Hnrnpk (heterogeneous nuclear ribonucleoprotein K) - Rat Genome Database

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Gene: Hnrnpk (heterogeneous nuclear ribonucleoprotein K) Heterocephalus glaber
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Symbol: Hnrnpk
Name: heterogeneous nuclear ribonucleoprotein K
RGD ID: 18923333
Description: ENCODES a protein that exhibits actinin binding (ortholog); ATPase binding (ortholog); C-rich single-stranded DNA binding (ortholog); INVOLVED IN acute-phase response (ortholog); camera-type eye development (ortholog); cellular response to amino acid stimulus (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Au-Kline Syndrome (ortholog); brain disease (ortholog); FOUND IN axon terminus (ortholog); catalytic step 2 spliceosome (ortholog); cell cortex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248097,538,568 - 7,548,272 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (ISO)
camera-type eye development  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to forskolin  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to lead ion  (ISO)
cellular response to rapamycin  (ISO)
cerebellum development  (ISO)
cerebral cortex development  (ISO)
hippocampus development  (ISO)
kidney development  (ISO)
liver development  (ISO)
lung development  (ISO)
male gonad development  (ISO)
modulation of chemical synaptic transmission  (ISO)
mRNA processing  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of branching morphogenesis of a nerve  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of mRNA splicing, via spliceosome  (ISO)
negative regulation of protein binding  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
ovarian follicle development  (ISO)
peripheral nervous system development  (ISO)
positive regulation of dendrite extension  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of low-density lipoprotein particle clearance  (ISO)
positive regulation of myelination  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of protein localization to cell surface  (ISO)
positive regulation of RNA splicing  (ISO)
positive regulation of synapse maturation  (ISO)
positive regulation of synaptic transmission  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
random inactivation of X chromosome  (ISO)
regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
regulation of postsynapse organization  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulatory ncRNA-mediated heterochromatin formation  (ISO)
response to activity  (ISO)
response to salt  (ISO)
RNA splicing  (IEA)
thymus development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Hnrnpk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248097,538,568 - 7,548,272 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
HNRNPK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38983,968,083 - 83,980,615 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl983,968,083 - 83,980,631 (-)EnsemblGRCh38hg38GRCh38
GRCh37986,582,998 - 86,595,530 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36985,772,912 - 85,785,339 (-)NCBINCBI36Build 36hg18NCBI36
Build 34983,812,645 - 83,824,636NCBI
Celera957,154,011 - 57,166,581 (-)NCBICelera
Cytogenetic Map9q21.32NCBI
HuRef956,408,631 - 56,421,199 (-)NCBIHuRef
CHM1_1986,729,595 - 86,742,166 (-)NCBICHM1_1
T2T-CHM13v2.0996,118,364 - 96,130,896 (-)NCBIT2T-CHM13v2.0
Hnrnpk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391358,538,946 - 58,551,157 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1358,538,956 - 58,551,157 (-)EnsemblGRCm39 Ensembl
GRCm381358,391,132 - 58,403,343 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1358,391,142 - 58,403,343 (-)EnsemblGRCm38mm10GRCm38
MGSCv371358,493,312 - 58,503,877 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361358,401,574 - 58,412,139 (-)NCBIMGSCv36mm8
Celera1359,454,314 - 59,464,879 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1331.04NCBI
Hnrnpk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8176,269,302 - 6,280,429 (+)NCBIGRCr8
mRatBN7.2176,262,936 - 6,275,001 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl176,262,998 - 6,274,997 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx176,288,534 - 6,297,617 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0177,821,878 - 7,830,965 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,284,906 - 6,293,989 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0176,664,730 - 6,676,753 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl176,665,659 - 6,676,654 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0178,868,934 - 8,881,126 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41712,196,630 - 12,205,720 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11712,196,629 - 12,205,720 (+)NCBI
