Nelfe (negative elongation factor complex member E) - Rat Genome Database

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Gene: Nelfe (negative elongation factor complex member E) Heterocephalus glaber
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Symbol: Nelfe
Name: negative elongation factor complex member E
RGD ID: 18923152
Description: ENCODES a protein that exhibits chromatin binding (ortholog); mRNA binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); negative regulation of transcription elongation by RNA polymerase II (ortholog); positive regulation of ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH proteasome-associated autoinflammatory syndrome 1 (ortholog); trichohepatoenteric syndrome (ortholog); FOUND IN chromatin (ortholog); nuclear body (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: negative elongation factor E
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,300,602 - 24,310,671 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,300,012 - 24,310,777 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Nelfe
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,300,602 - 24,310,671 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,300,012 - 24,310,777 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
NELFE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,952,087 - 31,958,971 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,952,087 - 31,959,038 (-)EnsemblGRCh38hg38GRCh38
GRCh37631,919,864 - 31,926,748 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,027,843 - 32,034,843 (-)NCBINCBI36Build 36hg18NCBI36
Build 34632,027,843 - 32,034,747NCBI
Celera633,519,627 - 33,526,530 (-)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,706,833 - 31,713,834 (-)NCBIHuRef
CHM1_1631,921,945 - 31,928,945 (-)NCBICHM1_1
T2T-CHM13v2.0631,805,292 - 31,812,176 (-)NCBIT2T-CHM13v2.0
Nelfe
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,069,367 - 35,075,348 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,069,367 - 35,075,348 (+)EnsemblGRCm39 Ensembl
GRCm381734,850,391 - 34,856,372 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,850,391 - 34,856,372 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,987,336 - 34,993,317 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,458,975 - 34,464,214 (+)NCBIMGSCv36mm8
Celera1737,945,699 - 37,951,680 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.4NCBI
Nelfe
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,981,259 - 3,987,016 (-)NCBIGRCr8
mRatBN7.2203,976,512 - 3,982,389 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,976,518 - 3,982,355 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,676,633 - 4,682,383 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,038,381 - 4,044,131 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,575,547 - 4,581,290 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,530,328 - 4,536,085 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,530,342 - 4,536,209 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,610,127 - 6,615,884 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,077,925 - 4,081,561 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,078,021 - 4,081,787 (-)NCBI
Celera204,048,306 - 4,054,061 (+)NCBICelera
Cytogenetic Map20p12NCBI
Nelfe
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437466,690 - 473,084 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955437467,018 - 473,084 (-)NCBIChiLan1.0ChiLan1.0
NELFE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,428,781 - 46,435,590 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,390,268 - 42,397,077 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,612,924 - 31,619,732 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,499,538 - 32,506,382 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,499,540 - 32,506,382 (-)Ensemblpanpan1.1panPan2
NELFE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,406,411 - 1,412,387 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,406,271 - 1,412,324 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,541,468 - 1,547,598 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,548,568 - 1,554,700 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,548,568 - 1,554,605 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,405,843 - 1,411,974 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,474,213 - 1,480,345 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,539,542 - 1,546,943 (-)NCBIUU_Cfam_GSD_1.0
Nelfe
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,965,333 - 35,971,346 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367271,589,942 - 1,598,182 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367271,589,942 - 1,596,009 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NELFE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl724,040,525 - 24,047,025 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1724,040,525 - 24,046,932 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,765,281 - 27,771,676 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NELFE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,063,298 - 40,069,714 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1740,063,755 - 40,198,451 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604431,868,805 - 31,875,524 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000023506   ⟹   ENSHGLP00000023290
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475424,300,602 - 24,310,671 (+)Ensembl
RefSeq Acc Id: XM_021259444   ⟹   XP_021115103
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475424,300,012 - 24,310,777 (+)NCBI
Protein Sequences
Protein RefSeqs XP_021115103 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000023290
RefSeq Acc Id: XP_021115103   ⟸   XM_021259444
- UniProtKB: A0AAX6T3N2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000023290   ⟸   ENSHGLT00000023506


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000016601 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000023506 ENTREZGENE
NCBI Gene Nelfe ENTREZGENE
UniProt A0AAX6T3N2 ENTREZGENE, UniProtKB/TrEMBL