G6pd (glucose-6-phosphate dehydrogenase) - Rat Genome Database

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Gene: G6pd (glucose-6-phosphate dehydrogenase) Heterocephalus glaber
Analyze
Symbol: G6pd
Name: glucose-6-phosphate dehydrogenase
RGD ID: 18923445
Description: ENCODES a protein that exhibits carbohydrate binding (ortholog); D-glucose binding (ortholog); glucose-6-phosphate dehydrogenase activity (ortholog); INVOLVED IN angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure (ortholog); angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure (ortholog); cellular response to oxidative stress (ortholog); PARTICIPATES IN pentose phosphate pathway; pentose phosphate pathway - oxidative phase; ribose 5-phosphate isomerase deficiency pathway; ASSOCIATED WITH acute kidney failure (ortholog); adrenoleukodystrophy (ortholog); ALAD-Deficiency Porphyria (ortholog); FOUND IN centriolar satellite (ortholog); cytoplasmic side of plasma membrane (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: glucose-6-phosphate 1-dehydrogenase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624946986,107 - 1,001,955 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624946989,376 - 1,001,787 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
adrenoleukodystrophy  (ISO)
ALAD-Deficiency Porphyria  (ISO)
anemia  (ISO)
autistic disorder  (ISO)
autosomal hemophilia A  (ISO)
Barth syndrome  (ISO)
Bloch-Sulzberger syndrome  (ISO)
Brain Injuries  (ISO)
cataract  (ISO)
cerebral creatine deficiency syndrome 1  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
chronic granulomatous disease  (ISO)
congenital hemolytic anemia  (ISO)
congenital hypothyroidism  (ISO)
congenital nonspherocytic hemolytic anemia  (ISO)
congenital nonspherocytic hemolytic anemia 1  (ISO)
contact dermatitis  (ISO)
Coronary Disease  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
dyskeratosis congenita  (ISO)
ectodermal dysplasia and immune deficiency  (ISO)
ectodermal dysplasia and immunodeficiency 1  (ISO)
Emery-Dreifuss muscular dystrophy  (ISO)
Experimental Diabetes Mellitus  (ISO)
factor VIII deficiency  (ISO)
favism  (ISO)
Fever  (ISO)
genetic disease  (ISO)
glucosephosphate dehydrogenase deficiency  (ISO)
Hemolysis  (ISO)
hemolytic anemia  (ISO)
hepatic encephalopathy  (ISO)
hepatocellular carcinoma  (ISO)
Hypercholesterolemia  (ISO)
hyperhomocysteinemia  (ISO)
Hypertriglyceridemia  (ISO)
hypomelanosis of Ito  (ISO)
immunodeficiency 14  (ISO)
immunodeficiency 33  (ISO)
Insulin Resistance  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Liver Injury  (ISO)
malaria  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
metachromatic leukodystrophy  (ISO)
Multi-Infarct Dementia  (ISO)
myocardial infarction  (ISO)
Neonatal Hyperbilirubinemia  (ISO)
neonatal jaundice  (ISO)
obesity  (ISO)
paraplegia  (ISO)
periventricular nodular heterotopia  (ISO)
phagocyte bactericidal dysfunction  (ISO)
phenylketonuria  (ISO)
Plasmodium falciparum malaria  (ISO)
Pulmonary Hypertension, Hypoxia-Induced  (ISO)
renovascular hypertension  (ISO)
severe congenital encephalopathy due to MECP2 mutation  (ISO)
Splenomegaly  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
Testicular Injury  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
G6pd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624946986,107 - 1,001,955 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624946989,376 - 1,001,787 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
G6PD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X154,531,390 - 154,547,569 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX154,517,825 - 154,547,572 (-)EnsemblGRCh38hg38GRCh38
GRCh37X153,759,605 - 153,775,784 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,412,800 - 153,428,981 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X153,323,309 - 153,339,173NCBI
CeleraX153,920,654 - 153,936,836 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX142,336,102 - 142,352,295 (-)NCBIHuRef
CHM1_1X153,671,375 - 153,687,556 (-)NCBICHM1_1
T2T-CHM13v2.0X152,767,773 - 152,783,952 (-)NCBIT2T-CHM13v2.0
G6pdx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X73,453,089 - 73,472,486 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX73,453,089 - 73,472,800 (-)EnsemblGRCm39 Ensembl
GRCm38X74,409,483 - 74,428,880 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,409,483 - 74,429,194 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X71,654,825 - 71,674,500 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X70,662,206 - 70,681,881 (-)NCBIMGSCv36mm8
CeleraX65,663,679 - 65,683,364 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX38.0NCBI
G6pd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X157,352,364 - 157,372,144 (-)NCBIGRCr8
GRCr8 EnsemblX157,352,373 - 157,372,144 (-)EnsemblGRCr8 Ensembl
