Grk3 (G protein-coupled receptor kinase 3) - Rat Genome Database

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Gene: Grk3 (G protein-coupled receptor kinase 3) Heterocephalus glaber
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Symbol: Grk3
Name: G protein-coupled receptor kinase 3
RGD ID: 18924210
Description: ENCODES a protein that exhibits beta-adrenergic receptor kinase activity (ortholog); D1 dopamine receptor binding (ortholog); G protein-coupled receptor kinase activity (ortholog); INVOLVED IN desensitization of G protein-coupled receptor signaling pathway (ortholog); G protein-coupled receptor signaling pathway (ortholog); inositol phosphate metabolic process (ortholog); PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; calcium signaling pathway via the calcium-sensing receptor; corticotropin-releasing hormone signaling pathway; ASSOCIATED WITH bipolar disorder (ortholog); Cardiomegaly (ortholog); Cocaine-Related Disorders (ortholog); FOUND IN axon terminus (ortholog); dendrite terminus (ortholog); dendritic shaft (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: beta-adrenergic receptor kinase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247471,576,681 - 1,758,201 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247471,567,540 - 1,758,251 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Grk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247471,576,681 - 1,758,201 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247471,567,540 - 1,758,251 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
GRK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382225,564,675 - 25,729,294 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2225,564,675 - 25,729,294 (+)EnsemblGRCh38hg38GRCh38
GRCh372225,960,642 - 26,125,261 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362224,290,861 - 24,455,259 (+)NCBINCBI36Build 36hg18NCBI36
Build 342224,285,499 - 24,444,470NCBI
Celera229,765,035 - 9,929,436 (+)NCBICelera
Cytogenetic Map22q12.1ENTREZGENE
HuRef228,948,071 - 9,073,051 (+)NCBIHuRef
CHM1_12225,919,893 - 26,084,649 (+)NCBICHM1_1
T2T-CHM13v2.02226,025,826 - 26,190,440 (+)NCBIT2T-CHM13v2.0
Grk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395113,058,344 - 113,163,518 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5113,058,348 - 113,163,657 (-)EnsemblGRCm39 Ensembl
GRCm385112,910,478 - 113,015,660 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5112,910,482 - 113,015,791 (-)EnsemblGRCm38mm10GRCm38
MGSCv375113,339,498 - 113,444,534 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365113,150,781 - 113,255,817 (-)NCBIMGSCv36mm8
Celera5110,031,311 - 110,133,492 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.29NCBI
Grk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81249,285,228 - 49,395,803 (+)NCBIGRCr8
mRatBN7.21243,624,778 - 43,735,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,624,897 - 43,731,262 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1244,792,406 - 44,899,008 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01245,404,111 - 45,510,489 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01244,464,630 - 44,571,012 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01249,626,871 - 49,750,389 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1249,626,871 - 49,746,272 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01251,433,367 - 51,510,797 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1245,261,279 - 45,319,394 (+)NCBICelera
Cytogenetic Map12q16NCBI
Grk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544219,640,145 - 19,785,803 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544219,640,145 - 19,785,803 (-)NCBIChiLan1.0ChiLan1.0
GRK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22335,460,616 - 35,733,621 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12238,268,625 - 38,432,427 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0226,579,664 - 6,789,846 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12224,353,530 - 24,516,416 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2224,353,533 - 24,509,560 (+)Ensemblpanpan1.1panPan2
GRK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12619,385,059 - 19,512,528 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2619,385,058 - 19,516,077 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2619,249,805 - 19,382,153 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02619,749,680 - 19,882,193 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2619,749,732 - 19,878,611 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12619,454,629 - 19,586,996 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02619,720,438 - 19,852,665 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02619,789,809 - 19,922,140 (+)NCBIUU_Cfam_GSD_1.0
Grk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118115,345,722 - 115,443,919 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936657426,787 - 521,198 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936657425,902 - 522,331 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1443,224,930 - 43,442,965 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11443,305,255 - 43,445,626 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21446,128,694 - 46,270,654 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1198,438,543 - 8,601,652 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl198,438,380 - 8,600,359 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045117,529,573 - 117,694,607 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004843328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01026504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01026505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01026506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01026507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01026508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01026509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01026510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01026511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01026512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01026513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01026514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000021441   ⟹   ENSHGLP00000021237
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247471,576,681 - 1,758,201 (-)Ensembl
RefSeq Acc Id: XM_004843328   ⟹   XP_004843385
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247471,574,750 - 1,758,201 (-)NCBI
RefSeq Acc Id: XM_021257130   ⟹   XP_021112789
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247471,574,750 - 1,758,251 (-)NCBI
RefSeq Acc Id: XM_021257131   ⟹   XP_021112790
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247471,574,750 - 1,758,251 (-)NCBI
RefSeq Acc Id: XM_021257132   ⟹   XP_021112791
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247471,574,750 - 1,758,251 (-)NCBI
RefSeq Acc Id: XM_021257133   ⟹   XP_021112792
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247471,567,540 - 1,758,251 (-)NCBI
RefSeq Acc Id: XM_021257134   ⟹   XP_021112793
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247471,567,540 - 1,758,251 (-)NCBI
RefSeq Acc Id: XM_021257135   ⟹   XP_021112794
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247471,574,750 - 1,724,130 (-)NCBI
RefSeq Acc Id: XM_021257136   ⟹   XP_021112795
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247471,586,010 - 1,758,251 (-)NCBI
RefSeq Acc Id: XP_021112793   ⟸   XM_021257134
- Peptide Label: isoform X6
- UniProtKB: A0AAX6SWS4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112792   ⟸   XM_021257133
- Peptide Label: isoform X5
- UniProtKB: A0AAX6SY78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112791   ⟸   XM_021257132
- Peptide Label: isoform X4
- UniProtKB: A0AAX6SWS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112790   ⟸   XM_021257131
- Peptide Label: isoform X2
- UniProtKB: A0AAX6SWC2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112789   ⟸   XM_021257130
- Peptide Label: isoform X1
- UniProtKB: A0AAX6SVQ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004843385   ⟸   XM_004843328
- Peptide Label: isoform X3
- UniProtKB: A0AAX6P4K3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112794   ⟸   XM_021257135
- Peptide Label: isoform X7
- UniProtKB: A0AAX6SV98 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112795   ⟸   XM_021257136
- Peptide Label: isoform X8
- UniProtKB: A0AAX6SYH5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000021237   ⟸   ENSHGLT00000021441


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000015175 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000021441 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) UniProtKB/TrEMBL
  Regulator of G-protein Signalling 4, domain 2 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  GPCR_kinase UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
  RGS_sf UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Grk3 ENTREZGENE
PANTHER BETA-ADRENERGIC RECEPTOR KINASE 2 UniProtKB/TrEMBL
  G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
PRINTS GPCRKINASE UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
SMART RGS UniProtKB/TrEMBL
  S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  Protein kinase-like (PK-like) UniProtKB/TrEMBL
  Regulator of G-protein signaling, RGS UniProtKB/TrEMBL
UniProt A0AAX6P4K3 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SV98 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SVQ3 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SWC2 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SWS2 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SWS4 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SY78 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SYH5 ENTREZGENE, UniProtKB/TrEMBL