Celera176,375,531 - 6,384,621 (+)NCBICelera
Cytogenetic Map17p14NCBI
Hnrnpk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554323,246,092 - 3,257,774 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554323,246,090 - 3,257,774 (+)NCBIChiLan1.0ChiLan1.0
HNRNPK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21183,127,645 - 83,139,337 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1983,133,588 - 83,145,280 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0940,898,593 - 40,911,159 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1983,324,235 - 83,336,884 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl983,324,238 - 83,336,756 (-)Ensemblpanpan1.1panPan2
HNRNPK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1175,499,334 - 75,511,525 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl175,499,393 - 75,511,425 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha176,149,689 - 76,161,319 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0175,800,635 - 75,812,819 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl175,800,674 - 75,812,816 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1175,615,073 - 75,626,694 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0175,377,881 - 75,389,506 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0176,080,753 - 76,092,378 (+)NCBIUU_Cfam_GSD_1.0
Hnrnpk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947122,185,614 - 122,197,809 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936828828,837 - 838,720 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936828827,660 - 839,088 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNRNPK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1030,975,702 - 30,987,956 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11030,975,639 - 30,987,955 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21035,102,731 - 35,115,113 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HNRNPK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11294,768,403 - 94,789,957 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1294,768,480 - 94,789,743 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603883,198,762 - 83,211,203 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_004862473   ⟹   XP_004862530
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248097,538,568 - 7,548,271 (-)NCBI
RefSeq Acc Id: XM_021242597   ⟹   XP_021098256
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248097,538,568 - 7,547,862 (-)NCBI
RefSeq Acc Id: XM_021242598   ⟹   XP_021098257
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248097,538,568 - 7,547,791 (-)NCBI
RefSeq Acc Id: XM_021242599   ⟹   XP_021098258
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248097,538,568 - 7,547,627 (-)NCBI
RefSeq Acc Id: XM_021242600   ⟹   XP_021098259
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248097,538,568 - 7,547,275 (-)NCBI
RefSeq Acc Id: XM_021242601   ⟹   XP_021098260
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248097,538,568 - 7,548,272 (-)NCBI
RefSeq Acc Id: XP_021098260   ⟸   XM_021242601
- Peptide Label: isoform X2
- UniProtKB: A0AAX6RSF3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004862530   ⟸   XM_004862473
- Peptide Label: isoform X1
- UniProtKB: G5ARM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098256   ⟸   XM_021242597
- Peptide Label: isoform X1
- UniProtKB: G5ARM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098257   ⟸   XM_021242598
- Peptide Label: isoform X1
- UniProtKB: G5ARM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098258   ⟸   XM_021242599
- Peptide Label: isoform X1
- UniProtKB: G5ARM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098259   ⟸   XM_021242600
- Peptide Label: isoform X1
- UniProtKB: G5ARM9 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000017317 ENTREZGENE
Ensembl Transcript ENSHGLT00000024515 ENTREZGENE
  ENSHGLT00000024516 ENTREZGENE
  ENSHGLT00000024517 ENTREZGENE
Gene3D-CATH 3.30.1370.10 UniProtKB/TrEMBL
InterPro KH_dom UniProtKB/TrEMBL
  KH_dom_type_1 UniProtKB/TrEMBL
  KH_dom_type_1_sf UniProtKB/TrEMBL
  ROK_N UniProtKB/TrEMBL
NCBI Gene Hnrnpk ENTREZGENE
PANTHER KH DOMAIN CONTAINING RNA BINDING PROTEIN UniProtKB/TrEMBL
Pfam KH_1 UniProtKB/TrEMBL
  ROKNT UniProtKB/TrEMBL
PROSITE KH_TYPE_1 UniProtKB/TrEMBL
SMART SM00322 UniProtKB/TrEMBL
Superfamily-SCOP SSF54791 UniProtKB/TrEMBL
UniProt A0AAX6RSF3 ENTREZGENE, UniProtKB/TrEMBL
  G5ARM9 ENTREZGENE, UniProtKB/TrEMBL