Pde10a (phosphodiesterase 10A) - Rat Genome Database

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Gene: Pde10a (phosphodiesterase 10A) Heterocephalus glaber
Analyze
Symbol: Pde10a
Name: phosphodiesterase 10A
RGD ID: 18929537
Description: ENCODES a protein that exhibits 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity (ortholog); cAMP binding (ortholog); cyclic-nucleotide phosphodiesterase activity (ortholog); INVOLVED IN cAMP catabolic process (ortholog); cGMP catabolic process (ortholog); regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Developmental Disabilities (ortholog); genetic disease (ortholog); Infantile-Onset Limb and Orofacial Dyskinesia (ortholog); FOUND IN cytosol (ortholog); extrinsic component of postsynaptic density membrane (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478513,497,495 - 13,880,345 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478513,208,518 - 13,885,261 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pde10a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478513,497,495 - 13,880,345 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478513,208,518 - 13,885,261 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PDE10A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386165,327,289 - 165,988,052 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6165,327,287 - 165,988,117 (-)EnsemblGRCh38hg38GRCh38
GRCh376165,740,778 - 166,076,729 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366165,664,519 - 165,995,574 (-)NCBINCBI36Build 36hg18NCBI36
Build 346165,714,945 - 166,045,996NCBI
Celera6166,478,886 - 166,814,271 (-)NCBICelera
Cytogenetic Map6q27NCBI
HuRef6163,202,267 - 163,537,621 (-)NCBIHuRef
CHM1_16166,003,719 - 166,338,432 (-)NCBICHM1_1
T2T-CHM13v2.06166,693,362 - 167,356,384 (-)NCBIT2T-CHM13v2.0
Pde10a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39178,742,719 - 9,205,480 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl178,744,204 - 9,205,480 (+)EnsemblGRCm39 Ensembl
GRCm38178,525,187 - 8,986,648 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl178,525,372 - 8,986,648 (+)EnsemblGRCm38mm10GRCm38
MGSCv37178,994,610 - 9,179,513 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36178,639,919 - 8,824,822 (+)NCBIMGSCv36mm8
Celera178,848,994 - 9,030,858 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map174.96NCBI
Pde10a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8154,313,343 - 54,765,668 (-)NCBIGRCr8
mRatBN7.2151,765,743 - 52,218,086 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl151,770,132 - 52,216,563 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx152,476,016 - 52,919,928 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0158,463,473 - 58,911,420 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0152,551,592 - 52,995,519 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0152,360,296 - 52,544,448 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl152,360,296 - 52,544,450 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0153,617,430 - 53,800,479 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4146,392,900 - 46,589,076 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1146,395,844 - 46,592,020 (-)NCBI
Celera147,539,418 - 47,723,290 (-)NCBICelera
Cytogenetic Map1q12NCBI
Pde10a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543916,114,530 - 16,365,146 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543916,114,530 - 16,370,648 (+)NCBIChiLan1.0ChiLan1.0
PDE10A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25185,514,841 - 186,181,000 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16183,411,044 - 184,076,963 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06163,274,252 - 163,612,749 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16168,259,978 - 168,596,401 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6168,265,707 - 168,645,231 (-)Ensemblpanpan1.1panPan2
PDE10A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1153,457,781 - 54,049,735 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl153,462,979 - 53,801,966 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha154,243,884 - 54,542,326 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0153,634,410 - 54,231,358 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl153,639,079 - 53,984,940 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1153,531,754 - 53,830,179 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0153,379,457 - 53,678,753 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0154,012,303 - 54,310,827 (-)NCBIUU_Cfam_GSD_1.0
Pde10a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946148,143,922 - 148,659,124 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648915,400,629 - 15,671,600 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648915,401,248 - 15,671,594 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE10A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl12,829,411 - 3,392,651 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113,120,418 - 3,394,236 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214,618,673 - 4,742,489 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE10A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11393,012,027 - 93,684,349 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1393,020,696 - 93,344,369 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604064,833,189 - 65,491,475 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004856934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013076714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013076715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013076717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021238021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021238022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021238023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021238024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021238025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01061747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01061781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000004982   ⟹   ENSHGLP00000004918
