Calr (calreticulin) - Rat Genome Database

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Gene: Calr (calreticulin) Heterocephalus glaber
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Symbol: Calr
Name: calreticulin
RGD ID: 18922029
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); complement component C1q complex binding (ortholog); hormone binding (ortholog); INVOLVED IN cardiac muscle cell differentiation (ortholog); cellular response to electrical stimulus (ortholog); cellular response to lithium ion (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); Aicardi-Goutieres Syndrome 4 (ortholog); alpha-mannosidosis (ortholog); FOUND IN acrosomal vesicle (ortholog); cell surface (ortholog); collagen-containing extracellular matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624901511,052 - 516,757 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624901511,295 - 515,208 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac muscle cell differentiation  (ISO)
cellular response to electrical stimulus  (ISO)
cellular response to lithium ion  (ISO)
cellular response to virus  (ISO)
cellular senescence  (ISO)
cortical actin cytoskeleton organization  (ISO)
ERAD pathway  (IEA)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of intracellular steroid hormone receptor signaling pathway  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of retinoic acid receptor signaling pathway  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of translation  (ISO)
negative regulation of trophoblast cell migration  (ISO)
peptide antigen assembly with MHC class I protein complex  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of dendritic cell chemotaxis  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of phagocytosis  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
protein export from nucleus  (ISO)
protein folding  (IEA)
protein localization to nucleus  (ISO)
protein maturation  (ISO)
protein stabilization  (ISO)
regulation of meiotic nuclear division  (ISO)
response to biphenyl  (ISO)
response to estradiol  (ISO)
response to glycoside  (ISO)
response to peptide  (ISO)
response to testosterone  (ISO)
response to xenobiotic stimulus  (ISO)
spermatogenesis  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Calr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624901511,052 - 516,757 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624901511,295 - 515,208 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
CALR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,938,609 - 12,944,489 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1912,938,578 - 12,944,489 (+)EnsemblGRCh38hg38GRCh38
GRCh371913,049,423 - 13,055,303 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,910,423 - 12,916,303 (+)NCBINCBI36Build 36hg18NCBI36
Build 341912,910,422 - 12,916,303NCBI
Celera1912,939,147 - 12,945,035 (+)NCBICelera
Cytogenetic Map19p13.13NCBI
HuRef1912,621,315 - 12,627,203 (+)NCBIHuRef
CHM1_11913,049,914 - 13,055,824 (+)NCBICHM1_1
T2T-CHM13v2.01913,063,097 - 13,068,974 (+)NCBIT2T-CHM13v2.0
Calr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,568,717 - 85,573,560 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl885,568,479 - 85,573,563 (-)EnsemblGRCm39 Ensembl
GRCm38884,842,088 - 84,846,931 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,841,850 - 84,846,934 (-)EnsemblGRCm38mm10GRCm38
MGSCv37887,365,987 - 87,370,830 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36887,731,955 - 87,736,972 (-)NCBIMGSCv36mm8
Celera889,141,243 - 89,146,089 (-)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.21NCBI
Calr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81940,213,367 - 40,218,262 (+)NCBIGRCr8
mRatBN7.21923,308,525 - 23,313,420 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,308,351 - 23,313,414 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,131,431 - 30,136,323 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01930,785,793 - 30,790,685 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01933,008,476 - 33,013,368 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01925,956,771 - 25,961,666 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,956,771 - 25,961,666 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,932,394 - 36,937,289 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,964,775 - 24,969,670 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11924,969,631 - 24,974,494 (+)NCBI
Celera1922,865,445 - 22,870,340 (+)NCBICelera
Cytogenetic Map19q11NCBI
Calr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,985,147 - 31,989,372 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541531,985,147 - 31,989,372 (+)NCBIChiLan1.0ChiLan1.0
CALR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22017,867,887 - 17,873,926 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11916,868,542 - 16,874,580 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01912,501,013 - 12,506,909 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11913,242,900 - 13,249,416 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,242,900 - 13,249,416 (+)Ensemblpanpan1.1panPan2
CALR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,251,390 - 49,255,291 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2049,251,777 - 49,255,245 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,123,639 - 49,127,542 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02049,768,253 - 49,772,156 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2049,768,253 - 49,772,135 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12048,979,448 - 48,983,351 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02049,405,934 - 49,409,839 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,648,459 - 49,652,362 (-)NCBIUU_Cfam_GSD_1.0
Calr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,355,637 - 208,360,018 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,994,648 - 1,999,430 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366591,994,695 - 1,999,070 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl266,098,229 - 66,102,132 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1266,098,263 - 66,102,074 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,283,767 - 66,287,604 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CALR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1611,618,691 - 11,624,299 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl611,618,396 - 11,623,792 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660748,162,943 - 8,168,575 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000012842   ⟹   ENSHGLP00000012705
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624901511,052 - 516,757 (+)Ensembl
RefSeq Acc Id: XM_004872406   ⟹   XP_004872463
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624901511,295 - 515,208 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004872463 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000012705
GenBank Protein JAN96853 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004872463   ⟸   XM_004872406
- UniProtKB: A0A0N8ESM3 (UniProtKB/TrEMBL),   G5BYW1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000012705   ⟸   ENSHGLT00000012842


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000009088 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000012842 ENTREZGENE
Gene3D-CATH 2.10.250.10 UniProtKB/TrEMBL
  2.60.120.200 UniProtKB/TrEMBL
  Helix hairpin bin UniProtKB/TrEMBL
InterPro Calret/calnex UniProtKB/TrEMBL
  Calret/calnex_CS UniProtKB/TrEMBL
  Calreticulin UniProtKB/TrEMBL
  Calreticulin/calnexin_P_dom_sf UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/TrEMBL
KEGG Report hgl:101719263 UniProtKB/TrEMBL
NCBI Gene Calr ENTREZGENE
PANTHER CALRETICULIN UniProtKB/TrEMBL
  PTHR11073 UniProtKB/TrEMBL
Pfam Calreticulin UniProtKB/TrEMBL
PIRSF Calreticulin UniProtKB/TrEMBL
PRINTS CALRETICULIN UniProtKB/TrEMBL
PROSITE CALRETICULIN_1 UniProtKB/TrEMBL
  CALRETICULIN_2 UniProtKB/TrEMBL
  CALRETICULIN_REPEAT UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/TrEMBL
  SSF63887 UniProtKB/TrEMBL
UniProt A0A0N8ESM3 ENTREZGENE, UniProtKB/TrEMBL
  G5BYW1 ENTREZGENE, UniProtKB/TrEMBL