Gla (galactosidase alpha) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Gla (galactosidase alpha) Heterocephalus glaber
Analyze
Symbol: Gla
Name: galactosidase alpha
RGD ID: 18918880
Description: ENCODES a protein that exhibits alpha-galactosidase activity (ortholog); catalytic activity (ortholog); galactoside binding (ortholog); INVOLVED IN aorta development (ortholog); bone mineralization (ortholog); glycosphingolipid catabolic process (ortholog); PARTICIPATES IN Fabry disease pathway; galactose metabolic pathway; galactosemia pathway; ASSOCIATED WITH angiokeratoma (ortholog); autistic disorder (ortholog); autosomal hemophilia A (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog); Golgi apparatus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alpha-galactosidase A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249021,163,611 - 1,173,177 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249021,163,360 - 1,173,087 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Gla
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249021,163,611 - 1,173,177 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249021,163,360 - 1,173,087 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
GLA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X101,397,803 - 101,407,925 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX101,393,273 - 101,408,012 (-)EnsemblGRCh38hg38GRCh38
GRCh37X100,652,791 - 100,662,913 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X100,539,435 - 100,549,657 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X100,458,941 - 100,469,096NCBI
CeleraX101,172,239 - 101,182,459 (-)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX90,459,075 - 90,468,889 (-)NCBIHuRef
CHM1_1X100,546,260 - 100,556,479 (-)NCBICHM1_1
T2T-CHM13v2.0X99,841,918 - 99,852,040 (-)NCBIT2T-CHM13v2.0
Gla
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X133,488,912 - 133,501,707 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX133,488,898 - 133,501,874 (-)EnsemblGRCm39 Ensembl
GRCm38X134,588,169 - 134,601,005 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX134,588,149 - 134,601,125 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X131,122,708 - 131,135,544 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X129,934,706 - 129,947,305 (-)NCBIMGSCv36mm8
CeleraX117,467,753 - 117,480,561 (-)NCBICelera
Cytogenetic MapXE3NCBI
cM MapX56.2NCBI
Gla
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X102,062,497 - 102,073,915 (-)NCBIGRCr8
mRatBN7.2X97,769,227 - 97,780,646 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX97,768,996 - 97,780,664 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX99,443,442 - 99,454,860 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X102,954,152 - 102,965,578 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X100,456,591 - 100,468,010 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X105,405,915 - 105,417,331 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX105,406,792 - 105,417,323 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X105,295,029 - 105,306,686 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X122,044,703 - 122,056,327 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX98,809,769 - 98,821,187 (-)NCBICelera
Cytogenetic MapXq32NCBI
Gla
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555037,521,930 - 7,535,817 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555037,526,077 - 7,535,817 (-)NCBIChiLan1.0ChiLan1.0
GLA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X100,997,182 - 101,007,409 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X101,000,787 - 101,010,979 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X90,600,412 - 90,610,594 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X100,732,311 - 100,742,280 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX100,732,311 - 100,742,280 (-)Ensemblpanpan1.1panPan2
GLA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X75,311,536 - 75,320,391 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX75,311,536 - 75,320,249 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X76,731,752 - 76,740,708 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX76,731,752 - 76,740,486 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X74,296,077 - 74,305,030 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X75,956,280 - 75,965,243 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X75,718,710 - 75,727,662 (-)NCBIUU_Cfam_GSD_1.0
Gla
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X62,990,371 - 63,000,657 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936813474,949 - 484,760 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936813474,938 - 484,753 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX83,023,903 - 83,032,570 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X83,024,582 - 83,032,273 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GLA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X89,738,097 - 89,749,740 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX89,737,966 - 89,750,539 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606514,657,735 - 14,667,684 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000002179   ⟹   ENSHGLP00000002131
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046249021,163,611 - 1,173,177 (+)Ensembl
RefSeq Acc Id: XM_004872567   ⟹   XP_004872624
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046249021,163,529 - 1,173,087 (+)NCBI
RefSeq Acc Id: XM_004872568   ⟹   XP_004872625
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046249021,163,525 - 1,173,087 (+)NCBI
RefSeq Acc Id: XM_004872569   ⟹   XP_004872626
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046249021,163,360 - 1,173,087 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004872624 (Get FASTA)   NCBI Sequence Viewer  
  XP_004872625 (Get FASTA)   NCBI Sequence Viewer  
  XP_004872626 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000002131
RefSeq Acc Id: XP_004872626   ⟸   XM_004872569
- Peptide Label: isoform X3
- UniProtKB: A0AAX6QGI0 (UniProtKB/TrEMBL),   G5C2S8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004872625   ⟸   XM_004872568
- Peptide Label: isoform X2
- UniProtKB: A0AAX6QC55 (UniProtKB/TrEMBL),   G5C2S8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004872624   ⟸   XM_004872567
- Peptide Label: isoform X1
- UniProtKB: A0AAX6QCD7 (UniProtKB/TrEMBL),   G5C2S8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000002131   ⟸   ENSHGLT00000002179


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000001617 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000002179 ENTREZGENE
Gene3D-CATH Aldolase class I UniProtKB/TrEMBL
  Golgi alpha-mannosidase II UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/TrEMBL
  Glyco_hydro_27 UniProtKB/TrEMBL
  Glyco_hydro_27/36_CS UniProtKB/TrEMBL
  Glyco_hydro_b UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/TrEMBL
  Melibiase/NAGA_C UniProtKB/TrEMBL
NCBI Gene Gla ENTREZGENE
PANTHER ALPHA-GALACTOSIDASE A UniProtKB/TrEMBL
  ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE UniProtKB/TrEMBL
Pfam Melibiase_2 UniProtKB/TrEMBL
  Melibiase_2_C UniProtKB/TrEMBL
PRINTS GLHYDRLASE27 UniProtKB/TrEMBL
PROSITE ALPHA_GALACTOSIDASE UniProtKB/TrEMBL
Superfamily-SCOP (Trans)glycosidases UniProtKB/TrEMBL
  Glycosyl hydrolase domain UniProtKB/TrEMBL
UniProt A0AAX6QC55 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QCD7 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QGI0 ENTREZGENE, UniProtKB/TrEMBL
  G5C2S8 ENTREZGENE, UniProtKB/TrEMBL