Tigar (TP53 induced glycolysis regulatory phosphatase) - Rat Genome Database

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Gene: Tigar (TP53 induced glycolysis regulatory phosphatase) Heterocephalus glaber
Analyze
Symbol: Tigar
Name: TP53 induced glycolysis regulatory phosphatase
RGD ID: 18924334
Description: ENCODES a protein that exhibits catalytic activity (inferred); fructose-2,6-bisphosphate 2-phosphatase activity (inferred); hydrolase activity (inferred); INVOLVED IN cardiac muscle cell apoptotic process (ortholog); cellular response to cobalt ion (ortholog); cellular response to hypoxia (ortholog); ASSOCIATED WITH episodic ataxia type 1 (ortholog); Hyperphosphatemic Familial Tumoral Calcinosis 1 (ortholog); lymphoproliferative syndrome 2 (ortholog); FOUND IN cytoplasm (ortholog); mitochondrial outer membrane (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: fructose-2,6-bisphosphatase TIGAR
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248601,417,131 - 1,457,717 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248601,416,419 - 1,455,953 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Tigar
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248601,417,131 - 1,457,717 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248601,416,419 - 1,455,953 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TIGAR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38124,321,213 - 4,360,028 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl124,307,763 - 4,360,028 (+)EnsemblGRCh38hg38GRCh38
GRCh37124,430,379 - 4,469,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36124,300,620 - 4,339,455 (+)NCBINCBI36Build 36hg18NCBI36
Build 34124,300,631 - 4,332,599NCBI
Celera126,052,425 - 6,091,264 (+)NCBICelera
Cytogenetic Map12p13.32NCBI
HuRef124,287,018 - 4,325,825 (+)NCBIHuRef
CHM1_1124,429,992 - 4,468,805 (+)NCBICHM1_1
T2T-CHM13v2.0124,327,996 - 4,366,805 (+)NCBIT2T-CHM13v2.0
Tigar
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396127,062,079 - 127,086,564 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6127,062,079 - 127,086,520 (-)EnsemblGRCm39 Ensembl
GRCm386127,085,116 - 127,109,552 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6127,085,116 - 127,109,557 (-)EnsemblGRCm38mm10GRCm38
MGSCv376127,035,134 - 127,059,570 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366127,052,982 - 127,075,160 (-)NCBIMGSCv36mm8
MGSCv366127,984,031 - 128,005,972 (-)NCBIMGSCv36mm8
Celera6128,766,834 - 128,786,116 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map661.92NCBI
Tigar
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84161,613,306 - 161,632,248 (-)NCBIGRCr8
mRatBN7.24159,927,136 - 159,946,077 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl687,509,809 - 87,510,466 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl4159,927,139 - 159,946,029 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4166,156,946 - 166,175,860 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04161,939,848 - 161,958,766 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04160,573,896 - 160,592,815 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04159,635,145 - 159,654,108 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4159,635,153 - 159,654,063 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04231,948,786 - 231,966,869 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44163,481,393 - 163,502,412 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4148,642,195 - 148,661,115 (-)NCBICelera
Cytogenetic Map4q42NCBI
Tigar
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554132,129,678 - 2,154,380 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554132,129,719 - 2,153,873 (+)NCBIChiLan1.0ChiLan1.0
TIGAR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2109,860,833 - 9,893,058 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1129,857,630 - 9,896,658 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0124,429,945 - 4,462,142 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1124,353,272 - 4,386,758 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl124,353,272 - 4,385,380 (+)Ensemblpanpan1.1panPan2
TIGAR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12740,521,751 - 40,549,304 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2740,523,314 - 40,549,332 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha276,132,902 - 6,160,282 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02740,877,557 - 40,905,336 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2740,877,558 - 40,905,335 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12740,815,806 - 40,843,030 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02740,791,244 - 40,818,291 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,543,778 - 5,570,944 (+)NCBIUU_Cfam_GSD_1.0