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462478513,497,495 - 13,879,485 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000004983   ⟹   ENSHGLP00000004919
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462478513,545,150 - 13,879,485 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000004984   ⟹   ENSHGLP00000004920
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462478513,610,579 - 13,879,485 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000004985   ⟹   ENSHGLP00000004921
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462478513,633,530 - 13,880,345 (+)Ensembl
RefSeq Acc Id: XM_004856934   ⟹   XP_004856991
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478513,544,740 - 13,885,261 (+)NCBI
RefSeq Acc Id: XM_013076714   ⟹   XP_012932168
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478513,550,477 - 13,885,261 (+)NCBI
RefSeq Acc Id: XM_013076715   ⟹   XP_012932169
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478513,208,518 - 13,885,261 (+)NCBI
RefSeq Acc Id: XM_013076717   ⟹   XP_012932171
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478513,545,086 - 13,885,261 (+)NCBI
RefSeq Acc Id: XM_021238021   ⟹   XP_021093680
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478513,210,028 - 13,885,261 (+)NCBI
RefSeq Acc Id: XM_021238022   ⟹   XP_021093681
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478513,210,028 - 13,885,261 (+)NCBI
RefSeq Acc Id: XM_021238023   ⟹   XP_021093682
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478513,497,417 - 13,885,261 (+)NCBI
RefSeq Acc Id: XM_021238024   ⟹   XP_021093683
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478513,609,989 - 13,885,261 (+)NCBI
RefSeq Acc Id: XM_021238025   ⟹   XP_021093684
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478513,497,409 - 13,885,261 (+)NCBI
RefSeq Acc Id: XP_012932169   ⟸   XM_013076715
- Peptide Label: isoform X5
- UniProtKB: A0AAX6R2A4 (UniProtKB/TrEMBL),   G5BDY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093680   ⟸   XM_021238021
- Peptide Label: isoform X1
- UniProtKB: A0AAX6RCK8 (UniProtKB/TrEMBL),   G5BDY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093681   ⟸   XM_021238022
- Peptide Label: isoform X2
- UniProtKB: A0AAX6RA42 (UniProtKB/TrEMBL),   G5BDY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093684   ⟸   XM_021238025
- Peptide Label: isoform X8
- UniProtKB: A0AAX6RBG7 (UniProtKB/TrEMBL),   G5BDY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093682   ⟸   XM_021238023
- Peptide Label: isoform X3
- UniProtKB: A0AAX6RD29 (UniProtKB/TrEMBL),   G5BDY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004856991   ⟸   XM_004856934
- Peptide Label: isoform X9
- UniProtKB: A0AAX6PRP5 (UniProtKB/TrEMBL),   G5BDY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012932171   ⟸   XM_013076717
- Peptide Label: isoform X6
- UniProtKB: A0AAX6R2B6 (UniProtKB/TrEMBL),   G5BDY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012932168   ⟸   XM_013076714
- Peptide Label: isoform X4
- UniProtKB: A0AAX6R1I2 (UniProtKB/TrEMBL),   G5BDY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093683   ⟸   XM_021238024
- Peptide Label: isoform X7
- UniProtKB: A0AAX6RBF9 (UniProtKB/TrEMBL),   G5BDY7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000004918   ⟸   ENSHGLT00000004982
Ensembl Acc Id: ENSHGLP00000004921   ⟸   ENSHGLT00000004985
Ensembl Acc Id: ENSHGLP00000004920   ⟸   ENSHGLT00000004984
Ensembl Acc Id: ENSHGLP00000004919   ⟸   ENSHGLT00000004983


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000003609 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000004982 ENTREZGENE
  ENSHGLT00000004983 ENTREZGENE
  ENSHGLT00000004985 ENTREZGENE
Gene3D-CATH 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain UniProtKB/TrEMBL
  3.30.450.40 UniProtKB/TrEMBL
InterPro GAF UniProtKB/TrEMBL
  GAF-like_dom_sf UniProtKB/TrEMBL
  HD/PDEase_dom UniProtKB/TrEMBL
  PDEase UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/TrEMBL
  PDEase_CS UniProtKB/TrEMBL
NCBI Gene Pde10a ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/TrEMBL
Pfam GAF UniProtKB/TrEMBL
  PDEase_I UniProtKB/TrEMBL
PRINTS PDIESTERASE1 UniProtKB/TrEMBL
PROSITE PDEASE_I_1 UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/TrEMBL
SMART GAF UniProtKB/TrEMBL
  HDc UniProtKB/TrEMBL
Superfamily-SCOP GAF domain-like UniProtKB/TrEMBL
  HD-domain/PDEase-like UniProtKB/TrEMBL
UniProt A0AAX6PRP5 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6R1I2 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6R2A4 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6R2B6 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RA42 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RBF9 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RBG7 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RCK8 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RD29 ENTREZGENE, UniProtKB/TrEMBL
  G5BDY7 ENTREZGENE, UniProtKB/TrEMBL