Nefl (neurofilament light chain) - Rat Genome Database

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Gene: Nefl (neurofilament light chain) Heterocephalus glaber
Analyze
Symbol: Nefl
Name: neurofilament light chain (Ensembl:neurofilament light)
RGD ID: 18925242
Description: ENCODES a protein that exhibits identical protein binding (ortholog); phospholipase binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN anterograde axonal transport (ortholog); axonal transport of mitochondrion (ortholog); axonogenesis (ortholog); ASSOCIATED WITH acute disseminated encephalomyelitis (ortholog); AIDS Dementia Complex (ortholog); Alzheimer's disease (ortholog); FOUND IN axon (ortholog); cholinergic synapse (ortholog); growth cone (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neurofilament light; Neurofilament light polypeptide; neurofilament, light polypeptide
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475820,062,685 - 20,068,609 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475820,063,109 - 20,068,459 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute disseminated encephalomyelitis  (ISO)
AIDS Dementia Complex  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
Anti-N-Methyl-D-Aspartate Receptor Encephalitis  (ISO)
Auditory Neuropathy  (ISO)
autosomal dominant distal hereditary motor neuronopathy  (ISO)
autosomal dominant distal hereditary motor neuronopathy 14  (ISO)
Charcot-Marie-Tooth disease  (ISO)
Charcot-Marie-Tooth disease dominant intermediate G  (ISO)
Charcot-Marie-Tooth disease type 1  (ISO)
Charcot-Marie-Tooth disease type 1C  (ISO)
Charcot-Marie-Tooth disease type 1F  (ISO)
Charcot-Marie-Tooth disease type 2E  (ISO)
Charcot-Marie-Tooth disease type 2EE  (ISO)
congenital hypothyroidism  (ISO)
COVID-19  (ISO)
Creutzfeldt-Jakob disease  (ISO)
demyelinating disease  (ISO)
depressive disorder  (ISO)
distal myopathy  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
fatal familial insomnia  (ISO)
frontotemporal dementia  (ISO)
Frontotemporal Lobar Degeneration  (ISO)
genetic disease  (ISO)
HIV Seropositivity  (ISO)
human immunodeficiency virus infectious disease  (ISO)
hypothyroidism  (ISO)
invasive ductal carcinoma  (ISO)
Lewy body dementia  (ISO)
Malnutrition  (ISO)
middle cerebral artery infarction  (ISO)
mild cognitive impairment  (ISO)
multiple sclerosis  (ISO)
neuromyelitis optica  (ISO)
neuropathy  (ISO)
Neurosyphilis  (ISO)
Parkinson's disease  (ISO)
peripheral nervous system disease  (ISO)
progressive multifocal leukoencephalopathy  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
sciatic neuropathy  (ISO)
sensorineural hearing loss  (ISO)
Sepsis  (ISO)
Sepsis-Associated Encephalopathy  (ISO)
Sjogren's syndrome  (ISO)
Spinal Cord Injuries  (ISO)
spinal muscular atrophy  (ISO)
Sporadic Creutzfeldt-Jakob Disease  (ISO)
Stroke  (ISO)
syphilis  (ISO)
Talipes Cavus  (ISO)
transient cerebral ischemia  (ISO)
vascular dementia  (ISO)
Wallerian Degeneration  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Nefl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475820,062,685 - 20,068,609 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475820,063,109 - 20,068,459 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
NEFL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38824,950,955 - 24,956,612 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl824,950,955 - 24,956,721 (-)EnsemblGRCh38hg38GRCh38
GRCh37824,808,468 - 24,814,126 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36824,864,385 - 24,870,043 (-)NCBINCBI36Build 36hg18NCBI36
Build 34824,866,239 - 24,869,946NCBI
Celera823,772,893 - 23,778,556 (-)NCBICelera
Cytogenetic Map8p21.2NCBI
HuRef823,353,235 - 23,359,150 (-)NCBIHuRef
CHM1_1825,010,797 - 25,016,712 (-)NCBICHM1_1
T2T-CHM13v2.0825,226,443 - 25,232,101 (-)NCBIT2T-CHM13v2.0
Nefl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391468,321,312 - 68,326,544 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1468,321,312 - 68,326,544 (+)EnsemblGRCm39 Ensembl
GRCm381468,083,863 - 68,089,095 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1468,083,863 - 68,089,095 (+)EnsemblGRCm38mm10GRCm38
MGSCv371468,701,941 - 68,705,802 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361467,037,214 - 67,041,075 (+)NCBIMGSCv36mm8
Celera1465,851,013 - 65,854,872 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1435.46NCBI
Nefl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81546,477,330 - 46,481,203 (+)NCBIGRCr8