Tigar
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945104,632,126 - 104,665,630 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366064,518,584 - 4,540,114 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366064,518,525 - 4,540,109 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIGAR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl566,044,686 - 66,067,377 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1566,044,679 - 66,067,571 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2568,266,609 - 68,289,947 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TIGAR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1114,354,911 - 4,381,762 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl114,355,053 - 4,381,273 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660633,861,799 - 3,888,740 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000006762   ⟹   ENSHGLP00000006680
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248601,417,131 - 1,457,717 (+)Ensembl
RefSeq Acc Id: XM_004869358   ⟹   XP_004869415
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248601,416,901 - 1,455,953 (+)NCBI
RefSeq Acc Id: XM_004869360   ⟹   XP_004869417
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248601,417,705 - 1,455,953 (+)NCBI
RefSeq Acc Id: XM_013067346   ⟹   XP_012922800
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248601,417,705 - 1,455,953 (+)NCBI
RefSeq Acc Id: XM_021248111   ⟹   XP_021103770
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248601,417,233 - 1,455,953 (+)NCBI
RefSeq Acc Id: XM_021248112   ⟹   XP_021103771
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248601,417,705 - 1,455,953 (+)NCBI
RefSeq Acc Id: XM_021248113   ⟹   XP_021103772
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248601,417,162 - 1,455,953 (+)NCBI
RefSeq Acc Id: XM_021248114   ⟹   XP_021103773
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248601,417,705 - 1,455,953 (+)NCBI
RefSeq Acc Id: XM_021248115   ⟹   XP_021103774
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248601,416,419 - 1,455,953 (+)NCBI
RefSeq Acc Id: XM_021248116   ⟹   XP_021103775
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248601,423,446 - 1,455,953 (+)NCBI
RefSeq Acc Id: XP_021103774   ⟸   XM_021248115
- Peptide Label: isoform X2
- UniProtKB: G5AS04 (UniProtKB/TrEMBL),   A0AAX6S493 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004869415   ⟸   XM_004869358
- Peptide Label: isoform X4
- UniProtKB: G5AS04 (UniProtKB/TrEMBL),   A0AAX6Q8F4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021103772   ⟸   XM_021248113
- Peptide Label: isoform X2
- UniProtKB: G5AS04 (UniProtKB/TrEMBL),   A0AAX6S493 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021103770   ⟸   XM_021248111
- Peptide Label: isoform X1
- UniProtKB: G5AS04 (UniProtKB/TrEMBL),   A0AAX6S3I2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021103773   ⟸   XM_021248114
- Peptide Label: isoform X2
- UniProtKB: G5AS04 (UniProtKB/TrEMBL),   A0AAX6S493 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012922800   ⟸   XM_013067346
- Peptide Label: isoform X3
- UniProtKB: G5AS04 (UniProtKB/TrEMBL),   A0AAX6QNC5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021103771   ⟸   XM_021248112
- Peptide Label: isoform X2
- UniProtKB: G5AS04 (UniProtKB/TrEMBL),   A0AAX6S493 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004869417   ⟸   XM_004869360
- Peptide Label: isoform X3
- UniProtKB: G5AS04 (UniProtKB/TrEMBL),   A0AAX6QNC5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021103775   ⟸   XM_021248116
- Peptide Label: isoform X2
- UniProtKB: G5AS04 (UniProtKB/TrEMBL),   A0AAX6S493 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000006680   ⟸   ENSHGLT00000006762


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000004878 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000006762 ENTREZGENE
Gene3D-CATH Phosphoglycerate mutase-like UniProtKB/TrEMBL
InterPro His_Pase_superF_clade-1 UniProtKB/TrEMBL
  His_PPase_superfam UniProtKB/TrEMBL
  PG/BPGM_mutase_AS UniProtKB/TrEMBL
  Phosphoglycerate_Mutase UniProtKB/TrEMBL
NCBI Gene Tigar ENTREZGENE
PANTHER FRUCTOSE-2,6-BISPHOSPHATASE TIGAR UniProtKB/TrEMBL
  FRUCTOSE-2,6-BISPHOSPHATASE TIGAR UniProtKB/TrEMBL
Pfam His_Phos_1 UniProtKB/TrEMBL
PROSITE PG_MUTASE UniProtKB/TrEMBL
SMART PGAM UniProtKB/TrEMBL
Superfamily-SCOP Phosphoglycerate mutase-like UniProtKB/TrEMBL
UniProt A0AAX6Q8F4 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QNC5 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6S3I2 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6S493 ENTREZGENE, UniProtKB/TrEMBL
  G5AS04 ENTREZGENE, UniProtKB/TrEMBL