mRatBN7.2X152,201,081 - 152,220,863 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX152,201,098 - 152,220,801 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX154,342,199 - 154,361,983 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,905,010 - 157,924,794 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X155,577,228 - 155,597,010 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,274,800 - 156,293,935 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,274,800 - 156,293,926 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,015,532 - 152,034,676 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X160,186,450 - 160,192,316 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1135,676,941 - 135,696,556 (+)NCBICelera
Cytogenetic MapXq37NCBI
G6pd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555801,045,294 - 1,057,083 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555801,045,294 - 1,058,129 (-)NCBIChiLan1.0ChiLan1.0
G6PD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X154,505,413 - 154,521,575 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X154,509,020 - 154,525,182 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X143,972,798 - 143,988,960 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X153,843,092 - 153,860,675 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,843,092 - 153,860,674 (-)Ensemblpanpan1.1panPan2
G6PD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X122,217,317 - 122,231,862 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX122,205,683 - 122,231,678 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X125,358,989 - 125,373,645 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX125,346,698 - 125,373,679 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X121,127,964 - 121,142,608 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X123,643,041 - 123,657,679 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X123,404,813 - 123,419,460 (-)NCBIUU_Cfam_GSD_1.0
G6pd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,532,130 - 119,548,019 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368091,269,914 - 1,285,889 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368091,269,900 - 1,285,853 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
G6PD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX125,029,150 - 125,041,040 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X125,029,147 - 125,041,040 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X143,553,693 - 143,556,137 (+)NCBISscrofa10.2Sscrofa10.2susScr3
G6PD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,768,028 - 128,788,366 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,770,268 - 128,786,961 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606566,762,820 - 66,779,827 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000001499   ⟹   ENSHGLP00000001455
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624946986,107 - 1,001,955 (-)Ensembl
RefSeq Acc Id: XM_004875022   ⟹   XP_004875079
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624946989,376 - 1,001,787 (-)NCBI
RefSeq Acc Id: XM_004875025   ⟹   XP_004875082
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624946989,376 - 1,001,380 (-)NCBI
RefSeq Acc Id: XM_021252339   ⟹   XP_021107998
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624946989,376 - 1,000,989 (-)NCBI
RefSeq Acc Id: XM_021252340   ⟹   XP_021107999
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624946989,376 - 1,001,383 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004875079 (Get FASTA)   NCBI Sequence Viewer  
  XP_004875082 (Get FASTA)   NCBI Sequence Viewer  
  XP_021107998 (Get FASTA)   NCBI Sequence Viewer  
  XP_021107999 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000001455
RefSeq Acc Id: XP_004875079   ⟸   XM_004875022
- Peptide Label: isoform X1
- UniProtKB: A0AAX6QJZ8 (UniProtKB/TrEMBL),   G5BFL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021107999   ⟸   XM_021252340
- Peptide Label: isoform X3
- UniProtKB: A0AAX6SHE7 (UniProtKB/TrEMBL),   G5BFL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004875082   ⟸   XM_004875025
- Peptide Label: isoform X2
- UniProtKB: A0AAX6QG72 (UniProtKB/TrEMBL),   G5BFL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021107998   ⟸   XM_021252339
- Peptide Label: isoform X2
- UniProtKB: A0AAX6QG72 (UniProtKB/TrEMBL),   G5BFL5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000001455   ⟸   ENSHGLT00000001499


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000001124 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000001499 ENTREZGENE
Gene3D-CATH Dihydrodipicolinate Reductase, domain 2 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro G6P_DH UniProtKB/TrEMBL
  G6P_DH_AS UniProtKB/TrEMBL
  G6P_DH_C UniProtKB/TrEMBL
  G6P_DH_NAD-bd UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
KEGG Report hgl:101712640 UniProtKB/TrEMBL
NCBI Gene G6pd ENTREZGENE
PANTHER GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE UniProtKB/TrEMBL
  GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD UniProtKB/TrEMBL
Pfam G6PD_C UniProtKB/TrEMBL
  G6PD_N UniProtKB/TrEMBL
PIRSF G6PD UniProtKB/TrEMBL
PRINTS G6PDHDRGNASE UniProtKB/TrEMBL
PROSITE G6P_DEHYDROGENASE UniProtKB/TrEMBL
Superfamily-SCOP Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-fold domains UniProtKB/TrEMBL
UniProt A0AAX6QG72 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QJZ8 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SHE7 ENTREZGENE, UniProtKB/TrEMBL
  G5BFL5 ENTREZGENE, UniProtKB/TrEMBL