBN7.21198,071,500 - 198,078,832 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1198,071,503 - 198,109,767 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1206,450,387 - 206,457,507 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,537,252 - 213,544,373 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01206,211,403 - 206,218,524 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01216,073,034 - 216,080,287 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1216,073,031 - 216,080,287 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01222,935,462 - 222,942,715 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41203,164,253 - 203,171,506 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11203,317,712 - 203,324,972 (-)NCBI
Celera1195,642,057 - 195,649,203 (-)NCBICelera
RH 2.0 Map11080.1RGD
Cytogenetic Map1q41NCBI
Th
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542213,943,552 - 13,951,137 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542213,943,590 - 13,951,102 (-)NCBIChiLan1.0ChiLan1.0
TH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v294,590,095 - 4,597,992 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1113,801,867 - 3,809,764 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0112,204,820 - 2,212,750 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1112,234,095 - 2,242,030 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,231,248 - 2,242,433 (-)Ensemblpanpan1.1panPan2
TH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,327,136 - 46,334,973 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,327,137 - 46,335,602 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1844,936,923 - 44,944,750 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01847,006,609 - 47,014,412 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1847,006,611 - 47,014,441 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11846,455,359 - 46,462,897 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,035,687 - 46,043,215 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,782,129 - 46,789,967 (-)NCBIUU_Cfam_GSD_1.0
Th
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049472,535,447 - 2,543,939 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936794478,614 - 487,061 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936794478,651 - 486,887 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl21,499,620 - 1,506,170 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.121,499,628 - 1,506,180 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,969,194 - 1,977,263 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11,966,460 - 1,977,218 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603899,163,059 - 99,174,711 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000026965   ⟹   ENSHGLP00000026727
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462476715,003,092 - 15,010,154 (-)Ensembl
RefSeq Acc Id: XM_004852098   ⟹   XP_004852155
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476715,003,073 - 15,010,201 (-)NCBI
RefSeq Acc Id: XM_013074740   ⟹   XP_012930194
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476715,003,073 - 15,010,207 (-)NCBI
RefSeq Acc Id: XM_021264416   ⟹   XP_021120075
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476715,003,073 - 15,010,202 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004852155 (Get FASTA)   NCBI Sequence Viewer  
  XP_012930194 (Get FASTA)   NCBI Sequence Viewer  
  XP_021120075 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000026727
RefSeq Acc Id: XP_012930194   ⟸   XM_013074740
- Peptide Label: isoform X3
- UniProtKB: G5C2F1 (UniProtKB/TrEMBL),   A0AAX6QWR2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021120075   ⟸   XM_021264416
- Peptide Label: isoform X2
- UniProtKB: G5C2F1 (UniProtKB/TrEMBL),   A0AAX6TEE4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004852155   ⟸   XM_004852098
- Peptide Label: isoform X1
- UniProtKB: G5C2F1 (UniProtKB/TrEMBL),   A0AAX6PH44 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000026727   ⟸   ENSHGLT00000026965


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000019013 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000026965 ENTREZGENE
Gene3D-CATH 3.30.70.260 UniProtKB/TrEMBL
  Aromatic amino acid hydroxylase UniProtKB/TrEMBL
InterPro ACT-like_dom_sf UniProtKB/TrEMBL
  ArAA_hydroxylase UniProtKB/TrEMBL
  ArAA_hydroxylase_Fe/CU_BS UniProtKB/TrEMBL
  ArAA_hydroxylase_sf UniProtKB/TrEMBL
  Aro-AA_hydroxylase_C_sf UniProtKB/TrEMBL
  Aromatic-AA_hydroxylase_C UniProtKB/TrEMBL
  Eu_TyrOH_cat UniProtKB/TrEMBL
  TH_ACT UniProtKB/TrEMBL
  Tyr_3_mOase UniProtKB/TrEMBL
  Tyrosine_3-monooxygenase-like UniProtKB/TrEMBL
  Tyrosine_hydroxylase_CS UniProtKB/TrEMBL
NCBI Gene Th ENTREZGENE
PANTHER AROMATIC AMINO ACID HYDROXYLASE UniProtKB/TrEMBL
  TYROSINE 3-MONOOXYGENASE UniProtKB/TrEMBL
Pfam Biopterin_H UniProtKB/TrEMBL
  TH_ACT UniProtKB/TrEMBL
  TOH_N UniProtKB/TrEMBL
PIRSF PIRSF000336 UniProtKB/TrEMBL
PRINTS FYWHYDRXLASE UniProtKB/TrEMBL
PROSITE BH4_AAA_HYDROXYL_1 UniProtKB/TrEMBL
  BH4_AAA_HYDROXYL_2 UniProtKB/TrEMBL
Superfamily-SCOP ACT-like UniProtKB/TrEMBL
  Aromatic aminoacid monoxygenases, catalytic and oligomerization domains UniProtKB/TrEMBL
UniProt A0AAX6PH44 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QWR2 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6TEE4 ENTREZGENE, UniProtKB/TrEMBL
  G5C2F1 ENTREZGENE, UniProtKB/TrEMBL