mRatBN7.21542,301,920 - 42,305,793 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1542,301,916 - 42,305,793 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1544,166,607 - 44,170,480 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01545,316,823 - 45,320,696 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01543,762,173 - 43,766,046 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01544,799,378 - 44,803,251 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1544,799,334 - 44,804,574 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01546,793,526 - 46,797,399 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41547,636,303 - 47,640,176 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11547,652,082 - 47,655,956 (+)NCBI
Celera1541,961,053 - 41,964,926 (+)NCBICelera
Cytogenetic Map15p12NCBI
Nefl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540347,946,353 - 47,952,026 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540347,946,413 - 47,951,734 (-)NCBIChiLan1.0ChiLan1.0
NEFL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2743,458,273 - 43,464,389 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1819,192,463 - 19,198,032 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0824,218,510 - 24,224,627 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1821,134,533 - 21,140,694 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl821,134,533 - 21,140,694 (-)Ensemblpanpan1.1panPan2
NEFL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12532,463,361 - 32,468,965 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2532,463,452 - 32,467,224 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2533,046,764 - 33,052,425 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02532,662,329 - 32,667,982 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2532,662,412 - 32,667,975 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12532,617,778 - 32,623,430 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02532,467,208 - 32,472,860 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02532,633,319 - 32,638,980 (+)NCBIUU_Cfam_GSD_1.0
Nefl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494310,389,433 - 10,393,833 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367571,642,222 - 1,645,697 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367571,642,122 - 1,646,499 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEFL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl148,991,331 - 8,997,112 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1148,991,321 - 8,996,900 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21410,087,492 - 10,093,071 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEFL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1823,077,085 - 23,083,213 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl823,077,086 - 23,083,222 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605219,090,237 - 19,096,168 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000024983   ⟹   ENSHGLP00000024761
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475820,062,685 - 20,068,609 (-)Ensembl
RefSeq Acc Id: XM_021261290   ⟹   XP_021116949
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475820,063,109 - 20,068,459 (-)NCBI
Protein Sequences
Protein RefSeqs XP_021116949 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB14271 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000024761
  ENSHGLP00000033707
RefSeq Acc Id: XP_021116949   ⟸   XM_021261290
- UniProtKB: G5BYB0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000024761   ⟸   ENSHGLT00000024983


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000017653 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000024983 ENTREZGENE
  ENSHGLT00000073598 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
  Single helix bin UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/TrEMBL
InterPro IF_conserved UniProtKB/TrEMBL
  IF_rod_dom UniProtKB/TrEMBL
  Intermed_filament_DNA-bd UniProtKB/TrEMBL
  Intermediate_filament UniProtKB/TrEMBL
NCBI Gene Nefl ENTREZGENE
PANTHER GLIAL FIBRILLARY ACIDIC PROTEIN UniProtKB/TrEMBL
  PTHR45652:SF8 UniProtKB/TrEMBL
Pfam Filament UniProtKB/TrEMBL
  Filament_head UniProtKB/TrEMBL
PROSITE IF_ROD_1 UniProtKB/TrEMBL
  IF_ROD_2 UniProtKB/TrEMBL
SMART Filament UniProtKB/TrEMBL
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/TrEMBL
UniProt G5BYB0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-30 Nefl  neurofilament light chain  Nefl  neurofilament light  Symbol and/or name change 5135510 APPROVED